Strain Name:
C57BL/6J-MtgxR1180Btlr/Mmmh
Stock Number:
039252-MU
Citation ID:
RRID:MMRRC_039252-MU
Other Names:
R1180 (G1), C57BL/6J-MtgxR1180Btlr
Major Collection:

Gene Information

Tk1
Name: thymidine kinase 1
Synonyms: D530002A18Rik, Tk-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 21877
Homologene: 37749
Foxp4
Name: forkhead box P4
Synonyms: 1200010K03Rik, 2310007G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74123
Homologene: 12536
Cadps
Name: Ca2+-dependent secretion activator
Synonyms: CAPS1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 27062
VEGA: 14
HGNC: HGNC:1426
Homologene: 2755
Jak2
Name: Janus kinase 2
Synonyms: C81284
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 16452
VEGA: 19
HGNC: HGNC:6192
Homologene: 21033
Sfmbt2
Name: Scm-like with four mbt domains 2
Synonyms: D330030P06Rik, D2Wsu23e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 353282
Homologene: 82485
2610021A01Rik
Name: RIKEN cDNA 2610021A01 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 668572
Ranbp2
Name: RAN binding protein 2
Synonyms: A430087B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19386
VEGA: 10
Homologene: 87808
Dock4
Name: dedicator of cytokinesis 4
Synonyms: 6330411N01Rik, EST N28122
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238130
VEGA: 12
Homologene: 56680
Shb
Name: src homology 2 domain-containing transforming protein B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230126
Homologene: 74458
Tenm2
Name: teneurin transmembrane protein 2
Synonyms: Odz2, Ten-m2, 2610040L17Rik, D3Bwg1534e, 9330187F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 23964
Homologene: 22672
Chd8
Name: chromodomain helicase DNA binding protein 8
Synonyms: Duplin, 5830451P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 67772
Homologene: 72405
Gprin3
Name: GPRIN family member 3
Synonyms: C030038J10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243385
Homologene: 52334
Pirb
Name: paired Ig-like receptor B
Synonyms: Lilrb3, Gp91
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18733
HGNC: HGNC:6607
Homologene: 134028
Hoxa3
Name: homeobox A3
Synonyms: Hox-1.5, Mo-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 15400
HGNC: HGNC:5104
Homologene: 40725
Nrbp1
Name: nuclear receptor binding protein 1
Synonyms: Nrbp, B230344L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 192292
HGNC: HGNC:7993
Homologene: 8373
Camk1d
Name: calcium/calmodulin-dependent protein kinase ID
Synonyms: CKLiK, A630059D12Rik, E030025C11Rik, CaMKIdelta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227541
Homologene: 121858
Flt3
Name: FMS-like tyrosine kinase 3
Synonyms: Flk2, wmfl, Flk-2, CD135, Flt-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14255
HGNC: HGNC:3765
Homologene: 3040
Shf
Name: Src homology 2 domain containing F
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 435684
Homologene: 44524
Myh6
Name: myosin, heavy polypeptide 6, cardiac muscle, alpha
Synonyms: alpha-MHC, Myhc-a, cardiomyopathy, hypertrophic 1, Myhca, alpha myosin, A830009F23Rik, alphaMHC, alpha cardiac MHC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 17888
HGNC: HGNC:7576
Homologene: 124414
Ttn
Name: titin
Synonyms: 2310057K23Rik, connectin, D830007G01Rik, D330041I19Rik, L56, shru, 1100001C23Rik, 2310036G12Rik, mdm, 2310074I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Myo16
Name: myosin XVI
Synonyms: BM140241, C230040D10Rik, Nyap3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244281
Homologene: 34710
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Fer1l6
Name: fer-1-like 6 (C. elegans)
Synonyms: EG631797
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 631797
Homologene: 53396
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241516
Homologene: 110349
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Kif6
Name: kinesin family member 6
Synonyms: D130004B10Rik, D130084M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 319991
Homologene: 35308
Cpd
Name: carboxypeptidase D
Synonyms: D830034L15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12874
HGNC: HGNC:2301
Homologene: 999
Mrpl44
Name: mitochondrial ribosomal protein L44
Synonyms: 1810030E18Rik, 5730593H20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 69163
Homologene: 11293
Htra4
Name: HtrA serine peptidase 4
Synonyms: B430206E18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 330723
Homologene: 17801
EU599041
Name: expressed sequence EU599041
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100170401
Spag16
Name: sperm associated antigen 16
Synonyms: 4930524F24Rik, Pf20, 4921511D23Rik, Wdr29, 4930585K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 66722
Homologene: 11572
Adam24
Name: a disintegrin and metallopeptidase domain 24 (testase 1)
Synonyms: Dtgn5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 13526
HGNC: HGNC:203
Homologene: 137232
Apcdd1
Name: adenomatosis polyposis coli down-regulated 1
Synonyms: EIG180, Drapc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 494504
VEGA: 18
Homologene: 77420
Tnni3k
Name: TNNI3 interacting kinase
Synonyms: D830019J24Rik, Cark
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 435766
Homologene: 41084
Olfr1155
Name: olfactory receptor 1155
Synonyms: GA_x6K02T2Q125-49426894-49425950, MOR174-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258636
Homologene: 133739
Ube2q2
Name: ubiquitin-conjugating enzyme E2Q family member 2
Synonyms: 3010021M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 109161
Homologene: 45455
Mx2
Name: MX dynamin-like GTPase 2
Synonyms: Mx-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 17858
Kiz
Name: kizuna centrosomal protein
Synonyms: LOC228730, Ncrna00153, Plk1s1, Gm114
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228730
Homologene: 10219
Gstm1
Name: glutathione S-transferase, mu 1
Synonyms: Gstb1, Gstb-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14862
HGNC: HGNC:4637
Homologene: 115474
Psmd8
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
Synonyms: C76433, 6720456J22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57296
HGNC: HGNC:9566
Homologene: 37686
Samsn1
Name: SAM domain, SH3 domain and nuclear localization signals, 1
Synonyms: Hacs1, 4930571B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 67742
Homologene: 11148
Mstn
Name: myostatin
Synonyms: Gdf8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17700
HGNC: HGNC:4223
Homologene: 3850
Pdzd3
Name: PDZ domain containing 3
Synonyms: Pdzk2, sodium-phosphate cotransporter IIa C-terminal-associated protein 2, NaPi-Cap2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 170761
VEGA: 9
Homologene: 11719
Olfr401
Name: olfactory receptor 401
Synonyms: MOR255-6, GA_x6K02T2P1NL-4278037-4278984
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258701
HGNC: HGNC:8282
Homologene: 73922
Zfp474
Name: zinc finger protein 474
Synonyms: 4933409D10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 66758
Homologene: 12027
Mipep
Name: mitochondrial intermediate peptidase
Synonyms: 5730405E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 70478
VEGA: 14
HGNC: HGNC:7104
Homologene: 4337
Utp14b
Name: UTP14B small subunit processome component
Synonyms: 4932411L21Rik, jsd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 195434
Homologene: 78703
Cxcr2
Name: chemokine (C-X-C motif) receptor 2
Synonyms: IL8RA, IL-8Rh, Gpcr16, IL-8rb, CD128, Il8rb, Cmkar2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12765
HGNC: HGNC:6027
Homologene: 10439
Kyat3
Name: kynurenine aminotransferase 3
Synonyms: KATIII, Kat3, Ccbl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229905
Homologene: 2994
Sec61g
Name: SEC61, gamma subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20335
Homologene: 40767
Spink13
Name: serine peptidase inhibitor, Kazal type 13
Synonyms: Gm10534
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 100038417
Homologene: 87519
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 20,585,157 bp
  • A to T, chromosome 1 at 53,064,008 bp
  • G to A, chromosome 1 at 69,923,658 bp
  • A to T, chromosome 1 at 74,158,368 bp
  • C to A, chromosome 1 at 78,665,445 bp
  • T to A, chromosome 1 at 79,777,960 bp
  • T to C, chromosome 1 at 90,781,855 bp
  • A to T, chromosome 2 at 5,362,025 bp
  • C to T, chromosome 2 at 10,402,066 bp
  • A to T, chromosome 2 at 76,969,703 bp
  • T to C, chromosome 2 at 82,975,226 bp
  • G to A, chromosome 2 at 87,943,146 bp
  • G to A, chromosome 2 at 122,368,682 bp
  • C to T, chromosome 2 at 146,970,007 bp
  • A to G, chromosome 3 at 108,014,811 bp
  • A to C, chromosome 3 at 142,737,770 bp
  • A to T, chromosome 3 at 154,875,513 bp
  • T to C, chromosome 4 at 45,423,996 bp
  • T to A, chromosome 5 at 31,245,813 bp
  • T to C, chromosome 5 at 147,341,238 bp
  • A to C, chromosome 6 at 52,170,402 bp
  • C to A, chromosome 6 at 59,354,936 bp
  • A to T, chromosome 7 at 3,717,638 bp
  • A to T, chromosome 7 at 29,175,400 bp
  • T to A, chromosome 7 at 41,625,717 bp
  • G to A, chromosome 7 at 43,226,307 bp
  • T to C, chromosome 8 at 10,396,908 bp
  • G to T, chromosome 8 at 25,033,719 bp
  • T to G, chromosome 8 at 40,681,428 bp
  • T to A, chromosome 9 at 44,249,246 bp
  • T to C, chromosome 9 at 55,195,416 bp
  • A to G, chromosome 10 at 58,465,463 bp
  • A to C, chromosome 11 at 16,504,722 bp
  • C to T, chromosome 11 at 36,063,177 bp
  • A to G, chromosome 11 at 74,121,580 bp
  • T to C, chromosome 11 at 76,801,753 bp
  • A to G, chromosome 11 at 117,822,095 bp
  • A to G, chromosome 12 at 40,640,414 bp
  • A to G, chromosome 14 at 12,457,836 bp
  • A to C, chromosome 14 at 52,221,108 bp
  • A to G, chromosome 14 at 54,944,468 bp
  • G to A, chromosome 14 at 60,834,056 bp
  • G to A, chromosome 15 at 58,602,311 bp
  • C to T, chromosome 16 at 75,873,648 bp
  • G to A, chromosome 16 at 97,556,009 bp
  • G to C, chromosome 17 at 47,880,353 bp
  • T to A, chromosome 17 at 49,832,256 bp
  • C to T, chromosome 18 at 52,638,742 bp
  • A to G, chromosome 18 at 62,608,170 bp
  • A to T, chromosome 18 at 62,937,097 bp
  • A to G, chromosome 19 at 29,282,499 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1180 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039252-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.