Strain Name:
C57BL/6J-MtgxR1084Btlr/Mmmh
Stock Number:
039170-MU
Citation ID:
RRID:MMRRC_039170-MU
Other Names:
R1084 (G1), C57BL/6J-MtgxR1084Btlr
Major Collection:

Gene Information

Rab6b
Name: RAB6B, member RAS oncogene family
Synonyms: C330006L04Rik, D9Bwg0185e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270192
Homologene: 39749
Mapk8
Name: mitogen-activated protein kinase 8
Synonyms: JNK1, c-Jun N-terminal kinase, Prkm8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 26419
HGNC: HGNC:6881
Homologene: 56760
Sec23a
Name: SEC23 homolog A, COPII coat complex component
Synonyms: Sec23r, Msec23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20334
Homologene: 4642
Glcci1
Name: glucocorticoid induced transcript 1
Synonyms: GIG18, 2310047L21Rik, Tssn1, A130036A18Rik, Fam117c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 170772
Homologene: 15773
Sf3b1
Name: splicing factor 3b, subunit 1
Synonyms: SAP155, Prp10, SF3b155, 2810001M05Rik, Targ4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 81898
Homologene: 6696
Sulf1
Name: sulfatase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240725
Homologene: 49408
Tpr
Name: translocated promoter region, nuclear basket protein
Synonyms: 2610029M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 108989
Homologene: 37753
Sec24a
Name: Sec24 related gene family, member A (S. cerevisiae)
Synonyms: 9430090N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 77371
Homologene: 70131
Mbd1
Name: methyl-CpG binding domain protein 1
Synonyms: PCM1, Cxxc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 17190
VEGA: 18
HGNC: HGNC:6916
Homologene: 8414
Myo1d
Name: myosin ID
Synonyms: 9930104H07Rik, D11Ertd9e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 338367
HGNC: HGNC:7598
Homologene: 45576
Dmxl2
Name: Dmx-like 2
Synonyms: E130119P06Rik, 6430411K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235380
HGNC: HGNC:2938
Homologene: 41022
Crygb
Name: crystallin, gamma B
Synonyms: DGcry-3, Cryg-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12965
HGNC: HGNC:2409
Homologene: 3816
Mcf2l
Name: mcf.2 transforming sequence-like
Synonyms: Dbs, C130040G20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17207
Homologene: 11804
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Morc2a
Name: microrchidia 2A
Synonyms: 8430403M08Rik, Zcwcc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74522
Homologene: 8966
Zfp142
Name: zinc finger protein 142
Synonyms: 9330177B18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 77264
Homologene: 3723
Dna2
Name: DNA replication helicase/nuclease 2
Synonyms: E130315B21Rik, Dna2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 327762
HGNC: HGNC:2939
Homologene: 6124
Tex15
Name: testis expressed gene 15
Synonyms: 2210014E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 104271
Homologene: 12837
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: Mdnah5, b2b1154Clo, b2b1134Clo, b2b1537Clo, b2b1565Clo, Dnahc5, b2b3491Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Eral1
Name: Era (G-protein)-like 1 (E. coli)
Synonyms: MERA-S, MERA-W, 2610524P08Rik, 9130407C09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 57837
HGNC: HGNC:3424
Homologene: 4167
Plekhh2
Name: pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 213556
VEGA: 17
Homologene: 35317
Abcg4
Name: ATP binding cassette subfamily G member 4
Synonyms: 6430517O04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 192663
Homologene: 75179
A1bg
Name: alpha-1-B glycoprotein
Synonyms: C44
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 117586
VEGA: 15
HGNC: HGNC:5
Homologene: 11167
Ltbp1
Name: latent transforming growth factor beta binding protein 1
Synonyms: LTBP-1, 9430031G15Rik, b2b1000Clo, Ltbp1L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268977
HGNC: HGNC:6714
Homologene: 522
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329628
Homologene: 14377
Cyp4b1
Name: cytochrome P450, family 4, subfamily b, polypeptide 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13120
HGNC: HGNC:2644
Homologene: 128045
Zfp276
Name: zinc finger protein (C2H2 type) 276
Synonyms: D8Ertd370e, D8Ertd377e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 57247
Homologene: 10731
Heg1
Name: heart development protein with EGF-like domains 1
Synonyms: LOC268884, 5530401I02Rik, 9530025L16Rik, 4632417D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 77446
Homologene: 35276
Gm6264
Name: predicted gene 6264
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 102638435
Homologene: 139073
Tnrc18
Name: trinucleotide repeat containing 18
Synonyms: EG381742, Zfp469
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231861
Homologene: 45603
Cyp3a59
Name: cytochrome P450, family 3, subfamily a, polypeptide 59
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100041449
Homologene: 135775
Arhgap9
Name: Rho GTPase activating protein 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216445
VEGA: 10
Homologene: 13041
Scel
Name: sciellin
Synonyms: 9230114I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 64929
VEGA: 14
Homologene: 2850
Ly6f
Name: lymphocyte antigen 6 complex, locus F
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 17071
Homologene: 113718
Zscan4d
Name: zinc finger and SCAN domain containing 4D
Synonyms: EG545913
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 545913
Homologene: 85986
Blvra
Name: biliverdin reductase A
Synonyms: Blvr, 2500001N03Rik, 0610006A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 109778
HGNC: HGNC:1062
Homologene: 572
Ocel1
Name: occludin/ELL domain containing 1
Synonyms: 9430098E02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 77090
Homologene: 11597
Ms4a8a
Name: membrane-spanning 4-domains, subfamily A, member 8A
Synonyms: 2010004L09Rik, CD20L5, Ms4a8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 64381
Homologene: 111037
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • AAGGGA to AAGGGAGGGA, chromosome 1 at 12,836,164 bp
  • C to G, chromosome 1 at 55,019,395 bp
  • C to T, chromosome 1 at 65,080,495 bp
  • T to C, chromosome 1 at 74,571,826 bp
  • G to A, chromosome 1 at 85,171,250 bp
  • A to G, chromosome 1 at 150,442,161 bp
  • A to G, chromosome 2 at 127,080,653 bp
  • T to C, chromosome 3 at 38,979,825 bp
  • A to G, chromosome 4 at 115,640,312 bp
  • A to G, chromosome 5 at 142,764,767 bp
  • A to T, chromosome 5 at 146,096,674 bp
  • C to T, chromosome 6 at 8,573,221 bp
  • A to T, chromosome 7 at 11,165,005 bp
  • T to C, chromosome 8 at 13,002,645 bp
  • A to G, chromosome 8 at 33,577,004 bp
  • G to T, chromosome 8 at 71,371,988 bp
  • G to A, chromosome 8 at 123,254,723 bp
  • C to T, chromosome 9 at 44,277,469 bp
  • A to T, chromosome 9 at 54,416,433 bp
  • C to T, chromosome 9 at 103,162,635 bp
  • C to T, chromosome 10 at 62,949,187 bp
  • A to G, chromosome 10 at 127,327,928 bp
  • A to G, chromosome 11 at 3,650,454 bp
  • A to G, chromosome 11 at 51,713,581 bp
  • C to T, chromosome 11 at 78,074,498 bp
  • T to C, chromosome 11 at 80,684,395 bp
  • A to T, chromosome 12 at 58,985,135 bp
  • T to A, chromosome 14 at 33,388,803 bp
  • G to T, chromosome 14 at 103,564,843 bp
  • G to A, chromosome 15 at 28,343,452 bp
  • T to A, chromosome 15 at 60,918,155 bp
  • T to C, chromosome 15 at 75,268,773 bp
  • A to G, chromosome 16 at 33,706,997 bp
  • C to A, chromosome 17 at 67,804,469 bp
  • G to A, chromosome 17 at 75,359,425 bp
  • C to T, chromosome 17 at 84,571,126 bp
  • A to G, chromosome 18 at 74,269,532 bp
  • T to A, chromosome 19 at 11,076,362 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1084 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039170-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.