Strain Name:
C57BL/6J-MtgxR1215Btlr/Mmmh
Stock Number:
039284-MU
Citation ID:
RRID:MMRRC_039284-MU
Other Names:
R1215 (G1), C57BL/6J-MtgxR1215Btlr
Major Collection:

Strain Information

Rpap3
Name: RNA polymerase II associated protein 3
Synonyms: 2310042P20Rik, D15Ertd682e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 71919
VEGA: 15
Homologene: 11613
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: MAP1C, dynein heavy chain, retrograde transport, Dnec1, Loa, 9930018I23Rik, Dnchc1, Swl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
E130308A19Rik
Name: RIKEN cDNA E130308A19 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230259
Homologene: 136157
Mff
Name: mitochondrial fission factor
Synonyms: 5230400G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 75734
Homologene: 87000
Slc43a2
Name: solute carrier family 43, member 2
Synonyms: 7630402D21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 215113
Homologene: 17555
Zfp871
Name: zinc finger protein 871
Synonyms: 9030612M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 208292
Homologene: 138401
Cntfr
Name: ciliary neurotrophic factor receptor
Synonyms: Cntfralpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12804
HGNC: HGNC:2170
Homologene: 9619
Cep295
Name: centrosomal protein 295
Synonyms: LOC382128, 5830418K08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 319675
Homologene: 27936
Trpm6
Name: transient receptor potential cation channel, subfamily M, member 6
Synonyms: CHAK2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225997
VEGA: 19
Homologene: 9767
Ush2a
Name: usherin
Synonyms: MUSH2A, A930011D15Rik, LOC381317, LOC269160, A930037M10Rik, Ushrn, Ush2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22283
Homologene: 66151
Fam184b
Name: family with sequence similarity 184, member B
Synonyms: 9630031F12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 58227
Homologene: 137353
Zfyve9
Name: zinc finger, FYVE domain containing 9
Synonyms: Madhip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230597
HGNC: HGNC:6775
Homologene: 3527
Mcc
Name: mutated in colorectal cancers
Synonyms: D18Ertd451e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 328949
HGNC: HGNC:6935
Homologene: 20539
Cfap44
Name: cilia and flagella associated protein 44
Synonyms: 6330444M21Rik, D16Ertd642e, Wdr52
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 212517
Homologene: 75085
Hs2st1
Name: heparan sulfate 2-O-sulfotransferase 1
Synonyms: Hs2st
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 23908
HGNC: HGNC:5193
Homologene: 8025
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239420
Homologene: 65982
Grb14
Name: growth factor receptor bound protein 14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 50915
HGNC: HGNC:4565
Homologene: 3303
Azin2
Name: antizyme inhibitor 2
Synonyms: 4933429I20Rik, Odcp, AZIN2, Adc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242669
Homologene: 62172
Ppp2r3a
Name: protein phosphatase 2, regulatory subunit B'', alpha
Synonyms: 3222402P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235542
HGNC: HGNC:9307
Homologene: 20595
Alkbh2
Name: alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase
Synonyms: Abh2, mABH2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231642
Homologene: 18393
Fmn1
Name: formin 1
Synonyms: Fmn, formin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14260
HGNC: HGNC:3768
Homologene: 121778
Slco4c1
Name: solute carrier organic anion transporter family, member 4C1
Synonyms: SLC21A20, PRO2176, OATP4C1, OATP-M1, OATP-H, C330017E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227394
Homologene: 62654
Cyp2a4
Name: cytochrome P450, family 2, subfamily a, polypeptide 4
Synonyms: Cyp15a1, D7Ucla4, testosterone 15alpha-hydroxylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13086
Homologene: 85917
Smyd4
Name: SET and MYND domain containing 4
Synonyms: G430029E23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 319822
Homologene: 35098
Dtd2
Name: D-tyrosyl-tRNA deacylase 2
Synonyms: 4930578F06Rik, B830049N13Rik, 6530401N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 328092
Homologene: 12634
Ces1a
Name: carboxylesterase 1A
Synonyms: Gm4976
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244595
HGNC: HGNC:1863
Homologene: 134142
Art5
Name: ADP-ribosyltransferase 5
Synonyms: Yac-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11875
Homologene: 7231
Nyap1
Name: neuronal tyrosine-phosphorylated phosphoinositide 3-kinase adaptor 1
Synonyms: Nyap1, 6430598A04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 243300
Homologene: 18320
Or13p10
Name: olfactory receptor family 13 subfamily P member 10
Synonyms: IH12, MOR258-5, GA_x6K02T2QD9B-18877756-18876809, Olfr62
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18363
4922502B01Rik
Name: RIKEN cDNA 4922502B01 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 105243282
VEGA: 8
Rsph14
Name: radial spoke head homolog 14 (Chlamydomonas)
Synonyms: 4933431K05Rik, Rtdr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71236
Homologene: 49382
Slc25a3
Name: solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3
Synonyms: Phc, 5730556H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18674
Homologene: 37649
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 82,741,888 bp
  • C to A, chromosome 1 at 96,828,871 bp
  • A to G, chromosome 1 at 188,957,282 bp
  • T to C, chromosome 2 at 64,917,264 bp
  • T to A, chromosome 2 at 113,693,030 bp
  • G to A, chromosome 3 at 144,465,141 bp
  • C to A, chromosome 4 at 41,662,064 bp
  • T to A, chromosome 4 at 59,690,743 bp
  • T to C, chromosome 4 at 108,650,229 bp
  • A to T, chromosome 4 at 118,666,299 bp
  • A to G, chromosome 4 at 128,949,696 bp
  • C to T, chromosome 5 at 45,584,178 bp
  • C to T, chromosome 5 at 114,124,226 bp
  • C to T, chromosome 5 at 137,735,133 bp
  • C to T, chromosome 7 at 26,314,801 bp
  • C to T, chromosome 7 at 102,097,909 bp
  • A to G, chromosome 8 at 93,032,690 bp
  • A to T, chromosome 8 at 109,250,996 bp
  • T to C, chromosome 9 at 15,327,882 bp
  • A to G, chromosome 9 at 101,212,684 bp
  • T to C, chromosome 10 at 75,025,066 bp
  • G to A, chromosome 10 at 91,117,308 bp
  • T to A, chromosome 11 at 75,390,295 bp
  • T to A, chromosome 11 at 75,562,862 bp
  • A to G, chromosome 12 at 52,004,956 bp
  • G to A, chromosome 12 at 110,636,509 bp
  • A to T, chromosome 15 at 48,004,831 bp
  • A to G, chromosome 15 at 97,701,053 bp
  • A to G, chromosome 16 at 44,419,303 bp
  • A to T, chromosome 17 at 32,775,972 bp
  • A to T, chromosome 18 at 44,468,494 bp
  • A to G, chromosome 19 at 18,796,498 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1215 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039284-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.