Strain Name:
C57BL/6J-MtgxR1192Btlr/Mmmh
Stock Number:
039264-MU
Citation ID:
RRID:MMRRC_039264-MU
Other Names:
R1192 (G1), C57BL/6J-MtgxR1192Btlr
Major Collection:

Gene Information

Polr3e
Name: polymerase (RNA) III (DNA directed) polypeptide E
Synonyms: Sin, RPC5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 26939
Homologene: 14052
Jarid2
Name: jumonji, AT rich interactive domain 2
Synonyms: Jmj, jumonji
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 16468
HGNC: HGNC:6196
Homologene: 31279
Eif4g3
Name: eukaryotic translation initiation factor 4 gamma, 3
Synonyms: eIF4GII, 4930523M17Rik, 1500002J22Rik, repro8, G1-419-52
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230861
HGNC: HGNC:3298
Homologene: 2789
Rfc1
Name: replication factor C (activator 1) 1
Synonyms: Recc1, RFC140, Alp145, 140kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19687
HGNC: HGNC:9969
Homologene: 2187
Ints14
Name: integrator complex subunit 14
Synonyms: 2010321M09Rik, Vwa9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 69882
VEGA: 9
Homologene: 12774
Uhrf1bp1
Name: UHRF1 (ICBP90) binding protein 1
Synonyms: 1110020K19Rik, F830021D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224648
Homologene: 9816
Palb2
Name: partner and localizer of BRCA2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233826
Homologene: 11652
Akap8l
Name: A kinase (PRKA) anchor protein 8-like
Synonyms: Nakap95
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 54194
VEGA: 17
Homologene: 8658
Nkiras2
Name: NFKB inhibitor interacting Ras-like protein 2
Synonyms: 2410003M04Rik, 4930527H08Rik, KBRAS2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71966
Homologene: 9738
Rfwd3
Name: ring finger and WD repeat domain 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234736
Homologene: 41230
Creld1
Name: cysteine-rich with EGF-like domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 171508
Homologene: 32265
Galnt14
Name: polypeptide N-acetylgalactosaminyltransferase 14
Synonyms: 0610033M06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 71685
Homologene: 56997
Arhgef3
Name: Rho guanine nucleotide exchange factor (GEF) 3
Synonyms: 1200004I24Rik, C76747, 9830169H03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 71704
VEGA: 14
HGNC: HGNC:683
Homologene: 41329
Tubgcp2
Name: tubulin, gamma complex associated protein 2
Synonyms: 1700022B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74237
Homologene: 55980
Ccdc88a
Name: coiled coil domain containing 88A
Synonyms: GIV, A430106J12Rik, C330012F17Rik, HkRP1, Girdin, D130005J21Rik, C130096N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 108686
Homologene: 41180
Pcgf3
Name: polycomb group ring finger 3
Synonyms: DONG1, RNF3A, D630042K08Rik, 2310035N15Rik, Rnf3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 69587
Homologene: 4605
Slc16a4
Name: solute carrier family 16 (monocarboxylic acid transporters), member 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229699
Homologene: 74529
Hoxa13
Name: homeobox A13
Synonyms: Hox-1.10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 15398
HGNC: HGNC:5102
Homologene: 73882
Exosc9
Name: exosome component 9
Synonyms: PM/Scl-75, Pmscl1, p6, p5, RRP45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 50911
HGNC: HGNC:9137
Homologene: 3693
Ahrr
Name: aryl-hydrocarbon receptor repressor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 11624
HGNC: HGNC:346
Homologene: 49215
Gen1
Name: GEN1, Holliday junction 5' flap endonuclease
Synonyms: 5830483C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 209334
VEGA: 12
Homologene: 35313
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: OTTMUSG00000005786, LOC380698
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380698
Homologene: 70869
Ctsq
Name: cathepsin Q
Synonyms: 1600010J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 104002
Homologene: 122226
Iqsec1
Name: IQ motif and Sec7 domain 1
Synonyms: BRAG2, cI-43, D6Ertd349e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232227
Homologene: 82429
Eri2
Name: exoribonuclease 2
Synonyms: Exod1, 4933424N09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71151
Homologene: 12383
Shox2
Name: short stature homeobox 2
Synonyms: 6330543G17Rik, Og12x, Prx3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20429
Homologene: 68535
Ankmy1
Name: ankyrin repeat and MYND domain containing 1
Synonyms: 4930483I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241158
Homologene: 9561
Anks4b
Name: ankyrin repeat and sterile alpha motif domain containing 4B
Synonyms: 2010013E14Rik, Harp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72074
Homologene: 49898
Shcbp1l
Name: Shc SH2-domain binding protein 1-like
Synonyms: 1700012A16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71836
Homologene: 12800
Cdh22
Name: cadherin 22
Synonyms: PB-cadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 104010
Homologene: 23148
Olfr798
Name: olfactory receptor 798
Synonyms: GA_x6K02T2PULF-11304679-11303744, MOR108-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258549
Homologene: 133881
Nans
Name: N-acetylneuraminic acid synthase (sialic acid synthase)
Synonyms: N-acetylneuraminic acid phosphate synthase, Sas, 4632418E04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 94181
Homologene: 10343
Arrdc1
Name: arrestin domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 215705
Homologene: 34835
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 92,883,894 bp
  • T to A, chromosome 1 at 153,425,507 bp
  • T to C, chromosome 2 at 24,926,140 bp
  • A to T, chromosome 2 at 165,135,283 bp
  • C to T, chromosome 3 at 36,552,755 bp
  • G to A, chromosome 3 at 66,973,910 bp
  • G to C, chromosome 3 at 107,298,873 bp
  • T to C, chromosome 4 at 46,502,430 bp
  • T to A, chromosome 4 at 138,171,186 bp
  • T to C, chromosome 5 at 65,293,911 bp
  • T to C, chromosome 5 at 108,486,188 bp
  • CCG to CCGCG, chromosome 6 at 52,260,635 bp
  • G to A, chromosome 6 at 90,671,976 bp
  • G to T, chromosome 6 at 113,489,479 bp
  • G to T, chromosome 7 at 119,792,317 bp
  • A to T, chromosome 7 at 120,174,066 bp
  • A to G, chromosome 7 at 120,933,308 bp
  • G to A, chromosome 7 at 122,128,209 bp
  • A to G, chromosome 7 at 140,029,838 bp
  • C to T, chromosome 8 at 111,288,242 bp
  • T to C, chromosome 9 at 64,966,763 bp
  • C to T, chromosome 10 at 129,626,037 bp
  • T to A, chromosome 11 at 29,504,049 bp
  • A to T, chromosome 11 at 59,067,199 bp
  • T to C, chromosome 11 at 100,625,980 bp
  • C to T, chromosome 12 at 11,255,218 bp
  • G to T, chromosome 13 at 44,906,545 bp
  • T to A, chromosome 13 at 61,039,045 bp
  • T to A, chromosome 13 at 74,214,403 bp
  • C to A, chromosome 14 at 27,379,706 bp
  • T to C, chromosome 17 at 27,890,071 bp
  • C to T, chromosome 17 at 32,332,483 bp
  • C to T, chromosome 17 at 73,545,138 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1192 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039264-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.