Strain Name:
C57BL/6J-MtgxR1070Btlr/Mmmh
Stock Number:
039156-MU
Citation ID:
RRID:MMRRC_039156-MU
Other Names:
R1070 (G1), C57BL/6J-MtgxR1070Btlr
Major Collection:

Strain Information

Kif5a
Name: kinesin family member 5A
Synonyms: Khc, Kns, Kif5, D10Bwg0738e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16572
VEGA: 10
HGNC: HGNC:6323
Homologene: 55861
Kdm4c
Name: lysine (K)-specific demethylase 4C
Synonyms: Jmjd2c, 2410141F18Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76804
Homologene: 41004
Pcif1
Name: phosphorylated CTD interacting factor 1
Synonyms: 2310022K11Rik, F730014I05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228866
Homologene: 11134
Pdzd2
Name: PDZ domain containing 2
Synonyms: LOC223364, Pdzk3, 4930537L06Rik, Gm21706, A930022H17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68070
Homologene: 23393
Net1
Name: neuroepithelial cell transforming gene 1
Synonyms: 0610025H04Rik, Net1 homolog, mNET1, 9530071N24Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56349
VEGA: 13
Homologene: 4283
Bptf
Name: bromodomain PHD finger transcription factor
Synonyms: Falz, 9430093H17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207165
HGNC: HGNC:3581
Homologene: 114397
Gtf3c3
Name: general transcription factor IIIC, polypeptide 3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98488
HGNC: HGNC:4666
Homologene: 40805
Sdhb
Name: succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Synonyms: 0710008N11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67680
Homologene: 2255
Ipo9
Name: importin 9
Synonyms: Imp9, 0710008K06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226432
Homologene: 5874
Raf1
Name: v-raf-leukemia viral oncogene 1
Synonyms: Craf1, 6430402F14Rik, c-Raf, sarcoma 3611 oncogene, Raf-1, v-Raf
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 110157
HGNC: HGNC:9829
Homologene: 48145
Npat
Name: nuclear protein in the AT region
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244879
HGNC: HGNC:7896
Homologene: 1888
Bach1
Name: BTB and CNC homology 1, basic leucine zipper transcription factor 1
Synonyms: 6230421P05Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12013
HGNC: HGNC:935
Homologene: 916
Tars3
Name: threonyl-tRNA synthetase 3
Synonyms: A530046H20Rik, Tarsl2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 272396
Homologene: 65036
Blzf1
Name: basic leucine zipper nuclear factor 1
Synonyms: 1700030G05Rik, Blzf1l, Golgin-45, Jem-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66352
HGNC: HGNC:1065
Homologene: 31187
Hes1
Name: hes family bHLH transcription factor 1
Synonyms: bHLHb39, Hry
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 15205
HGNC: HGNC:5192
Homologene: 38067
Kcnk2
Name: potassium channel, subfamily K, member 2
Synonyms: TREK-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16526
HGNC: HGNC:6277
Homologene: 7794
Rap1gap2
Name: RAP1 GTPase activating protein 2
Synonyms: Garnl4, LOC380710
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380711
Homologene: 56695
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Rimoc1
Name: RAB7A interacting MON1-CCZ1 complex subunit 1
Synonyms: AW549877
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 106064
VEGA: 15
Homologene: 27085
Ifi208
Name: interferon activated gene 208
Synonyms: E430029J22Rik, Pydc3, Pyr-rv1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100033459
HGNC: HGNC:5395
Homologene: 115929
A2ml1
Name: alpha-2-macroglobulin like 1
Synonyms: BC048546, Ovos2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232400
Homologene: 45969
Ugt2b38
Name: UDP glucuronosyltransferase 2 family, polypeptide B38
Synonyms: 9430041C03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100559
Homologene: 137225
Krt78
Name: keratin 78
Synonyms: 2310030B04Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 332131
VEGA: 15
Homologene: 65261
Itih1
Name: inter-alpha trypsin inhibitor, heavy chain 1
Synonyms: Intin1, Itih-1, inter-alpha (globulin) inhibitor, H1 polypeptide
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16424
HGNC: HGNC:6166
Homologene: 1667
Vmn2r79
Name: vomeronasal 2, receptor 79
Synonyms: EG621430
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 621430
Homologene: 115466
Agtr1b
Name: angiotensin II receptor, type 1b
Synonyms: AT1B, Angtr-1b, Agtr-1b
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11608
HGNC: HGNC:336
Homologene: 84871
Strip1
Name: striatin interacting protein 1
Synonyms: 6530401O14Rik, 6330569M22Rik, Fam40a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229707
Homologene: 35064
Sned1
Name: sushi, nidogen and EGF-like domains 1
Synonyms: Snep, 6720455I24Rik, D430044C15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208777
Homologene: 14708
Vcam1
Name: vascular cell adhesion molecule 1
Synonyms: CD106, Vcam-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22329
Homologene: 838
Actr3b
Name: ARP3 actin-related protein 3B
Synonyms: ARP11, Arp3b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 242894
Homologene: 4180
Or5p57
Name: olfactory receptor family 5 subfamily P member 57
Synonyms: GA_x6K02T2PBJ9-10395807-10394869, MOR204-32, Olfr480
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56861
Homologene: 72039
Or5h25
Name: olfactory receptor family 5 subfamily H member 25
Synonyms: GA_x54KRFPKG5P-55338697-55337768, MOR183-7P, Olfr193, MOR113-7P, Olfr1540-ps1, MOR113-7P
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 257972
Homologene: 128162
Mylk4
Name: myosin light chain kinase family, member 4
Synonyms: EG238564
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238564
Homologene: 66243
Ldc1
Name: leucine decarboxylase 1
Synonyms: LOC332942, Gm853
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 332942
Homologene: 128653
Sult2a8
Name: sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 8
Synonyms: 2810007J24Rik, mL-STL
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76971
Rab3a
Name: RAB3A, member RAS oncogene family
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 19339
HGNC: HGNC:9777
Homologene: 20629
Or7a35
Name: olfactory receptor family 7 subfamily A member 35
Synonyms: GA_x6K02T2QGN0-2794907-2793948, MOR139-4, Olfr1351
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 259042
Homologene: 133668
Inhbe
Name: inhibin beta-E
Synonyms: activin betaE, activin beta-E
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16326
VEGA: 10
Homologene: 7381
Rdh12
Name: retinol dehydrogenase 12
Synonyms: A930033N07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 77974
Homologene: 110830
Heatr4
Name: HEAT repeat containing 4
Synonyms: Gm17673
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 101055670
Homologene: 45728
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 54,417,778 bp
  • G to A, chromosome 1 at 93,281,654 bp
  • T to C, chromosome 1 at 135,406,543 bp
  • T to A, chromosome 1 at 150,689,590 bp
  • A to G, chromosome 1 at 164,303,930 bp
  • C to T, chromosome 1 at 173,683,044 bp
  • A to G, chromosome 1 at 189,256,763 bp
  • T to C, chromosome 2 at 164,889,138 bp
  • A to T, chromosome 3 at 20,315,748 bp
  • T to C, chromosome 3 at 107,627,408 bp
  • C to T, chromosome 3 at 116,110,903 bp
  • T to A, chromosome 4 at 74,373,628 bp
  • T to C, chromosome 4 at 130,219,156 bp
  • T to C, chromosome 4 at 140,971,236 bp
  • A to G, chromosome 5 at 25,848,493 bp
  • T to G, chromosome 5 at 87,412,373 bp
  • T to C, chromosome 6 at 115,637,699 bp
  • T to C, chromosome 6 at 128,543,300 bp
  • T to A, chromosome 7 at 14,413,773 bp
  • T to C, chromosome 7 at 65,655,696 bp
  • T to C, chromosome 7 at 87,003,473 bp
  • T to C, chromosome 7 at 108,066,651 bp
  • A to G, chromosome 8 at 70,757,194 bp
  • T to A, chromosome 9 at 53,572,592 bp
  • C to T, chromosome 10 at 79,017,850 bp
  • T to C, chromosome 10 at 127,245,406 bp
  • T to C, chromosome 10 at 127,351,513 bp
  • A to G, chromosome 11 at 74,437,027 bp
  • G to T, chromosome 11 at 107,055,055 bp
  • T to C, chromosome 12 at 79,213,748 bp
  • T to C, chromosome 12 at 83,978,067 bp
  • A to T, chromosome 13 at 3,912,930 bp
  • T to C, chromosome 13 at 32,724,818 bp
  • G to T, chromosome 14 at 30,942,456 bp
  • C to A, chromosome 15 at 3,986,366 bp
  • A to G, chromosome 15 at 12,389,966 bp
  • A to G, chromosome 15 at 101,946,293 bp
  • T to C, chromosome 16 at 30,067,283 bp
  • A to G, chromosome 16 at 59,109,819 bp
  • T to C, chromosome 16 at 87,720,121 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1070 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039156-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.