Strain Name:
C57BL/6J-MtgxR1142Btlr/Mmmh
Stock Number:
039215-MU
Citation ID:
RRID:MMRRC_039215-MU
Other Names:
R1142 (G1), C57BL/6J-MtgxR1142Btlr
Major Collection:

Gene Information

Met
Name: met proto-oncogene
Synonyms: HGF receptor, c-Met, Par4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17295
HGNC: HGNC:7029
Homologene: 206
Jmjd1c
Name: jumonji domain containing 1C
Synonyms: D630035I23Rik, TRIP8, 5430433L24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 108829
Homologene: 3129
Hsp90ab1
Name: heat shock protein 90 alpha (cytosolic), class B member 1
Synonyms: Hsp90, Hsp84, C81438, Hspcb, Hsp84-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 15516
HGNC: HGNC:5258
Homologene: 74306
Brix1
Name: BRX1, biogenesis of ribosomes
Synonyms: 1110064N10Rik, Bxdc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 67832
Homologene: 10133
Zc3h13
Name: zinc finger CCCH type containing 13
Synonyms: 4930570G11Rik, 2600010B19Rik, 3110050K21Rik, C87618
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 67302
VEGA: 14
Cad
Name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Synonyms: 2410008J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 69719
HGNC: HGNC:1424
Homologene: 1412
Dph6
Name: diphthamine biosynthesis 6
Synonyms: Diphthine ammonia ligase, 5730421E18Rik, Atpbd4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66632
Homologene: 80244
Tnc
Name: tenascin C
Synonyms: TN, Hxb, cytotactin, C130033P17Rik, tenascin-C, hexabrachion, TN-C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21923
HGNC: HGNC:5318
Homologene: 55636
Slc38a9
Name: solute carrier family 38, member 9
Synonyms: 4833412L08Rik, 9130023D20Rik, 6720411P22Rik, 9430067K09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 268706
VEGA: 13
Homologene: 18139
Itga9
Name: integrin alpha 9
Synonyms: D9Ertd428e, 6720458D17Rik, 2610002H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 104099
HGNC: HGNC:6145
Homologene: 1664
Alx3
Name: aristaless-like homeobox 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 11694
HGNC: HGNC:449
Homologene: 4737
Lamc3
Name: laminin gamma 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 23928
HGNC: HGNC:6494
Homologene: 21222
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Phkg1
Name: phosphorylase kinase gamma 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18682
HGNC: HGNC:8930
Homologene: 68508
F830045P16Rik
Name: RIKEN cDNA F830045P16 gene
Synonyms: Sirpb3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228592
Homologene: 136180
Col6a5
Name: collagen, type VI, alpha 5
Synonyms: Gm7455, Col6a5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 665033
Homologene: 122792
Gjb3
Name: gap junction protein, beta 3
Synonyms: Gjb-3, connexin 31, D4Wsu144e, Cx31, Cnx31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14620
HGNC: HGNC:4285
Homologene: 7338
Vmn2r91
Name: vomeronasal 2, receptor 91
Synonyms: EG665210
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 665210
Homologene: 115024
Pdlim3
Name: PDZ and LIM domain 3
Synonyms: ALP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 53318
Homologene: 75063
Aldh18a1
Name: aldehyde dehydrogenase 18 family, member A1
Synonyms: Pycs, 2810433K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 56454
HGNC: HGNC:9722
Homologene: 2142
Cxadr
Name: coxsackie virus and adenovirus receptor
Synonyms: 2610206D03Rik, CAR, MCAR, MCVADR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 13052
HGNC: HGNC:2559
Homologene: 1024
Vmn1r85
Name: vomeronasal 1 receptor 85
Synonyms: V1rj3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 252909
Homologene: 74338
Apobr
Name: apolipoprotein B receptor
Synonyms: Apob48r, Apob-48r
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 171504
Homologene: 26695
Crnn
Name: cornulin
Synonyms: LOC381457
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 381457
HGNC: HGNC:1230
Homologene: 9416
Ephx3
Name: epoxide hydrolase 3
Synonyms: Abhd9, 2310063B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 71932
Homologene: 69386
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 2 at 31,940,721 bp
  • A to G, chromosome 2 at 114,647,779 bp
  • T to A, chromosome 2 at 129,460,332 bp
  • T to C, chromosome 3 at 93,148,035 bp
  • T to C, chromosome 3 at 107,600,664 bp
  • C to T, chromosome 4 at 64,013,994 bp
  • G to A, chromosome 4 at 127,326,431 bp
  • T to C, chromosome 5 at 31,070,562 bp
  • A to G, chromosome 5 at 129,873,232 bp
  • T to A, chromosome 6 at 17,527,183 bp
  • T to C, chromosome 7 at 13,084,554 bp
  • A to G, chromosome 7 at 126,587,482 bp
  • C to A, chromosome 8 at 45,918,961 bp
  • A to G, chromosome 9 at 105,934,317 bp
  • C to A, chromosome 9 at 118,607,130 bp
  • T to C, chromosome 10 at 67,225,345 bp
  • T to C, chromosome 13 at 112,714,210 bp
  • T to C, chromosome 14 at 75,315,984 bp
  • G to T, chromosome 15 at 10,485,724 bp
  • A to G, chromosome 16 at 37,013,217 bp
  • A to G, chromosome 16 at 78,334,839 bp
  • T to A, chromosome 17 at 18,136,443 bp
  • G to A, chromosome 17 at 32,185,274 bp
  • C to A, chromosome 17 at 45,568,974 bp
  • A to G, chromosome 19 at 40,551,213 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1142 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039215-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.