Strain Name:
C57BL/6J-MtgxR0976Btlr/Mmmh
Stock Number:
039105-MU
Citation ID:
RRID:MMRRC_039105-MU
Other Names:
R0976 (G1), C57BL/6J-MtgxR0976Btlr
Major Collection:

Gene Information

Cntnap2
Name: contactin associated protein-like 2
Synonyms: 5430425M22Rik, Caspr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 66797
Homologene: 69159
Top1
Name: topoisomerase (DNA) I
Synonyms: Top-1, D130064I21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 21969
Homologene: 2467
Axin1
Name: axin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12005
HGNC: HGNC:903
Homologene: 2614
Ppp4r1
Name: protein phosphatase 4, regulatory subunit 1
Synonyms: Pp4r1, 3110001J10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 70351
HGNC: HGNC:9320
Homologene: 81737
Trappc9
Name: trafficking protein particle complex 9
Synonyms: 4632408O18Rik, 2900005P22Rik, Nibp, TRS130, 1810044A24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 76510
VEGA: 15
Homologene: 81931
Cux1
Name: cut-like homeobox 1
Synonyms: Cux, CDP, Cux-1, Cutl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13047
HGNC: HGNC:2557
Arap2
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
Synonyms: Centd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 212285
Homologene: 9064
Tbc1d8
Name: TBC1 domain family, member 8
Synonyms: BUB2-like protein 1, HBLP1, AD3, GRAM domain
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 54610
Homologene: 31421
Pid1
Name: phosphotyrosine interaction domain containing 1
Synonyms: 5033414K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98496
Homologene: 9924
Stag1
Name: stromal antigen 1
Synonyms: SA-1, Scc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20842
Homologene: 21191
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: D130015N03Rik, 2810449H11Rik, tbl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Arl10
Name: ADP-ribosylation factor-like 10
Synonyms: ARL10, Arm1, Arl10a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 56795
Homologene: 10550
Pex1
Name: peroxisomal biogenesis factor 1
Synonyms: ZWS1, 5430414H02Rik, E330005K07Rik, peroxisome biogenesis factor 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71382
HGNC: HGNC:8850
Homologene: 27006
Gabrr3
Name: gamma-aminobutyric acid (GABA) receptor, rho 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 328699
VEGA: 16
Homologene: 26716
Slit2
Name: slit guidance ligand 2
Synonyms: Slil3, Drad-1, E130320P19Rik, E030015M03Rik, b2b1200.1Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20563
Homologene: 3516
Ptges2
Name: prostaglandin E synthase 2
Synonyms: GBF-1, GBF1, 0610038H10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 96979
Homologene: 11819
Cul7
Name: cullin 7
Synonyms: p193, 2510004L20Rik, p185, C230011P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 66515
Homologene: 56683
Terf2ip
Name: telomeric repeat binding factor 2, interacting protein
Synonyms: Rap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 57321
Homologene: 10357
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: LOC224126, Hapip, 2210407G14Rik, E530005C20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Tgfb3
Name: transforming growth factor, beta 3
Synonyms: Tgfb-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 21809
VEGA: 12
Homologene: 2433
Pkd1l3
Name: polycystic kidney disease 1 like 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244646
Homologene: 14627
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241516
Homologene: 110349
Ccr6
Name: chemokine (C-C motif) receptor 6
Synonyms: Cmkbr6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12458
VEGA: 17
HGNC: HGNC:1607
Homologene: 3214
Pcdh10
Name: protocadherin 10
Synonyms: 6430703F07Rik, 6430521D13Rik, OL-pc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18526
Homologene: 74967
Taok2
Name: TAO kinase 2
Synonyms: MAP3K17, TAO2, TAO1, PSK1, 1110033K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381921
Homologene: 74531
Myh3
Name: myosin, heavy polypeptide 3, skeletal muscle, embryonic
Synonyms: MyHC-emb, Myhs-e, Myhse
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17883
HGNC: HGNC:7573
Homologene: 20553
Mndal
Name: myeloid nuclear differentiation antigen like
Synonyms: Ifi212
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100040462
HGNC: HGNC:5395
Homologene: 115929
D630003M21Rik
Name: RIKEN cDNA D630003M21 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228846
Homologene: 18598
Cyp3a57
Name: cytochrome P450, family 3, subfamily a, polypeptide 57
Synonyms: EG622127
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 622127
Homologene: 135775
Nrg2
Name: neuregulin 2
Synonyms: NTAK, Don1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 100042150
HGNC: HGNC:7998
Homologene: 75024
Fam83f
Name: family with sequence similarity 83, member F
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 213956
VEGA: 15
Homologene: 16313
H2bc18
Name: H2B clustered histone 18
Synonyms: H2b-616, Hist2h2bb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 319189
Homologene: 136264
Wdr35
Name: WD repeat domain 35
Synonyms: 4930459M12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 74682
Homologene: 10814
Nek2
Name: NIMA (never in mitosis gene a)-related expressed kinase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18005
HGNC: HGNC:7745
Homologene: 74441
Dsc1
Name: desmocollin 1
Synonyms: Dsc1b, Dsc1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13505
VEGA: 18
HGNC: HGNC:3035
Homologene: 22761
Olfr52
Name: olfactory receptor 52
Synonyms: IE6, MOR185-6, GA_x6K02T2Q125-47650922-47649963
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18352
Homologene: 105200
Vmn2r69
Name: vomeronasal 2, receptor 69
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330581
Homologene: 115466
Cyp2c67
Name: cytochrome P450, family 2, subfamily c, polypeptide 67
Synonyms: C730004C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 545288
Homologene: 74936
Aldh2
Name: aldehyde dehydrogenase 2, mitochondrial
Synonyms: Ahd5, Ahd-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11669
HGNC: HGNC:404
Homologene: 55480
Pdcd2l
Name: programmed cell death 2-like
Synonyms: 6030457N17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68079
Homologene: 41861
Isyna1
Name: myo-inositol 1-phosphate synthase A1
Synonyms: 1300017C10Rik, inositol-3-phosphate synthase 1, myo-inositol 1-phosphate synthase A1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 71780
Homologene: 6222
1700056E22Rik
Name: RIKEN cDNA 1700056E22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 73363
Homologene: 137387
AC242409.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 39,406,801 bp
  • A to T, chromosome 1 at 84,159,225 bp
  • T to A, chromosome 1 at 173,862,845 bp
  • C to T, chromosome 1 at 184,033,505 bp
  • A to G, chromosome 1 at 191,827,237 bp
  • T to A, chromosome 2 at 32,397,525 bp
  • A to G, chromosome 2 at 82,998,031 bp
  • A to G, chromosome 2 at 86,181,808 bp
  • A to G, chromosome 2 at 158,201,093 bp
  • A to G, chromosome 2 at 160,717,423 bp
  • T to C, chromosome 3 at 45,380,801 bp
  • T to A, chromosome 3 at 96,270,086 bp
  • C to A, chromosome 5 at 3,633,943 bp
  • T to A, chromosome 5 at 48,000,300 bp
  • T to A, chromosome 5 at 62,649,884 bp
  • T to C, chromosome 5 at 121,576,450 bp
  • T to A, chromosome 5 at 136,313,290 bp
  • A to G, chromosome 5 at 145,390,468 bp
  • C to T, chromosome 6 at 47,271,230 bp
  • G to T, chromosome 7 at 34,196,346 bp
  • T to C, chromosome 7 at 85,406,900 bp
  • C to T, chromosome 7 at 126,875,151 bp
  • C to A, chromosome 8 at 70,596,286 bp
  • C to T, chromosome 8 at 109,670,609 bp
  • T to A, chromosome 8 at 112,011,717 bp
  • A to T, chromosome 9 at 66,439,878 bp
  • T to C, chromosome 9 at 100,776,824 bp
  • G to A, chromosome 9 at 100,930,016 bp
  • C to A, chromosome 11 at 67,083,735 bp
  • T to C, chromosome 12 at 8,986,104 bp
  • G to A, chromosome 12 at 86,069,832 bp
  • T to C, chromosome 13 at 54,575,808 bp
  • T to C, chromosome 14 at 19,415,963 bp
  • T to A, chromosome 15 at 72,999,974 bp
  • T to A, chromosome 15 at 80,692,084 bp
  • T to C, chromosome 16 at 34,385,390 bp
  • G to T, chromosome 16 at 59,461,524 bp
  • T to A, chromosome 17 at 8,256,422 bp
  • A to G, chromosome 17 at 26,188,086 bp
  • T to A, chromosome 17 at 46,663,190 bp
  • T to C, chromosome 17 at 65,841,018 bp
  • T to C, chromosome 18 at 20,095,041 bp
  • A to G, chromosome 18 at 36,021,091 bp
  • G to T, chromosome 19 at 39,643,374 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0976 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039105-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.