Strain Name:
C57BL/6J-MtgxR1165Btlr/Mmmh
Stock Number:
039238-MU
Citation ID:
RRID:MMRRC_039238-MU
Other Names:
R1165 (G1), C57BL/6J-MtgxR1165Btlr
Major Collection:

Gene Information

Slc6a1
Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 1
Synonyms: Gat1, Gabt1, GAT-1, XT-1, Xtrp1, Gabt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232333
Homologene: 2290
Dysf
Name: dysferlin
Synonyms: 2310004N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 26903
HGNC: HGNC:3097
Homologene: 20748
Rtel1
Name: regulator of telomere elongation helicase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269400
Homologene: 13168
Fam91a1
Name: family with sequence similarity 91, member A1
Synonyms: D15Ertd621e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 210998
VEGA: 15
Homologene: 13388
Hectd1
Name: HECT domain E3 ubiquitin protein ligase 1
Synonyms: A630086P08Rik, b2b327Clo, opm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 207304
VEGA: 12
Homologene: 9115
Zfp407
Name: zinc finger protein 407
Synonyms: 6430585N13Rik, LOC240469, LOC381139
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240476
Homologene: 86402
Ank3
Name: ankyrin 3, epithelial
Synonyms: Ank-3, AnkG, Ankyrin-G, Ankyrin-3, 2900054D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 11735
HGNC: HGNC:494
Homologene: 56908
Abcg2
Name: ATP binding cassette subfamily G member 2 (Junior blood group)
Synonyms: Bcrp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 26357
HGNC: HGNC:74
Homologene: 55852
Rasgrp1
Name: RAS guanyl releasing protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19419
HGNC: HGNC:9878
Homologene: 4195
Slc19a2
Name: solute carrier family 19 (thiamine transporter), member 2
Synonyms: DDA1, THTR1, TRMA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 116914
Homologene: 38258
Tsen2
Name: tRNA splicing endonuclease subunit 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 381802
Homologene: 41622
Bod1l
Name: biorientation of chromosomes in cell division 1-like
Synonyms: A230054D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 665775
Homologene: 45109
Vps13d
Name: vacuolar protein sorting 13D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230895
Homologene: 15583
Pdgfrb
Name: platelet derived growth factor receptor, beta polypeptide
Synonyms: Pdgfr, CD140b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 18596
HGNC: HGNC:8804
Homologene: 1960
Angptl6
Name: angiopoietin-like 6
Synonyms: AGF, 6330404E11Rik, Angiopoietin-related growth factor, Arp5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 70726
Homologene: 88931
Glb1l2
Name: galactosidase, beta 1-like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244757
Homologene: 71790
Brca2
Name: breast cancer 2, early onset
Synonyms: RAB163, Fancd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12190
HGNC: HGNC:1101
Homologene: 41
Casp8ap2
Name: caspase 8 associated protein 2
Synonyms: FLASH, D4Ertd659e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 26885
HGNC: HGNC:1510
Homologene: 8066
Cwc22
Name: CWC22 spliceosome-associated protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 80744
Homologene: 6048
AU040320
Name: expressed sequence AU040320
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100317
Homologene: 11764
Ccr1
Name: chemokine (C-C motif) receptor 1
Synonyms: Cmkbr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12768
VEGA: 9
HGNC: HGNC:1602
Homologene: 20344
Trim17
Name: tripartite motif-containing 17
Synonyms: Rnf16, terf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 56631
Homologene: 9387
Pcdhac1
Name: protocadherin alpha subfamily C, 1
Synonyms: CNRc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 353236
HGNC: HGNC:8676
Homologene: 49561
Adtrp
Name: androgen dependent TFPI regulating protein
Synonyms: 9530008L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 109254
Homologene: 13107
Hipk1
Name: homeodomain interacting protein kinase 1
Synonyms: 1110062K04Rik, Myak
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 15257
Homologene: 56483
Celf5
Name: CUGBP, Elav-like family member 5
Synonyms: 4930565A21Rik, Brunol5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 319586
Homologene: 75172
Olfr371
Name: olfactory receptor 371
Synonyms: GA_x6K02T2NUPS-13298842-13299780, MOR141-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 258858
Homologene: 65998
Gas7
Name: growth arrest specific 7
Synonyms: Gas7-cb, B230343A10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14457
HGNC: HGNC:4169
Homologene: 69015
Zfp120
Name: zinc finger protein 120
Synonyms: MZF31, E030042N05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 104348
Homologene: 138454
Snx25
Name: sorting nexin 25
Synonyms: LOC382008, SBBI31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102141
Homologene: 23744
Edem1
Name: ER degradation enhancer, mannosidase alpha-like 1
Synonyms: A130059K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 192193
Homologene: 33836
Hpd
Name: 4-hydroxyphenylpyruvic acid dioxygenase
Synonyms: Fla, Hppd, Flp, Laf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 15445
HGNC: HGNC:5147
Homologene: 1620
Spag16
Name: sperm associated antigen 16
Synonyms: 4930524F24Rik, 4930585K05Rik, Pf20, Wdr29, 4921511D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 66722
Homologene: 11572
Traf3ip3
Name: TRAF3 interacting protein 3
Synonyms: 6030423D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 215243
Homologene: 11885
Col15a1
Name: collagen, type XV, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12819
HGNC: HGNC:2192
Homologene: 1396
Cyp2d26
Name: cytochrome P450, family 2, subfamily d, polypeptide 26
Synonyms: 1300006E06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 76279
VEGA: 15
Homologene: 130660
Slc22a27
Name: solute carrier family 22, member 27
Synonyms: AB056442, mOAT6 related protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 171405
Homologene: 77136
Coro1b
Name: coronin, actin binding protein 1B
Synonyms: coronin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 23789
HGNC: HGNC:2253
Homologene: 40790
Rrs1
Name: ribosome biogenesis regulator 1
Synonyms: D1Ertd701e, 5730466A07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 59014
Homologene: 41014
2210408I21Rik
Name: RIKEN cDNA 2210408I21 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 72371
Homologene: 89234
Insyn2b
Name: inhibitory synaptic factor family member 2B
Synonyms: Fam196b, Gm6041
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 574403
VEGA: 11
Homologene: 107175
1520401A03Rik
Name: RIKEN cDNA 1520401A03 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 320309
Fdxr
Name: ferredoxin reductase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14149
HGNC: HGNC:3642
Homologene: 3033
H6pd
Name: hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
Synonyms: Gpd-1, Gpd1, G6pd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100198
HGNC: HGNC:4795
Homologene: 48275
Olfr809
Name: olfactory receptor 809
Synonyms: GA_x6K02T2PULF-11454600-11455541, MOR108-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258321
Homologene: 138308
Trmu
Name: tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
Synonyms: 1600025P05Rik, Trmt1, 1110005N20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 72026
Homologene: 5589
Tmem198
Name: transmembrane protein 198
Synonyms: Tmem198a, Tmem198-1, A230078I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 319998
Homologene: 44245
Gm14410
Name: predicted gene 14410
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 100043403
Wnt2
Name: wingless-type MMTV integration site family, member 2
Synonyms: Irp, m-irp, Mirp, Wnt2a, Wnt-2, Int1l1, 2610510E18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 22413
Homologene: 20719
Gm10699
Name: predicted gene 10699
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Best2
Name: bestrophin 2
Synonyms: Vmd2l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 212989
Homologene: 41187
Retnlg
Name: resistin like gamma
Synonyms: Xcp1, Relmg, Fizz3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 245195
VEGA: 16
Homologene: 138458
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 9,545,767 bp
  • A to G, chromosome 1 at 69,996,877 bp
  • A to T, chromosome 1 at 75,479,932 bp
  • G to A, chromosome 1 at 164,263,445 bp
  • A to C, chromosome 1 at 193,184,478 bp
  • A to T, chromosome 2 at 77,903,898 bp
  • A to T, chromosome 2 at 117,284,939 bp
  • A to T, chromosome 2 at 150,119,929 bp
  • A to C, chromosome 2 at 177,193,489 bp
  • A to G, chromosome 2 at 181,334,939 bp
  • T to C, chromosome 3 at 103,761,524 bp
  • C to T, chromosome 4 at 32,640,563 bp
  • T to C, chromosome 4 at 47,257,275 bp
  • A to T, chromosome 4 at 126,823,640 bp
  • A to G, chromosome 4 at 145,126,471 bp
  • A to G, chromosome 4 at 149,995,956 bp
  • A to T, chromosome 5 at 41,821,053 bp
  • A to G, chromosome 5 at 123,176,090 bp
  • T to A, chromosome 5 at 150,542,747 bp
  • T to C, chromosome 6 at 17,989,947 bp
  • C to A, chromosome 6 at 58,678,300 bp
  • T to A, chromosome 6 at 84,067,069 bp
  • T to A, chromosome 6 at 108,851,253 bp
  • T to C, chromosome 6 at 114,311,829 bp
  • A to G, chromosome 6 at 115,561,435 bp
  • G to A, chromosome 8 at 14,090,530 bp
  • T to G, chromosome 8 at 46,035,715 bp
  • C to T, chromosome 8 at 85,011,160 bp
  • T to A, chromosome 8 at 85,230,771 bp
  • T to G, chromosome 9 at 20,878,308 bp
  • T to C, chromosome 9 at 26,794,101 bp
  • A to T, chromosome 9 at 123,963,494 bp
  • C to A, chromosome 10 at 69,898,302 bp
  • A to T, chromosome 10 at 81,471,338 bp
  • A to G, chromosome 10 at 129,776,433 bp
  • A to G, chromosome 11 at 34,402,740 bp
  • A to G, chromosome 11 at 58,971,215 bp
  • T to C, chromosome 11 at 67,670,686 bp
  • C to A, chromosome 11 at 115,271,782 bp
  • A to T, chromosome 12 at 51,764,164 bp
  • A to G, chromosome 13 at 41,814,303 bp
  • T to G, chromosome 13 at 77,334,287 bp
  • T to C, chromosome 15 at 58,430,669 bp
  • C to A, chromosome 15 at 82,794,041 bp
  • A to G, chromosome 15 at 85,892,674 bp
  • A to G, chromosome 16 at 48,873,654 bp
  • A to C, chromosome 17 at 23,710,515 bp
  • A to G, chromosome 18 at 37,007,704 bp
  • T to C, chromosome 18 at 61,064,002 bp
  • C to T, chromosome 18 at 84,559,773 bp
  • C to A, chromosome 19 at 4,149,902 bp
  • T to C, chromosome 19 at 7,909,694 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1165 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039238-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.