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Strain Name:
C57BL/6J-MtgxR1173Btlr/Mmmh
Stock Number:
039246-MU
Citation ID:
RRID:MMRRC_039246-MU
Other Names:
R1173 (G1), C57BL/6J-MtgxR1173Btlr
Major Collection:

Strain Information

Vangl2
Name: VANGL planar cell polarity 2
Synonyms: Lpp1, C530001F03Rik, skam17Jus, Ltap, strabismus, loop-tail, ska17, Lootl
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 93840
Homologene: 62161
Tyrp1
Name: tyrosinase-related protein 1
Synonyms: Tyrp, isa, TRP-1, TRP1, Oca3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22178
Homologene: 464
Ddc
Name: dopa decarboxylase
Synonyms: aromatic L-amino acid decarboxylase, Aadc
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13195
HGNC: HGNC:2719
Homologene: 618
Emx1
Name: empty spiracles homeobox 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13796
HGNC: HGNC:3340
Homologene: 55799
Qtrt1
Name: queuine tRNA-ribosyltransferase catalytic subunit 1
Synonyms: Tgt, tRNA-guanine transglycosylase, 2610028E17Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 60507
VEGA: 9
Homologene: 11061
Zbtb32
Name: zinc finger and BTB domain containing 32
Synonyms: Tzfp, 4930524C15Rik, PLZP, Rog
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 58206
Homologene: 8661
Trip10
Name: thyroid hormone receptor interactor 10
Synonyms: Cip4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106628
VEGA: 17
Homologene: 99728
Sfswap
Name: splicing factor SWAP
Synonyms: 6330437E22Rik, 1190005N23Rik, Sfrs8
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231769
Homologene: 134548
Kazn
Name: kazrin, periplakin interacting protein
Synonyms: 2310007B04Rik, 9030409G11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71529
Homologene: 16235
Xrcc6
Name: X-ray repair complementing defective repair in Chinese hamster cells 6
Synonyms: Ku p70, Ku70, G22p1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14375
HGNC: HGNC:4055
Homologene: 37483
Srbd1
Name: S1 RNA binding domain 1
Synonyms: D530025C17Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78586
VEGA: 17
Homologene: 9994
Gfm2
Name: G elongation factor, mitochondrial 2
Synonyms: MST027, EFG2, A930009M04Rik, 6530419G12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 320806
Homologene: 6238
Frem1
Name: Fras1 related extracellular matrix protein 1
Synonyms: eyem02Jus, heb, QBRICK, crf11, eyes2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329872
Homologene: 27049
Impdh2
Name: inosine monophosphate dehydrogenase 2
Synonyms: IMP dehydrogenase type II
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 23918
HGNC: HGNC:6053
Homologene: 48919
Lamc1
Name: laminin, gamma 1
Synonyms: Lamb2, laminin B2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226519
HGNC: HGNC:6492
Homologene: 1724
Kank4
Name: KN motif and ankyrin repeat domains 4
Synonyms: Ankrd38
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242553
Homologene: 18244
Adam30
Name: a disintegrin and metallopeptidase domain 30
Synonyms: 4933424D07Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71078
HGNC: HGNC:208
Homologene: 11038
Adamts12
Name: ADAM metallopeptidase with thrombospondin type 1 motif 12
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239337
VEGA: 15
Homologene: 12808
Zmynd11
Name: zinc finger, MYND domain containing 11
Synonyms: 2210402G22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66505
Homologene: 4828
Magi3
Name: membrane associated guanylate kinase, WW and PDZ domain containing 3
Synonyms: 4732496O19Rik, 6530407C02Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99470
Homologene: 26431
Retsat
Name: retinol saturase (all trans retinol 13,14 reductase)
Synonyms: 0610039N19Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67442
Homologene: 41195
Cdh23
Name: cadherin related 23 (otocadherin)
Synonyms: 4930542A03Rik, USH1D, mdfw, ahl, bob, nmf112, nmf181, nmf252, sals
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22295
Homologene: 11142
Aoc1l3
Name: amine oxidase copper containing 1-like 3
Synonyms: SVS I, Svs1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243377
HGNC: HGNC:80
Homologene: 18250
Cul9
Name: cullin 9
Synonyms: 1810035I07Rik, Parc
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78309
Homologene: 56696
Nlrp9c
Name: NLR family, pyrin domain containing 9C
Synonyms: Nalp9c, Nalp-zeta
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330490
Homologene: 116072
Dclre1b
Name: DNA cross-link repair 1B
Synonyms: mSNM1B, Apollo, SNMIB
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 140917
Homologene: 32553
Ahnak2
Name: AHNAK nucleoprotein 2
Synonyms: LOC382643
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100041194
Homologene: 131081
Cdh7
Name: cadherin 7, type 2
Synonyms: CDH7L1, 9330156F07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241201
HGNC: HGNC:1766
Homologene: 68391
Ppfia4
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
Synonyms: 1110008G13Rik, LOC100042382, Liprin-alpha4, Gm3812
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68507
HGNC: HGNC:9248
Homologene: 66200
Slc16a7
Name: solute carrier family 16 (monocarboxylic acid transporters), member 7
Synonyms: MCT2, 4921534N07Rik, D630004K10Rik, 9030411M13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20503
Homologene: 20990
Bbox1
Name: gamma-butyrobetaine hydroxylase 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 170442
HGNC: HGNC:964
Homologene: 2967
Htra4
Name: HtrA serine peptidase 4
Synonyms: B430206E18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330723
Homologene: 17801
Ghrhr
Name: growth hormone releasing hormone receptor
Synonyms: Ghrfr
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14602
HGNC: HGNC:4266
Homologene: 640
Bpi
Name: bactericidal permeablility increasing protein
Synonyms: 9230105K17Rik, Bpifd1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329547
HGNC: HGNC:1095
Homologene: 37519
Vmn2r72
Name: vomeronasal 2, receptor 72
Synonyms: EG244114, Vmn2r72-ps
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244114
Homologene: 115466
Map3k19
Name: mitogen-activated protein kinase kinase kinase 19
Synonyms: Ysk4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22625
Homologene: 19318
Eml6
Name: echinoderm microtubule associated protein like 6
Synonyms: 2900083P10Rik, C230094A16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237711
Homologene: 104282
Fsd2
Name: fibronectin type III and SPRY domain containing 2
Synonyms: Spryd1, 9830160G03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244091
Homologene: 18252
Rxfp2
Name: relaxin/insulin-like family peptide receptor 2
Synonyms: Great, LGR8, Gpr106
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 140498
Homologene: 15402
Agxt2
Name: alanine-glyoxylate aminotransferase 2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 268782
Homologene: 12887
Fah
Name: fumarylacetoacetate hydrolase
Synonyms: swst
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14085
HGNC: HGNC:3579
Homologene: 110
Idh1
Name: isocitrate dehydrogenase 1 (NADP+), soluble
Synonyms: Idh-1, Id-1, E030024J03Rik, IDPc
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15926
HGNC: HGNC:5382
Homologene: 21195
Accsl
Name: 1-aminocyclopropane-1-carboxylate synthase (inactive)-like
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381411
Homologene: 86007
Psg18
Name: pregnancy specific beta-1-glycoprotein 18
Synonyms: mmCGM6, Cea-3, Cea3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26438
HGNC: HGNC:9524
Homologene: 110989
Kcnq3
Name: potassium voltage-gated channel, subfamily Q, member 3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110862
HGNC: HGNC:6297
Homologene: 20949
Hoxa9
Name: homeobox A9
Synonyms: D6a9, Hox-1.7
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15405
HGNC: HGNC:5109
Homologene: 7766
Cd151
Name: CD151 antigen
Synonyms: SFA-1, PETA-3, Tspan24
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12476
HGNC: HGNC:1630
Homologene: 20916
Vmn2r12
Name: vomeronasal 2, receptor 12
Synonyms: Gm6769
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 627569
Homologene: 129606
Vdr
Name: vitamin D (1,25-dihydroxyvitamin D3) receptor
Synonyms: Nr1i1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22337
Homologene: 37297
Glipr1l2
Name: GLI pathogenesis-related 1 like 2
Synonyms: 4921508O11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67537
Homologene: 17579
Bivm
Name: basic, immunoglobulin-like variable motif containing
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 246229
Homologene: 9783
Spmip4
Name: sperm microtubule inner protein 4
Synonyms: 4921507P07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70821
Homologene: 69433
Gpr149
Name: G protein-coupled receptor 149
Synonyms: PGR10, 9630018L10Rik, Ieda, R35
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229357
Homologene: 16359
Slc30a3
Name: solute carrier family 30 (zinc transporter), member 3
Synonyms: Znt3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22784
Homologene: 74470
Dkk1
Name: dickkopf WNT signaling pathway inhibitor 1
Synonyms: mdkk-1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13380
HGNC: HGNC:2891
Homologene: 7689
Fmo6
Name: flavin containing monooxygenase 6
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226565
Homologene: 68130
AC132379.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Zfp185
Name: zinc finger protein 185
Synonyms: P1-
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 22673
Homologene: 137227
Amz1
Name: archaelysin family metallopeptidase 1
Synonyms: 6530401C20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231842
Homologene: 18290
Or2a5
Name: olfactory receptor family 2 subfamily A member 5
Synonyms: GA_x6K02T2P3E9-4663051-4662119, MOR261-13, Olfr448
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 258270
HGNC: HGNC:8232
Homologene: 64846
Vmn1r123
Name: vomeronasal 1 receptor 123
Synonyms: LOC384695, Gm1446
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384695
Homologene: 104166
Vmn1r158
Name: vomeronasal 1 receptor 158
Synonyms: Gm16455
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043067
Homologene: 104166
Dmrtc2
Name: doublesex and mab-3 related transcription factor like family C2
Synonyms: 4933432E21Rik, Dmrt7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71241
Homologene: 75260
Meox2
Name: mesenchyme homeobox 2
Synonyms: Gax, Mox-2, Mox2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 17286
HGNC: HGNC:7014
Homologene: 4330
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 44,126,782 bp
  • G to T, chromosome 1 at 65,161,160 bp
  • G to A, chromosome 1 at 110,061,132 bp
  • T to A, chromosome 1 at 116,820,820 bp
  • A to G, chromosome 1 at 127,823,880 bp
  • A to G, chromosome 1 at 134,332,283 bp
  • T to C, chromosome 1 at 153,247,231 bp
  • A to T, chromosome 1 at 162,926,141 bp
  • G to T, chromosome 1 at 172,004,786 bp
  • A to T, chromosome 2 at 93,866,244 bp
  • T to C, chromosome 2 at 110,265,611 bp
  • A to T, chromosome 2 at 158,267,740 bp
  • A to G, chromosome 3 at 62,604,467 bp
  • G to A, chromosome 3 at 98,162,906 bp
  • A to C, chromosome 3 at 103,803,876 bp
  • A to G, chromosome 3 at 104,061,630 bp
  • C to T, chromosome 4 at 80,844,868 bp
  • A to G, chromosome 4 at 82,950,352 bp
  • T to C, chromosome 4 at 98,765,569 bp
  • A to T, chromosome 4 at 142,159,038 bp
  • A to T, chromosome 5 at 31,086,810 bp
  • A to T, chromosome 5 at 109,092,854 bp
  • G to A, chromosome 5 at 122,788,418 bp
  • G to A, chromosome 5 at 129,507,143 bp
  • A to T, chromosome 5 at 140,751,936 bp
  • T to C, chromosome 5 at 150,051,556 bp
  • T to C, chromosome 6 at 42,897,351 bp
  • C to A, chromosome 6 at 48,990,239 bp
  • T to A, chromosome 6 at 50,589,141 bp
  • A to G, chromosome 6 at 52,225,713 bp
  • T to A, chromosome 6 at 55,388,269 bp
  • T to C, chromosome 6 at 72,603,651 bp
  • T to C, chromosome 6 at 85,188,371 bp
  • T to C, chromosome 7 at 18,354,817 bp
  • C to T, chromosome 7 at 21,162,332 bp
  • T to A, chromosome 7 at 22,790,445 bp
  • T to A, chromosome 7 at 24,874,313 bp
  • C to A, chromosome 7 at 26,380,435 bp
  • T to A, chromosome 7 at 30,591,267 bp
  • T to C, chromosome 7 at 81,559,770 bp
  • T to C, chromosome 7 at 84,601,136 bp
  • T to A, chromosome 7 at 85,751,944 bp
  • A to C, chromosome 7 at 141,470,656 bp
  • T to C, chromosome 8 at 25,030,619 bp
  • A to G, chromosome 9 at 21,412,486 bp
  • T to C, chromosome 9 at 108,561,829 bp
  • G to A, chromosome 10 at 60,312,392 bp
  • C to A, chromosome 10 at 112,083,466 bp
  • A to T, chromosome 10 at 125,231,372 bp
  • A to C, chromosome 11 at 11,846,634 bp
  • A to G, chromosome 11 at 29,749,824 bp
  • T to C, chromosome 12 at 37,109,152 bp
  • A to T, chromosome 12 at 112,785,789 bp
  • T to A, chromosome 13 at 9,689,549 bp
  • A to G, chromosome 13 at 97,165,200 bp
  • T to C, chromosome 15 at 10,373,751 bp
  • T to C, chromosome 15 at 11,071,757 bp
  • T to A, chromosome 15 at 66,000,042 bp
  • A to G, chromosome 15 at 82,031,163 bp
  • A to T, chromosome 15 at 97,869,333 bp
  • C to T, chromosome 17 at 8,920,546 bp
  • C to G, chromosome 17 at 46,522,175 bp
  • T to A, chromosome 17 at 57,253,363 bp
  • C to T, chromosome 17 at 86,098,512 bp
  • T to C, chromosome 19 at 30,547,250 bp
  • A to T, chromosome X at 72,999,323 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1173 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039246-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.