Strain Name:
C57BL/6J-MtgxR1017Btlr/Mmmh
Stock Number:
039121-MU
Citation ID:
RRID:MMRRC_039121-MU
Other Names:
R1017 (G1), C57BL/6J-MtgxR1017Btlr
Major Collection:

Strain Information

Kifc3
Name: kinesin family member C3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16582
HGNC: HGNC:6326
Homologene: 124421
Vldlr
Name: very low density lipoprotein receptor
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 22359
Homologene: 443
Gon4l
Name: gon-4 like
Synonyms: 2610100B20Rik, 1500041I23Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76022
Homologene: 13002
Mrps6
Name: mitochondrial ribosomal protein S6
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 121022
Homologene: 41871
Hira
Name: histone cell cycle regulator
Synonyms: Tuple1, Gm15797, D16Ertd95e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 15260
HGNC: HGNC:4916
Homologene: 48172
Ltbp4
Name: latent transforming growth factor beta binding protein 4
Synonyms: 2310046A13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108075
HGNC: HGNC:6717
Homologene: 2645
Sik3
Name: SIK family kinase 3
Synonyms: 5730525O22Rik, 9030204A07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70661
Homologene: 57023
Cyp7a1
Name: cytochrome P450, family 7, subfamily a, polypeptide 1
Synonyms: cholesterol 7 alpha hydroxylase
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13122
HGNC: HGNC:2651
Homologene: 30987
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Raver1
Name: ribonucleoprotein, PTB-binding 1
Synonyms: 1300006N24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71766
VEGA: 9
Homologene: 12410
Hoxa3
Name: homeobox A3
Synonyms: Hox-1.5, Mo-10
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15400
HGNC: HGNC:5104
Homologene: 40725
Itgb3bp
Name: integrin beta 3 binding protein (beta3-endonexin)
Synonyms: 4930471O16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67733
HGNC: HGNC:6157
Homologene: 8617
Gsx2
Name: GS homeobox 2
Synonyms: Gsh2, Gsh-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14843
Homologene: 15377
Cdh6
Name: cadherin 6
Synonyms: K-cadherin, cad6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12563
VEGA: 15
HGNC: HGNC:1765
Homologene: 21027
Cdh23
Name: cadherin related 23 (otocadherin)
Synonyms: 4930542A03Rik, USH1D, mdfw, ahl, bob, nmf112, nmf181, nmf252, sals
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22295
Homologene: 11142
Zfp605
Name: zinc finger protein 605
Synonyms: A830023I12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 675812
Homologene: 52335
Dscam
Name: DS cell adhesion molecule
Synonyms: 4932410A21Rik, Down syndrome cell adhesion molecule
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13508
HGNC: HGNC:3039
Homologene: 74393
Gm10306
Name: predicted gene 10306
Type: Gene
Species: Mouse
Chromosome: 4
Irak3
Name: interleukin-1 receptor-associated kinase 3
Synonyms: IRAK-M, 4833428C18Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 73914
Homologene: 36215
Fer1l4
Name: fer-1 like family member 4
Synonyms: 9130402C12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74562
Homologene: 19075
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Dnase1l2
Name: deoxyribonuclease 1-like 2
Synonyms: 4733401H14Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66705
HGNC: HGNC:2958
Homologene: 74391
Ahnak
Name: AHNAK nucleoprotein
Synonyms: DY6, 2310047C17Rik, 1110004P15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Fscb
Name: fibrous sheath CABYR binding protein
Synonyms: EG623046
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 623046
VEGA: 12
Homologene: 136275
Arhgef10l
Name: Rho guanine nucleotide exchange factor 10-like
Synonyms: 2810441C07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72754
Homologene: 10017
Acrbp
Name: proacrosin binding protein
Synonyms: sp32, OY-TES-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54137
Homologene: 9641
Cpa3
Name: carboxypeptidase A3, mast cell
Synonyms: MC-CPA, mMC-CPA, mast cell carboxypeptidase A
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12873
HGNC: HGNC:2298
Homologene: 122138
Osbpl6
Name: oxysterol binding protein-like 6
Synonyms: ORP-6, 1110062M20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99031
Homologene: 101447
Ctnnb1
Name: catenin beta 1
Synonyms: beta-catenin, Catnb, beta catenin, catenin (cadherin associated protein), beta 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12387
HGNC: HGNC:2514
Homologene: 1434
Rims4
Name: regulating synaptic membrane exocytosis 4
Synonyms: Rim4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241770
Homologene: 18123
Mdga1
Name: MAM domain containing glycosylphosphatidylinositol anchor 1
Synonyms: Mamdc3, 1200011I03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74762
Homologene: 17780
Zdhhc14
Name: zinc finger, DHHC domain containing 14
Synonyms: New1cp, B530001K09Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224454
VEGA: 17
Homologene: 62301
Lmln
Name: leishmanolysin-like (metallopeptidase M8 family)
Synonyms: 5330415H22Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239833
Homologene: 13198
Or8k27
Name: olfactory receptor family 8 subfamily K member 27
Synonyms: Olfr1065, GA_x6K02T2Q125-47915274-47914333, MOR190-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258403
Homologene: 74195
Or2k2
Name: olfactory receptor family 2 subfamily K member 2
Synonyms: MOR262-1, GA_x6K02T2N78B-1272842-1273783, Olfr267
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258922
HGNC: HGNC:8264
Homologene: 17436
Spdl1
Name: spindle apparatus coiled-coil protein 1
Synonyms: 2810049B11Rik, 2600001J17Rik, 1700018I02Rik, Ccdc99
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70385
Homologene: 9837
Polrmt
Name: polymerase (RNA) mitochondrial (DNA directed)
Synonyms: 1110018N15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216151
HGNC: HGNC:9200
Homologene: 37996
Brinp2
Name: bone morphogenic protein/retinoic acid inducible neural-specific 2
Synonyms: 6430517E21Rik, Fam5b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240843
Homologene: 10905
Or8k25
Name: olfactory receptor family 8 subfamily K member 25
Synonyms: MOR188-1, MOR188-9, MOR188-1, GA_x6K02T2Q125-47883395-47882454, Olfr1061, MOR188-7, Olfr1515
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259022
Homologene: 79468
Baiap2l2
Name: BAI1-associated protein 2-like 2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 207495
Homologene: 11811
Rsl1d1
Name: ribosomal L1 domain containing 1
Synonyms: 2410005K20Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66409
Homologene: 41052
Mtmr11
Name: myotubularin related protein 11
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 194126
Homologene: 82382
Ccin
Name: calicin
Synonyms: 4933417A14Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 442829
HGNC: HGNC:1568
Homologene: 4306
Nat8f7
Name: N-acetyltransferase 8 (GCN5-related) family member 7
Synonyms: Gm4477
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 100043497
Homologene: 76450
Tulp1
Name: TUB like protein 1
Synonyms: Tulp1l
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22157
Homologene: 2491
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 158,249,451 bp
  • A to G, chromosome 2 at 76,549,719 bp
  • A to T, chromosome 2 at 86,413,511 bp
  • A to T, chromosome 2 at 86,445,428 bp
  • T to C, chromosome 2 at 156,049,478 bp
  • C to T, chromosome 2 at 163,863,929 bp
  • A to G, chromosome 2 at 180,195,420 bp
  • T to C, chromosome 3 at 20,239,633 bp
  • T to A, chromosome 3 at 88,858,496 bp
  • A to C, chromosome 3 at 96,164,477 bp
  • A to T, chromosome 4 at 6,272,307 bp
  • A to G, chromosome 4 at 43,985,222 bp
  • A to T, chromosome 4 at 58,785,115 bp
  • A to G, chromosome 4 at 94,556,720 bp
  • A to G, chromosome 4 at 99,769,487 bp
  • C to A, chromosome 4 at 140,515,306 bp
  • T to C, chromosome 5 at 75,077,262 bp
  • C to T, chromosome 5 at 110,127,994 bp
  • G to T, chromosome 6 at 52,172,406 bp
  • T to C, chromosome 6 at 85,707,570 bp
  • C to T, chromosome 6 at 125,061,260 bp
  • A to G, chromosome 7 at 27,306,076 bp
  • C to T, chromosome 8 at 95,105,785 bp
  • T to C, chromosome 9 at 21,079,590 bp
  • C to T, chromosome 9 at 46,195,809 bp
  • T to A, chromosome 9 at 120,950,728 bp
  • T to A, chromosome 10 at 60,331,793 bp
  • C to T, chromosome 10 at 79,743,509 bp
  • T to C, chromosome 10 at 120,142,884 bp
  • T to C, chromosome 11 at 34,819,290 bp
  • T to C, chromosome 11 at 58,998,353 bp
  • T to A, chromosome 12 at 64,473,468 bp
  • C to T, chromosome 15 at 13,051,476 bp
  • A to G, chromosome 15 at 79,261,243 bp
  • T to C, chromosome 16 at 11,203,252 bp
  • T to A, chromosome 16 at 18,899,347 bp
  • T to G, chromosome 16 at 33,088,176 bp
  • T to A, chromosome 16 at 92,058,458 bp
  • T to A, chromosome 16 at 96,833,433 bp
  • T to A, chromosome 17 at 5,493,649 bp
  • C to T, chromosome 17 at 24,442,472 bp
  • T to C, chromosome 17 at 28,364,303 bp
  • T to A, chromosome 17 at 29,850,548 bp
  • A to T, chromosome 19 at 9,010,543 bp
  • A to C, chromosome 19 at 27,241,333 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1017 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039121-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.