Strain Name:
C57BL/6J-MtgxR1124Btlr/Mmmh
Stock Number:
039197-MU
Citation ID:
RRID:MMRRC_039197-MU
Other Names:
R1124 (G1), C57BL/6J-MtgxR1124Btlr
Major Collection:

Strain Information

Drd2
Name: dopamine receptor D2
Synonyms: D2 receptor, Drd-2, D2R
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13489
VEGA: 9
HGNC: HGNC:3023
Homologene: 22561
Myh7
Name: myosin, heavy polypeptide 7, cardiac muscle, beta
Synonyms: MYH-beta/slow, Myhc-b, B-MHC, beta-MHC, betaMHC, MyHC-I, Myhcb
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 140781
HGNC: HGNC:7577
Homologene: 68044
Xrn1
Name: 5'-3' exoribonuclease 1
Synonyms: Dhm2, mXrn1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 24127
Homologene: 5894
Nckap1
Name: NCK-associated protein 1
Synonyms: Hem2, Hem-2, mh19, Nap1, H19
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 50884
HGNC: HGNC:7666
Homologene: 8384
Zfp106
Name: zinc finger protein 106
Synonyms: Cd-1, H3a, sirm, Sh3bp3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20402
Homologene: 40787
Trip12
Name: thyroid hormone receptor interactor 12
Synonyms: Gtl6, 1110036I07Rik, 6720416K24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14897
Homologene: 44226
Tbc1d23
Name: TBC1 domain family, member 23
Synonyms: D030022P07Rik, 4930451A13Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67581
VEGA: 16
Homologene: 10126
C2cd3
Name: C2 calcium-dependent domain containing 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 277939
Homologene: 19524
Pirb
Name: paired Ig-like receptor B
Synonyms: Gp91, Lilrb3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18733
Homologene: 134028
Macrod2
Name: mono-ADP ribosylhydrolase 2
Synonyms: 2610107G07Rik, 2900006F19Rik, 1110033L15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72899
Homologene: 85987
Ccdc174
Name: coiled-coil domain containing 174
Synonyms: C130022K22Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232236
Homologene: 9523
Ush2a
Name: usherin
Synonyms: MUSH2A, LOC269160, Ush2a, A930037M10Rik, A930011D15Rik, LOC381317, Ushrn
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Tnfrsf1b
Name: tumor necrosis factor receptor superfamily, member 1b
Synonyms: TNFBR, p75 TNFR, TNFalpha-R2, TNF-R2, TNFRII, p75, TNF-alphaR2, Tnfr2, TNF-R75, TNF-R-II, TNFR80, CD120b
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21938
Homologene: 829
Gm4934
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Pmfbp1
Name: polyamine modulated factor 1 binding protein 1
Synonyms: 1700016D22Rik, F77
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56523
Homologene: 23182
Aadacl4fm1
Name: AADACL4 family member 1
Synonyms: LOC381572, 9430007A20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381572
Homologene: 28662
Vmn2r115
Name: vomeronasal 2, receptor 115
Synonyms: V2Rp4, EG638102
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 638102
Homologene: 86604
Vmn1r204
Name: vomeronasal 1 receptor 204
Synonyms: Gm11301
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 632793
Homologene: 110880
Grm3
Name: glutamate receptor, metabotropic 3
Synonyms: 0710001G23Rik, mGlu3, mGluR3, Gprc1c
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 108069
HGNC: HGNC:4595
Homologene: 651
Fbxw14
Name: F-box and WD-40 domain protein 14
Synonyms: Fbxo12, Fbx12, E330009N23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 50757
Homologene: 110776
Vmn2r93
Name: vomeronasal 2, receptor 93
Synonyms: EG627132
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627132
Homologene: 129750
Dnaaf11
Name: dynein axonemal assembly factor 11
Synonyms: LRTP, Lrrc6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 54562
Homologene: 34534
Mogat2
Name: monoacylglycerol O-acyltransferase 2
Synonyms: DGAT2L5, Mgat2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233549
Homologene: 57020
3425401B19Rik
Name: RIKEN cDNA 3425401B19 gene
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100504518
VEGA: 14
Homologene: 54908
Gys2
Name: glycogen synthase 2
Synonyms: LGS, glycogen synthase, liver
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232493
HGNC: HGNC:4707
Homologene: 56580
AC165412.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Aadacl4fm4
Name: AADACL4 family member 4
Synonyms: LOC230890, Gm436
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230890
Homologene: 135765
Or8k23
Name: olfactory receptor family 8 subfamily K member 23
Synonyms: Olfr1056, GA_x6K02T2Q125-47827833-47826892, MOR186-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259020
Homologene: 27328
Anxa10
Name: annexin A10
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 26359
HGNC: HGNC:534
Homologene: 21409
Rasa4
Name: RAS p21 protein activator 4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54153
Homologene: 5080
Bcl11a
Name: BCL11 transcription factor A
Synonyms: Evi9b, 2810047E18Rik, D930021L15Rik, CTIP1, COUP-TF interacting protein 1, Evi9a, Evi9, mouse myeloid leukemia gene, Evi9c
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14025
Homologene: 11284
Bhlhe41
Name: basic helix-loop-helix family, member e41
Synonyms: 6430520M22Rik, Sharp1, DEC2, Bhlhb3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 79362
Homologene: 137371
Gm14184
Name: predicted gene 14184
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 84,737,037 bp
  • G to T, chromosome 1 at 188,753,536 bp
  • T to A, chromosome 2 at 40,875,051 bp
  • C to T, chromosome 2 at 80,517,942 bp
  • T to A, chromosome 2 at 86,355,895 bp
  • C to T, chromosome 2 at 120,534,714 bp
  • A to G, chromosome 2 at 140,452,627 bp
  • A to G, chromosome 3 at 59,865,218 bp
  • A to G, chromosome 4 at 144,528,624 bp
  • T to C, chromosome 4 at 144,670,275 bp
  • A to T, chromosome 4 at 145,224,356 bp
  • C to T, chromosome 5 at 9,570,297 bp
  • A to G, chromosome 5 at 136,105,656 bp
  • T to C, chromosome 6 at 91,899,580 bp
  • A to G, chromosome 6 at 142,446,013 bp
  • A to G, chromosome 6 at 145,863,730 bp
  • T to A, chromosome 7 at 3,719,732 bp
  • A to G, chromosome 7 at 99,232,644 bp
  • A to G, chromosome 7 at 100,422,681 bp
  • C to T, chromosome 8 at 62,061,004 bp
  • A to G, chromosome 8 at 109,530,483 bp
  • T to C, chromosome 9 at 49,395,640 bp
  • A to G, chromosome 9 at 96,003,865 bp
  • T to A, chromosome 9 at 109,276,168 bp
  • A to T, chromosome 11 at 24,163,928 bp
  • A to T, chromosome 11 at 99,699,673 bp
  • A to T, chromosome 13 at 22,557,039 bp
  • A to C, chromosome 13 at 59,716,654 bp
  • C to T, chromosome 14 at 32,662,082 bp
  • A to T, chromosome 14 at 54,973,870 bp
  • T to A, chromosome 15 at 66,438,415 bp
  • A to T, chromosome 16 at 57,214,162 bp
  • G to T, chromosome 17 at 18,298,448 bp
  • ATCTTCT to ATCT, chromosome 17 at 23,359,988 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1124 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039197-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.