Strain Name:
C57BL/6J-MtgxR1159Btlr/Mmmh
Stock Number:
039232-MU
Citation ID:
RRID:MMRRC_039232-MU
Other Names:
R1159 (G1), C57BL/6J-MtgxR1159Btlr
Major Collection:

Gene Information

Hps5
Name: HPS5, biogenesis of lysosomal organelles complex 2 subunit 2
Synonyms: ruby eye 2, Hermansky-Pudlak syndrome 5, ru-2, ru2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 246694
Homologene: 35333
Zfa-ps
Name: zinc finger protein, autosomal, pseudogene
Synonyms: Zfa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22639
Igf2bp2
Name: insulin-like growth factor 2 mRNA binding protein 2
Synonyms: IMP-2, C330012H03Rik, IMP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 319765
Homologene: 4774
Anp32b
Name: acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
Synonyms: PHAPI2a, 2410015B15Rik, PAL31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67628
Homologene: 137872
Sacm1l
Name: SAC1 suppressor of actin mutations 1-like (yeast)
Synonyms: Sac1p, SAC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 83493
VEGA: 9
Homologene: 6320
Nup98
Name: nucleoporin 98
Synonyms: Nup96
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269966
HGNC: HGNC:8068
Homologene: 35472
Akap9
Name: A kinase (PRKA) anchor protein (yotiao) 9
Synonyms: G1-448-15, repro12, mei2-5, 5730481H23Rik, AKAP450
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100986
HGNC: HGNC:379
Homologene: 134583
Trim24
Name: tripartite motif-containing 24
Synonyms: D430004I05Rik, A130082H20Rik, Tif1a, TIF1alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 21848
Homologene: 20830
Lamb2
Name: laminin, beta 2
Synonyms: Lams, Lamb-2, npht
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 16779
HGNC: HGNC:6487
Homologene: 1723
Slc38a10
Name: solute carrier family 38, member 10
Synonyms: 1810073N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 72055
Homologene: 41556
Tox
Name: thymocyte selection-associated high mobility group box
Synonyms: 1700007F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 252838
Homologene: 8822
Fubp1
Name: far upstream element (FUSE) binding protein 1
Synonyms: FBP, 9530027K12Rik, Fubp, Fubp4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 51886
HGNC: HGNC:4004
Homologene: 48253
Ptprc
Name: protein tyrosine phosphatase, receptor type, C
Synonyms: CD45, B220, T200, Ly-5, Lyt-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19264
HGNC: HGNC:9666
Homologene: 2126
Macrod2
Name: mono-ADP ribosylhydrolase 2
Synonyms: 2900006F19Rik, 2610107G07Rik, 1110033L15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 72899
Homologene: 85987
Cdk10
Name: cyclin-dependent kinase 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234854
HGNC: HGNC:1770
Homologene: 55769
Avil
Name: advillin
Synonyms: DOC6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 11567
Homologene: 38200
Cacna1c
Name: calcium channel, voltage-dependent, L type, alpha 1C subunit
Synonyms: Cav1.2, (alpha)1 subunit, L-type Cav1.2, D930026N18Rik, Cchl1a1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12288
HGNC: HGNC:1390
Homologene: 55484
Fgd5
Name: FYVE, RhoGEF and PH domain containing 5
Synonyms: ZFYVE23, C330025N11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232237
Homologene: 27798
Serpinb6d
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6d
Synonyms: SPI3D, Gm11390
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238568
HGNC: HGNC:8950
Unc79
Name: unc-79 homolog
Synonyms: Mlca3, 9030205A07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217843
Homologene: 41397
Gxylt2
Name: glucoside xylosyltransferase 2
Synonyms: Glt8d4, LOC232313
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232313
Homologene: 16823
Rev3l
Name: REV3 like, DNA directed polymerase zeta catalytic subunit
Synonyms: Sez4, Rev
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19714
HGNC: HGNC:9968
Homologene: 48147
Cfap65
Name: cilia and flagella associated protein 65
Synonyms: B230363K08Rik, Ccdc108
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241116
Homologene: 28093
Nt5dc1
Name: 5'-nucleotidase domain containing 1
Synonyms: Nt5c2l1, 6030401B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 319638
Homologene: 16281
Top2b
Name: topoisomerase (DNA) II beta
Synonyms: Top-2, D230016L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21974
Homologene: 134711
Vmn2r66
Name: vomeronasal 2, receptor 66
Synonyms: F830104D24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233437
Homologene: 115466
B020004J07Rik
Name: RIKEN cDNA B020004J07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 545662
Homologene: 128627
Aass
Name: aminoadipate-semialdehyde synthase
Synonyms: Lorsdh, LOR/SDH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 30956
Homologene: 4212
Gcnt1
Name: glucosaminyl (N-acetyl) transferase 1, core 2
Synonyms: beta-1, 6-N-acetylglucosaminyltransferase, IGnT, 5630400D21Rik, C2 GlcNAcT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 14537
HGNC: HGNC:4203
Homologene: 37486
Ano5
Name: anoctamin 5
Synonyms: Gdd1, Tmem16e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233246
Homologene: 100071
Rgs22
Name: regulator of G-protein signalling 22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 626596
Homologene: 75047
Parp14
Name: poly (ADP-ribose) polymerase family, member 14
Synonyms: collaborator of Stat6, 1600029O10Rik, CoaSt6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 547253
Homologene: 19697
Ercc3
Name: excision repair cross-complementing rodent repair deficiency, complementation group 3
Synonyms: XPB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13872
HGNC: HGNC:3435
Homologene: 96
1110020G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Ppig
Name: peptidyl-prolyl isomerase G (cyclophilin G)
Synonyms: SRCyp, B230312B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228005
Homologene: 3520
Mtif2
Name: mitochondrial translational initiation factor 2
Synonyms: IF-2mt, 2410112O06Rik, 2310038D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76784
HGNC: HGNC:7441
Homologene: 1840
Cryge
Name: crystallin, gamma E
Synonyms: Cryg-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12968
Homologene: 128417
Acss2
Name: acyl-CoA synthetase short-chain family member 2
Synonyms: Acas2, Acs1, AceCS1, Acas1, ACAS, acetyl-CoA synthetase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 60525
Homologene: 6469
Rxfp4
Name: relaxin family peptide receptor 4
Synonyms: Gpr100, Rln3r2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242093
Homologene: 18775
Cu463345.1
Name: Uncharacterized protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Mfsd13b
Name: major facilitator superfamily domain containing 13B
Synonyms: 4933427G17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74466
Homologene: 62261
Rpl31-ps20
Name: ribosomal protein L31, pseudogene 20
Synonyms: Gm6635
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 625917
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 65,050,808 bp
  • A to T, chromosome 1 at 74,929,340 bp
  • A to G, chromosome 1 at 138,072,319 bp
  • T to A, chromosome 2 at 69,750,224 bp
  • A to G, chromosome 2 at 140,395,725 bp
  • T to C, chromosome 2 at 155,551,218 bp
  • A to G, chromosome 3 at 88,652,587 bp
  • A to G, chromosome 3 at 152,215,592 bp
  • T to G, chromosome 4 at 6,697,600 bp
  • T to C, chromosome 4 at 46,471,478 bp
  • A to G, chromosome 4 at 60,839,391 bp
  • T to C, chromosome 4 at 101,838,027 bp
  • C to T, chromosome 5 at 3,960,865 bp
  • G to A, chromosome 6 at 23,115,138 bp
  • T to C, chromosome 6 at 37,956,477 bp
  • T to C, chromosome 6 at 91,988,502 bp
  • A to G, chromosome 6 at 100,804,641 bp
  • C to T, chromosome 6 at 118,612,625 bp
  • A to T, chromosome 7 at 46,772,554 bp
  • T to C, chromosome 7 at 51,579,474 bp
  • A to T, chromosome 7 at 84,995,405 bp
  • T to A, chromosome 7 at 102,160,716 bp
  • T to C, chromosome 7 at 121,014,543 bp
  • T to C, chromosome 8 at 123,228,323 bp
  • T to C, chromosome 9 at 108,481,408 bp
  • T to C, chromosome 9 at 123,566,411 bp
  • T to C, chromosome 10 at 34,398,173 bp
  • T to A, chromosome 10 at 39,851,925 bp
  • T to A, chromosome 10 at 52,543,558 bp
  • T to C, chromosome 10 at 127,011,790 bp
  • C to A, chromosome 11 at 29,540,729 bp
  • A to G, chromosome 11 at 120,105,475 bp
  • T to G, chromosome 12 at 103,047,052 bp
  • T to A, chromosome 13 at 33,671,229 bp
  • T to C, chromosome 14 at 16,430,329 bp
  • G to A, chromosome 15 at 9,106,837 bp
  • A to T, chromosome 15 at 36,040,693 bp
  • G to A, chromosome 16 at 22,061,853 bp
  • G to A, chromosome 16 at 35,856,760 bp
  • C to T, chromosome 18 at 32,264,558 bp
  • C to A, chromosome 19 at 17,329,804 bp
  • A to T, chromosome 19 at 30,160,762 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1159 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039232-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.