Strain Name:
C57BL/6J-MtgxR1112Btlr/Mmmh
Stock Number:
039185-MU
Citation ID:
RRID:MMRRC_039185-MU
Other Names:
R1112 (G1), C57BL/6J-MtgxR1112Btlr
Major Collection:

Gene Information

Atrn
Name: attractin
Synonyms: Mgca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11990
HGNC: HGNC:885
Homologene: 22542
Prkd3
Name: protein kinase D3
Synonyms: Prkcn, PKD3, 4930557O20Rik, 5730497N19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 75292
HGNC: HGNC:9408
Homologene: 2055
Hap1
Name: huntingtin-associated protein 1
Synonyms: HAP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 15114
HGNC: HGNC:4812
Homologene: 2935
Orc4
Name: origin recognition complex, subunit 4
Synonyms: Orc4P, Orc4, Orc4l, mMmORC4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 26428
HGNC: HGNC:8490
Homologene: 8059
Fxr2
Name: fragile X mental retardation, autosomal homolog 2
Synonyms: Fxr2h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 23879
HGNC: HGNC:4024
Homologene: 21014
Slc12a2
Name: solute carrier family 12, member 2
Synonyms: sodium/potassium/chloride cotransporters, Nkcc1, sy-ns, mBSC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 20496
VEGA: 18
Homologene: 20283
Fam172a
Name: family with sequence similarity 172, member A
Synonyms: pEN87, 1110033M05Rik, 9430037D06Rik, 2610318O14Rik, 53-E6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 68675
VEGA: 13
Homologene: 12933
Gtf3c3
Name: general transcription factor IIIC, polypeptide 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98488
HGNC: HGNC:4666
Homologene: 40805
Cops7b
Name: COP9 signalosome subunit 7B
Synonyms: D1Wsu66e, COP9 complex S7b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 26895
Homologene: 8068
Fabp3
Name: fatty acid binding protein 3, muscle and heart
Synonyms: Fabph4, Fabph1, Mdgi, Fabph-4, Fabph-1, Fabp3, H-FABP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14077
HGNC: HGNC:3557
Homologene: 68379
Jak1
Name: Janus kinase 1
Synonyms: C130039L05Rik, BAP004
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16451
HGNC: HGNC:6190
Homologene: 1678
Ak7
Name: adenylate kinase 7
Synonyms: 4930502N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 78801
VEGA: 12
Homologene: 14268
Kirrel
Name: kirre like nephrin family adhesion molecule 1
Synonyms: Kirrel1, 6720469N11Rik, Neph1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 170643
Homologene: 10089
Srpr
Name: signal recognition particle receptor ('docking protein')
Synonyms: 1300011P19Rik, D11Mgi27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67398
Homologene: 2364
Gorasp2
Name: golgi reassembly stacking protein 2
Synonyms: GRS2, ENSMUSG00000075299, 9430094F20Rik, GRASP55, GOLPH2, 5730520M13Rik, p59
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70231
Homologene: 9180
Uggt1
Name: UDP-glucose glycoprotein glucosyltransferase 1
Synonyms: A930007H10Rik, C820010P03Rik, 0910001L17Rik, Ugcgl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 320011
Homologene: 10586
Ctnnd2
Name: catenin (cadherin associated protein), delta 2
Synonyms: Nprap, neurojugin, Catnd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18163
VEGA: 15
HGNC: HGNC:2516
Homologene: 55574
Scn4a
Name: sodium channel, voltage-gated, type IV, alpha
Synonyms: mH2, Nav1.4, SkM1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 110880
Homologene: 283
Myh13
Name: myosin, heavy polypeptide 13, skeletal muscle
Synonyms: extraocular myosin, EO Myosin, MyHC-eo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 544791
HGNC: HGNC:7571
Homologene: 55780
Myef2
Name: myelin basic protein expression factor 2, repressor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17876
Homologene: 69079
Madd
Name: MAP-kinase activating death domain
Synonyms: Rab3 GEP, 9630059K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228355
HGNC: HGNC:6766
Homologene: 14249
Serpinb6d
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6d
Synonyms: SPI3D, Gm11390
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238568
HGNC: HGNC:8950
Sycp2
Name: synaptonemal complex protein 2
Synonyms: 4930518F03Rik, 3830402K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 320558
Homologene: 8604
Hsd3b5
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5
Synonyms: 3(beta)HSDV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 15496
Homologene: 104115
Slfn10-ps
Name: schlafen 10, pseudogene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237887
Pcdhb22
Name: protocadherin beta 22
Synonyms: PcdhbV, Pcdhb15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93893
HGNC: HGNC:8686
Homologene: 113752
Olfr394
Name: olfactory receptor 394
Synonyms: MOR135-8, GA_x6K02T2P1NL-4043306-4042374
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 259009
Homologene: 133669
Bscl2
Name: Berardinelli-Seip congenital lipodystrophy 2 (seipin)
Synonyms: seipin, Gng3lg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 14705
Homologene: 32032
Foxn1
Name: forkhead box N1
Synonyms: whn, Hfh11, D11Bhm185e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 15218
Homologene: 2664
Zfp692
Name: zinc finger protein 692
Synonyms: Zfp692-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103836
Homologene: 9889
Sned1
Name: sushi, nidogen and EGF-like domains 1
Synonyms: 6720455I24Rik, Snep, D430044C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 208777
Homologene: 14708
Dusp10
Name: dual specificity phosphatase 10
Synonyms: 2610306G15Rik, MKP5, MKP-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 63953
HGNC: HGNC:3065
Homologene: 5215
Padi4
Name: peptidyl arginine deiminase, type IV
Synonyms: PAD type IV, Pad4, Pdi4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18602
Homologene: 7883
Slc36a4
Name: solute carrier family 36 (proton/amino acid symporter), member 4
Synonyms: 6330573I15Rik, PAT4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 234967
Homologene: 56300
Olfr586
Name: olfactory receptor 586
Synonyms: GA_x6K02T2PBJ9-5836380-5835439, MOR8-2, MOR8-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259115
Homologene: 131143
Usp17la
Name: ubiquitin specific peptidase 17-like A
Synonyms: Dub1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13531
Homologene: 131315
Ubash3b
Name: ubiquitin associated and SH3 domain containing, B
Synonyms: TULA-2, 2810457I06Rik, Sts-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72828
Homologene: 13152
Kif1c
Name: kinesin family member 1C
Synonyms: N-3 kinsin, D11Bwg1349e, Orch3, B430105J22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16562
HGNC: HGNC:6317
Homologene: 4821
Clstn2
Name: calsyntenin 2
Synonyms: CSTN2, Cst-2, CS2, 2900042C18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 64085
Homologene: 49698
Gpr33
Name: G protein-coupled receptor 33
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 14762
HGNC: HGNC:4489
Homologene: 7345
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 36,173,546 bp
  • C to T, chromosome 1 at 54,417,778 bp
  • A to G, chromosome 1 at 86,589,160 bp
  • G to A, chromosome 1 at 93,281,654 bp
  • A to T, chromosome 1 at 184,036,900 bp
  • A to T, chromosome 2 at 48,933,572 bp
  • C to A, chromosome 2 at 70,690,814 bp
  • A to G, chromosome 2 at 91,143,599 bp
  • A to C, chromosome 2 at 125,097,586 bp
  • A to G, chromosome 2 at 130,999,161 bp
  • A to T, chromosome 2 at 178,352,536 bp
  • C to T, chromosome 3 at 87,089,151 bp
  • C to T, chromosome 3 at 98,630,077 bp
  • A to G, chromosome 4 at 101,157,086 bp
  • C to T, chromosome 4 at 130,312,387 bp
  • C to T, chromosome 4 at 140,758,116 bp
  • C to T, chromosome 7 at 103,122,404 bp
  • T to C, chromosome 7 at 104,859,426 bp
  • T to A, chromosome 9 at 15,723,515 bp
  • A to G, chromosome 9 at 35,214,959 bp
  • T to C, chromosome 9 at 41,028,116 bp
  • T to C, chromosome 9 at 97,458,228 bp
  • T to C, chromosome 11 at 58,311,562 bp
  • A to T, chromosome 11 at 67,354,750 bp
  • A to G, chromosome 11 at 69,652,248 bp
  • T to G, chromosome 11 at 70,724,815 bp
  • A to C, chromosome 11 at 73,888,234 bp
  • A to G, chromosome 11 at 78,371,030 bp
  • A to T, chromosome 11 at 83,029,517 bp
  • C to T, chromosome 11 at 100,354,317 bp
  • T to C, chromosome 11 at 106,320,466 bp
  • A to G, chromosome 12 at 52,023,372 bp
  • A to G, chromosome 12 at 105,713,572 bp
  • A to G, chromosome 13 at 33,669,135 bp
  • A to G, chromosome 13 at 77,761,886 bp
  • T to C, chromosome 15 at 30,921,880 bp
  • T to C, chromosome 17 at 78,966,408 bp
  • A to T, chromosome 18 at 37,519,768 bp
  • A to T, chromosome 18 at 57,937,752 bp
  • G to C, chromosome 19 at 8,839,734 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1112 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039185-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.