Strain Name:
C57BL/6J-MtgxR0975Btlr/Mmmh
Stock Number:
039104-MU
Citation ID:
RRID:MMRRC_039104-MU
Other Names:
R0975 (G1), C57BL/6J-MtgxR0975Btlr
Major Collection:

Gene Information

Esr2
Name: estrogen receptor 2 (beta)
Synonyms: ER beta, ERbeta, oestrogen receptor beta, Estrb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 13983
HGNC: HGNC:3468
Homologene: 1100
Pomt1
Name: protein-O-mannosyltransferase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 99011
HGNC: HGNC:9202
Homologene: 68548
Atl3
Name: atlastin GTPase 3
Synonyms: 5730596K20Rik, 4633402C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 109168
VEGA: 19
Homologene: 9149
Plcb4
Name: phospholipase C, beta 4
Synonyms: A930039J07Rik, C230058B11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 18798
HGNC: HGNC:9059
Homologene: 8471
Ppil2
Name: peptidylprolyl isomerase (cyclophilin)-like 2
Synonyms: C130078A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 66053
HGNC: HGNC:9261
Homologene: 8643
Cdr2
Name: cerebellar degeneration-related 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 12585
HGNC: HGNC:1799
Homologene: 7262
Arap2
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
Synonyms: Centd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 212285
Homologene: 9064
Coro1c
Name: coronin, actin binding protein 1C
Synonyms: CRN2, coronin 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 23790
HGNC: HGNC:2254
Homologene: 56537
Prpf8
Name: pre-mRNA processing factor 8
Synonyms: Sfprp8l, Prp8, DBF3/PRP8, D11Bwg0410e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 192159
Homologene: 4706
Tonsl
Name: tonsoku-like, DNA repair protein
Synonyms: 2810439M11Rik, Nfkbil2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 72749
HGNC: HGNC:7801
Homologene: 22754
Bag1
Name: BCL2-associated athanogene 1
Synonyms: Rap46
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 12017
HGNC: HGNC:937
Homologene: 3190
Gm14403
Name: predicted gene 14403
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 433520
Tmem131
Name: transmembrane protein 131
Synonyms: Neg, D1Bwg0491e, YR-23, CC28, Rw1, 2610524E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 56030
Homologene: 32428
Mcm9
Name: minichromosome maintenance 9 homologous recombination repair factor
Synonyms: 9030408O17Rik, Mcmdc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 71567
VEGA: 10
Homologene: 13546
Snx29
Name: sorting nexin 29
Synonyms: 4933437K13Rik, LOC385605, Rundc2a, LOC381035, Gm11170
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 74478
Homologene: 32706
Klhl28
Name: kelch-like 28
Synonyms: 4122402F11Rik, 2810440N09Rik, 4931401E10Rik, Btbd5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 66689
VEGA: 12
Homologene: 23036
Cul7
Name: cullin 7
Synonyms: p185, p193, 2510004L20Rik, C230011P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 66515
Homologene: 56683
Nfix
Name: nuclear factor I/X
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 18032
HGNC: HGNC:7788
Homologene: 1872
Recql5
Name: RecQ protein-like 5
Synonyms: Recql5b, Recq5b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 170472
HGNC: HGNC:9950
Homologene: 31232
Ampd2
Name: adenosine monophosphate deaminase 2
Synonyms: 1200014F01Rik, Ampd-2, m4521Dajl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 109674
HGNC: HGNC:469
Homologene: 2979
Khsrp
Name: KH-type splicing regulatory protein
Synonyms: 6330409F21Rik, KSRP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 16549
VEGA: 17
HGNC: HGNC:6316
Homologene: 2734
Sec31a
Name: Sec31 homolog A (S. cerevisiae)
Synonyms: 1810024J13Rik, Sec31l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 69162
Homologene: 42056
Gnl2
Name: guanine nucleotide binding protein-like 2 (nucleolar)
Synonyms: Ngp-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230737
Homologene: 6858
Tmeff2
Name: transmembrane protein with EGF-like and two follistatin-like domains 2
Synonyms: 7630402F16Rik, 4832418D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 56363
Homologene: 9417
Myh6
Name: myosin, heavy polypeptide 6, cardiac muscle, alpha
Synonyms: alphaMHC, alpha myosin, Myhca, alpha cardiac MHC, A830009F23Rik, Myhc-a, cardiomyopathy, hypertrophic 1, alpha-MHC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 17888
HGNC: HGNC:7576
Homologene: 124414
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 545370
Homologene: 23741
Efcab6
Name: EF-hand calcium binding domain 6
Synonyms: 4931407K02Rik, 4932408N08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 77627
Homologene: 11259
Stk31
Name: serine threonine kinase 31
Synonyms: C330007K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 77485
Homologene: 12677
Rad9b
Name: RAD9 checkpoint clamp component B
Synonyms: A630082N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231724
Homologene: 17006
Wfdc6b
Name: WAP four-disulfide core domain 6B
Synonyms: Wfdc6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 433502
Homologene: 79014
Ccdc88b
Name: coiled-coil domain containing 88B
Synonyms: 2610041P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 78317
VEGA: 19
Homologene: 49992
Arhgap5
Name: Rho GTPase activating protein 5
Synonyms: p190-B, p190B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 11855
VEGA: 12
HGNC: HGNC:675
Homologene: 907
Ccdc39
Name: coiled-coil domain containing 39
Synonyms: 4921507O14Rik, D3Ertd789e, b2b1735Clo, b2b1304Clo, b2b2025.1Clo, prh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 51938
Homologene: 12149
Gm5346
Name: predicted gene 5346
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 384813
Homologene: 78104
Fbxw14
Name: F-box and WD-40 domain protein 14
Synonyms: Fbxo12, E330009N23Rik, Fbx12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 50757
Homologene: 110776
Frmpd1
Name: FERM and PDZ domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 666060
Homologene: 8939
Olfr353
Name: olfactory receptor 353
Synonyms: MOR127-3, GA_x6K02T2NLDC-33585366-33584431
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258943
HGNC: HGNC:8221
Homologene: 115503
Mug1
Name: murinoglobulin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 17836
Homologene: 136663
Vmn2r9
Name: vomeronasal 2, receptor 9
Synonyms: EG435864
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 435864
Homologene: 129606
Olfr177
Name: olfactory receptor 177
Synonyms: GA_x54KRFPKG5P-55091371-55090442, MOR184-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 258998
Homologene: 121500
Col20a1
Name: collagen, type XX, alpha 1
Synonyms: 1700051I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 73368
Homologene: 75138
Tmem63c
Name: transmembrane protein 63c
Synonyms: 9330187M14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217733
Homologene: 33129
Slc5a4b
Name: solute carrier family 5 (neutral amino acid transporters, system A), member 4b
Synonyms: SGLT3b, 2010104G07Rik, SAAT1, pSGLT2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 64454
Homologene: 56968
Elmo1
Name: engulfment and cell motility 1
Synonyms: 6330578D22Rik, C230095H21Rik, CED-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 140580
Homologene: 56685
Larp1b
Name: La ribonucleoprotein domain family, member 1B
Synonyms: Larp2, 4933421B21Rik, 1700108L22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 214048
Homologene: 103869
Zfp827
Name: zinc finger protein 827
Synonyms: D630040G17Rik, 2810449M09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 622675
Homologene: 45622
Cyp2c68
Name: cytochrome P450, family 2, subfamily c, polypeptide 68
Synonyms: 9030012A22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 433247
Homologene: 74936
Cyp2c67
Name: cytochrome P450, family 2, subfamily c, polypeptide 67
Synonyms: C730004C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 545288
Homologene: 74936
Hoxd12
Name: homeobox D12
Synonyms: Hox-4.7, Hox-5.6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 15432
HGNC: HGNC:5135
Homologene: 7369
Trmt10a
Name: tRNA methyltransferase 10A
Synonyms: 3110023L08Rik, Rg9mtd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 108943
Homologene: 6886
C530008M17Rik
Name: RIKEN cDNA C530008M17 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 320827
Homologene: 136278
Vmn1r192
Name: vomeronasal 1 receptor 192
Synonyms: V1ri1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 252907
Homologene: 110880
Klhl3
Name: kelch-like 3
Synonyms: 7530408C15Rik, EG627648
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 100503085
HGNC: HGNC:6354
Homologene: 79542
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 36,854,885 bp
  • T to C, chromosome 1 at 50,938,205 bp
  • A to C, chromosome 1 at 150,577,377 bp
  • T to A, chromosome 2 at 32,253,895 bp
  • C to A, chromosome 2 at 36,890,550 bp
  • G to T, chromosome 2 at 74,675,934 bp
  • T to C, chromosome 2 at 135,987,912 bp
  • G to A, chromosome 2 at 164,613,785 bp
  • T to G, chromosome 2 at 177,509,424 bp
  • A to T, chromosome 2 at 181,006,826 bp
  • T to C, chromosome 3 at 33,844,125 bp
  • A to G, chromosome 3 at 40,970,490 bp
  • T to C, chromosome 3 at 108,077,121 bp
  • G to A, chromosome 3 at 138,156,809 bp
  • T to C, chromosome 4 at 40,937,152 bp
  • C to T, chromosome 4 at 45,279,000 bp
  • A to G, chromosome 4 at 125,048,378 bp
  • A to T, chromosome 5 at 62,730,886 bp
  • T to C, chromosome 5 at 76,856,318 bp
  • A to C, chromosome 5 at 100,395,904 bp
  • T to G, chromosome 5 at 108,843,303 bp
  • C to G, chromosome 5 at 113,882,121 bp
  • C to T, chromosome 5 at 122,334,257 bp
  • C to G, chromosome 6 at 49,423,409 bp
  • A to T, chromosome 6 at 121,878,539 bp
  • G to A, chromosome 7 at 120,958,391 bp
  • A to G, chromosome 8 at 43,625,118 bp
  • A to G, chromosome 8 at 79,061,185 bp
  • G to A, chromosome 8 at 84,726,526 bp
  • T to A, chromosome 9 at 109,271,239 bp
  • G to A, chromosome 10 at 53,538,646 bp
  • A to G, chromosome 10 at 76,081,407 bp
  • T to C, chromosome 11 at 75,508,674 bp
  • A to C, chromosome 11 at 115,923,256 bp
  • T to G, chromosome 12 at 52,517,144 bp
  • C to T, chromosome 12 at 64,951,688 bp
  • C to T, chromosome 12 at 76,145,308 bp
  • T to A, chromosome 12 at 87,075,069 bp
  • T to A, chromosome 13 at 20,251,137 bp
  • T to A, chromosome 13 at 22,187,463 bp
  • C to T, chromosome 13 at 58,013,863 bp
  • A to G, chromosome 14 at 54,953,369 bp
  • T to A, chromosome 15 at 76,638,932 bp
  • T to A, chromosome 15 at 83,973,331 bp
  • A to T, chromosome 16 at 11,347,871 bp
  • T to A, chromosome 16 at 17,107,213 bp
  • T to A, chromosome 16 at 58,873,150 bp
  • T to A, chromosome 17 at 46,663,190 bp
  • T to A, chromosome 17 at 57,027,066 bp
  • G to A, chromosome 19 at 6,846,625 bp
  • G to A, chromosome 19 at 7,521,135 bp
  • T to G, chromosome 19 at 39,609,178 bp
  • T to C, chromosome 19 at 39,703,358 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0975 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039104-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.