Strain Name:
C57BL/6J-MtgxR0967Btlr/Mmmh
Stock Number:
039096-MU
Citation ID:
RRID:MMRRC_039096-MU
Other Names:
R0967 (G1), C57BL/6J-MtgxR0967Btlr
Major Collection:

Gene Information

Hgf
Name: hepatocyte growth factor
Synonyms: NK1, NK2, HGF/SF, C230052L06Rik, scatter factor, SF/HGF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 15234
HGNC: HGNC:4893
Homologene: 503
Rubcn
Name: RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein
Synonyms: 1700021K19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 100502698
Homologene: 15687
Rfx3
Name: regulatory factor X, 3 (influences HLA class II expression)
Synonyms: C230093O12Rik, MRFX3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 19726
HGNC: HGNC:9984
Homologene: 7917
Usp7
Name: ubiquitin specific peptidase 7
Synonyms: 2210010O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 252870
Homologene: 2592
Camk1g
Name: calcium/calmodulin-dependent protein kinase I gamma
Synonyms: CaMKIgamma, CLICK-III
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 215303
Homologene: 48706
Scn8a
Name: sodium channel, voltage-gated, type VIII, alpha
Synonyms: C630029C19Rik, nur14, NaCh6, med, seal, motor end-plate disease, nmf2, mnd-2, mnd2, NMF335, ataxia 3, nmf335, Nav1.6, nmf58
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 20273
Homologene: 7927
Gse1
Name: genetic suppressor element 1, coiled-coil protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 382034
Homologene: 40964
Zc3h13
Name: zinc finger CCCH type containing 13
Synonyms: 2600010B19Rik, 3110050K21Rik, 4930570G11Rik, C87618
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 67302
VEGA: 14
Chd9
Name: chromodomain helicase DNA binding protein 9
Synonyms: 9030205D12Rik, 1810014J18Rik, AD013, A330063D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 109151
Homologene: 11844
Hsd17b4
Name: hydroxysteroid (17-beta) dehydrogenase 4
Synonyms: perMFE-2, MFE-2, multifunctional protein 2, MFP2, 17[b]-HSD, Mfp-2, D-bifunctional protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 15488
HGNC: HGNC:5213
Homologene: 358
Med21
Name: mediator complex subunit 21
Synonyms: Surb7, D6Ertd782e, Srb7, 0610007L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 108098
Homologene: 3148
Hif1a
Name: hypoxia inducible factor 1, alpha subunit
Synonyms: MOP1, HIF1alpha, HIF-1alpha, bHLHe78
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 15251
HGNC: HGNC:4910
Homologene: 1171
Prpf8
Name: pre-mRNA processing factor 8
Synonyms: Sfprp8l, Prp8, DBF3/PRP8, D11Bwg0410e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 192159
Homologene: 4706
Cndp1
Name: carnosine dipeptidase 1 (metallopeptidase M20 family)
Synonyms: Cn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 338403
Homologene: 57178
Lgr6
Name: leucine-rich repeat-containing G protein-coupled receptor 6
Synonyms: A530037C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 329252
Homologene: 49680
Cyc1
Name: cytochrome c-1
Synonyms: Cyct1, 2610002H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 66445
VEGA: 15
HGNC: HGNC:2579
Homologene: 55617
Sec24b
Name: Sec24 related gene family, member B (S. cerevisiae)
Synonyms: SEC24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 99683
Homologene: 55968
Plagl1
Name: pleiomorphic adenoma gene-like 1
Synonyms: Zac1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 22634
HGNC: HGNC:9046
Homologene: 31401
Fli1
Name: Friend leukemia integration 1
Synonyms: EWSR2, Sic1, SIC-1, Fli-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 14247
HGNC: HGNC:3749
Homologene: 55624
Mttp
Name: microsomal triglyceride transfer protein
Synonyms: MTP, 1810043K16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 17777
HGNC: HGNC:7467
Homologene: 212
Hsh2d
Name: hematopoietic SH2 domain containing
Synonyms: ALX, Hsh2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 209488
Homologene: 13142
Kif5c
Name: kinesin family member 5C
Synonyms: Khc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 16574
HGNC: HGNC:6325
Homologene: 56234
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 239420
Homologene: 65982
Vmn2r70
Name: vomeronasal 2, receptor 70
Synonyms: EG620835
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 670940
Homologene: 115466
Olfr205
Name: olfactory receptor 205
Synonyms: GA_x54KRFPKG5P-55543875-55542958, MOR182-11P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 257881
Homologene: 79469
Ripk4
Name: receptor-interacting serine-threonine kinase 4
Synonyms: Ankrd3, DIk, PKK, RIP4, ANKK2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 72388
HGNC: HGNC:496
Homologene: 10772
Adamts19
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 19
Synonyms: D230034E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 240322
VEGA: 18
Homologene: 15860
Ssc5d
Name: scavenger receptor cysteine rich family, 5 domains
Synonyms: A430110N23Rik, s5d-srcrb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 269855
Homologene: 77555
Ms4a15
Name: membrane-spanning 4-domains, subfamily A, member 15
Synonyms: Gm1286, LOC383468, E530011F12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 545279
Homologene: 27391
Rassf8
Name: Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
Synonyms: mHoj-1, 5133400D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 71323
Homologene: 5219
Rars2
Name: arginyl-tRNA synthetase 2, mitochondrial
Synonyms: Rarsl, 1500002I10Rik, PRO1992
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 109093
Homologene: 5707
Olfr718-ps1
Name: olfactory receptor 718, pseudogene 1
Synonyms: GA_x6K02T2PH54-2346206-2347174, MOR0-10P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 258006
Ccrl2
Name: chemokine (C-C motif) receptor-like 2
Synonyms: Ackr5, 1810047I05Rik, L-CCR, Cmkbr1l2, CCR11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 54199
HGNC: HGNC:1612
Homologene: 2948
Atxn7l3
Name: ataxin 7-like 3
Synonyms: E030022H21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217218
Homologene: 35401
Vmn2r81
Name: vomeronasal 2, receptor 81
Synonyms: V2rf2, pheromone recepter, EC1-VR2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 216144
Homologene: 83483
Cplane2
Name: ciliogenesis and planar polarity effector 2
Synonyms: LOC279260, Rsg1, b2b2804Clo, b2b2827Clo, 6330545A04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 76166
Homologene: 12793
Olfr503
Name: olfactory receptor 503
Synonyms: MOR34-9, MOR34-9, Olfr1548, MOR34-12, GA_x6K02T2PBJ9-10874315-10875286, MOR34-8P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 259143
Homologene: 121509
Vmn2r51
Name: vomeronasal 2, receptor 51
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 100042921
Homologene: 113703
Mos
Name: Moloney sarcoma oncogene
Synonyms: c-mos
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 17451
HGNC: HGNC:7199
Homologene: 3919
Gk2
Name: glycerol kinase 2
Synonyms: Gk-rs2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 14626
HGNC: HGNC:4291
Homologene: 133273
Lpcat2b
Name: lysophosphatidylcholine acyltransferase 2B
Synonyms: Aytl1b, 4921521K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 70902
Homologene: 86793
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 134,994,012 bp
  • T to C, chromosome 1 at 193,350,296 bp
  • T to A, chromosome 2 at 49,698,116 bp
  • C to T, chromosome 3 at 129,996,782 bp
  • A to G, chromosome 3 at 138,092,723 bp
  • A to G, chromosome 4 at 3,870,932 bp
  • A to G, chromosome 4 at 34,646,587 bp
  • T to C, chromosome 4 at 141,219,851 bp
  • T to A, chromosome 5 at 16,593,841 bp
  • T to C, chromosome 5 at 97,456,296 bp
  • T to A, chromosome 5 at 107,434,218 bp
  • A to G, chromosome 5 at 143,137,839 bp
  • T to C, chromosome 6 at 145,819,950 bp
  • A to G, chromosome 6 at 146,650,199 bp
  • T to A, chromosome 7 at 4,944,343 bp
  • T to G, chromosome 7 at 10,100,085 bp
  • A to G, chromosome 7 at 85,559,619 bp
  • T to C, chromosome 7 at 108,544,789 bp
  • G to A, chromosome 8 at 72,200,460 bp
  • T to C, chromosome 8 at 90,989,479 bp
  • T to A, chromosome 8 at 120,570,855 bp
  • T to A, chromosome 9 at 32,461,449 bp
  • G to A, chromosome 9 at 111,055,686 bp
  • T to C, chromosome 10 at 13,128,242 bp
  • T to C, chromosome 10 at 79,248,023 bp
  • T to A, chromosome 11 at 75,494,430 bp
  • C to G, chromosome 11 at 102,292,435 bp
  • G to A, chromosome 12 at 73,937,670 bp
  • T to C, chromosome 14 at 75,343,739 bp
  • T to C, chromosome 15 at 47,857,831 bp
  • T to C, chromosome 15 at 76,345,648 bp
  • A to G, chromosome 15 at 101,035,646 bp
  • A to T, chromosome 16 at 8,696,654 bp
  • C to A, chromosome 16 at 32,825,717 bp
  • T to A, chromosome 16 at 59,329,183 bp
  • A to T, chromosome 16 at 97,744,172 bp
  • C to A, chromosome 18 at 50,183,261 bp
  • G to T, chromosome 18 at 58,972,740 bp
  • G to A, chromosome 18 at 84,634,652 bp
  • A to T, chromosome 19 at 10,979,321 bp
  • A to G, chromosome 19 at 27,806,351 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0967 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039096-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.