Strain Name:
C57BL/6J-MtgxR1122Btlr/Mmmh
Stock Number:
039195-MU
Citation ID:
RRID:MMRRC_039195-MU
Other Names:
R1122 (G1), C57BL/6J-MtgxR1122Btlr
Major Collection:

Strain Information

Map2k5
Name: mitogen-activated protein kinase kinase 5
Synonyms: MEK5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 23938
VEGA: 9
HGNC: HGNC:6845
Homologene: 115933
Gad2
Name: glutamic acid decarboxylase 2
Synonyms: GAD65, Gad-2, 6330404F12Rik, GAD(65)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14417
HGNC: HGNC:4093
Homologene: 20223
Rnf220
Name: ring finger protein 220
Synonyms: 5730503K05Rik, 4931406I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66743
Homologene: 10036
Syt4
Name: synaptotagmin IV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 20983
VEGA: 18
Homologene: 7559
Pdzd2
Name: PDZ domain containing 2
Synonyms: 4930537L06Rik, LOC223364, A930022H17Rik, Pdzk3, Gm21706
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 68070
Homologene: 23393
Slc6a4
Name: solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Synonyms: 5-HTT, Htt, Sert
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 15567
Homologene: 817
Wdfy3
Name: WD repeat and FYVE domain containing 3
Synonyms: Ggtb3, 2610509D04Rik, Bwf1, D5Ertd66e, Bchs, Alfy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72145
Homologene: 22855
Cyb5a
Name: cytochrome b5 type A (microsomal)
Synonyms: 0610009N12Rik, Cyb5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 109672
HGNC: HGNC:2570
Homologene: 41475
Nckap1
Name: NCK-associated protein 1
Synonyms: mh19, Hem-2, H19, Nap1, Hem2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 50884
HGNC: HGNC:7666
Homologene: 8384
Plekha5
Name: pleckstrin homology domain containing, family A member 5
Synonyms: PEPP2, 2810431N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 109135
Homologene: 10377
Gtf3c3
Name: general transcription factor IIIC, polypeptide 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98488
HGNC: HGNC:4666
Homologene: 40805
Acadvl
Name: acyl-Coenzyme A dehydrogenase, very long chain
Synonyms: VLCAD
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11370
HGNC: HGNC:92
Homologene: 5
D930028M14Rik
Name: RIKEN cDNA D930028M14 gene
Synonyms: EG434147
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434147
Tnc
Name: tenascin C
Synonyms: Hxb, TN-C, TN, C130033P17Rik, tenascin-C, cytotactin, hexabrachion
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21923
HGNC: HGNC:5318
Homologene: 55636
Exosc10
Name: exosome component 10
Synonyms: PM/Scl-100, PM-Scl, RRP6, p4, p3, p2, Pmscl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 50912
HGNC: HGNC:9138
Homologene: 31105
Kifc5b
Name: kinesin family member C5B
Synonyms: kinesin family c-terminal 5B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 16580
VEGA: 17
HGNC: HGNC:6389
Homologene: 83229
Slc7a8
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 8
Synonyms: LAT2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 50934
VEGA: 14
Homologene: 8166
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Fhip2a
Name: FHF complex subunit HOOK interacting protein 2A
Synonyms: Fam160b1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226252
VEGA: 19
Homologene: 28133
Nav3
Name: neuron navigator 3
Synonyms: Pomfil1p, POMFIL1, 4732483H20Rik, unc53H3, steerin 3, 9630020C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 260315
Homologene: 56688
Mrc1
Name: mannose receptor, C type 1
Synonyms: CD206, MR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17533
HGNC: HGNC:7228
Homologene: 37622
Uqcc4
Name: ubiquinol-cytochrome c reductase complex assembly factor 4
Synonyms: BC003965
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 214489
VEGA: 17
Homologene: 52829
Chtf18
Name: CTF18, chromosome transmission fidelity factor 18
Synonyms: 6030457M03Rik, CTF18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 214901
Homologene: 32532
AC165146.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Lrrc15
Name: leucine rich repeat containing 15
Synonyms: 5430427N11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74488
Homologene: 26080
Arhgap15
Name: Rho GTPase activating protein 15
Synonyms: 5830480G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76117
Homologene: 41271
Itgav
Name: integrin alpha V
Synonyms: vitronectin receptor alpha polypeptide (VNRA), CD51, alphav-integrin, 1110004F14Rik, 2610028E01Rik, D430040G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16410
HGNC: HGNC:6150
Homologene: 20510
Tbc1d7
Name: TBC1 domain family, member 7
Synonyms: 2610009C09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67046
VEGA: 13
Homologene: 9538
Adgrb1
Name: adhesion G protein-coupled receptor B1
Synonyms: B830018M07Rik, Bai1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 107831
HGNC: HGNC:943
Homologene: 1287
Gm5581
Name: predicted gene 5581
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 108169183
Tec
Name: tec protein tyrosine kinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 21682
Homologene: 1302
Entrep1
Name: endosomal transmembrane epsin interactor 1
Synonyms: LOC381217, Fam189a2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 381217
VEGA: 19
Homologene: 3540
Slco4c1
Name: solute carrier organic anion transporter family, member 4C1
Synonyms: SLC21A20, PRO2176, OATP4C1, OATP-M1, OATP-H, C330017E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227394
Homologene: 62654
Aif1
Name: allograft inflammatory factor 1
Synonyms: G1, Iba1, D17H6S50E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 11629
HGNC: HGNC:352
Homologene: 1226
Or1o2
Name: olfactory receptor family 1 subfamily O member 2
Synonyms: MOR156-2, GA_x6K02T2PSCP-1672287-1671355, Olfr97
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258505
Homologene: 133051
Pus7l
Name: pseudouridylate synthase 7-like
Synonyms: 3000003F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 78895
Homologene: 12842
Rem1
Name: rad and gem related GTP binding protein 1
Synonyms: E030011C07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19700
Homologene: 7514
Or12d12
Name: olfactory receptor family 12 subfamily D member 12
Synonyms: MOR250-2, GA_x6K02T2PSCP-1761617-1760691, Olfr101
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258831
Homologene: 133728
Zfp729b
Name: zinc finger protein 729b
Synonyms: AA987161
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 100416706
Homologene: 133713
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 54,427,391 bp
  • A to G, chromosome 1 at 96,828,836 bp
  • G to A, chromosome 2 at 14,261,336 bp
  • A to T, chromosome 2 at 22,623,451 bp
  • A to T, chromosome 2 at 44,142,295 bp
  • A to G, chromosome 2 at 76,715,332 bp
  • C to T, chromosome 2 at 80,517,942 bp
  • A to G, chromosome 2 at 83,791,939 bp
  • G to A, chromosome 2 at 152,634,535 bp
  • A to T, chromosome 4 at 64,007,881 bp
  • C to T, chromosome 4 at 117,278,080 bp
  • T to C, chromosome 4 at 148,566,364 bp
  • T to C, chromosome 5 at 72,779,449 bp
  • T to C, chromosome 5 at 101,882,966 bp
  • A to T, chromosome 6 at 131,167,792 bp
  • G to A, chromosome 6 at 140,570,317 bp
  • A to G, chromosome 7 at 25,155,396 bp
  • A to G, chromosome 9 at 63,263,163 bp
  • A to T, chromosome 10 at 109,760,537 bp
  • G to A, chromosome 11 at 70,011,377 bp
  • T to C, chromosome 11 at 77,027,186 bp
  • A to G, chromosome 13 at 43,154,846 bp
  • A to G, chromosome 13 at 67,595,284 bp
  • T to A, chromosome 14 at 19,401,879 bp
  • T to C, chromosome 14 at 54,724,107 bp
  • A to G, chromosome 15 at 12,457,895 bp
  • C to A, chromosome 15 at 74,547,685 bp
  • A to G, chromosome 15 at 94,523,657 bp
  • T to C, chromosome 16 at 30,273,901 bp
  • T to C, chromosome 17 at 25,184,872 bp
  • T to C, chromosome 17 at 25,724,623 bp
  • T to A, chromosome 17 at 26,924,061 bp
  • G to A, chromosome 17 at 35,172,151 bp
  • T to A, chromosome 17 at 37,232,043 bp
  • T to A, chromosome 17 at 37,300,128 bp
  • T to A, chromosome 18 at 31,440,202 bp
  • A to G, chromosome 18 at 84,877,839 bp
  • T to C, chromosome 19 at 23,975,392 bp
  • A to T, chromosome 19 at 57,382,301 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1122 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039195-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.