Strain Name:
C57BL/6J-MtgxR1134Btlr/Mmmh
Stock Number:
039207-MU
Citation ID:
RRID:MMRRC_039207-MU
Other Names:
R1134 (G1), C57BL/6J-MtgxR1134Btlr
Major Collection:

Strain Information

Vps33a
Name: VPS33A CORVET/HOPS core subunit
Synonyms: bf, 3830421M04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 77573
Homologene: 11294
Cd40
Name: CD40 antigen
Synonyms: p50, Bp50, Cd40, Tnfrsf5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21939
Homologene: 954
Gk5
Name: glycerol kinase 5
Synonyms: G630067D24Rik, C330018K18Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235533
Homologene: 15141
Morc3
Name: microrchidia 3
Synonyms: Zcwcc3, D16Jhu32e, 1110051N18Rik, 1110051N18Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 338467
Homologene: 32257
Rev1
Name: REV1, DNA directed polymerase
Synonyms: Rev1l, REV1, 1110027I23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 56210
Homologene: 32309
Zcchc8
Name: zinc finger, CCHC domain containing 8
Synonyms: 5730565F05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70650
Homologene: 32349
Trrap
Name: transformation/transcription domain-associated protein
Synonyms: transactivation/transformation-domain associated protein
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100683
Homologene: 39246
Bcl6
Name: B cell leukemia/lymphoma 6
Synonyms: Bcl5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12053
HGNC: HGNC:1001
Homologene: 7640
Klhl28
Name: kelch-like 28
Synonyms: 4122402F11Rik, 4931401E10Rik, 2810440N09Rik, Btbd5
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 66689
VEGA: 12
Homologene: 23036
Ms4a4d
Name: membrane-spanning 4-domains, subfamily A, member 4D
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66607
Homologene: 113790
Trpa1
Name: transient receptor potential cation channel, subfamily A, member 1
Synonyms: ANKTM1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 277328
HGNC: HGNC:497
Homologene: 7189
Col1a2
Name: collagen, type I, alpha 2
Synonyms: Cola2, Cola-2, Col1a-2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12843
HGNC: HGNC:2198
Homologene: 69
Tbx15
Name: T-box 15
Synonyms: Tbx14, de, Tbx8
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 21384
Homologene: 7967
Otog
Name: otogelin
Synonyms: Otgn
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18419
HGNC: HGNC:8516
Homologene: 8421
Or13p3
Name: olfactory receptor family 13 subfamily P member 3
Synonyms: MOR258-1, GA_x6K02T2QD9B-18838170-18837232, Olfr1341
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258852
Homologene: 27281
Ugt2b38
Name: UDP glucuronosyltransferase 2 family, polypeptide B38
Synonyms: 9430041C03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100559
Homologene: 137225
Plcl2
Name: phospholipase C-like 2
Synonyms: Plce2, PRIP-2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224860
VEGA: 17
HGNC: HGNC:9064
Homologene: 9052
Lhfpl2
Name: lipoma HMGIC fusion partner-like 2
Synonyms: vgim
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218454
HGNC: HGNC:6588
Homologene: 4222
Parp14
Name: poly (ADP-ribose) polymerase family, member 14
Synonyms: 1600029O10Rik, CoaSt6, collaborator of Stat6
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 547253
Homologene: 19697
Pgap4
Name: post-GPI attachment to proteins GalNAc transferase 4
Synonyms: Tmem246, 9330170P15Rik, 2810432L12Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67063
Homologene: 12080
Endou
Name: endonuclease, polyU-specific
Synonyms: Tcl-30, Pp11r
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 19011
VEGA: 15
Homologene: 48394
Tdpoz4
Name: TD and POZ domain containing 4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 399675
Homologene: 130121
Fabp12
Name: fatty acid binding protein 12
Synonyms: 1700008G05Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 75497
Homologene: 67746
Erich2
Name: glutamate rich 2
Synonyms: 4933404M02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66748
Homologene: 75226
Or8k21
Name: olfactory receptor family 8 subfamily K member 21
Synonyms: Olfr1053, Olfr1053-ps1, MOR187-4, GA_x6K02T2Q125-47793414-47792471
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257974
Homologene: 74197
Tmem225
Name: transmembrane protein 225
Synonyms: 1700030E15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75667
VEGA: 9
Homologene: 52854
Frmd3
Name: FERM domain containing 3
Synonyms: 4.1O, P410, 9430066I12Rik, EPB41L4O
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242506
Homologene: 16012
Plekhg2
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 2
Synonyms: Clg
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101497
Homologene: 16341
Dusp6
Name: dual specificity phosphatase 6
Synonyms: 1300019I03Rik, PYST1, MKP3, MKP-3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67603
VEGA: 10
HGNC: HGNC:3072
Homologene: 55621
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 14,881,748 bp
  • G to A, chromosome 1 at 38,057,687 bp
  • T to A, chromosome 2 at 70,536,191 bp
  • T to C, chromosome 2 at 86,315,181 bp
  • T to A, chromosome 2 at 165,070,818 bp
  • T to C, chromosome 3 at 10,247,671 bp
  • A to T, chromosome 3 at 93,797,218 bp
  • G to T, chromosome 3 at 99,316,323 bp
  • T to C, chromosome 4 at 49,586,832 bp
  • G to A, chromosome 4 at 74,170,630 bp
  • A to G, chromosome 4 at 118,710,279 bp
  • T to G, chromosome 5 at 87,412,373 bp
  • A to G, chromosome 5 at 123,570,912 bp
  • C to G, chromosome 5 at 123,717,027 bp
  • T to A, chromosome 5 at 144,793,218 bp
  • G to A, chromosome 6 at 4,518,822 bp
  • G to T, chromosome 7 at 28,362,001 bp
  • A to G, chromosome 7 at 46,298,514 bp
  • T to C, chromosome 9 at 40,149,847 bp
  • A to G, chromosome 9 at 96,133,407 bp
  • T to C, chromosome 10 at 99,264,954 bp
  • A to G, chromosome 12 at 64,951,617 bp
  • C to T, chromosome 13 at 94,174,252 bp
  • A to G, chromosome 15 at 97,713,866 bp
  • C to A, chromosome 16 at 23,968,365 bp
  • A to G, chromosome 16 at 35,834,902 bp
  • T to C, chromosome 16 at 93,870,669 bp
  • G to A, chromosome 17 at 50,608,110 bp
  • C to T, chromosome 19 at 11,557,934 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1134 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039207-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.