Strain Name:
C57BL/6J-MtgxR1181Btlr/Mmmh
Stock Number:
039253-MU
Citation ID:
RRID:MMRRC_039253-MU
Other Names:
R1181 (G1), C57BL/6J-MtgxR1181Btlr
Major Collection:

Gene Information

Pald1
Name: phosphatase domain containing, paladin 1
Synonyms: paladin, X99384
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 27355
VEGA: 10
Homologene: 8453
Hgf
Name: hepatocyte growth factor
Synonyms: scatter factor, NK1, SF/HGF, HGF/SF, NK2, C230052L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 15234
HGNC: HGNC:4893
Homologene: 503
Eps8
Name: epidermal growth factor receptor pathway substrate 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 13860
HGNC: HGNC:3420
Homologene: 3272
Fastk
Name: Fas-activated serine/threonine kinase
Synonyms: 0610011K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 66587
Homologene: 4884
Serinc3
Name: serine incorporator 3
Synonyms: TMS-1, DIFF33, AIGP1, Tde1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 26943
Homologene: 38230
Ankrd12
Name: ankyrin repeat domain 12
Synonyms: ANCO-2, GAC-1, 2900001A12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106585
Homologene: 9059
Pds5a
Name: PDS5 cohesin associated factor A
Synonyms: E230024D05Rik, 9030416H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71521
Homologene: 22877
Tenm2
Name: teneurin transmembrane protein 2
Synonyms: Ten-m2, D3Bwg1534e, 9330187F13Rik, 2610040L17Rik, Odz2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 23964
Homologene: 22672
Trim66
Name: tripartite motif-containing 66
Synonyms: D7H11orf29, Tif1d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330627
Homologene: 28044
Pirb
Name: paired Ig-like receptor B
Synonyms: Gp91, Lilrb3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18733
HGNC: HGNC:6607
Homologene: 134028
Prune2
Name: prune homolog 2
Synonyms: 6330414G02Rik, A330102H22Rik, A230083H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 353211
VEGA: 19
Homologene: 18939
Nob1
Name: NIN1/RPN12 binding protein 1 homolog
Synonyms: ART-4, Nob1p, 1700021I09Rik, Psmd8bp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67619
Homologene: 31924
Nupl1
Name: nucleoporin like 1
Synonyms: 1700017F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 71844
VEGA: 14
Homologene: 40924
Ehbp1
Name: EH domain binding protein 1
Synonyms: KIAA0903-like, Flj21950
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216565
Homologene: 22880
Shf
Name: Src homology 2 domain containing F
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 435684
Homologene: 44524
Tulp3
Name: tubby-like protein 3
Synonyms: 2310022L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 22158
Homologene: 20711
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Cped1
Name: cadherin-like and PC-esterase domain containing 1
Synonyms: A430107O13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 214642
Homologene: 57014
Klhl5
Name: kelch-like 5
Synonyms: 1300013C10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71778
HGNC: HGNC:6356
Homologene: 56736
Olfr444
Name: olfactory receptor 444
Synonyms: GA_x6K02T2P3E9-4602571-4601639, MOR261-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258650
Homologene: 88438
Zfp454
Name: zinc finger protein 454
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237758
Homologene: 72226
Gp1ba
Name: glycoprotein 1b, alpha polypeptide
Synonyms: GP Ib-alpha, GPIb-alpha, GPIba
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14723
HGNC: HGNC:4439
Homologene: 143
Actn3
Name: actinin alpha 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 11474
HGNC: HGNC:165
Homologene: 862
Cdr2l
Name: cerebellar degeneration-related protein 2-like
Synonyms: D030068L24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237988
Homologene: 35390
Mettl14
Name: methyltransferase like 14
Synonyms: G430022H21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 210529
Homologene: 10865
Tbc1d7
Name: TBC1 domain family, member 7
Synonyms: 2610009C09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67046
VEGA: 13
Homologene: 9538
Apcdd1
Name: adenomatosis polyposis coli down-regulated 1
Synonyms: EIG180, Drapc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 494504
VEGA: 18
Homologene: 77420
Tnni3k
Name: TNNI3 interacting kinase
Synonyms: Cark, D830019J24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 435766
Homologene: 41084
Olfr1155
Name: olfactory receptor 1155
Synonyms: GA_x6K02T2Q125-49426894-49425950, MOR174-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258636
Homologene: 133739
Slfn8
Name: schlafen 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 276950
Homologene: 45432
Gstm1
Name: glutathione S-transferase, mu 1
Synonyms: Gstb-1, Gstb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14862
HGNC: HGNC:4637
Homologene: 115474
Ecm1
Name: extracellular matrix protein 1
Synonyms: p85
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 13601
HGNC: HGNC:3153
Homologene: 3260
Olfr503
Name: olfactory receptor 503
Synonyms: GA_x6K02T2PBJ9-10874315-10875286, MOR34-9, MOR34-8P, MOR34-12, MOR34-9, Olfr1548
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259143
Homologene: 121509
Bnipl
Name: BCL2/adenovirus E1B 19kD interacting protein like
Synonyms: BNIPL-2, BNIPL-1, BNIPL2, BNIPL1, PP753, BNIPL, 1700128A13Rik, BNIP-S
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 171388
Homologene: 15900
Olfr1463
Name: olfactory receptor 1463
Synonyms: GA_x6K02T2RE5P-3560863-3561795, MOR202-29P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258120
HGNC: HGNC:8324
Homologene: 133886
Bod1
Name: biorientation of chromosomes in cell division 1
Synonyms: 2310022M17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69556
Homologene: 16300
Gm6797
Name: predicted pseudogene 6797
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 387284
Homologene: 85956
Tas2r121
Name: taste receptor, type 2, member 121
Synonyms: Tas2r21, mT2r48, mGR21, T2R21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387349
Homologene: 41542
Kyat3
Name: kynurenine aminotransferase 3
Synonyms: KATIII, Kat3, Ccbl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229905
Homologene: 2994
Plekha2
Name: pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2
Synonyms: TAPP2, 6430512N22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 83436
Homologene: 41822
Sec61g
Name: SEC61, gamma subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20335
Homologene: 40767
Spink13
Name: serine peptidase inhibitor, Kazal type 13
Synonyms: Gm10534
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 100038417
Homologene: 87519
Ubqln5
Name: ubiquilin 5
Synonyms: 4931431F19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70980
Homologene: 78030
Olfr676
Name: olfactory receptor 676
Synonyms: GA_x6K02T2PBJ9-7664016-7664969, MOR32-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259099
Homologene: 64955
Cbarp
Name: calcium channel, voltage-dependent, beta subunit associated regulatory protein
Synonyms: R29144/1, Dos
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 100503659
Homologene: 82309
Olfr808
Name: olfactory receptor 808
Synonyms: GA_x6K02T2PULF-11446184-11447122, MOR112-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258930
Homologene: 17438
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 2 at 76,969,703 bp
  • G to A, chromosome 2 at 87,943,146 bp
  • G to A, chromosome 2 at 122,368,682 bp
  • T to C, chromosome 2 at 163,625,526 bp
  • C to A, chromosome 3 at 95,245,649 bp
  • G to A, chromosome 3 at 95,735,350 bp
  • A to G, chromosome 3 at 108,014,811 bp
  • C to T, chromosome 3 at 123,374,002 bp
  • A to C, chromosome 3 at 142,737,770 bp
  • A to T, chromosome 3 at 154,875,513 bp
  • G to C, chromosome 5 at 16,618,925 bp
  • C to T, chromosome 5 at 24,441,731 bp
  • T to C, chromosome 5 at 65,162,885 bp
  • A to T, chromosome 5 at 65,627,202 bp
  • T to G, chromosome 6 at 22,215,562 bp
  • T to A, chromosome 6 at 42,955,558 bp
  • A to T, chromosome 6 at 128,325,952 bp
  • A to T, chromosome 6 at 132,700,169 bp
  • T to C, chromosome 6 at 137,522,854 bp
  • A to T, chromosome 7 at 3,717,638 bp
  • T to A, chromosome 7 at 104,128,741 bp
  • T to A, chromosome 7 at 105,035,814 bp
  • C to A, chromosome 7 at 108,545,302 bp
  • C to T, chromosome 7 at 109,484,577 bp
  • A to C, chromosome 8 at 25,059,202 bp
  • G to A, chromosome 8 at 107,421,490 bp
  • A to G, chromosome 10 at 61,347,587 bp
  • G to T, chromosome 10 at 80,135,494 bp
  • A to G, chromosome 10 at 129,768,164 bp
  • A to C, chromosome 11 at 16,504,722 bp
  • C to T, chromosome 11 at 22,062,831 bp
  • T to C, chromosome 11 at 31,666,943 bp
  • C to T, chromosome 11 at 36,063,177 bp
  • T to C, chromosome 11 at 50,873,586 bp
  • C to T, chromosome 11 at 70,641,427 bp
  • T to C, chromosome 11 at 83,016,745 bp
  • T to A, chromosome 11 at 115,394,179 bp
  • T to C, chromosome 13 at 43,153,139 bp
  • A to T, chromosome 14 at 60,244,670 bp
  • T to C, chromosome 17 at 66,042,574 bp
  • A to G, chromosome 18 at 62,608,170 bp
  • A to T, chromosome 18 at 62,937,097 bp
  • T to A, chromosome 19 at 4,872,610 bp
  • C to A, chromosome 19 at 13,234,831 bp
  • T to C, chromosome 19 at 17,123,105 bp
  • T to A, chromosome X at 8,641,765 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1181 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039253-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.