Strain Name:
C57BL/6J-MtgxR1013Btlr/Mmmh
Stock Number:
039117-MU
Citation ID:
RRID:MMRRC_039117-MU
Other Names:
R1013 (G1), C57BL/6J-MtgxR1013Btlr
Major Collection:

Gene Information

Plg
Name: plasminogen
Synonyms: Pg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18815
VEGA: 17
HGNC: HGNC:9071
Homologene: 55452
Psenen
Name: presenilin enhancer gamma secretase subunit
Synonyms: 1700023M09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 66340
Homologene: 11952
Cuedc1
Name: CUE domain containing 1
Synonyms: C330016O16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103841
Homologene: 9933
Bclaf1
Name: BCL2-associated transcription factor 1
Synonyms: 2610102K23Rik, 5730534O06Rik, 2810454G14Rik, 2700025J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 72567
Homologene: 8832
Zfp729a
Name: zinc finger protein 729a
Synonyms: A530054K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 212281
Homologene: 133713
Calcr
Name: calcitonin receptor
Synonyms: Clr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12311
HGNC: HGNC:1440
Homologene: 1320
Ppp3cb
Name: protein phosphatase 3, catalytic subunit, beta isoform
Synonyms: Cnab, 1110063J16Rik, PP2BA beta, CnAbeta, Calnb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 19056
HGNC: HGNC:9315
Homologene: 56429
Sorl1
Name: sortilin-related receptor, LDLR class A repeats-containing
Synonyms: 2900010L19Rik, mSorLA, Sorla, LR11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20660
Homologene: 2336
Mcm6
Name: minichromosome maintenance complex component 6
Synonyms: Mcmd6, D1Wsu22e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17219
HGNC: HGNC:6949
Homologene: 4322
Cul2
Name: cullin 2
Synonyms: 1300003D18Rik, 4932411N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 71745
HGNC: HGNC:2552
Homologene: 2662
Wdr92
Name: WD repeat domain 92
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103784
Homologene: 16321
Zfp354a
Name: zinc finger protein 354A
Synonyms: Tcf17, kid1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 21408
Homologene: 55921
Zcchc14
Name: zinc finger, CCHC domain containing 14
Synonyms: Bdg29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 142682
Homologene: 9037
Col28a1
Name: collagen, type XXVIII, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 213945
Homologene: 66345
Itga4
Name: integrin alpha 4
Synonyms: VLA-4 receptor, alpha 4 subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16401
HGNC: HGNC:6140
Homologene: 37364
Unc13c
Name: unc-13 homolog C
Synonyms: 1500037O19Rik, Unc13h3, Munc13-3, D9Ertd414e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 208898
Homologene: 45443
Megf10
Name: multiple EGF-like-domains 10
Synonyms: 3000002B06Rik, LOC240312
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 70417
Homologene: 23771
Olfr1395
Name: olfactory receptor 1395
Synonyms: GA_x6K02T2QP88-6286247-6285294, MOR277-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258877
Homologene: 105890
Mroh2a
Name: maestro heat-like repeat family member 2A
Synonyms: Heatr7b1, ENSMUSG00000044873, OTTMUSG00000020804
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100040766
Homologene: 85300
C8a
Name: complement component 8, alpha polypeptide
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230558
HGNC: HGNC:1352
Homologene: 472
Hivep1
Name: human immunodeficiency virus type I enhancer binding protein 1
Synonyms: alphaA-CRYBP1, Cryabp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 110521
VEGA: 13
HGNC: HGNC:4920
Homologene: 1596
Rims4
Name: regulating synaptic membrane exocytosis 4
Synonyms: Rim4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241770
Homologene: 18123
Ttc28
Name: tetratricopeptide repeat domain 28
Synonyms: TPRBK, 2310015L07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 209683
Homologene: 41023
4930527J03Rik
Name: RIKEN cDNA 4930527J03 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Flt4
Name: FMS-like tyrosine kinase 4
Synonyms: VEGFR3, Flt-4, VEGFR-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14257
HGNC: HGNC:3767
Homologene: 7321
Pcdhb17
Name: protocadherin beta 17
Synonyms: Pcdhb16, PcdhbQ
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93888
Homologene: 81881
Olfr1061
Name: olfactory receptor 1061
Synonyms: MOR188-1, MOR188-7, Olfr1515, GA_x6K02T2Q125-47883395-47882454, MOR188-9, MOR188-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 259022
Homologene: 79468
Il10rb
Name: interleukin 10 receptor, beta
Synonyms: D16H21S58, Crfb4, Il10r2, CRF2-4, 6620401D04Rik, D21S58h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 16155
HGNC: HGNC:5965
Homologene: 523
1700056E22Rik
Name: RIKEN cDNA 1700056E22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 73363
Homologene: 137387
Kyat3
Name: kynurenine aminotransferase 3
Synonyms: KATIII, Ccbl2, Kat3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229905
Homologene: 2994
Trim3
Name: tripartite motif-containing 3
Synonyms: HAC1, BERP1, Rnf22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 55992
Homologene: 21290
Bicdl2
Name: BICD family like cargo adaptor 2
Synonyms: Ccdc64b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 212733
VEGA: 17
Homologene: 17815
Mrpl11
Name: mitochondrial ribosomal protein L11
Synonyms: 2410001P07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66419
VEGA: 19
Homologene: 6768
Gm8369
Name: predicted gene 8369
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 666926
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 88,234,612 bp
  • T to G, chromosome 1 at 128,349,041 bp
  • ACCC to ACC, chromosome 1 at 178,276,503 bp
  • C to T, chromosome 1 at 184,033,505 bp
  • A to G, chromosome 2 at 79,320,503 bp
  • G to A, chromosome 2 at 86,413,975 bp
  • C to T, chromosome 2 at 163,863,929 bp
  • T to C, chromosome 3 at 142,726,246 bp
  • T to C, chromosome 4 at 104,828,039 bp
  • T to C, chromosome 5 at 111,276,965 bp
  • A to T, chromosome 6 at 3,692,621 bp
  • A to G, chromosome 6 at 7,999,452 bp
  • A to G, chromosome 7 at 30,562,377 bp
  • G to A, chromosome 7 at 105,617,895 bp
  • A to G, chromosome 8 at 121,606,925 bp
  • T to C, chromosome 9 at 42,002,559 bp
  • T to C, chromosome 9 at 73,933,332 bp
  • T to A, chromosome 10 at 20,332,076 bp
  • A to G, chromosome 11 at 17,228,183 bp
  • G to A, chromosome 11 at 49,149,150 bp
  • C to T, chromosome 11 at 49,636,339 bp
  • T to C, chromosome 11 at 51,060,850 bp
  • C to T, chromosome 11 at 88,188,027 bp
  • A to G, chromosome 13 at 42,156,962 bp
  • T to C, chromosome 13 at 67,619,507 bp
  • T to A, chromosome 14 at 20,524,004 bp
  • A to G, chromosome 16 at 91,414,693 bp
  • G to A, chromosome 17 at 12,378,721 bp
  • A to G, chromosome 17 at 23,665,403 bp
  • C to A, chromosome 18 at 3,425,535 bp
  • A to G, chromosome 18 at 37,485,967 bp
  • A to G, chromosome 18 at 57,261,219 bp
  • T to C, chromosome 19 at 4,963,623 bp
  • TG to TGNG, chromosome 19 at 11,511,783 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1013 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039117-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.