Strain Name:
C57BL/6J-MtgxR1145Btlr/Mmmh
Stock Number:
039218-MU
Citation ID:
RRID:MMRRC_039218-MU
Other Names:
R1145 (G1), C57BL/6J-MtgxR1145Btlr
Major Collection:

Strain Information

Ldb2
Name: LIM domain binding 2
Synonyms: CLIM1, Ldb3, CLP-36, CLIM-1b, CLIM-1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16826
HGNC: HGNC:6533
Homologene: 989
Inpp5k
Name: inositol polyphosphate 5-phosphatase K
Synonyms: C62, PI-5-phosphatase related, putative PI-5-phosphatase, Pps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19062
Homologene: 75059
Eif4g3
Name: eukaryotic translation initiation factor 4 gamma, 3
Synonyms: eIF4GII, 1500002J22Rik, 4930523M17Rik, G1-419-52, repro8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230861
HGNC: HGNC:3298
Homologene: 2789
Zc3h4
Name: zinc finger CCCH-type containing 4
Synonyms: LOC330474, Bwq1, Kiaa1064-hp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330474
Homologene: 87150
Taf2
Name: TATA-box binding protein associated factor 2
Synonyms: TAFII150, CIF150, TAF2B, 4732460C16Rik, 150kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 319944
VEGA: 15
Homologene: 31137
Agk
Name: acylglycerol kinase
Synonyms: MuLK, 2610037M15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 69923
Homologene: 41239
Slc43a2
Name: solute carrier family 43, member 2
Synonyms: 7630402D21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 215113
Homologene: 17555
Otud6b
Name: OTU domain containing 6B
Synonyms: 2600013N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72201
Homologene: 6064
Tap2
Name: transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Synonyms: MTP2, PSF2, Ham2, Ham-2, Tap-2, HAM2, Abcb3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 21355
HGNC: HGNC:44
Homologene: 37323
Cpxm2
Name: carboxypeptidase X 2 (M14 family)
Synonyms: 4632435C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 55987
Homologene: 69259
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 545370
Homologene: 23741
Unc80
Name: unc-80, NALCN activator
Synonyms: C230061B10Rik, C030018G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329178
Homologene: 122243
Ptpro
Name: protein tyrosine phosphatase, receptor type, O
Synonyms: D28, PTPROt, PTP-phi, PTP-BK, PTP-U2, GLEPP1, PTP-oc, Ptpn15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19277
HGNC: HGNC:9678
Homologene: 21564
Vmn2r115
Name: vomeronasal 2, receptor 115
Synonyms: EG638102, V2Rp4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 638102
Homologene: 86604
Vwa3a
Name: von Willebrand factor A domain containing 3A
Synonyms: E030013G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233813
Homologene: 18607
Arhgef5
Name: Rho guanine nucleotide exchange factor (GEF) 5
Synonyms: 2210412D05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 54324
Homologene: 66300
Odad2
Name: outer dynein arm docking complex subunit 2
Synonyms: 4930463I21Rik, Armc4, b2b227.1Clo, b2b643Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 74934
VEGA: 18
Homologene: 9992
Sel1l3
Name: sel-1 suppressor of lin-12-like 3 (C. elegans)
Synonyms: 2310045A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231238
Homologene: 9054
Ctsj
Name: cathepsin J
Synonyms: rat gene/Cathepsin L-related protein, CatRLP, CATP, Cat P, Ctsp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 26898
VEGA: 13
HGNC: HGNC:2537
Homologene: 137246
C1s1
Name: complement component 1, s subcomponent 1
Synonyms: C1s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 50908
HGNC: HGNC:1247
Homologene: 1314
Eml6
Name: echinoderm microtubule associated protein like 6
Synonyms: 2900083P10Rik, C230094A16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237711
Homologene: 104282
Glp1r
Name: glucagon-like peptide 1 receptor
Synonyms: GLP-1R, GLP1Rc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14652
VEGA: 17
HGNC: HGNC:4324
Homologene: 1558
Pnpla2
Name: patatin-like phospholipase domain containing 2
Synonyms: 1110001C14Rik, 0610039C21Rik, Atgl, desnutrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 66853
Homologene: 10687
Abi3bp
Name: ABI family member 3 binding protein
Synonyms: 5033411B22Rik, D930038M13Rik, eratin, TARSH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 320712
VEGA: 16
Homologene: 134172
Zfp385a
Name: zinc finger protein 385A
Synonyms: Hzf, Zfp385
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 29813
VEGA: 15
Homologene: 8479
Dnali1
Name: dynein, axonemal, light intermediate polypeptide 1
Synonyms: 1700023A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 75563
Homologene: 2586
Krtdap
Name: keratinocyte differentiation associated protein
Synonyms: sk221, Kdap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 64661
Homologene: 52619
AC159637.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Gm10553
Name: predicted gene 10553
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Gm11143
Name: predicted gene 11143
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Loxl4
Name: lysyl oxidase-like 4
Synonyms: 4833426I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 67573
Homologene: 12977
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 66,472,088 bp
  • T to C, chromosome 1 at 85,100,449 bp
  • A to T, chromosome 1 at 150,679,607 bp
  • T to A, chromosome 4 at 14,812,532 bp
  • T to C, chromosome 4 at 125,065,547 bp
  • C to T, chromosome 4 at 138,165,818 bp
  • A to G, chromosome 5 at 44,532,674 bp
  • C to T, chromosome 5 at 53,131,827 bp
  • T to C, chromosome 6 at 40,352,438 bp
  • C to A, chromosome 6 at 43,273,088 bp
  • T to G, chromosome 6 at 69,617,408 bp
  • C to A, chromosome 6 at 124,540,800 bp
  • T to A, chromosome 6 at 137,443,594 bp
  • G to A, chromosome 7 at 16,416,913 bp
  • A to T, chromosome 7 at 30,789,550 bp
  • T to C, chromosome 7 at 120,793,343 bp
  • A to G, chromosome 7 at 132,057,648 bp
  • T to C, chromosome 7 at 141,455,416 bp
  • A to G, chromosome 11 at 29,777,430 bp
  • T to A, chromosome 11 at 75,566,989 bp
  • T to C, chromosome 11 at 75,633,459 bp
  • C to T, chromosome 12 at 93,928,280 bp
  • C to T, chromosome 13 at 61,002,543 bp
  • GCTTCTTCTTCTTCTTCTT to GCTTCTTCTTCTTCTT, chromosome 15 at 55,016,461 bp
  • A to T, chromosome 15 at 103,317,943 bp
  • T to C, chromosome 16 at 56,668,276 bp
  • ATCTTCT to ATCT, chromosome 17 at 23,359,988 bp
  • T to C, chromosome 17 at 30,919,432 bp
  • C to A, chromosome 17 at 34,215,940 bp
  • G to T, chromosome 18 at 7,268,436 bp
  • A to T, chromosome 19 at 42,608,555 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1145 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039218-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.