Strain Name:
C57BL/6J-MtgxR1147Btlr/Mmmh
Stock Number:
039220-MU
Citation ID:
RRID:MMRRC_039220-MU
Other Names:
R1147 (G1), C57BL/6J-MtgxR1147Btlr
Major Collection:

Gene Information

Kifc3
Name: kinesin family member C3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 16582
HGNC: HGNC:6326
Homologene: 124421
Arhgef12
Name: Rho guanine nucleotide exchange factor (GEF) 12
Synonyms: 2310014B11Rik, LARG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 69632
VEGA: 9
Homologene: 9088
Zfat
Name: zinc finger and AT hook domain containing
Synonyms: Zfp406, LOC380993, Zfat1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 380993
Homologene: 16829
Trrap
Name: transformation/transcription domain-associated protein
Synonyms: transactivation/transformation-domain associated protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100683
Homologene: 39246
Zfp106
Name: zinc finger protein 106
Synonyms: Sh3bp3, Cd-1, sirm, H3a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20402
Homologene: 40787
Ralgapa1
Name: Ral GTPase activating protein, alpha subunit 1
Synonyms: 4930400K19Rik, 2310003F20Rik, Tulip1, Garnl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 56784
VEGA: 12
Homologene: 84805
Ash1l
Name: ASH1 like histone lysine methyltransferase
Synonyms: KMT2H, 8030453L17Rik, E430018P19Rik, chromatin remodeling factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 192195
Homologene: 10225
Tox
Name: thymocyte selection-associated high mobility group box
Synonyms: 1700007F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 252838
Homologene: 8822
Fabp3
Name: fatty acid binding protein 3, muscle and heart
Synonyms: H-FABP, Mdgi, Fabp3, Fabph-1, Fabph4, Fabph1, Fabph-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14077
HGNC: HGNC:3557
Homologene: 68379
Slc6a11
Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 11
Synonyms: GAT4, Gat3, Gabt4, D930045G19Rik, E130202I16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243616
Homologene: 129935
Htt
Name: huntingtin
Synonyms: Hdh, htt, IT15, C430023I11Rik, huntingtin, HD
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 15194
HGNC: HGNC:4851
Homologene: 1593
Ptprs
Name: protein tyrosine phosphatase, receptor type, S
Synonyms: PTP-NU3, Ptpt9, PTPsigma, RPTPsigma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 19280
HGNC: HGNC:9681
Homologene: 20626
Kirrel
Name: kirre like nephrin family adhesion molecule 1
Synonyms: Neph1, 6720469N11Rik, Kirrel1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 170643
Homologene: 10089
Chd6
Name: chromodomain helicase DNA binding protein 6
Synonyms: 6330406J24Rik, 5430439G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71389
Homologene: 32772
Tecpr2
Name: tectonin beta-propeller repeat containing 2
Synonyms: 4930573I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104859
VEGA: 12
Homologene: 8897
Ppp1r13l
Name: protein phosphatase 1, regulatory subunit 13 like
Synonyms: IASPP, wa3, NFkB interacting protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 333654
Homologene: 84635
Adam20
Name: a disintegrin and metallopeptidase domain 20
Synonyms: 4930529F22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 384806
HGNC: HGNC:199
Homologene: 128364
Arsi
Name: arylsulfatase i
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 545260
Homologene: 44428
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: PKHDL1, D86 mRNA, fibrocystin L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 192190
Homologene: 16332
Pde5a
Name: phosphodiesterase 5A, cGMP-specific
Synonyms: Pde5, PDE5A1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242202
HGNC: HGNC:8784
Homologene: 842
Sybu
Name: syntabulin (syntaxin-interacting)
Synonyms: Golsyn/Syntabulin, A830027B17Rik, 5730410E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 319613
VEGA: 15
Homologene: 9838
Oog3
Name: oogenesin 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100012
Homologene: 129883
Ptpro
Name: protein tyrosine phosphatase, receptor type, O
Synonyms: PTP-BK, PTP-U2, D28, PTP-oc, GLEPP1, PTP-phi, Ptpn15, PTPROt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19277
HGNC: HGNC:9678
Homologene: 21564
Col5a2
Name: collagen, type V, alpha 2
Synonyms: 1110014L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12832
HGNC: HGNC:2210
Homologene: 20119
Aknad1
Name: AKNA domain containing 1
Synonyms: 4921525H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329738
Homologene: 51892
Stx18
Name: syntaxin 18
Synonyms: 4933425D03Rik, 1810035L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71116
Homologene: 9655
Ces1f
Name: carboxylesterase 1F
Synonyms: TGH-2, CesML1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234564
HGNC: HGNC:1863
Homologene: 134311
Meis3
Name: Meis homeobox 3
Synonyms: Mrg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17537
Homologene: 7425
Vmn2r15
Name: vomeronasal 2, receptor 15
Synonyms: EG211223
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 211223
Homologene: 129606
Hrg
Name: histidine-rich glycoprotein
Synonyms: D18020, D16JH2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 94175
HGNC: HGNC:5181
Homologene: 137650
Ccdc110
Name: coiled-coil domain containing 110
Synonyms: LOC212392
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 212392
Homologene: 17668
Scamp1
Name: secretory carrier membrane protein 1
Synonyms: 4930505M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 107767
Homologene: 37975
Cd19
Name: CD19 antigen
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12478
HGNC: HGNC:1633
Homologene: 1341
Kcnh2
Name: potassium voltage-gated channel, subfamily H (eag-related), member 2
Synonyms: M-erg, merg1a, ERG1, LQT, ether a go-go related, Lqt2, merg1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16511
HGNC: HGNC:6251
Homologene: 201
Sfi1
Name: Sfi1 homolog, spindle assembly associated (yeast)
Synonyms: 2310047I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 78887
Homologene: 12707
Vmn2r114
Name: vomeronasal 2, receptor 114
Synonyms: EG666002
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 666002
Homologene: 86604
Ptk6
Name: PTK6 protein tyrosine kinase 6
Synonyms: Sik, Tksk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20459
HGNC: HGNC:9617
Homologene: 68494
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: Dnahc7b, LOC227058
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227058
Homologene: 41287
Nlrp4d
Name: NLR family, pyrin domain containing 4D
Synonyms: Nalp-beta, Nalp4d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 384752
A530032D15Rik
Name: RIKEN cDNA A530032D15Rik gene
Synonyms: LOC381287
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381287
Homologene: 131208
Dsel
Name: dermatan sulfate epimerase-like
Synonyms: DS-epi2, 9330132E09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 319901
Homologene: 12964
Prob1
Name: proline rich basic protein 1
Synonyms: Gm1614, LOC381148
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 381148
Homologene: 83773
Ano8
Name: anoctamin 8
Synonyms: Tmem16h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 382014
Homologene: 124473
Rsad1
Name: radical S-adenosyl methionine domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237926
Homologene: 41252
Olfr434
Name: olfactory receptor 434
Synonyms: MOR261-10, GA_x6K02T2P3E9-4341246-4340281
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258366
Homologene: 133700
Flacc1
Name: flagellum associated containing coiled-coil domains 1
Synonyms: 4933405P16Rik, 4933425F06Rik, Als2cr12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 108812
Homologene: 51399
Trub2
Name: TruB pseudouridine (psi) synthase family member 2
Synonyms: G430055L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227682
Homologene: 41056
Vmn2r33
Name: vomeronasal 2, receptor 33
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 624512
Homologene: 113703
Olfr692
Name: olfactory receptor 692
Synonyms: GA_x6K02T2PBJ9-7994144-7995106, MOR36-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258352
Homologene: 64859
Lsamp
Name: limbic system-associated membrane protein
Synonyms: D930023J12Rik, Lamp, Lam, B130007O04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 268890
HGNC: HGNC:6705
Homologene: 20533
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 45,376,771 bp
  • A to G, chromosome 1 at 46,340,266 bp
  • A to T, chromosome 1 at 58,669,463 bp
  • C to G, chromosome 1 at 85,099,505 bp
  • T to C, chromosome 1 at 111,862,209 bp
  • A to G, chromosome 2 at 29,787,632 bp
  • A to T, chromosome 2 at 120,520,536 bp
  • C to T, chromosome 2 at 160,990,271 bp
  • C to T, chromosome 2 at 181,195,797 bp
  • C to T, chromosome 3 at 87,089,151 bp
  • A to T, chromosome 3 at 88,984,887 bp
  • T to A, chromosome 3 at 108,752,541 bp
  • C to T, chromosome 3 at 122,794,313 bp
  • A to T, chromosome 4 at 6,823,055 bp
  • C to T, chromosome 4 at 130,312,387 bp
  • A to G, chromosome 4 at 144,158,412 bp
  • T to A, chromosome 5 at 24,324,387 bp
  • T to C, chromosome 5 at 34,851,252 bp
  • T to G, chromosome 5 at 38,126,923 bp
  • T to A, chromosome 5 at 109,293,206 bp
  • G to A, chromosome 5 at 144,804,766 bp
  • A to T, chromosome 6 at 43,217,212 bp
  • T to A, chromosome 6 at 114,244,870 bp
  • T to A, chromosome 6 at 137,443,594 bp
  • C to T, chromosome 7 at 7,554,145 bp
  • A to T, chromosome 7 at 10,388,717 bp
  • G to A, chromosome 7 at 16,183,776 bp
  • A to G, chromosome 7 at 19,375,847 bp
  • G to A, chromosome 7 at 105,369,277 bp
  • T to A, chromosome 7 at 126,411,045 bp
  • T to C, chromosome 8 at 40,795,618 bp
  • A to G, chromosome 8 at 45,944,084 bp
  • C to A, chromosome 8 at 71,482,017 bp
  • C to T, chromosome 8 at 93,258,281 bp
  • T to C, chromosome 8 at 95,137,918 bp
  • C to T, chromosome 9 at 43,044,256 bp
  • CCTCTC to CCTCTCTC, chromosome 11 at 3,177,419 bp
  • T to C, chromosome 11 at 94,544,140 bp
  • A to T, chromosome 12 at 55,702,480 bp
  • T to G, chromosome 12 at 110,941,438 bp
  • A to G, chromosome 13 at 94,224,886 bp
  • A to G, chromosome 15 at 44,537,441 bp
  • A to T, chromosome 15 at 44,746,255 bp
  • A to T, chromosome 15 at 68,212,583 bp
  • G to T, chromosome 16 at 22,961,004 bp
  • G to A, chromosome 16 at 42,174,136 bp
  • A to T, chromosome 17 at 23,311,063 bp
  • T to C, chromosome 17 at 56,423,504 bp
  • G to A, chromosome 18 at 35,654,806 bp
  • G to A, chromosome 18 at 60,916,651 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1147 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039220-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.