Strain Name:
C57BL/6J-MtgxR1265Btlr/Mmmh
Stock Number:
039332-MU
Citation ID:
RRID:MMRRC_039332-MU
Other Names:
R1265 (G1), C57BL/6J-MtgxR1265Btlr
Major Collection:

Gene Information

Foxp4
Name: forkhead box P4
Synonyms: 1200010K03Rik, 2310007G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74123
Homologene: 12536
Phf3
Name: PHD finger protein 3
Synonyms: 2310061N19Rik, AU020177
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 213109
HGNC: HGNC:8921
Homologene: 9040
Urb2
Name: URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 382038
Homologene: 8859
Abi1
Name: abl interactor 1
Synonyms: E3B1, Ssh3bp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11308
Homologene: 38053
Tenm2
Name: teneurin transmembrane protein 2
Synonyms: Ten-m2, D3Bwg1534e, 9330187F13Rik, 2610040L17Rik, Odz2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 23964
Homologene: 22672
Tcf4
Name: transcription factor 4
Synonyms: SEF-2, ITF-2, MITF-2B, MITF-2A, ME2, E2.2, TFE, E2-2, SEF2-1, ASP-I2, ITF-2b, 5730422P05Rik, bHLHb19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 21413
Homologene: 2407
Sox11
Name: SRY (sex determining region Y)-box 11
Synonyms: end1, 6230403H02Rik, 1110038H03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20666
Homologene: 37733
Fam120a
Name: family with sequence similarity 120, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218236
VEGA: 13
Homologene: 8752
Alg2
Name: asparagine-linked glycosylation 2 (alpha-1,3-mannosyltransferase)
Synonyms: ALPG2, CDGIi, 1300013N08Rik, 1110018A23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56737
Homologene: 5930
Igf2r
Name: insulin-like growth factor 2 receptor
Synonyms: Mpr300, CI-MPR, IGF-II/CI-MPR, M6P/IGF2R, CD222, mannose-6-phosphate receptor, cation independent
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 16004
HGNC: HGNC:5467
Homologene: 676
Ppip5k2
Name: diphosphoinositol pentakisphosphate kinase 2
Synonyms: Vip2, Hisppd1, Cfap160
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227399
Homologene: 49409
Pkp2
Name: plakophilin 2
Synonyms: 1200012P04Rik, 1200008D14Rik, Pkp2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 67451
HGNC: HGNC:9024
Homologene: 3364
Nphs2
Name: nephrosis 2, podocin
Synonyms: podocin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 170484
Homologene: 22826
Ank1
Name: ankyrin 1, erythroid
Synonyms: Ank-1, pale
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11733
HGNC: HGNC:492
Homologene: 55427
Tsc2
Name: TSC complex subunit 2
Synonyms: tuberin, Nafld, tuberous sclerosis 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22084
VEGA: 17
Homologene: 462
Tbx10
Name: T-box 10
Synonyms: Tbx7, Tbx13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 109575
VEGA: 19
Homologene: 37399
Ltbp1
Name: latent transforming growth factor beta binding protein 1
Synonyms: LTBP-1, 9430031G15Rik, b2b1000Clo, Ltbp1L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268977
HGNC: HGNC:6714
Homologene: 522
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Thsd7a
Name: thrombospondin, type I, domain containing 7A
Synonyms: LOC330267
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330267
Homologene: 46582
Nsd3
Name: nuclear receptor binding SET domain protein 3
Synonyms: WHISTLE, Whsc1l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234135
Homologene: 56960
Pdzd7
Name: PDZ domain containing 7
Synonyms: Pdzk7, EG435601
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 100503041
Homologene: 129509
Cntnap5a
Name: contactin associated protein-like 5A
Synonyms: Caspr5-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 636808
Homologene: 43974
Or3a1d
Name: olfactory receptor family 3 subfamily A member 1D
Synonyms: GA_x6K02T2P1NL-4481525-4480578, MOR255-3, Olfr411
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258704
Homologene: 74999
Slc38a3
Name: solute carrier family 38, member 3
Synonyms: 0610012J02Rik, D9Ucla2, Snat3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 76257
Homologene: 4983
Aebp1
Name: AE binding protein 1
Synonyms: ACLP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11568
HGNC: HGNC:303
Homologene: 878
Ly6h
Name: lymphocyte antigen 6 complex, locus H
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 23934
HGNC: HGNC:6728
Homologene: 1758
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 30,829,833 bp
  • A to G, chromosome 1 at 97,719,900 bp
  • A to G, chromosome 1 at 116,428,518 bp
  • A to G, chromosome 1 at 156,318,747 bp
  • T to C, chromosome 2 at 22,946,722 bp
  • C to T, chromosome 2 at 41,476,654 bp
  • T to C, chromosome 4 at 47,474,289 bp
  • T to C, chromosome 6 at 12,317,419 bp
  • T to A, chromosome 8 at 23,117,037 bp
  • T to C, chromosome 8 at 25,682,562 bp
  • A to G, chromosome 8 at 124,025,153 bp
  • A to G, chromosome 9 at 107,651,986 bp
  • T to C, chromosome 11 at 5,871,740 bp
  • C to T, chromosome 11 at 36,063,177 bp
  • T to C, chromosome 11 at 74,346,940 bp
  • T to C, chromosome 12 at 27,341,736 bp
  • G to T, chromosome 13 at 48,885,743 bp
  • T to A, chromosome 15 at 75,566,183 bp
  • A to G, chromosome 16 at 16,225,304 bp
  • A to T, chromosome 17 at 12,694,124 bp
  • A to T, chromosome 17 at 24,621,614 bp
  • G to C, chromosome 17 at 47,880,353 bp
  • A to G, chromosome 17 at 75,225,285 bp
  • T to C, chromosome 18 at 69,642,932 bp
  • T to C, chromosome 19 at 3,996,625 bp
  • T to C, chromosome 19 at 45,040,685 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1265 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039332-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.