Strain Name:
C57BL/6J-MtgxR1200Btlr/Mmmh
Stock Number:
039270-MU
Citation ID:
RRID:MMRRC_039270-MU
Other Names:
R1200 (G1), C57BL/6J-MtgxR1200Btlr
Major Collection:

Gene Information

Exo1
Name: exonuclease 1
Synonyms: 5730442G03Rik, Msa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 26909
HGNC: HGNC:3511
Homologene: 31352
Dip2b
Name: disco interacting protein 2 homolog B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 239667
Homologene: 72227
Dpp3
Name: dipeptidylpeptidase 3
Synonyms: 4930533O14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 75221
VEGA: 19
HGNC: HGNC:3008
Homologene: 40210
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: D130015N03Rik, 2810449H11Rik, tbl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Axin2
Name: axin 2
Synonyms: Axil, Conductin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 12006
HGNC: HGNC:904
Homologene: 3420
Pex1
Name: peroxisomal biogenesis factor 1
Synonyms: peroxisome biogenesis factor 1, 5430414H02Rik, E330005K07Rik, ZWS1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 71382
HGNC: HGNC:8850
Homologene: 27006
Rnf17
Name: ring finger protein 17
Synonyms: MMIP-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 30054
VEGA: 14
Homologene: 23727
Twf1
Name: twinfilin actin binding protein 1
Synonyms: actin monomer-binding protein, Twinfilin-1, twinfilin, Ptk9, A6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 19230
HGNC: HGNC:9620
Homologene: 48140
Amph
Name: amphiphysin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 218038
HGNC: HGNC:471
Homologene: 121585
Sh3bgrl2
Name: SH3 domain binding glutamic acid-rich protein like 2
Synonyms: A930014C21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 212531
Homologene: 12876
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: b2b1537Clo, b2b1565Clo, b2b3491Clo, b2b1154Clo, Mdnah5, Dnahc5, b2b1134Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Pld1
Name: phospholipase D1
Synonyms: Pld1a, Pld1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 18805
HGNC: HGNC:9067
Homologene: 116234
Myh15
Name: myosin, heavy chain 15
Synonyms: EG667772
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 667772
VEGA: 16
Homologene: 18929
Prdm1
Name: PR domain containing 1, with ZNF domain
Synonyms: PRDI-BF1, b2b1765Clo, Blimp1, Blimp-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 12142
HGNC: HGNC:9346
Homologene: 925
Neb
Name: nebulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Cplane1
Name: ciliogenesis and planar polarity effector 1
Synonyms: Hug, Jbts17, b2b012Clo, 2410089E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 73692
Homologene: 11315
Ptchd3
Name: patched domain containing 3
Synonyms: 4933440L20Rik, 4930451E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 74675
Homologene: 111041
Stard9
Name: START domain containing 9
Synonyms: E230025N21Rik, 4831403C07Rik, Kif16a, N-3 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 668880
Homologene: 130712
Nr1h5
Name: nuclear receptor subfamily 1, group H, member 5
Synonyms: FXRB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 381463
Homologene: 131277
Atp11b
Name: ATPase, class VI, type 11B
Synonyms: 1110019I14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 76295
Homologene: 32919
Clstn3
Name: calsyntenin 3
Synonyms: CSTN3, alcadein-beta, Cst-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232370
Homologene: 22836
4930562C15Rik
Name: RIKEN cDNA 4930562C15 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 78809
Homologene: 53527
Fam227a
Name: family with sequence similarity 227, member A
Synonyms: 4933432B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 75729
Homologene: 123434
Fam83b
Name: family with sequence similarity 83, member B
Synonyms: C530008M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 208994
Homologene: 19478
Vmn2r13
Name: vomeronasal 2, receptor 13
Synonyms: Gm4867
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231589
HGNC: null
Homologene: 129606
Kcnh7
Name: potassium voltage-gated channel, subfamily H (eag-related), member 7
Synonyms: 9330137I11Rik, Kv11.3, erg3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 170738
Homologene: 13249
Ntn5
Name: netrin 5
Synonyms: LOC243967
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 243967
Homologene: 17106
Abcc2
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Synonyms: Mrp2, Cmoat, multidrug resistance protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 12780
HGNC: HGNC:53
Homologene: 68052
Spice1
Name: spindle and centriole associated protein 1
Synonyms: D16Ertd480e, Ccdc52
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 212514
Homologene: 16931
Lcp1
Name: lymphocyte cytosolic protein 1
Synonyms: D14Ertd310e, L-plastin, Pls2, L-fimbrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 18826
HGNC: HGNC:6528
Homologene: 80174
Flot2
Name: flotillin 2
Synonyms: reggie-2, Esa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 14252
HGNC: HGNC:3758
Homologene: 3293
Zbtb49
Name: zinc finger and BTB domain containing 49
Synonyms: 4930518A03Rik, Zfp509
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 75079
Homologene: 34825
Akp3
Name: alkaline phosphatase 3, intestine, not Mn requiring
Synonyms: IAP, Akp-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 11648
Homologene: 134333
Olfr1053
Name: olfactory receptor 1053
Synonyms: GA_x6K02T2Q125-47793414-47792471, Olfr1053-ps1, MOR187-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 257974
Homologene: 74197
Acat1
Name: acetyl-Coenzyme A acetyltransferase 1
Synonyms: Acat, 6330585C21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 110446
HGNC: HGNC:93
Homologene: 6
Olfr612
Name: olfactory receptor 612
Synonyms: GA_x6K02T2PBJ9-6251685-6250741, EG545985, MOR15-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 545985
HGNC: null
Homologene: 79675
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 87,125,260 bp
  • A to G, chromosome 1 at 175,904,451 bp
  • T to C, chromosome 2 at 52,167,645 bp
  • T to C, chromosome 2 at 62,777,395 bp
  • A to T, chromosome 2 at 86,315,133 bp
  • C to A, chromosome 2 at 120,673,636 bp
  • A to T, chromosome 3 at 28,049,286 bp
  • G to C, chromosome 3 at 35,788,206 bp
  • A to G, chromosome 3 at 102,947,862 bp
  • G to A, chromosome 5 at 3,606,411 bp
  • T to C, chromosome 5 at 38,213,331 bp
  • T to G, chromosome 5 at 109,174,202 bp
  • G to T, chromosome 6 at 124,459,170 bp
  • G to T, chromosome 7 at 45,692,382 bp
  • T to A, chromosome 7 at 103,539,067 bp
  • T to A, chromosome 9 at 53,583,510 bp
  • T to C, chromosome 9 at 66,486,124 bp
  • T to C, chromosome 9 at 76,492,312 bp
  • C to T, chromosome 9 at 83,577,631 bp
  • A to G, chromosome 10 at 44,450,130 bp
  • C to T, chromosome 11 at 78,054,805 bp
  • C to A, chromosome 11 at 108,931,550 bp
  • T to C, chromosome 11 at 121,831,261 bp
  • G to A, chromosome 13 at 19,142,028 bp
  • C to T, chromosome 14 at 56,467,706 bp
  • T to A, chromosome 14 at 75,229,302 bp
  • A to G, chromosome 15 at 8,219,399 bp
  • A to G, chromosome 15 at 28,246,257 bp
  • A to G, chromosome 15 at 79,612,537 bp
  • A to T, chromosome 15 at 94,586,358 bp
  • C to A, chromosome 15 at 100,209,745 bp
  • T to C, chromosome 16 at 4,849,672 bp
  • T to C, chromosome 16 at 44,375,798 bp
  • T to A, chromosome 16 at 49,096,519 bp
  • T to C, chromosome 19 at 4,923,129 bp
  • A to T, chromosome 19 at 43,833,987 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1200 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039270-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.