Strain Name:
C57BL/6J-MtgxR1162Btlr/Mmmh
Stock Number:
039235-MU
Citation ID:
RRID:MMRRC_039235-MU
Other Names:
R1162 (G1), C57BL/6J-MtgxR1162Btlr
Major Collection:

Gene Information

Vangl2
Name: VANGL planar cell polarity 2
Synonyms: Lpp1, C530001F03Rik, skam17Jus, Ltap, strabismus, loop-tail, ska17, Lootl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 93840
Homologene: 62161
Nup155
Name: nucleoporin 155
Synonyms: D930027M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 170762
VEGA: 15
HGNC: HGNC:8063
Homologene: 43155
Cops4
Name: COP9 signalosome subunit 4
Synonyms: COP9 complex S4, D5Ertd774e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 26891
Homologene: 8067
Sirt2
Name: sirtuin 2
Synonyms: SIR2L2, Sir2l, 5730427M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 64383
Homologene: 40823
Dscaml1
Name: DS cell adhesion molecule like 1
Synonyms: 4930435C18Rik, 4921507G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 114873
VEGA: 9
Homologene: 79549
Dgkh
Name: diacylglycerol kinase, eta
Synonyms: 5930402B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 380921
VEGA: 14
HGNC: HGNC:2854
Homologene: 99373
Morc3
Name: microrchidia 3
Synonyms: 1110051N18Rik, D16Jhu32e, 1110051N18Rik, Zcwcc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 338467
Homologene: 32257
Sap130
Name: Sin3A associated protein
Synonyms: 2610304F09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 269003
VEGA: 18
Homologene: 11577
Nav2
Name: neuron navigator 2
Synonyms: POMFIL2, Unc53H2, HELAD1, RAINB2, 5330421F07Rik, Rainb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 78286
Homologene: 52330
Sucla2
Name: succinate-Coenzyme A ligase, ADP-forming, beta subunit
Synonyms: 4930547K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 20916
Homologene: 2856
Trak1
Name: trafficking protein, kinesin binding 1
Synonyms: 2310001H13Rik, hyrt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67095
Homologene: 25103
Sh3glb2
Name: SH3-domain GRB2-like endophilin B2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227700
Homologene: 10595
Ccn3
Name: cellular communication network factor 3
Synonyms: C130088N23Rik, CCN3, Nov
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18133
HGNC: HGNC:7885
Homologene: 1884
Cul7
Name: cullin 7
Synonyms: p193, 2510004L20Rik, p185, C230011P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 66515
Homologene: 56683
Nfix
Name: nuclear factor I/X
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18032
HGNC: HGNC:7788
Homologene: 1872
9430015G10Rik
Name: RIKEN cDNA 9430015G10 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230996
Homologene: 51678
Adamts12
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239337
VEGA: 15
Homologene: 12808
Lrrc4
Name: leucine rich repeat containing 4
Synonyms: Nag14, NGL-2, NGL2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 192198
Homologene: 36403
Trub1
Name: TruB pseudouridine (psi) synthase family member 1
Synonyms: 9030425C13Rik, 2610009I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 72133
VEGA: 19
Homologene: 34714
Sec31b
Name: Sec31 homolog B (S. cerevisiae)
Synonyms: LOC240667, Sec31l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 240667
Homologene: 56708
Ksr2
Name: kinase suppressor of ras 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 333050
Homologene: 45469
Tab2
Name: TGF-beta activated kinase 1/MAP3K7 binding protein 2
Synonyms: Tak1 binding protein 2, 1110030N06Rik, A530078N03Rik, Map3k7ip2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 68652
Homologene: 9019
Dock10
Name: dedicator of cytokinesis 10
Synonyms: Jr5, Jr4, ZIZ3, 9330153B10Rik, A630054M16Rik, Zizimin3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 210293
Homologene: 45952
Slc16a10
Name: solute carrier family 16 (monocarboxylic acid transporters), member 10
Synonyms: PRO0813, TAT1, 2610103N14Rik, Mct10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 72472
VEGA: 10
Homologene: 75089
Olfr508
Name: olfactory receptor 508
Synonyms: GA_x6K02T2PBJ9-10959726-10960658, MOR204-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258769
Homologene: 72039
Gpatch1
Name: G patch domain containing 1
Synonyms: 1300003A17Rik, Gpatc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67471
Homologene: 41217
Unc13a
Name: unc-13 homolog A
Synonyms: Munc13-1, 2410078G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 382018
Homologene: 11279
Olfr132
Name: olfactory receptor 132
Synonyms: MOR256-49, GA_x6K02T2PSCP-2579687-2578746
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 257889
Homologene: 46430
Zfp595
Name: zinc finger protein 595
Synonyms: A230042K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218314
Homologene: 120258
Myh4
Name: myosin, heavy polypeptide 4, skeletal muscle
Synonyms: MyHC-IIb, MHC2B, Myhsf, MM, MYH-2B, Minmus, Minimsc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17884
HGNC: HGNC:7574
Homologene: 123880
Kcnj2
Name: potassium inwardly-rectifying channel, subfamily J, member 2
Synonyms: IRK1, Kir2.1, Kcnf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16518
HGNC: HGNC:6263
Homologene: 20249
Vmn2r105
Name: vomeronasal 2, receptor 105
Synonyms: EG627743
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 627743
Homologene: 129680
Dgkz
Name: diacylglycerol kinase zeta
Synonyms: mDGK[z], E130307B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 104418
HGNC: HGNC:2857
Homologene: 37831
Ppef2
Name: protein phosphatase, EF hand calcium-binding domain 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19023
HGNC: HGNC:9244
Homologene: 55959
Mapkbp1
Name: mitogen-activated protein kinase binding protein 1
Synonyms: Jnkbp1, 2810483F24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 26390
Homologene: 69109
Igsf9b
Name: immunoglobulin superfamily, member 9B
Synonyms: LOC235086, AI414108
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235086
Homologene: 19472
Zfp872
Name: zinc finger protein 872
Synonyms: 9530015I07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 619310
Sox5
Name: SRY (sex determining region Y)-box 5
Synonyms: A730017D01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20678
Homologene: 21378
Insl5
Name: insulin-like 5
Synonyms: relaxin/insulin-like factor 2, RIF2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 23919
HGNC: HGNC:6088
Homologene: 48350
Phf2
Name: PHD finger protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18676
VEGA: 13
HGNC: HGNC:8920
Homologene: 3934
Scn11a
Name: sodium channel, voltage-gated, type XI, alpha
Synonyms: SNS2, NaN, NaT, NSS2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 24046
VEGA: 9
Homologene: 8041
Vmn2r60
Name: vomeronasal 2, receptor 60
Synonyms: Casr-rs3, EG637898, Gprc2a-rs3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 637898
Homologene: 129683
Gm7275
Name: predicted gene 7275
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 639644
VEGA: 16
Sgce
Name: sarcoglycan, epsilon
Synonyms: e-SG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20392
Homologene: 31205
Flt4
Name: FMS-like tyrosine kinase 4
Synonyms: VEGFR3, VEGFR-3, Flt-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14257
HGNC: HGNC:3767
Homologene: 7321
Nab1
Name: Ngfi-A binding protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17936
HGNC: HGNC:7626
Homologene: 4352
Yrdc
Name: yrdC domain containing (E.coli)
Synonyms: IRIP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230734
Homologene: 11635
Mrpl43
Name: mitochondrial ribosomal protein L43
Synonyms: bMRP36a, 4930442D21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 94067
VEGA: 19
Homologene: 41847
Tspan32
Name: tetraspanin 32
Synonyms: D7Wsu37e, Tssc6, Art-1, Tspan32, Phemx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 27027
Homologene: 10650
Gpr137c
Name: G protein-coupled receptor 137C
Synonyms: LOC380893, TM7SF1L2, 6330416L11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 70713
Homologene: 28613
Olfr194
Name: olfactory receptor 194
Synonyms: GA_x54KRFPKG5P-55348161-55347241, MOR182-7P, MOR182-13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 433031
Homologene: 122781
Trat1
Name: T cell receptor associated transmembrane adaptor 1
Synonyms: Trim, C030046M14Rik, Tcrim
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 77647
VEGA: 16
Homologene: 41130
4930423O20Rik
Name: RIKEN cDNA 4930423O20 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Pwwp4a
Name: PWWP domain containing 4A
Synonyms: Gm14685
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 574404
Homologene: 128534
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 52,490,027 bp
  • T to A, chromosome 1 at 80,568,842 bp
  • A to G, chromosome 1 at 172,004,847 bp
  • A to T, chromosome 2 at 30,350,588 bp
  • A to T, chromosome 2 at 91,944,444 bp
  • A to G, chromosome 2 at 120,025,318 bp
  • C to T, chromosome 4 at 103,018,241 bp
  • T to C, chromosome 4 at 124,854,461 bp
  • T to C, chromosome 4 at 156,122,418 bp
  • A to C, chromosome 5 at 92,253,121 bp
  • T to C, chromosome 5 at 100,530,157 bp
  • A to G, chromosome 5 at 117,554,955 bp
  • A to G, chromosome 6 at 4,691,419 bp
  • C to A, chromosome 6 at 28,831,084 bp
  • A to G, chromosome 6 at 143,960,812 bp
  • A to T, chromosome 7 at 28,785,822 bp
  • A to G, chromosome 7 at 35,303,480 bp
  • A to T, chromosome 7 at 42,195,771 bp
  • A to G, chromosome 7 at 49,536,040 bp
  • A to G, chromosome 7 at 108,630,913 bp
  • T to A, chromosome 7 at 143,006,998 bp
  • T to A, chromosome 8 at 71,647,917 bp
  • G to A, chromosome 8 at 84,726,526 bp
  • A to G, chromosome 9 at 22,199,614 bp
  • T to C, chromosome 9 at 27,326,889 bp
  • T to C, chromosome 9 at 45,752,349 bp
  • A to G, chromosome 9 at 119,805,644 bp
  • G to T, chromosome 9 at 121,453,341 bp
  • A to G, chromosome 10 at 7,924,719 bp
  • T to C, chromosome 10 at 40,076,553 bp
  • C to T, chromosome 11 at 49,636,339 bp
  • A to G, chromosome 11 at 67,258,613 bp
  • T to A, chromosome 11 at 111,072,967 bp
  • A to T, chromosome 13 at 48,819,641 bp
  • A to T, chromosome 13 at 67,317,195 bp
  • A to G, chromosome 14 at 45,244,158 bp
  • C to T, chromosome 14 at 73,560,634 bp
  • A to G, chromosome 14 at 78,624,451 bp
  • A to T, chromosome 15 at 8,157,760 bp
  • T to A, chromosome 15 at 11,277,458 bp
  • T to A, chromosome 15 at 54,747,782 bp
  • A to G, chromosome 16 at 48,074,032 bp
  • T to C, chromosome 16 at 48,740,209 bp
  • T to C, chromosome 16 at 59,119,372 bp
  • A to T, chromosome 16 at 70,381,850 bp
  • A to C, chromosome 16 at 93,853,108 bp
  • C to T, chromosome 17 at 20,227,711 bp
  • A to T, chromosome 17 at 38,131,093 bp
  • T to A, chromosome 17 at 46,663,190 bp
  • C to T, chromosome 18 at 31,648,173 bp
  • C to A, chromosome 19 at 44,517,648 bp
  • T to G, chromosome 19 at 45,006,358 bp
  • G to A, chromosome 19 at 57,472,759 bp
  • G to T, chromosome X at 73,127,655 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1162 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039235-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.