Strain Name:
C57BL/6J-MtgxR1262Btlr/Mmmh
Stock Number:
039329-MU
Citation ID:
RRID:MMRRC_039329-MU
Other Names:
R1262 (G1), C57BL/6J-MtgxR1262Btlr
Major Collection:

Gene Information

Syt6
Name: synaptotagmin VI
Synonyms: 3110037A08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 54524
Homologene: 10301
Chmp7
Name: charged multivesicular body protein 7
Synonyms: 4930596K11Rik, 6330407G04Rik, CHMP family, member 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105513
VEGA: 14
Homologene: 14613
Aak1
Name: AP2 associated kinase 1
Synonyms: D6Ertd245e, 5530400K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 269774
Homologene: 128746
Nupl1
Name: nucleoporin like 1
Synonyms: 1700017F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 71844
VEGA: 14
Homologene: 40924
Cenpk
Name: centromere protein K
Synonyms: C530004N04Rik, Solt, B130045K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 60411
VEGA: 13
Homologene: 11035
Foxp2
Name: forkhead box P2
Synonyms: 2810043D05Rik, D0Kist7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 114142
Homologene: 134404
Or52h1
Name: olfactory receptor family 52 subfamily H member 1
Synonyms: Olfr648, GA_x6K02T2PBJ9-6914780-6913830, MOR31-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258746
Homologene: 82999
Nipsnap3b
Name: nipsnap homolog 3B
Synonyms: 2700063N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66536
Homologene: 75044
Ltbp1
Name: latent transforming growth factor beta binding protein 1
Synonyms: Ltbp1L, b2b1000Clo, 9430031G15Rik, LTBP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268977
HGNC: HGNC:6714
Homologene: 522
Poln
Name: DNA polymerase N
Synonyms: POL4P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 272158
Homologene: 131253
Cyp2b10
Name: cytochrome P450, family 2, subfamily b, polypeptide 10
Synonyms: Cyp2b, Cyp2b20, p16, phenobarbitol inducible, type b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13088
HGNC: HGNC:2615
Homologene: 73894
Snx25
Name: sorting nexin 25
Synonyms: LOC382008, SBBI31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102141
Homologene: 23744
Lrriq1
Name: leucine-rich repeats and IQ motif containing 1
Synonyms: Gm1557, LOC380658, 4930503E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 74978
Homologene: 46007
Ttc7
Name: tetratricopeptide repeat domain 7
Synonyms: hea, 1700007L07Rik, 1110035E02Rik, fsn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 225049
Homologene: 12515
Sh3tc1
Name: SH3 domain and tetratricopeptide repeats 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231147
Homologene: 10360
Tas1r2
Name: taste receptor, type 1, member 2
Synonyms: T1r2, Gpr71, TR2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 83770
Homologene: 75323
Or51b6b
Name: olfactory receptor family 51 subfamily B member 6B
Synonyms: GA_x6K02T2PBJ9-6384836-6383883, MOR1-4, Olfr623
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259126
Homologene: 133591
BC048679
Name: cDNA sequence BC048679
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 210321
Homologene: 130364
Gm10109
Name: predicted gene 10109
Synonyms: EG638411
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 638411
Btbd7
Name: BTB (POZ) domain containing 7
Synonyms: E130118E17Rik, FUP1, 5730507E09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238386
VEGA: 12
Homologene: 34300
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 3 at 103,585,340 bp
  • G to T, chromosome 4 at 53,015,166 bp
  • G to A, chromosome 4 at 139,655,288 bp
  • C to A, chromosome 5 at 34,113,383 bp
  • A to G, chromosome 5 at 35,702,012 bp
  • T to A, chromosome 6 at 15,416,039 bp
  • T to C, chromosome 6 at 86,935,488 bp
  • C to T, chromosome 7 at 25,915,411 bp
  • G to A, chromosome 7 at 44,222,462 bp
  • A to G, chromosome 7 at 81,495,341 bp
  • G to A, chromosome 7 at 103,660,441 bp
  • A to G, chromosome 7 at 104,179,416 bp
  • T to A, chromosome 8 at 46,105,291 bp
  • T to C, chromosome 10 at 103,234,137 bp
  • A to G, chromosome 12 at 102,787,951 bp
  • T to A, chromosome 13 at 104,230,785 bp
  • A to T, chromosome 14 at 60,244,670 bp
  • C to T, chromosome 14 at 69,719,450 bp
  • A to G, chromosome 17 at 75,225,285 bp
  • C to T, chromosome 17 at 87,340,936 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1262 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039329-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.