Strain Name:
C57BL/6J-MtgxR1121Btlr/Mmmh
Stock Number:
039194-MU
Citation ID:
RRID:MMRRC_039194-MU
Other Names:
R1121 (G1), C57BL/6J-MtgxR1121Btlr
Major Collection:

Gene Information

Zmpste24
Name: zinc metallopeptidase, STE24
Synonyms: A530043O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230709
Homologene: 4277
Aldh1l1
Name: aldehyde dehydrogenase 1 family, member L1
Synonyms: Fthfd, 1810048F20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 107747
HGNC: HGNC:3978
Homologene: 122031
Casp8
Name: caspase 8
Synonyms: MACH, FLICE, Mch5, Caspase-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12370
HGNC: HGNC:1509
Homologene: 7657
Itk
Name: IL2 inducible T cell kinase
Synonyms: Emt, Tsk, Tcsk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16428
HGNC: HGNC:6171
Homologene: 4051
Cuedc1
Name: CUE domain containing 1
Synonyms: C330016O16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103841
Homologene: 9933
Prtg
Name: protogenin
Synonyms: Igdcc5, A230098A12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235472
Homologene: 54453
Micu1
Name: mitochondrial calcium uptake 1
Synonyms: Cbara1, C730016L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216001
HGNC: HGNC:1530
Homologene: 4431
Hnrnpul1
Name: heterogeneous nuclear ribonucleoprotein U-like 1
Synonyms: E130317O14Rik, Hnrpul1, E1BAP5, E1B-AP5, Hnrnpul
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232989
Homologene: 31419
Fkbp15
Name: FK506 binding protein 15
Synonyms: C430014M02Rik, FKBP133
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 338355
Homologene: 28743
Uhrf1
Name: ubiquitin-like, containing PHD and RING finger domains, 1
Synonyms: ICBP90, Np95
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18140
Homologene: 7866
Fam120a
Name: family with sequence similarity 120, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218236
VEGA: 13
Homologene: 8752
Erc2
Name: ELKS/RAB6-interacting/CAST family member 2
Synonyms: ELKS2alpha, D14Ertd171e, CAST
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 238988
Homologene: 69188
Cops7a
Name: COP9 signalosome subunit 7A
Synonyms: COP9 complex S7a, D6Ertd35e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 26894
Homologene: 22685
Ppip5k2
Name: diphosphoinositol pentakisphosphate kinase 2
Synonyms: Cfap160, Hisppd1, Vip2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227399
Homologene: 49409
Dock2
Name: dedicator of cyto-kinesis 2
Synonyms: Hch, MBC, CED-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 94176
HGNC: HGNC:2988
Homologene: 37984
Wdr72
Name: WD repeat domain 72
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 546144
Homologene: 52326
Vwa7
Name: von Willebrand factor A domain containing 7
Synonyms: G7c, D17H6S56E-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 27762
Homologene: 11895
Sptbn5
Name: spectrin beta, non-erythrocytic 5
Synonyms: Spnb5, EG640524
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 640524
Homologene: 41150
Olfr214
Name: olfactory receptor 214
Synonyms: GA_x54KRFPKN04-58190962-58191900, MOR119-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258754
Homologene: 133694
Me3
Name: malic enzyme 3, NADP(+)-dependent, mitochondrial
Synonyms: 1700020C08Rik, B230207H15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 109264
HGNC: HGNC:6985
Homologene: 100773
Ap3b2
Name: adaptor-related protein complex 3, beta 2 subunit
Synonyms: Naptb, beta3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11775
HGNC: HGNC:567
Homologene: 55837
Fam214b
Name: family with sequence similarity 214, member B
Synonyms: B230312A22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230088
Homologene: 32625
Ankar
Name: ankyrin and armadillo repeat containing
Synonyms: 4932422E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 319695
Homologene: 85163
Ugt2a3
Name: UDP glucuronosyltransferase 2 family, polypeptide A3
Synonyms: 2010321J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72094
Homologene: 55988
Xkr7
Name: X-linked Kx blood group related 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228787
Homologene: 19390
Pcdhb14
Name: protocadherin beta 14
Synonyms: 2210006M07Rik, Pcdhb17, PcdhbN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93885
Homologene: 70876
Niban3
Name: niban apoptosis regulator 3
Synonyms: Bcnp1, Fam129c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 100037278
Homologene: 45462
Zpld2
Name: zona pellucida like domain containing 2
Synonyms: Gm7534
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 665186
Homologene: 104039
Dpysl2
Name: dihydropyrimidinase-like 2
Synonyms: TOAD-64, Crmp2, Ulip2, DRP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12934
HGNC: HGNC:3014
Homologene: 74392
Spef1l
Name: sperm flagellar 1 like
Synonyms: LOC381933, 6430531B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381933
Homologene: 134514
Ipp
Name: IAP promoted placental gene
Synonyms: Mipp, D4Jhu8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16351
HGNC: HGNC:6108
Homologene: 4309
Fam98a
Name: family with sequence similarity 98, member A
Synonyms: 2810405J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 72722
Homologene: 41042
Thnsl1
Name: threonine synthase-like 1 (bacterial)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 208967
Homologene: 32609
Rem1
Name: rad and gem related GTP binding protein 1
Synonyms: E030011C07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19700
Homologene: 7514
Vmn1r26
Name: vomeronasal 1 receptor 26
Synonyms: V1rc17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 171190
Grin2d
Name: glutamate receptor, ionotropic, NMDA2D (epsilon 4)
Synonyms: NMDAR2D, NR2D, GluRepsilon4, GluN2D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14814
HGNC: HGNC:4588
Homologene: 648
Islr
Name: immunoglobulin superfamily containing leucine-rich repeat
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 26968
VEGA: 9
HGNC: HGNC:6133
Homologene: 4050
G6pc3
Name: glucose 6 phosphatase, catalytic, 3
Synonyms: 0710001K01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68401
Homologene: 16304
Pnlip
Name: pancreatic lipase
Synonyms: 1810007A24Rik, PTL, pancreatic triglyceride lipase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 69060
VEGA: 19
HGNC: HGNC:9155
Homologene: 30999
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 58,824,260 bp
  • G to A, chromosome 1 at 72,651,663 bp
  • A to T, chromosome 1 at 97,756,860 bp
  • A to G, chromosome 2 at 21,212,164 bp
  • T to A, chromosome 2 at 120,069,390 bp
  • G to A, chromosome 2 at 152,634,535 bp
  • C to T, chromosome 2 at 153,054,423 bp
  • T to C, chromosome 4 at 43,034,947 bp
  • G to A, chromosome 4 at 62,340,335 bp
  • T to A, chromosome 4 at 116,520,675 bp
  • A to T, chromosome 4 at 121,081,321 bp
  • T to C, chromosome 4 at 134,202,937 bp
  • A to T, chromosome 5 at 87,327,689 bp
  • T to C, chromosome 6 at 58,008,662 bp
  • A to T, chromosome 6 at 90,589,384 bp
  • T to G, chromosome 6 at 116,557,229 bp
  • T to C, chromosome 6 at 124,962,416 bp
  • G to T, chromosome 7 at 25,740,907 bp
  • T to G, chromosome 7 at 45,854,347 bp
  • T to A, chromosome 7 at 81,464,195 bp
  • T to C, chromosome 7 at 89,736,613 bp
  • T to A, chromosome 7 at 139,976,630 bp
  • G to T, chromosome 8 at 71,602,503 bp
  • T to C, chromosome 9 at 58,157,762 bp
  • T to G, chromosome 9 at 72,906,167 bp
  • C to T, chromosome 9 at 74,154,908 bp
  • C to T, chromosome 10 at 59,788,982 bp
  • T to A, chromosome 11 at 34,756,291 bp
  • A to G, chromosome 11 at 46,331,894 bp
  • A to T, chromosome 11 at 88,183,438 bp
  • G to A, chromosome 11 at 102,189,942 bp
  • A to T, chromosome 13 at 48,910,437 bp
  • T to C, chromosome 14 at 28,475,655 bp
  • C to T, chromosome 14 at 66,862,552 bp
  • T to A, chromosome 17 at 35,017,794 bp
  • T to A, chromosome 17 at 56,312,917 bp
  • C to A, chromosome 17 at 75,538,534 bp
  • T to A, chromosome 18 at 37,449,592 bp
  • A to G, chromosome 19 at 58,680,908 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1121 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039194-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.