Strain Name:
C57BL/6J-MtgxR1242Btlr/Mmmh
Stock Number:
039309-MU
Citation ID:
RRID:MMRRC_039309-MU
Other Names:
R1242 (G1), C57BL/6J-MtgxR1242Btlr
Major Collection:

Gene Information

Dtnb
Name: dystrobrevin, beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13528
HGNC: HGNC:3058
Homologene: 74875
Gtf2h1
Name: general transcription factor II H, polypeptide 1
Synonyms: p62, 62kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14884
HGNC: HGNC:4655
Homologene: 3885
Nup214
Name: nucleoporin 214
Synonyms: D2H9S46E, CAN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227720
HGNC: HGNC:8064
Homologene: 38008
Il3
Name: interleukin 3
Synonyms: Il-3, PSF, MCGF, HCGF, BPA, Csfmu
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16187
HGNC: HGNC:6011
Homologene: 49243
Gucy1a1
Name: guanylate cyclase 1, soluble, alpha 1
Synonyms: alpha 1 sGC, 1200016O07Rik, sGC-alpha1, Gucy1a3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 60596
HGNC: HGNC:4685
Homologene: 37360
Exosc7
Name: exosome component 7
Synonyms: 2610002K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 66446
Homologene: 8994
Mgat5b
Name: mannoside acetylglucosaminyltransferase 5, isoenzyme B
Synonyms: GnT-IX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268510
Homologene: 27821
Bbs7
Name: Bardet-Biedl syndrome 7 (human)
Synonyms: 8430406N16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 71492
Homologene: 12395
Hfm1
Name: HFM1, ATP-dependent DNA helicase homolog
Synonyms: LOC381663, A330009G12Rik, Sec63d1, Mer3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 330149
Homologene: 87103
Rp1
Name: retinitis pigmentosa 1 (human)
Synonyms: oxygen-regulated protein 1, Orp1, mG145, Dcdc3, Rp1h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19888
Homologene: 4564
Tent5c
Name: terminal nucleotidyltransferase 5C
Synonyms: 4930431B09Rik, Fam46c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74645
Homologene: 56783
Hpse2
Name: heparanase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 545291
VEGA: 19
Homologene: 19680
Vmn1r173
Name: vomeronasal 1 receptor 173
Synonyms: Gm5892
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 545934
Homologene: 79577
Xkr4
Name: X-linked Kx blood group related 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 497097
Homologene: 45848
Sardh
Name: sarcosine dehydrogenase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 192166
Homologene: 5149
Cobll1
Name: Cobl-like 1
Synonyms: Coblr1, D430044D16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 319876
Homologene: 8933
Olfr1396
Name: olfactory receptor 1396
Synonyms: GA_x6K02T2QP88-6321048-6321995, MOR276-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258334
Homologene: 28537
Fam170a
Name: family with sequence similarity 170, member A
Synonyms: LOC225497, Znfd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225497
VEGA: 18
Homologene: 86702
Cnr2
Name: cannabinoid receptor 2 (macrophage)
Synonyms: CB2-R, cannabinoid receptor 2 (spleen), CB2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12802
HGNC: HGNC:2160
Homologene: 1389
Vmn1r38
Name: vomeronasal 1 receptor 38
Synonyms: V1rc13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 171186
Homologene: 110800
Defb30
Name: defensin beta 30
Synonyms: 4930449O14Rik, 2410125J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 73670
Homologene: 86862
AC122379.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Cmc2
Name: COX assembly mitochondrial protein 2
Synonyms: 1110046L09Rik, 2310061C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 66531
Homologene: 41350
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 3,216,137 bp
  • T to A, chromosome 1 at 4,344,962 bp
  • T to A, chromosome 2 at 27,235,563 bp
  • C to T, chromosome 2 at 31,977,770 bp
  • T to C, chromosome 2 at 65,151,169 bp
  • A to G, chromosome 3 at 36,578,427 bp
  • C to T, chromosome 3 at 82,105,953 bp
  • A to T, chromosome 3 at 100,472,876 bp
  • T to A, chromosome 4 at 135,916,983 bp
  • T to A, chromosome 5 at 106,874,901 bp
  • A to C, chromosome 6 at 66,776,360 bp
  • C to T, chromosome 7 at 23,703,225 bp
  • T to C, chromosome 7 at 46,812,751 bp
  • T to C, chromosome 8 at 116,911,198 bp
  • C to T, chromosome 9 at 123,131,882 bp
  • A to T, chromosome 11 at 49,112,901 bp
  • T to C, chromosome 11 at 54,267,103 bp
  • A to G, chromosome 11 at 116,978,404 bp
  • T to A, chromosome 12 at 3,732,627 bp
  • T to A, chromosome 13 at 3,361,109 bp
  • A to T, chromosome 14 at 63,036,006 bp
  • A to G, chromosome 18 at 50,282,139 bp
  • G to A, chromosome 19 at 42,966,977 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1242 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039309-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.