Strain Name:
C57BL/6J-MtgxR1185Btlr/Mmmh
Stock Number:
039257-MU
Citation ID:
RRID:MMRRC_039257-MU
Other Names:
R1185 (G1), C57BL/6J-MtgxR1185Btlr
Major Collection:

Gene Information

Tjp2
Name: tight junction protein 2
Synonyms: ZO-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 21873
VEGA: 19
Homologene: 3541
Ltbp4
Name: latent transforming growth factor beta binding protein 4
Synonyms: 2310046A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 108075
HGNC: HGNC:6717
Homologene: 2645
Sorbs1
Name: sorbin and SH3 domain containing 1
Synonyms: 9530001P15Rik, c-Cbl-associated protein, CAP, Sh3d5, Ponsin, 2310065E01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 20411
VEGA: 19
Homologene: 83252
Akap9
Name: A kinase (PRKA) anchor protein (yotiao) 9
Synonyms: mei2-5, G1-448-15, 5730481H23Rik, AKAP450, repro12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 100986
HGNC: HGNC:379
Homologene: 134583
Focad
Name: focadhesin
Synonyms: BC057079
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230393
Homologene: 9842
Mdn1
Name: midasin AAA ATPase 1
Synonyms: LOC213784, D4Abb1e, 4833432B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 100019
Homologene: 39689
Brap
Name: BRCA1 associated protein
Synonyms: 3010002G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 72399
HGNC: HGNC:1099
Homologene: 4926
Cecr2
Name: CECR2, histone acetyl-lysine reader
Synonyms: Gtl4, cat eye syndrome chromosome region, candidate 2, 2610101O16Rik, 2810409N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 330409
HGNC: HGNC:1840
Homologene: 64662
Lrrn2
Name: leucine rich repeat protein 2, neuronal
Synonyms: 5730406J09Rik, NLRR-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 16980
Homologene: 21274
Aimp2
Name: aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
Synonyms: Jtv1, Aimp2(p38)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231872
Homologene: 4594
Zfp459
Name: zinc finger protein 459
Synonyms: Rslcan-14, 9930025G17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 328274
Pgap3
Name: post-GPI attachment to proteins 3
Synonyms: CAB2, Perld1, D430035D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 320655
Homologene: 5484
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 94109
Homologene: 69536
Muc19
Name: mucin 19
Synonyms: apomucin, sld
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 239611
Ghr
Name: growth hormone receptor
Synonyms: GHR/BP, GHBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 14600
HGNC: HGNC:4263
Homologene: 134
Myo16
Name: myosin XVI
Synonyms: BM140241, C230040D10Rik, Nyap3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 244281
Homologene: 34710
Trpm3
Name: transient receptor potential cation channel, subfamily M, member 3
Synonyms: LTRPC3, 6330504P12Rik, MLSN2, melastatin 2, B930001P07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 226025
VEGA: 19
Homologene: 62287
Tnr
Name: tenascin R
Synonyms: restrictin, TN-R, janusin, J1-tenascin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 21960
Homologene: 124416
Proser3
Name: proline and serine rich 3
Synonyms: BC053749
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 333193
Homologene: 116064
Celsr2
Name: cadherin, EGF LAG seven-pass G-type receptor 2
Synonyms: Adgrc2, mfmi1, EGFL2, flamingo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 53883
HGNC: HGNC:3231
Homologene: 1078
Itgb2l
Name: integrin beta 2-like
Synonyms: 5033406G21Rik, pactolus
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 16415
Neb
Name: nebulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Arhgef25
Name: Rho guanine nucleotide exchange factor (GEF) 25
Synonyms: GEFT, 2410008H17Rik, D10Ertd610e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 52666
VEGA: 10
Homologene: 32691
Unc13a
Name: unc-13 homolog A
Synonyms: Munc13-1, 2410078G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 382018
Homologene: 11279
Ppp1r9b
Name: protein phosphatase 1, regulatory subunit 9B
Synonyms: spinophilin, SPL, neurabin II, Spn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217124
HGNC: HGNC:9298
Homologene: 32787
Sfi1
Name: Sfi1 homolog, spindle assembly associated (yeast)
Synonyms: 2310047I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 78887
Homologene: 12707
AC211878.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
Cps1
Name: carbamoyl-phosphate synthetase 1
Synonyms: 4732433M03Rik, CPS, D1Ucla3, CPSase I
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 227231
HGNC: HGNC:2323
Homologene: 68208
Tcaf3
Name: TRPM8 channel-associated factor 3
Synonyms: Fam115e, Eapa2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 403088
Homologene: 74374
Cd69
Name: CD69 antigen
Synonyms: AIM, VEA, 5830438K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 12515
HGNC: HGNC:1694
Homologene: 128584
Hirip3
Name: HIRA interacting protein 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233876
HGNC: HGNC:4917
Homologene: 18218
Rsph10b
Name: radial spoke head 10 homolog B (Chlamydomonas)
Synonyms: 4930526H21Rik, Rsph10b2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
Homologene: 18321
Zfp27
Name: zinc finger protein 27
Synonyms: mkr-4, Zfp-27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 22689
Homologene: 81823
Olfr135
Name: olfactory receptor 135
Synonyms: GA_x6K02T2PSCP-2656648-2657586, MOR256-48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 258329
Homologene: 110603
Timd4
Name: T cell immunoglobulin and mucin domain containing 4
Synonyms: TIM-4, Tim4, B430010N18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 276891
Homologene: 51381
CAAA01123846.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
Zfp39
Name: zinc finger protein 39
Synonyms: CTfin33, Zfp-39
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 22698
Homologene: 69102
Lmod1
Name: leiomodin 1 (smooth muscle)
Synonyms: 9530015K06Rik, 1D, D1, 64kD D1, SM-Lmod
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 93689
HGNC: HGNC:6647
Homologene: 8118
Fam162b
Name: family with sequence similarity 162, member B
Synonyms: 9430073N08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 77296
VEGA: 10
Homologene: 82459
Ttc30a1
Name: tetratricopeptide repeat domain 30A1
Synonyms: 4930506L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 78802
Homologene: 136638
Dusp13
Name: dual specificity phosphatase 13
Synonyms: TS-DSP6, TMDP, LMW-DSP6, LOC382853
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 27389
Homologene: 121602
Vmn1r11
Name: vomeronasal 1 receptor 11
Synonyms: V1rc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 113860
Homologene: 128345
Purg
Name: purine-rich element binding protein G
Synonyms: 4930486B15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 75029
Homologene: 22747
Ac165356.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
Jrkl
Name: Jrk-like
Synonyms: C030035D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 77532
VEGA: 9
HGNC: HGNC:6200
Homologene: 2797
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 67,195,199 bp
  • A to G, chromosome 1 at 132,939,221 bp
  • A to G, chromosome 1 at 135,364,229 bp
  • G to A, chromosome 1 at 159,852,286 bp
  • A to G, chromosome 2 at 52,296,298 bp
  • A to T, chromosome 2 at 75,980,352 bp
  • T to C, chromosome 3 at 108,399,709 bp
  • T to C, chromosome 4 at 32,735,576 bp
  • A to G, chromosome 4 at 88,178,187 bp
  • C to A, chromosome 4 at 156,351,101 bp
  • A to G, chromosome 5 at 3,948,783 bp
  • T to C, chromosome 5 at 121,675,279 bp
  • A to G, chromosome 5 at 143,904,691 bp
  • G to A, chromosome 5 at 143,966,462 bp
  • T to C, chromosome 6 at 42,591,434 bp
  • T to A, chromosome 6 at 57,137,507 bp
  • C to T, chromosome 6 at 120,758,205 bp
  • C to T, chromosome 6 at 129,270,185 bp
  • G to C, chromosome 7 at 27,310,535 bp
  • T to C, chromosome 7 at 29,895,829 bp
  • G to A, chromosome 7 at 30,546,147 bp
  • C to T, chromosome 7 at 106,083,479 bp
  • AAGAG to AAG, chromosome 7 at 126,863,660 bp
  • T to A, chromosome 8 at 10,633,624 bp
  • T to C, chromosome 8 at 16,358,348 bp
  • T to G, chromosome 8 at 33,386,869 bp
  • C to T, chromosome 8 at 71,661,833 bp
  • T to C, chromosome 9 at 13,244,933 bp
  • A to G, chromosome 10 at 51,590,343 bp
  • A to G, chromosome 10 at 127,183,781 bp
  • TCGC to TC, chromosome 11 at 3,146,254 bp
  • CCTCTC to CCTCTCTC, chromosome 11 at 3,177,419 bp
  • C to A, chromosome 11 at 46,817,648 bp
  • T to C, chromosome 11 at 58,902,844 bp
  • T to C, chromosome 11 at 95,001,986 bp
  • T to C, chromosome 11 at 98,391,134 bp
  • A to G, chromosome 12 at 87,773,708 bp
  • T to G, chromosome 13 at 67,408,481 bp
  • A to G, chromosome 14 at 21,735,018 bp
  • T to A, chromosome 15 at 3,328,062 bp
  • A to G, chromosome 15 at 91,878,549 bp
  • A to G, chromosome 16 at 96,429,040 bp
  • T to A, chromosome 17 at 38,209,183 bp
  • G to A, chromosome 19 at 22,914,417 bp
  • A to G, chromosome 19 at 24,131,163 bp
  • T to A, chromosome 19 at 40,382,606 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1185 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039257-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.