Strain Name:
C57BL/6J-MtgxR1086Btlr/Mmmh
Stock Number:
039172-MU
Citation ID:
RRID:MMRRC_039172-MU
Other Names:
R1086 (G1), C57BL/6J-MtgxR1086Btlr
Major Collection:

Gene Information

Chd7
Name: chromodomain helicase DNA binding protein 7
Synonyms: Flo, GENA 60, WBE1, Cyn, A730019I05Rik, Gena 52, Cycn, Dz, Edy, Lda, Mt, Obt, Todo, GENA 47, Whi
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320790
Homologene: 19067
Abca12
Name: ATP-binding cassette, sub-family A (ABC1), member 12
Synonyms: 4832428G11Rik, 4833417A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74591
Homologene: 45441
Lrp5
Name: low density lipoprotein receptor-related protein 5
Synonyms: LRP7, LR3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 16973
HGNC: HGNC:6697
Homologene: 1746
Ano6
Name: anoctamin 6
Synonyms: 2900059G15Rik, F730003B03Rik, Tmem16f
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105722
VEGA: 15
Homologene: 27888
Ptprg
Name: protein tyrosine phosphatase, receptor type, G
Synonyms: RPTPgamma, 5430405N12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 19270
HGNC: HGNC:9671
Homologene: 2129
Tacc2
Name: transforming, acidic coiled-coil containing protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57752
Homologene: 5087
Zfp462
Name: zinc finger protein 462
Synonyms: Zfpip, Gt4-2, 9430078C22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242466
Homologene: 41430
Dis3l2
Name: DIS3 like 3'-5' exoribonuclease 2
Synonyms: 4930429A22Rik, 8030493P09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 208718
Homologene: 62417
Rabgap1
Name: RAB GTPase activating protein 1
Synonyms: Gapcena
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227800
Homologene: 49301
Sap130
Name: Sin3A associated protein
Synonyms: 2610304F09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 269003
VEGA: 18
Homologene: 11577
Zfp407
Name: zinc finger protein 407
Synonyms: 6430585N13Rik, LOC381139, LOC240469
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240476
Homologene: 86402
Tg
Name: thyroglobulin
Synonyms: Tgn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 21819
Homologene: 2430
Uba6
Name: ubiquitin-like modifier activating enzyme 6
Synonyms: Ube1l2, 5730469D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231380
Homologene: 10080
Gps2
Name: G protein pathway suppressor 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 56310
HGNC: HGNC:4550
Homologene: 49599
Saal1
Name: serum amyloid A-like 1
Synonyms: 5031425D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 78935
Homologene: 34706
Cwc22
Name: CWC22 spliceosome-associated protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 80744
Homologene: 6048
Skor2
Name: SKI family transcriptional corepressor 2
Synonyms: Gm7348, Corl2, Fussel18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 664805
VEGA: 18
Homologene: 64797
Ttll5
Name: tubulin tyrosine ligase-like family, member 5
Synonyms: STAMP, D630041K24Rik, 1700048H13Rik, 2310009M18Rik, 4930556H18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 320244
Homologene: 9013
Ltbr
Name: lymphotoxin B receptor
Synonyms: Tnfrsf3, TNF-R-III, Tnfbr, Ltar, TNFCR, TNFR2-RP, LTbetaR, LT beta-R, LT-beta receptor, TNF receptor-related protein, TNFRrp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17000
HGNC: HGNC:6718
Homologene: 1753
Itgam
Name: integrin alpha M
Synonyms: Mac-1, F730045J24Rik, CD11b/CD18, Cd11b, CR3, complement receptor type 3, CD11B (p170), complement component receptor 3 alpha, Ly-40, Mac-1 alpha, Mac-1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16409
HGNC: HGNC:6149
Homologene: 526
Itpr2
Name: inositol 1,4,5-triphosphate receptor 2
Synonyms: Ip3r2, Itpr5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16439
HGNC: HGNC:6181
Homologene: 37593
Ptprd
Name: protein tyrosine phosphatase, receptor type, D
Synonyms: 3000002J10Rik, B230219D21Rik, 1110002J03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 19266
HGNC: HGNC:9668
Got1l1
Name: glutamic-oxaloacetic transaminase 1-like 1
Synonyms: 1700083M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 76615
Homologene: 65045
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239420
Homologene: 65982
Rnh1
Name: ribonuclease/angiogenin inhibitor 1
Synonyms: RNH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 107702
Homologene: 2204
Unc5d
Name: unc-5 netrin receptor D
Synonyms: Unc5h4, D930029E11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 210801
Homologene: 15450
Mug1
Name: murinoglobulin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17836
Homologene: 136663
Mdga2
Name: MAM domain containing glycosylphosphatidylinositol anchor 2
Synonyms: Mamdc1, 9330209L04Rik, 6720489L24Rik, Tg(Prnp-PFN1*G118V)838Kiaei, Adp, Mdga2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 320772
Homologene: 45659
Nwd2
Name: NACHT and WD repeat domain containing 2
Synonyms: 3110047P20Rik, B830017A01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 319807
Homologene: 14974
Haus1
Name: HAUS augmin-like complex, subunit 1
Synonyms: Ccdc5, spindle associated, HEI-C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225745
VEGA: 18
Homologene: 15516
Serpina1d
Name: serine (or cysteine) peptidase inhibitor, clade A, member 1D
Synonyms: Spi1-4, PI4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20703
HGNC: HGNC:8941
Homologene: 20103
Cyp2s1
Name: cytochrome P450, family 2, subfamily s, polypeptide 1
Synonyms: 1200011C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74134
Homologene: 75274
Ppfia3
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
Synonyms: 2410127E16Rik, Liprin-alpha3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76787
HGNC: HGNC:9247
Homologene: 37833
Olfr187
Name: olfactory receptor 187
Synonyms: MOR183-8, GA_x54KRFPKG5P-55265713-55264787
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 258319
Homologene: 133069
Ppp2r3a
Name: protein phosphatase 2, regulatory subunit B'', alpha
Synonyms: 3222402P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235542
HGNC: HGNC:9307
Homologene: 20595
Agbl4
Name: ATP/GTP binding protein-like 4
Synonyms: 4930578N11Rik, 4931433A01Rik, Ccp6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 78933
Homologene: 84880
Pfkm
Name: phosphofructokinase, muscle
Synonyms: PFK-M, Pfk-4, Pfkx, Pfk4, PFK-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18642
VEGA: 15
HGNC: HGNC:8877
Homologene: 20101
Cfap100
Name: cilia and flagella associated protein 100
Synonyms: Ccdc37, C230069K22Rik, C030041G11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243538
Homologene: 18456
Slc18b1
Name: solute carrier family 18, subfamily B, member 1
Synonyms: 1110021L09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 76306
Homologene: 33473
Brox
Name: BRO1 domain and CAAX motif containing
Synonyms: 0610010K06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71678
Homologene: 13499
Slc16a13
Name: solute carrier family 16 (monocarboxylic acid transporters), member 13
Synonyms: 1700007D07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69309
Homologene: 71749
Tedc2
Name: tubulin epsilon and delta complex 2
Synonyms: 1600002H07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 72016
Homologene: 45943
Rwdd2b
Name: RWD domain containing 2B
Synonyms: ORF5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 53858
HGNC: HGNC:1302
Homologene: 9654
Gm10304
Name: predicted gene 10304
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Gm10354
Name: predicted gene 10354
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100503549
Homologene: 69402
B3gnt8
Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
Synonyms: B3galt7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232984
Homologene: 18886
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 71,295,061 bp
  • G to A, chromosome 1 at 86,990,149 bp
  • A to G, chromosome 1 at 183,282,488 bp
  • T to C, chromosome 2 at 37,469,446 bp
  • T to A, chromosome 2 at 77,924,480 bp
  • A to G, chromosome 4 at 8,866,458 bp
  • G to T, chromosome 4 at 55,013,000 bp
  • T to C, chromosome 4 at 76,133,258 bp
  • C to A, chromosome 4 at 104,328,572 bp
  • G to C, chromosome 4 at 110,478,594 bp
  • T to C, chromosome 5 at 14,978,790 bp
  • C to T, chromosome 5 at 63,806,574 bp
  • C to A, chromosome 5 at 86,127,719 bp
  • T to A, chromosome 6 at 90,403,908 bp
  • T to A, chromosome 6 at 121,885,854 bp
  • G to A, chromosome 6 at 125,312,740 bp
  • C to A, chromosome 6 at 146,350,045 bp
  • C to G, chromosome 7 at 25,628,311 bp
  • A to T, chromosome 7 at 25,805,997 bp
  • C to G, chromosome 7 at 45,361,758 bp
  • T to C, chromosome 7 at 46,689,459 bp
  • T to C, chromosome 7 at 128,080,264 bp
  • A to T, chromosome 7 at 130,626,497 bp
  • T to G, chromosome 7 at 141,163,369 bp
  • A to G, chromosome 8 at 27,197,979 bp
  • A to C, chromosome 8 at 28,875,630 bp
  • G to A, chromosome 9 at 101,153,822 bp
  • T to C, chromosome 10 at 23,803,795 bp
  • A to G, chromosome 11 at 69,915,224 bp
  • A to G, chromosome 11 at 70,219,024 bp
  • T to C, chromosome 12 at 66,506,102 bp
  • G to A, chromosome 12 at 85,891,079 bp
  • T to G, chromosome 12 at 103,763,787 bp
  • C to T, chromosome 14 at 11,952,706 bp
  • T to A, chromosome 15 at 47,695,755 bp
  • A to C, chromosome 15 at 66,684,062 bp
  • T to C, chromosome 15 at 95,949,962 bp
  • T to C, chromosome 15 at 98,131,665 bp
  • T to A, chromosome 16 at 59,036,263 bp
  • C to T, chromosome 16 at 87,436,558 bp
  • T to A, chromosome 17 at 24,216,317 bp
  • C to A, chromosome 17 at 24,216,318 bp
  • G to A, chromosome 18 at 31,650,620 bp
  • A to C, chromosome 18 at 76,859,299 bp
  • A to C, chromosome 18 at 77,766,853 bp
  • C to T, chromosome 18 at 84,559,773 bp
  • T to C, chromosome 19 at 3,649,476 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1086 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039172-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.