Strain Name:
C57BL/6J-MtgxR1161Btlr/Mmmh
Stock Number:
039234-MU
Citation ID:
RRID:MMRRC_039234-MU
Other Names:
R1161 (G1), C57BL/6J-MtgxR1161Btlr
Major Collection:

Gene Information

Rgs7
Name: regulator of G protein signaling 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 24012
Homologene: 2193
Camk1g
Name: calcium/calmodulin-dependent protein kinase I gamma
Synonyms: CaMKIgamma, CLICK-III
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 215303
Homologene: 48706
Ckap5
Name: cytoskeleton associated protein 5
Synonyms: 4930432B04Rik, 3110043H24Rik, D730027C18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 75786
Homologene: 8844
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: 9930018I23Rik, dynein heavy chain, retrograde transport, Dnec1, MAP1C, Swl, Dnchc1, Loa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Tep1
Name: telomerase associated protein 1
Synonyms: Tp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21745
VEGA: 14
Homologene: 5157
Fzd3
Name: frizzled class receptor 3
Synonyms: D930050A07Rik, Fz3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14365
HGNC: HGNC:4041
Homologene: 23004
Snrnp40
Name: small nuclear ribonucleoprotein 40 (U5)
Synonyms: 0610009C03Rik, Wdr57
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66585
Homologene: 3538
Bcl10
Name: B cell leukemia/lymphoma 10
Synonyms: BCL-10, cE10, mE10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12042
HGNC: HGNC:989
Homologene: 2912
Tmeff2
Name: transmembrane protein with EGF-like and two follistatin-like domains 2
Synonyms: 4832418D20Rik, 7630402F16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 56363
Homologene: 9417
Trp73
Name: transformation related protein 73
Synonyms: TAp73, deltaNp73, p73
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 22062
Homologene: 3960
Fam160a1
Name: family with sequence similarity 160, member A1
Synonyms: 9930021J17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229488
Homologene: 85149
Srrm3
Name: serine/arginine repetitive matrix 3
Synonyms: 2900083I11Rik, SRm300-like, Srrm2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 58212
Homologene: 136723
Svep1
Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Synonyms: 4833413O10Rik, Polydom, 1110021D17Rik, D430029O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 64817
Homologene: 23386
Ipcef1
Name: interaction protein for cytohesin exchange factors 1
Synonyms: A130090K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 320495
Homologene: 32271
Def6
Name: differentially expressed in FDCP 6
Synonyms: SLAT, IBP, 6430538D02Rik, 2410003F05Rik, IRF-4-binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 23853
HGNC: HGNC:2760
Homologene: 11103
Usp29
Name: ubiquitin specific peptidase 29
Synonyms: Ocat
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57775
Homologene: 49641
C4b
Name: complement component 4B (Chido blood group)
Synonyms: C4, Ss
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12268
Homologene: 36030
Dnm3
Name: dynamin 3
Synonyms: B230343F03Rik, 9630020E24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 103967
Homologene: 22906
Ccdc106
Name: coiled-coil domain containing 106
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232821
Homologene: 81845
H2-T24
Name: histocompatibility 2, T region locus 24
Synonyms: H-2T24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 15042
Homologene: 69019
Eme1
Name: essential meiotic structure-specific endonuclease 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268465
Homologene: 16123
Scn11a
Name: sodium channel, voltage-gated, type XI, alpha
Synonyms: NaN, SNS2, NSS2, NaT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 24046
VEGA: 9
Homologene: 8041
Olfr857
Name: olfactory receptor 857
Synonyms: GA_x6K02T2PVTD-13452606-13453535, MOR146-8P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 257963
Homologene: 134093
Pde4c
Name: phosphodiesterase 4C, cAMP specific
Synonyms: E130301F19Rik, Dpde1, dunce
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 110385
HGNC: HGNC:8782
Homologene: 20256
Ifit1bl1
Name: interferon induced protein with tetratricpeptide repeats 1B like 1
Synonyms: Gm14446
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 667373
Homologene: 78213
Prx
Name: periaxin
Synonyms: L-Periaxin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19153
Homologene: 76542
Tmem38a
Name: transmembrane protein 38A
Synonyms: TRIC-A, 1110001E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74166
Homologene: 11449
Mmel1
Name: membrane metallo-endopeptidase-like 1
Synonyms: NEPLP beta, Nep2, NEPLP alpha, Nl1, Mell1, NEPLP gamma, SEP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 27390
Homologene: 22778
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 51,181,787 bp
  • T to A, chromosome 1 at 162,353,574 bp
  • T to C, chromosome 1 at 175,079,455 bp
  • T to C, chromosome 1 at 193,348,354 bp
  • T to G, chromosome 2 at 91,599,375 bp
  • A to G, chromosome 3 at 85,672,468 bp
  • T to G, chromosome 3 at 145,930,425 bp
  • T to A, chromosome 4 at 58,069,416 bp
  • C to G, chromosome 4 at 130,378,043 bp
  • A to G, chromosome 4 at 154,081,323 bp
  • C to T, chromosome 4 at 154,895,214 bp
  • CAAGAAGAAGAAGAA to CAAGAAGAAGAA, chromosome 5 at 135,854,392 bp
  • G to A, chromosome 7 at 5,059,540 bp
  • A to G, chromosome 7 at 6,961,530 bp
  • T to C, chromosome 7 at 27,519,677 bp
  • A to G, chromosome 8 at 70,749,923 bp
  • T to A, chromosome 8 at 72,579,970 bp
  • A to G, chromosome 9 at 19,713,180 bp
  • C to T, chromosome 9 at 119,755,057 bp
  • T to A, chromosome 10 at 6,980,288 bp
  • G to A, chromosome 11 at 94,645,542 bp
  • G to A, chromosome 12 at 110,636,509 bp
  • A to T, chromosome 14 at 50,833,903 bp
  • G to A, chromosome 14 at 65,212,088 bp
  • G to A, chromosome 17 at 28,217,619 bp
  • A to G, chromosome 17 at 34,729,593 bp
  • G to T, chromosome 17 at 36,014,996 bp
  • A to G, chromosome 19 at 34,593,696 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1161 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039234-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.