Strain Name:
C57BL/6J-MtgxR1225Btlr/Mmmh
Stock Number:
039294-MU
Citation ID:
RRID:MMRRC_039294-MU
Other Names:
R1225 (G1), C57BL/6J-MtgxR1225Btlr
Major Collection:

Gene Information

Dicer1
Name: dicer 1, ribonuclease type III
Synonyms: 1110006F08Rik, D12Ertd7e, Dicer1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 192119
VEGA: 12
Homologene: 13251
Bmp6
Name: bone morphogenetic protein 6
Synonyms: Vgr1, D13Wsu115e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 12161
VEGA: 13
HGNC: HGNC:1073
Homologene: 1300
Fancd2
Name: Fanconi anemia, complementation group D2
Synonyms: 2410150O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 211651
HGNC: HGNC:3585
Homologene: 13212
Arid1a
Name: AT rich interactive domain 1A (SWI-like)
Synonyms: 1110030E03Rik, BAF250a, Osa1, Smarcf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 93760
Homologene: 21216
Med15
Name: mediator complex subunit 15
Synonyms: A230074L19Rik, Pcqap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 94112
VEGA: 16
Slc9a8
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 8
Synonyms: 1200006P13Rik, 6430709P13Rik, NHE8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 77031
Homologene: 75041
Git2
Name: GIT ArfGAP 2
Synonyms: Cat-2, 9630056M03Rik, ARF GTPase activating protein 2, 1500036H07Rik, B230104M05Rik, 5830420E16Rik, Cool associated tyrosine phosphorylated-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 26431
HGNC: HGNC:4273
Homologene: 41336
Son
Name: Son DNA binding protein
Synonyms: 2900011L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 20658
Homologene: 10551
Snx29
Name: sorting nexin 29
Synonyms: LOC385605, LOC381035, Gm11170, Rundc2a, 4933437K13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 74478
Homologene: 32706
Crebbp
Name: CREB binding protein
Synonyms: CBP, KAT3A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 12914
HGNC: HGNC:2348
Homologene: 68393
Nbeal2
Name: neurobeachin-like 2
Synonyms: 1110014F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235627
Homologene: 86422
Angptl4
Name: angiopoietin-like 4
Synonyms: FIAF, BK89, NG27, HFARP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 57875
Homologene: 10755
Cmip
Name: c-Maf inducing protein
Synonyms: 4933407C03Rik, 5830471E12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 74440
Homologene: 18869
Eif5b
Name: eukaryotic translation initiation factor 5B
Synonyms: IF2, A030003E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226982
Homologene: 134613
Blzf1
Name: basic leucine zipper nuclear factor 1
Synonyms: Jem-1, Golgin-45, Blzf1l, 1700030G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 66352
HGNC: HGNC:1065
Homologene: 31187
Pde4d
Name: phosphodiesterase 4D, cAMP specific
Synonyms: 9630011N22Rik, Dpde3, dunce
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 238871
HGNC: HGNC:8783
Vmn1r28
Name: vomeronasal 1 receptor 28
Synonyms: V1rc25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 171198
Homologene: 138094
Slc46a2
Name: solute carrier family 46, member 2
Synonyms: TSO-1C12, Ly110, Tscot, 5430429N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 30936
Homologene: 23273
Olfr720
Name: olfactory receptor 720
Synonyms: GA_x6K02T2PLTE-6544896-6543946, MOR274-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 258387
Homologene: 74036
Dennd4a
Name: DENN/MADD domain containing 4A
Synonyms: F730015K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 102442
VEGA: 9
Homologene: 55933
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: Dnahc9, D11Ertd686e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Stxbp5
Name: syntaxin binding protein 5 (tomosyn)
Synonyms: tomosyn 1, 0710001E20Rik, LGL3, 4930565N16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 78808
Homologene: 16402
Atp2c2
Name: ATPase, Ca++ transporting, type 2C, member 2
Synonyms: 1810010G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 69047
Homologene: 73463
Fsip1
Name: fibrous sheath-interacting protein 1
Synonyms: 1700012M13Rik, 4933432K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 71313
Homologene: 12390
Olfr201
Name: olfactory receptor 201
Synonyms: GA_x54KRFPKG5P-55483936-55483010, MOR182-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 258996
Homologene: 37011
Ahnak
Name: AHNAK nucleoprotein (desmoyokin)
Synonyms: 2310047C17Rik, 1110004P15Rik, DY6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
F13a1
Name: coagulation factor XIII, A1 subunit
Synonyms: Factor XIIIA, 1200014I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 74145
VEGA: 13
HGNC: HGNC:3531
Homologene: 20077
1300017J02Rik
Name: RIKEN cDNA 1300017J02 gene
Synonyms: mICA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 71775
Homologene: 826
Abcb10
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 10
Synonyms: ABC-me
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 56199
HGNC: HGNC:41
Homologene: 6474
AC073590.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
Gm9742
Name: predicted gene 9742
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 791083
VEGA: 13
Olfr695
Name: olfactory receptor 695
Synonyms: MOR283-6, GA_x6K02T2PBJ9-9092181-9091234
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258591
Homologene: 133597
Dedd
Name: death effector domain-containing
Synonyms: DEFT, Dedpro1, KE05, FLDED1, CASP8IP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 21945
HGNC: HGNC:2755
Homologene: 7980
Papss1
Name: 3'-phosphoadenosine 5'-phosphosulfate synthase 1
Synonyms: Asapk, SK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 23971
HGNC: HGNC:8603
Homologene: 81740
Hoga1
Name: 4-hydroxy-2-oxoglutarate aldolase 1
Synonyms: Dhdpsl, 0610010D20Rik, Npl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 67432
Homologene: 12130
Sema3g
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 218877
Homologene: 10602
Heatr4
Name: HEAT repeat containing 4
Synonyms: Gm17673
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 101055670
Homologene: 45728
Setbp1
Name: SET binding protein 1
Synonyms: Seb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 240427
Homologene: 9192
A730013G03Rik
Name: RIKEN cDNA A730013G03 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 320952
Prickle4
Name: prickle planar cell polarity protein 4
Synonyms: LOC381104
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 381104
Homologene: 22752
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 38,037,628 bp
  • T to A, chromosome 1 at 90,811,516 bp
  • T to C, chromosome 1 at 164,299,596 bp
  • G to A, chromosome 1 at 171,340,295 bp
  • T to A, chromosome 1 at 192,833,645 bp
  • C to A, chromosome 2 at 118,248,350 bp
  • T to C, chromosome 2 at 167,471,523 bp
  • T to C, chromosome 3 at 131,579,301 bp
  • A to T, chromosome 4 at 59,914,125 bp
  • A to G, chromosome 4 at 133,687,365 bp
  • A to T, chromosome 5 at 114,733,178 bp
  • C to T, chromosome 6 at 58,265,966 bp
  • T to C, chromosome 6 at 113,535,861 bp
  • A to T, chromosome 7 at 106,714,524 bp
  • T to C, chromosome 8 at 117,445,371 bp
  • C to A, chromosome 8 at 119,735,245 bp
  • C to T, chromosome 8 at 123,962,052 bp
  • A to G, chromosome 9 at 64,911,675 bp
  • A to T, chromosome 9 at 103,254,839 bp
  • T to C, chromosome 9 at 110,632,886 bp
  • T to C, chromosome 10 at 9,812,391 bp
  • A to G, chromosome 11 at 65,871,060 bp
  • C to T, chromosome 12 at 83,978,046 bp
  • C to T, chromosome 12 at 104,691,607 bp
  • T to A, chromosome 12 at 114,406,550 bp
  • T to C, chromosome 13 at 8,029,839 bp
  • T to C, chromosome 13 at 37,025,851 bp
  • A to G, chromosome 13 at 38,346,281 bp
  • A to T, chromosome 13 at 109,950,221 bp
  • T to A, chromosome 14 at 14,175,600 bp
  • A to G, chromosome 14 at 31,220,679 bp
  • A to T, chromosome 16 at 4,126,956 bp
  • T to C, chromosome 16 at 11,420,686 bp
  • G to T, chromosome 16 at 17,722,788 bp
  • T to C, chromosome 16 at 59,269,224 bp
  • C to T, chromosome 16 at 91,657,340 bp
  • C to T, chromosome 17 at 33,781,191 bp
  • T to G, chromosome 17 at 47,688,689 bp
  • T to A, chromosome 18 at 78,858,208 bp
  • T to A, chromosome 19 at 9,002,883 bp
  • T to G, chromosome 19 at 42,070,189 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1225 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039294-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.