Strain Name:
C57BL/6J-MtgxR1174Btlr/Mmmh
Stock Number:
039247-MU
Citation ID:
RRID:MMRRC_039247-MU
Other Names:
R1174 (G1), C57BL/6J-MtgxR1174Btlr
Major Collection:

Gene Information

Vangl2
Name: VANGL planar cell polarity 2
Synonyms: loop-tail, C530001F03Rik, ska17, skam17Jus, Lootl, Lpp1, strabismus, Ltap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 93840
Homologene: 62161
Tle4
Name: transducin-like enhancer of split 4
Synonyms: 5730411M05Rik, ESTM14, Bce1, Grg4, ESTM13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 21888
VEGA: 19
Homologene: 38259
Qtrt1
Name: queuine tRNA-ribosyltransferase catalytic subunit 1
Synonyms: tRNA-guanine transglycosylase, Tgt, 2610028E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 60507
VEGA: 9
Homologene: 11061
Rgs12
Name: regulator of G-protein signaling 12
Synonyms: 4632412M04Rik, 1200016K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 71729
HGNC: HGNC:9994
Homologene: 2195
Neurl4
Name: neuralized E3 ubiquitin protein ligase 4
Synonyms: 0610025P10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 216860
Homologene: 13029
Cox4i1
Name: cytochrome c oxidase subunit 4I1
Synonyms: Cox4a, Cox4, COXIV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 12857
HGNC: HGNC:2265
Homologene: 37537
Ubap2l
Name: ubiquitin-associated protein 2-like
Synonyms: 3110083O19Rik, A430103N23Rik, NICE-4, 4932431F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 74383
Homologene: 136291
Pcnt
Name: pericentrin (kendrin)
Synonyms: m275Asp, Pcnt2, m239Asp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 18541
VEGA: 10
Laptm4a
Name: lysosomal-associated protein transmembrane 4A
Synonyms: Mtrp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 17775
HGNC: HGNC:6924
Homologene: 7427
2610318N02Rik
Name: RIKEN cDNA 2610318N02 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 70458
Homologene: 79715
Borcs5
Name: BLOC-1 related complex subunit 5
Synonyms: 5830457J20Rik, Loh12cr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 67774
Homologene: 12188
Sos1
Name: SOS Ras/Rac guanine nucleotide exchange factor 1
Synonyms: 4430401P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 20662
VEGA: 17
Homologene: 4117
Lamc1
Name: laminin, gamma 1
Synonyms: laminin B2, Lamb2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226519
HGNC: HGNC:6492
Homologene: 1724
Adamts12
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 239337
VEGA: 15
Homologene: 12808
Klf6
Name: Kruppel-like factor 6
Synonyms: BCD1, Ierepo1, CPBP, FM2, FM6, Ierepo3, Copeb, Zf9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 23849
VEGA: 13
HGNC: HGNC:2235
Homologene: 996
Dnajb11
Name: DnaJ heat shock protein family (Hsp40) member B11
Synonyms: 1810031F23Rik, ABBP-2, Dj9, ERdj3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 67838
Homologene: 9464
Robo4
Name: roundabout guidance receptor 4
Synonyms: 1200012D01Rik, Magic roundabout
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 74144
Homologene: 10397
Tdo2
Name: tryptophan 2,3-dioxygenase
Synonyms: chky, TO, TDO
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 56720
Homologene: 4132
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Acz, Pico
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 26875
Homologene: 69111
Mrm3
Name: mitochondrial rRNA methyltransferase 3
Synonyms: HC90, Rnmtl1, 4833420N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 67390
Homologene: 10033
Map3k5
Name: mitogen-activated protein kinase kinase kinase 5
Synonyms: ASK, ASK1, 7420452D20Rik, Mekk5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 26408
HGNC: HGNC:6857
Homologene: 38114
Muc6
Name: mucin 6, gastric
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 353328
HGNC: HGNC:7517
Homologene: 18768
Svs1
Name: seminal vesicle secretory protein 1
Synonyms: SVS I
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 243377
Homologene: 18250
Pik3r4
Name: phosphoinositide-3-kinase regulatory subunit 4
Synonyms: p150, Vps15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 75669
HGNC: HGNC:8982
Homologene: 24678
Sis
Name: sucrase isomaltase (alpha-glucosidase)
Synonyms: sucrase-isomaltase, 2010204N08Rik, Si-s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 69983
Homologene: 37424
Cdh7
Name: cadherin 7, type 2
Synonyms: CDH7L1, 9330156F07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 241201
HGNC: HGNC:1766
Homologene: 68391
Mfsd13a
Name: major facilitator superfamily domain containing 13a
Synonyms: 4930538D17Rik, Tmem180, 4930449A08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 75146
Homologene: 12592
Ghrhr
Name: growth hormone releasing hormone receptor
Synonyms: Ghrfr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 14602
HGNC: HGNC:4266
Homologene: 640
Txlnb
Name: taxilin beta
Synonyms: Mdp77, 2310001N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 378431
Homologene: 44534
Fes
Name: feline sarcoma oncogene
Synonyms: c-fes
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 14159
HGNC: HGNC:3657
Homologene: 37563
Map3k19
Name: mitogen-activated protein kinase kinase kinase 19
Synonyms: Ysk4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 22625
Homologene: 19318
Eml6
Name: echinoderm microtubule associated protein like 6
Synonyms: 2900083P10Rik, C230094A16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 237711
Homologene: 104282
Actn3
Name: actinin alpha 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 11474
HGNC: HGNC:165
Homologene: 862
Rxfp2
Name: relaxin/insulin-like family peptide receptor 2
Synonyms: Great, Gpr106, LGR8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 140498
Homologene: 15402
Agxt2
Name: alanine-glyoxylate aminotransferase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 268782
Homologene: 12887
Rin1
Name: Ras and Rab interactor 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 225870
VEGA: 19
Homologene: 3170
Serpinb9d
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9d
Synonyms: ovalbumin, AT2, Spi9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 20726
HGNC: HGNC:8955
Homologene: 69093
Tas2r140
Name: taste receptor, type 2, member 140
Synonyms: mTRB3, Tas2r40, T2R40, mt2r64, TRB5, Tas2r13, TRB3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 387616
Homologene: 87013
Idh1
Name: isocitrate dehydrogenase 1 (NADP+), soluble
Synonyms: IDPc, Idh-1, Id-1, E030024J03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 15926
HGNC: HGNC:5382
Homologene: 21195
Hoxa9
Name: homeobox A9
Synonyms: D6a9, Hox-1.7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 15405
HGNC: HGNC:5109
Homologene: 7766
Vmn2r12
Name: vomeronasal 2, receptor 12
Synonyms: Gm6769
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 627569
Homologene: 129606
Alpk1
Name: alpha-kinase 1
Synonyms: 8430410J10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 71481
Homologene: 11849
Glipr1l2
Name: GLI pathogenesis-related 1 like 2
Synonyms: 4921508O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 67537
Homologene: 17579
Bivm
Name: basic, immunoglobulin-like variable motif containing
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 246229
Homologene: 9783
Pramef6
Name: PRAME family member 6
Synonyms: Gm13099
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 195555
Homologene: 133722
4921507P07Rik
Name: RIKEN cDNA 4921507P07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 70821
Homologene: 69433
Gpr149
Name: G protein-coupled receptor 149
Synonyms: PGR10, Ieda, R35, 9630018L10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229357
Homologene: 16359
AC132379.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
Lypd6b
Name: LY6/PLAUR domain containing 6B
Synonyms: 2310010M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 71897
Homologene: 12419
Zfp185
Name: zinc finger protein 185
Synonyms: P1-
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 22673
Homologene: 137227
Vwa1
Name: von Willebrand factor A domain containing 1
Synonyms: 4932416A11Rik, WARP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 246228
Homologene: 11270
Cpeb4
Name: cytoplasmic polyadenylation element binding protein 4
Synonyms: 4930447D24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 67579
Homologene: 12736
Gm1818
Name: predicted gene 1818
Synonyms: LOC217536
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217536
VEGA: 12
Gm10093
Name: predicted pseudogene 10093
Synonyms: EG15181
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 15181
VEGA: 17
Ssxb8
Name: synovial sarcoma, X member B8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 631002
Homologene: 85956
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 44,126,782 bp
  • G to T, chromosome 1 at 65,161,160 bp
  • G to A, chromosome 1 at 110,061,132 bp
  • T to A, chromosome 1 at 116,820,820 bp
  • A to G, chromosome 1 at 127,823,880 bp
  • T to C, chromosome 1 at 153,247,231 bp
  • G to T, chromosome 1 at 172,004,786 bp
  • C to T, chromosome 2 at 49,943,597 bp
  • A to G, chromosome 3 at 62,604,467 bp
  • A to G, chromosome 3 at 72,958,104 bp
  • A to T, chromosome 3 at 81,974,376 bp
  • A to T, chromosome 3 at 90,023,500 bp
  • T to A, chromosome 3 at 127,680,810 bp
  • T to G, chromosome 4 at 143,897,328 bp
  • C to T, chromosome 4 at 155,773,266 bp
  • T to C, chromosome 5 at 14,677,646 bp
  • T to A, chromosome 5 at 34,966,465 bp
  • A to T, chromosome 5 at 109,092,854 bp
  • T to C, chromosome 5 at 150,051,556 bp
  • C to A, chromosome 6 at 48,990,239 bp
  • T to A, chromosome 6 at 50,589,141 bp
  • A to G, chromosome 6 at 52,225,713 bp
  • T to A, chromosome 6 at 55,388,269 bp
  • T to C, chromosome 6 at 133,054,871 bp
  • T to A, chromosome 6 at 134,710,133 bp
  • A to T, chromosome 7 at 80,377,951 bp
  • C to T, chromosome 7 at 141,648,101 bp
  • C to A, chromosome 8 at 120,674,050 bp
  • A to G, chromosome 9 at 21,412,486 bp
  • C to T, chromosome 9 at 37,413,052 bp
  • G to T, chromosome 9 at 105,663,174 bp
  • A to G, chromosome 10 at 17,842,756 bp
  • G to A, chromosome 10 at 20,056,648 bp
  • A to T, chromosome 10 at 76,393,044 bp
  • C to A, chromosome 10 at 112,083,466 bp
  • A to G, chromosome 11 at 29,749,824 bp
  • T to C, chromosome 11 at 31,920,472 bp
  • T to C, chromosome 11 at 69,903,721 bp
  • T to C, chromosome 11 at 76,250,024 bp
  • T to C, chromosome 12 at 8,936,716 bp
  • A to G, chromosome 12 at 48,556,199 bp
  • A to G, chromosome 13 at 5,861,712 bp
  • C to T, chromosome 13 at 33,200,625 bp
  • T to C, chromosome 15 at 10,373,751 bp
  • T to C, chromosome 15 at 11,071,757 bp
  • T to A, chromosome 16 at 17,117,582 bp
  • T to A, chromosome 16 at 22,870,673 bp
  • A to T, chromosome 17 at 78,492,078 bp
  • A to C, chromosome 17 at 80,445,608 bp
  • A to G, chromosome 19 at 4,864,756 bp
  • C to A, chromosome 19 at 5,055,203 bp
  • C to T, chromosome 19 at 14,468,262 bp
  • T to A, chromosome 19 at 46,374,686 bp
  • T to G, chromosome X at 8,689,823 bp
  • A to T, chromosome X at 72,999,323 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1174 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039247-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.