Strain Name:
C57BL/6J-MtgxR1140Btlr/Mmmh
Stock Number:
039213-MU
Citation ID:
RRID:MMRRC_039213-MU
Other Names:
R1140 (G1), C57BL/6J-MtgxR1140Btlr
Major Collection:

Gene Information

Myh7
Name: myosin, heavy polypeptide 7, cardiac muscle, beta
Synonyms: Myhcb, MYH-beta/slow, beta-MHC, Myhc-b, B-MHC, betaMHC, MyHC-I
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 140781
HGNC: HGNC:7577
Homologene: 68044
Cep83
Name: centrosomal protein 83
Synonyms: Ccdc41, 5730513H21Rik, 2600001G24Rik, 4921537D05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 77048
VEGA: 10
Homologene: 9396
Taok3
Name: TAO kinase 3
Synonyms: 2900006A08Rik, A430105I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 330177
Homologene: 83279
Aurka
Name: aurora kinase A
Synonyms: AIRK1, IAK1, Ark1, Aurora-A, aurora A, Stk6, Ayk1, IAK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20878
Homologene: 2670
Dis3l2
Name: DIS3 like 3'-5' exoribonuclease 2
Synonyms: 4930429A22Rik, 8030493P09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 208718
Homologene: 62417
Heatr1
Name: HEAT repeat containing 1
Synonyms: B130016L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 217995
VEGA: 13
Homologene: 34562
Parg
Name: poly (ADP-ribose) glycohydrolase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 26430
HGNC: HGNC:8605
Homologene: 50532
Dock7
Name: dedicator of cytokinesis 7
Synonyms: LOC242555, m, 3110056M06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67299
Homologene: 23566
Xxylt1
Name: xyloside xylosyltransferase 1
Synonyms: AI480653
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 268880
Homologene: 17610
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: 6820443O06Rik, Nesp2g, nesprin-2, syne-2, Cpfl8, diminished cone electroretinogram, dice, D12Ertd777e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 319565
Homologene: 56700
Sis
Name: sucrase isomaltase (alpha-glucosidase)
Synonyms: sucrase-isomaltase, 2010204N08Rik, Si-s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 69983
Homologene: 37424
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241516
Homologene: 110349
Tfip11
Name: tuftelin interacting protein 11
Synonyms: Tip39
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 54723
Homologene: 40813
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC9, MUC5, 2300002I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Ahnak
Name: AHNAK nucleoprotein (desmoyokin)
Synonyms: 1110004P15Rik, DY6, 2310047C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Tbc1d2b
Name: TBC1 domain family, member 2B
Synonyms: 1810061M12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67016
Homologene: 56694
Ece2
Name: endothelin converting enzyme 2
Synonyms: 9630025D12Rik, 6330509A19Rik, 1810009K13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 107522
Homologene: 56679
Npr2
Name: natriuretic peptide receptor 2
Synonyms: cn, guanylyl cyclase-B, pwe
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230103
HGNC: HGNC:7944
Homologene: 2970
Fam234b
Name: family with sequence similarity 234, member B
Synonyms: 8430419L09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74525
Homologene: 12572
Olfr389
Name: olfactory receptor 389
Synonyms: MOR135-6, GA_x6K02T2P1NL-3932085-3931147
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 259011
Homologene: 85925
Arfgef3
Name: ARFGEF family member 3
Synonyms: B930094H20Rik, BIG3, D10Bwg1379e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215821
VEGA: 10
Homologene: 41366
Speg
Name: SPEG complex locus
Synonyms: BPEG, SPEG, Apeg1, D1Bwg1450e, SPEGalpha, SPEGbeta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11790
Homologene: 55619
Fanca
Name: Fanconi anemia, complementation group A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14087
HGNC: HGNC:3582
Homologene: 108
6430548M08Rik
Name: RIKEN cDNA 6430548M08 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234797
Homologene: 8825
Aldh18a1
Name: aldehyde dehydrogenase 18 family, member A1
Synonyms: 2810433K04Rik, Pycs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 56454
HGNC: HGNC:9722
Homologene: 2142
Dsc2
Name: desmocollin 2
Synonyms: Dsc2a, Dsc2b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13506
HGNC: HGNC:3036
Homologene: 8397
Fndc1
Name: fibronectin type III domain containing 1
Synonyms: 1110027O12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 68655
Ptdss1
Name: phosphatidylserine synthase 1
Synonyms: PtdSer Synthase-1, PSS-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 19210
VEGA: 13
HGNC: HGNC:9587
Homologene: 7494
Mtnr1b
Name: melatonin receptor 1B
Synonyms: Mt2, Mel1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244701
HGNC: HGNC:7464
Homologene: 4350
Gsc
Name: goosecoid homeobox
Synonyms: goosecoid
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 14836
HGNC: HGNC:4612
Homologene: 7744
Samsn1
Name: SAM domain, SH3 domain and nuclear localization signals, 1
Synonyms: 4930571B16Rik, Hacs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 67742
Homologene: 11148
Fastkd5
Name: FAST kinase domains 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 380601
Homologene: 36400
Stk32c
Name: serine/threonine kinase 32C
Synonyms: Pkek, YANK3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57740
Homologene: 75157
Tmem233
Name: transmembrane protein 233
Synonyms: Gm13843
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 545798
Homologene: 54444
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 75,429,095 bp
  • A to T, chromosome 1 at 86,821,438 bp
  • T to A, chromosome 2 at 82,975,034 bp
  • C to T, chromosome 2 at 130,616,215 bp
  • T to C, chromosome 2 at 172,357,229 bp
  • C to T, chromosome 3 at 72,951,616 bp
  • A to G, chromosome 4 at 43,648,353 bp
  • A to G, chromosome 4 at 99,065,406 bp
  • T to C, chromosome 5 at 112,335,561 bp
  • A to T, chromosome 5 at 116,051,308 bp
  • T to C, chromosome 5 at 117,228,053 bp
  • A to T, chromosome 6 at 135,225,758 bp
  • C to T, chromosome 7 at 139,125,179 bp
  • A to G, chromosome 7 at 141,858,996 bp
  • T to A, chromosome 8 at 120,150,135 bp
  • A to C, chromosome 8 at 123,313,129 bp
  • T to C, chromosome 9 at 15,874,234 bp
  • A to G, chromosome 9 at 90,226,376 bp
  • T to A, chromosome 10 at 18,597,348 bp
  • A to G, chromosome 10 at 94,737,890 bp
  • T to A, chromosome 11 at 73,776,854 bp
  • T to C, chromosome 12 at 75,945,064 bp
  • A to T, chromosome 12 at 104,473,102 bp
  • T to A, chromosome 13 at 12,429,823 bp
  • T to C, chromosome 13 at 66,963,356 bp
  • T to C, chromosome 14 at 32,296,243 bp
  • T to C, chromosome 14 at 54,972,882 bp
  • T to C, chromosome 16 at 20,630,774 bp
  • T to A, chromosome 16 at 31,007,848 bp
  • C to T, chromosome 16 at 75,888,742 bp
  • T to C, chromosome 17 at 7,775,426 bp
  • C to A, chromosome 18 at 20,032,212 bp
  • T to A, chromosome 19 at 9,004,245 bp
  • T to C, chromosome 19 at 40,574,285 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1140 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039213-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.