Strain Name:
C57BL/6J-MtgxR0969Btlr/Mmmh
Stock Number:
039098-MU
Citation ID:
RRID:MMRRC_039098-MU
Other Names:
R0969 (G1), C57BL/6J-MtgxR0969Btlr
Major Collection:

Gene Information

Suclg1
Name: succinate-CoA ligase, GDP-forming, alpha subunit
Synonyms: 1500000I01Rik, Sucla1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 56451
Homologene: 55785
Pibf1
Name: progesterone immunomodulatory binding factor 1
Synonyms: 4933438D16Rik, 4930513H15Rik, D14Ertd581e, 1700017E21Rik, 4933439E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 52023
VEGA: 14
Homologene: 4628
Pcnt
Name: pericentrin (kendrin)
Synonyms: m275Asp, Pcnt2, m239Asp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 18541
VEGA: 10
Srek1
Name: splicing regulatory glutamine/lysine-rich protein 1
Synonyms: SRrp86, AL118220, Sfrs12, SRrp508
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 218543
Homologene: 10581
Ipo5
Name: importin 5
Synonyms: 1110011C18Rik, RanBP5, 5730478E03Rik, Kpnb3, IMB3, importin beta 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 70572
VEGA: 14
HGNC: HGNC:6402
Homologene: 1710
Cep350
Name: centrosomal protein 350
Synonyms: 4933409L06Rik, 6430546F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 74081
Homologene: 8879
F2rl2
Name: coagulation factor II (thrombin) receptor-like 2
Synonyms: PAR3, PAR-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 14064
HGNC: HGNC:3539
Homologene: 36151
Taf2
Name: TATA-box binding protein associated factor 2
Synonyms: TAF2B, 4732460C16Rik, CIF150, TAFII150, 150kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 319944
VEGA: 15
Homologene: 31137
Dhx8
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 8
Synonyms: mDEAH6, Ddx8, RNA helicase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217207
HGNC: HGNC:2749
Homologene: 3628
Cd2
Name: CD2 antigen
Synonyms: LFA-2, Ly-37, Ly37
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 12481
HGNC: HGNC:1639
Homologene: 1338
Zfp961
Name: zinc finger protein 961
Synonyms: A230105L22Rik, BC049349
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234413
Homologene: 136286
Trpm4
Name: transient receptor potential cation channel, subfamily M, member 4
Synonyms: 1110030C19Rik, LTRPC4, TRPM4B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 68667
Homologene: 23033
Cndp1
Name: carnosine dipeptidase 1 (metallopeptidase M20 family)
Synonyms: Cn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 338403
Homologene: 57178
Nipbl
Name: NIPBL cohesin loading factor
Synonyms: 4933421G18Rik, 4921518A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 71175
VEGA: 15
Homologene: 15850
Pnpla7
Name: patatin-like phospholipase domain containing 7
Synonyms: E430013P11Rik, NRE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241274
Homologene: 62431
Tctn1
Name: tectonic family member 1
Synonyms: Tect1, G730031O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 654470
Homologene: 49770
Pkd1l1
Name: polycystic kidney disease 1 like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 171395
Homologene: 51376
Gpx3
Name: glutathione peroxidase 3
Synonyms: GPx, EGPx, extracellular GPx, plasma GPx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 14778
HGNC: HGNC:4555
Homologene: 20480
Col1a2
Name: collagen, type I, alpha 2
Synonyms: Col1a-2, Cola-2, Cola2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 12843
HGNC: HGNC:2198
Homologene: 69
Epha3
Name: Eph receptor A3
Synonyms: Tyro4, End3, Hek, Hek4, Cek4, Mek4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 13837
VEGA: 16
HGNC: HGNC:3387
Homologene: 21083
Slc35e1
Name: solute carrier family 35, member E1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 270066
Homologene: 49075
Olfr73
Name: olfactory receptor 73
Synonyms: GA_x6K02T2Q125-49527073-49526132, mOR-EG, MOR174-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 117004
Homologene: 133889
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 380698
Homologene: 70869
Slco6c1
Name: solute carrier organic anion transporter family, member 6c1
Synonyms: 4933404A18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 74441
Homologene: 65259
Ugt2b38
Name: UDP glucuronosyltransferase 2 family, polypeptide B38
Synonyms: 9430041C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 100559
Homologene: 137225
Cep85l
Name: centrosomal protein 85-like
Synonyms: Gm9766
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 100038725
VEGA: 10
Homologene: 52598
Trpv3
Name: transient receptor potential cation channel, subfamily V, member 3
Synonyms: VRL3, Nh, 1110036I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 246788
Homologene: 17040
Ccl20
Name: chemokine (C-C motif) ligand 20
Synonyms: CKb4, MIP-3[a], MIP3A, Scya20, ST38, exodus-1, MIP-3A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 20297
Homologene: 3375
CT025661.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
Sned1
Name: sushi, nidogen and EGF-like domains 1
Synonyms: Snep, D430044C15Rik, 6720455I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 208777
Homologene: 14708
Acot11
Name: acyl-CoA thioesterase 11
Synonyms: Them1, BFIT1, 2010309H15Rik, Thea, 1110020M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 329910
Homologene: 11977
Ccdc66
Name: coiled-coil domain containing 66
Synonyms: E230015L20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 320234
VEGA: 14
Homologene: 35309
St8sia6
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
Synonyms: 1700007J08Rik, ST8Sia VI, Siat8f
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241230
Homologene: 17112
Afg1l
Name: AFG1 like ATPase
Synonyms: Lace1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 215951
Homologene: 5782
Slco5a1
Name: solute carrier organic anion transporter family, member 5A1
Synonyms: A630033C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 240726
Homologene: 57135
Ttll8
Name: tubulin tyrosine ligase-like family, member 8
Synonyms: 1700019P01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 239591
Homologene: 52766
Upk1b
Name: uroplakin 1B
Synonyms: Tspan20, Upk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 22268
VEGA: 16
Homologene: 5065
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 12,989,892 bp
  • T to A, chromosome 1 at 83,117,917 bp
  • G to A, chromosome 1 at 93,281,654 bp
  • A to C, chromosome 1 at 97,119,960 bp
  • A to T, chromosome 1 at 155,940,826 bp
  • T to A, chromosome 2 at 13,696,869 bp
  • T to C, chromosome 2 at 25,050,953 bp
  • T to C, chromosome 2 at 88,034,248 bp
  • T to A, chromosome 3 at 101,276,055 bp
  • C to T, chromosome 4 at 106,760,080 bp
  • T to G, chromosome 5 at 87,412,373 bp
  • A to G, chromosome 5 at 122,241,777 bp
  • G to A, chromosome 6 at 4,518,822 bp
  • T to A, chromosome 6 at 73,271,116 bp
  • A to G, chromosome 7 at 45,327,907 bp
  • T to G, chromosome 8 at 71,968,295 bp
  • T to C, chromosome 8 at 72,492,571 bp
  • A to G, chromosome 9 at 109,651,612 bp
  • T to C, chromosome 10 at 42,318,621 bp
  • T to C, chromosome 10 at 53,281,496 bp
  • T to C, chromosome 10 at 76,427,951 bp
  • T to C, chromosome 11 at 8,936,898 bp
  • T to C, chromosome 11 at 54,909,026 bp
  • T to C, chromosome 11 at 59,131,646 bp
  • C to T, chromosome 11 at 73,278,938 bp
  • T to C, chromosome 11 at 101,739,700 bp
  • A to T, chromosome 13 at 95,700,953 bp
  • G to A, chromosome 13 at 103,752,503 bp
  • A to G, chromosome 14 at 27,497,362 bp
  • C to A, chromosome 14 at 99,196,386 bp
  • T to A, chromosome 14 at 120,944,525 bp
  • A to T, chromosome 15 at 8,292,228 bp
  • T to A, chromosome 15 at 55,031,157 bp
  • T to C, chromosome 15 at 88,933,935 bp
  • A to G, chromosome 16 at 38,787,299 bp
  • A to T, chromosome 16 at 63,566,636 bp
  • G to A, chromosome 18 at 84,634,652 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0969 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039098-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.