Strain Name:
C57BL/6J-MtgxR1280Btlr/Mmmh
Stock Number:
039346-MU
Citation ID:
RRID:MMRRC_039346-MU
Other Names:
R1280 (G1), C57BL/6J-MtgxR1280Btlr
Major Collection:

Gene Information

Vps54
Name: VPS54 GARP complex subunit
Synonyms: mSLP8, Vps54l, 5330404P15Rik, wr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 245944
Homologene: 5605
Brd2
Name: bromodomain containing 2
Synonyms: Fsrg1, Ring3, Rnf3, D17H6S113E, Frg-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14312
HGNC: HGNC:1103
Homologene: 74540
Atp5g3
Name: ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228033
HGNC: HGNC:843
Homologene: 133873
Dync2h1
Name: dynein cytoplasmic 2 heavy chain 1
Synonyms: DHC2, D330044F14Rik, Dnchc2, m152Asp, m407Asp, 4432416O06Rik, DHC1b, D030010H02Rik, b2b414Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 110350
HGNC: HGNC:2962
Homologene: 14468
Cabp1
Name: calcium binding protein 1
Synonyms: caldendrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 29867
HGNC: HGNC:1384
Homologene: 99790
Ttn
Name: titin
Synonyms: D830007G01Rik, connectin, 1100001C23Rik, 2310036G12Rik, mdm, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru, L56
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Zfp831
Name: zinc finger protein 831
Synonyms: ENSMUSG00000050600, OTTMUSG00000017459
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 100043757
Homologene: 19013
Gjb3
Name: gap junction protein, beta 3
Synonyms: Cx31, Gjb-3, connexin 31, D4Wsu144e, Cnx31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14620
HGNC: HGNC:4285
Homologene: 7338
Olfr1368
Name: olfactory receptor 1368
Synonyms: MOR256-15, GA_x6K02T2QHY8-12104556-12105500
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 258527
Homologene: 105156
Neil1
Name: nei endonuclease VIII-like 1 (E. coli)
Synonyms: 2810450N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72774
Homologene: 11616
Klhdc7a
Name: kelch domain containing 7A
Synonyms: B230308G19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242721
Homologene: 17567
Myo18b
Name: myosin XVIIIb
Synonyms: 4933411E19Rik, 4932408L24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74376
Homologene: 53435
Socs4
Name: suppressor of cytokine signaling 4
Synonyms: A730004F22Rik, Socs7, 3110032M18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 67296
Homologene: 15442
Rbm12
Name: RNA binding motif protein 12
Synonyms: SWAN, 9430070C08Rik, 5730420G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 75710
HGNC: HGNC:9898
Homologene: 34993
Alkbh2
Name: alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase
Synonyms: Abh2, mABH2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231642
Homologene: 18393
Fez1
Name: fasciculation and elongation protein zeta 1 (zygin I)
Synonyms: UNC76, UNC-76
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235180
HGNC: HGNC:3659
Homologene: 21063
Tdrd9
Name: tudor domain containing 9
Synonyms: 4930441E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 74691
Homologene: 14311
Cers6
Name: ceramide synthase 6
Synonyms: CerS6, 4732462C07Rik, Lass6, similar to TRH1, T1L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241447
Homologene: 72228
Tekt4
Name: tektin 4
Synonyms: 1700010L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 71840
Homologene: 25745
Ubqln3
Name: ubiquilin 3
Synonyms: 4933400K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244178
Homologene: 9700
Mzf1
Name: myeloid zinc finger 1
Synonyms: Znf42, Zfp121, Zfp98, Mzf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 109889
Homologene: 9633
Entpd2
Name: ectonucleoside triphosphate diphosphohydrolase 2
Synonyms: NTPDase2, Cd39l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12496
HGNC: HGNC:3364
Homologene: 20333
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 2 at 25,399,484 bp
  • G to A, chromosome 2 at 69,068,689 bp
  • G to T, chromosome 2 at 73,909,370 bp
  • A to T, chromosome 2 at 76,778,164 bp
  • T to C, chromosome 2 at 156,096,829 bp
  • A to G, chromosome 2 at 174,704,059 bp
  • G to A, chromosome 4 at 127,326,431 bp
  • G to A, chromosome 4 at 139,965,453 bp
  • A to G, chromosome 5 at 112,723,805 bp
  • C to T, chromosome 5 at 114,124,226 bp
  • T to C, chromosome 5 at 115,175,471 bp
  • A to T, chromosome 7 at 13,053,083 bp
  • A to G, chromosome 7 at 104,142,076 bp
  • A to G, chromosome 9 at 7,071,934 bp
  • GACAAACA to GACA, chromosome 9 at 36,870,549 bp
  • T to C, chromosome 9 at 57,146,901 bp
  • T to A, chromosome 11 at 21,277,868 bp
  • T to C, chromosome 12 at 112,039,408 bp
  • C to T, chromosome 13 at 21,142,167 bp
  • A to T, chromosome 14 at 47,290,913 bp
  • T to A, chromosome 17 at 25,471,887 bp
  • T to C, chromosome 17 at 34,114,150 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1280 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039346-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.