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Strain Name:
C57BL/6J-MtgxR1109Btlr/Mmmh
Stock Number:
039182-MU
Citation ID:
RRID:MMRRC_039182-MU
Other Names:
R1109 (G1), C57BL/6J-MtgxR1109Btlr
Major Collection:

Strain Information

Lrrn1
Name: leucine rich repeat protein 1, neuronal
Synonyms: NLRR-1, 2810047E21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16979
Homologene: 32036
Tgfa
Name: transforming growth factor alpha
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21802
Homologene: 2431
Gad2
Name: glutamic acid decarboxylase 2
Synonyms: GAD65, Gad-2, 6330404F12Rik, GAD(65)
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14417
HGNC: HGNC:4093
Homologene: 20223
Dnmt1
Name: DNA methyltransferase 1
Synonyms: MTase, Dnmt1o, Cxxc9, MommeD2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13433
VEGA: 9
HGNC: HGNC:2976
Homologene: 124071
Dock5
Name: dedicator of cytokinesis 5
Synonyms: lr2, 1110060D06Rik, rlc
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 68813
VEGA: 14
Homologene: 57016
Vps35l
Name: VPS35 endosomal protein sorting factor like
Synonyms: 9030624J02Rik, Vsp35l
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71517
Homologene: 10659
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 87,596,728 bp
  • A to T, chromosome 1 at 131,758,798 bp
  • A to T, chromosome 1 at 139,456,758 bp
  • G to C, chromosome 1 at 152,845,583 bp
  • A to T, chromosome 1 at 157,177,638 bp
  • G to T, chromosome 2 at 22,681,394 bp
  • G to A, chromosome 2 at 22,690,159 bp
  • G to A, chromosome 2 at 24,216,590 bp
  • G to T, chromosome 2 at 25,587,526 bp
  • A to G, chromosome 2 at 76,730,737 bp
  • G to T, chromosome 2 at 126,797,793 bp
  • T to C, chromosome 2 at 160,899,021 bp
  • T to G, chromosome 3 at 5,399,870 bp
  • T to C, chromosome 3 at 79,598,861 bp
  • G to T, chromosome 3 at 88,536,660 bp
  • T to C, chromosome 3 at 100,027,351 bp
  • C to T, chromosome 3 at 102,997,394 bp
  • T to G, chromosome 3 at 121,779,596 bp
  • C to T, chromosome 3 at 146,475,298 bp
  • T to A, chromosome 3 at 154,792,777 bp
  • T to C, chromosome 4 at 11,365,205 bp
  • C to T, chromosome 4 at 40,755,722 bp
  • T to C, chromosome 4 at 43,305,719 bp
  • T to C, chromosome 4 at 56,786,723 bp
  • T to C, chromosome 4 at 88,196,747 bp
  • G to T, chromosome 4 at 101,771,355 bp
  • T to C, chromosome 4 at 106,749,348 bp
  • T to A, chromosome 4 at 141,627,984 bp
  • A to G, chromosome 5 at 109,339,786 bp
  • G to A, chromosome 5 at 120,710,419 bp
  • A to T, chromosome 5 at 143,068,369 bp
  • A to T, chromosome 5 at 143,137,619 bp
  • A to C, chromosome 6 at 28,419,167 bp
  • A to G, chromosome 6 at 33,442,016 bp
  • A to T, chromosome 6 at 39,399,334 bp
  • A to G, chromosome 6 at 48,064,922 bp
  • A to C, chromosome 6 at 48,497,443 bp
  • A to T, chromosome 6 at 54,989,569 bp
  • G to T, chromosome 6 at 55,968,260 bp
  • G to T, chromosome 6 at 86,270,090 bp
  • A to G, chromosome 6 at 107,567,264 bp
  • T to C, chromosome 7 at 13,734,873 bp
  • A to T, chromosome 7 at 16,961,467 bp
  • A to T, chromosome 7 at 97,383,684 bp
  • A to T, chromosome 7 at 118,775,329 bp
  • T to A, chromosome 8 at 22,243,692 bp
  • G to T, chromosome 8 at 105,618,928 bp
  • T to A, chromosome 8 at 106,053,482 bp
  • T to C, chromosome 8 at 119,482,655 bp
  • A to T, chromosome 9 at 20,922,388 bp
  • G to A, chromosome 9 at 70,631,079 bp
  • A to G, chromosome 9 at 79,699,723 bp
  • A to T, chromosome 9 at 109,650,060 bp
  • T to C, chromosome 10 at 13,008,753 bp
  • T to C, chromosome 10 at 75,438,165 bp
  • T to C, chromosome 11 at 58,732,916 bp
  • T to A, chromosome 11 at 60,493,066 bp
  • T to A, chromosome 11 at 65,026,816 bp
  • T to A, chromosome 11 at 69,804,804 bp
  • T to A, chromosome 11 at 69,915,681 bp
  • T to C, chromosome 11 at 101,278,785 bp
  • A to G, chromosome 11 at 120,812,324 bp
  • A to G, chromosome 12 at 72,073,996 bp
  • G to A, chromosome 12 at 76,603,603 bp
  • A to C, chromosome 12 at 79,272,127 bp
  • G to T, chromosome 12 at 80,590,631 bp
  • A to G, chromosome 13 at 73,557,080 bp
  • C to T, chromosome 14 at 14,349,317 bp
  • T to C, chromosome 14 at 50,533,702 bp
  • A to G, chromosome 14 at 67,806,478 bp
  • A to T, chromosome 14 at 104,479,764 bp
  • G to T, chromosome 15 at 76,446,509 bp
  • T to C, chromosome 15 at 85,112,815 bp
  • T to A, chromosome 16 at 33,763,591 bp
  • G to A, chromosome 17 at 22,040,152 bp
  • G to A, chromosome 17 at 23,819,617 bp
  • G to A, chromosome 17 at 31,111,236 bp
  • T to A, chromosome 17 at 56,399,430 bp
  • T to A, chromosome 17 at 56,601,228 bp
  • T to C, chromosome 17 at 57,525,829 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1109 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039182-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.