Strain Name:
C57BL/6J-MtgxR1282Btlr/Mmmh
Stock Number:
039348-MU
Citation ID:
RRID:MMRRC_039348-MU
Other Names:
R1282 (G1), C57BL/6J-MtgxR1282Btlr
Major Collection:

Gene Information

Foxp4
Name: forkhead box P4
Synonyms: 1200010K03Rik, 2310007G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 74123
Homologene: 12536
Espl1
Name: extra spindle pole bodies 1, separase
Synonyms: separase, PRCE, PRCE, ESP1, SSE, Cerp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 105988
VEGA: 15
Homologene: 32151
Prrc2b
Name: proline-rich coiled-coil 2B
Synonyms: 5830434P21Rik, Bat2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 227723
Homologene: 106649
Dnajc7
Name: DnaJ heat shock protein family (Hsp40) member C7
Synonyms: 2010004G07Rik, 2010003F24Rik, mTpr2, mDj11, Ttc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 56354
Homologene: 68306
Atp2a2
Name: ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
Synonyms: D5Wsu150e, sarco/endoplasmic reticulum Ca2+-ATPase 2, SERCA2B, SERCA2, Serca2a, 9530097L16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 11938
HGNC: HGNC:812
Homologene: 80167
Resf1
Name: retroelement silencing factor 1
Synonyms: 2810474O19Rik, GET
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 67246
Homologene: 19251
Mbd1
Name: methyl-CpG binding domain protein 1
Synonyms: Cxxc3, PCM1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 17190
VEGA: 18
HGNC: HGNC:6916
Homologene: 8414
Slf1
Name: SMC5-SMC6 complex localization factor 1
Synonyms: C730024G01Rik, Brctd1, Ankrd32, 2700017A04Rik, Brctx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 105377
Homologene: 13000
Ipo9
Name: importin 9
Synonyms: Imp9, 0710008K06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226432
Homologene: 5874
Supt6
Name: SPT6, histone chaperone and transcription elongation factor
Synonyms: Supt6h, 5131400N11Rik, SPT6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 20926
Homologene: 40661
Sfr1
Name: SWI5 dependent recombination repair 1
Synonyms: 6330577E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 67788
VEGA: 19
Homologene: 12189
Snx11
Name: sorting nexin 11
Synonyms: 4933439F10Rik, A930041K09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 74479
Homologene: 12568
Scd2
Name: stearoyl-Coenzyme A desaturase 2
Synonyms: Scd-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 20250
VEGA: 19
Homologene: 136612
H2-K1
Name: histocompatibility 2, K1, K region
Synonyms: H-2K
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 14972
HGNC: HGNC:4931
Homologene: 128352
Kcnu1
Name: potassium channel, subfamily U, member 1
Synonyms: Slo3, Kcnma3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 16532
Homologene: 7392
Svep1
Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Synonyms: 1110021D17Rik, 4833413O10Rik, D430029O09Rik, Polydom
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 64817
Homologene: 23386
Scn7a
Name: sodium channel, voltage-gated, type VII, alpha
Synonyms: 1110034K09Rik, Scn6a, Nax, Nav2.3, NaG, Nav2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20272
Homologene: 55706
Snrk
Name: SNF related kinase
Synonyms: 2010012F07Rik, SNRK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 20623
Homologene: 9797
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Exoc3
Name: exocyst complex component 3
Synonyms: Sec6l1, 2810050O03Rik, E430013E20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 211446
VEGA: 13
Homologene: 38296
Cyp2b10
Name: cytochrome P450, family 2, subfamily b, polypeptide 10
Synonyms: phenobarbitol inducible, type b, p16, Cyp2b20, Cyp2b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 13088
HGNC: HGNC:2615
Homologene: 73894
Cfap65
Name: cilia and flagella associated protein 65
Synonyms: Ccdc108, B230363K08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 241116
Homologene: 28093
Greb1l
Name: growth regulation by estrogen in breast cancer-like
Synonyms: mKIAA4095, AK220484
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 381157
Homologene: 73393
Gjb3
Name: gap junction protein, beta 3
Synonyms: Gjb-3, connexin 31, Cx31, Cnx31, D4Wsu144e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 14620
HGNC: HGNC:4285
Homologene: 7338
Olfr683
Name: olfactory receptor 683
Synonyms: GA_x6K02T2PBJ9-7773007-7772066, MOR40-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 259047
Homologene: 133645
Gm12789
Name: predicted gene 12789
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 381536
Vmn2r28
Name: vomeronasal 2, receptor 28
Synonyms: EG665255
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 665255
Homologene: 129605
Fbxw15
Name: F-box and WD-40 domain protein 15
Synonyms: Fbxo12J
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 382105
Homologene: 110776
Prag1
Name: PEAK1 related kinase activating pseudokinase 1
Synonyms: NACK, D8Ertd82e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 244418
Homologene: 18256
Alkbh2
Name: alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase
Synonyms: Abh2, mABH2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231642
Homologene: 18393
Traf3ip2
Name: TRAF3 interacting protein 2
Synonyms: Act1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 103213
HGNC: HGNC:1343
Homologene: 15885
Rtp3
Name: receptor transporter protein 3
Synonyms: Tmem7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235636
Homologene: 135957
Vmn2r67
Name: vomeronasal 2, receptor 67
Synonyms: EG620672
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 620672
Homologene: 115466
Acmsd
Name: amino carboxymuconate semialdehyde decarboxylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 266645
Homologene: 44520
Fastkd3
Name: FAST kinase domains 3
Synonyms: 2310010B21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 69577
VEGA: 13
Homologene: 11457
Dnase1l3
Name: deoxyribonuclease 1-like 3
Synonyms: DNasegamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 13421
HGNC: HGNC:2959
Homologene: 3630
AC122012.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
Rep15
Name: RAB15 effector protein
Synonyms: 2210417D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 66532
Homologene: 11985
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 74,925,104 bp
  • T to C, chromosome 1 at 127,738,560 bp
  • A to G, chromosome 1 at 135,402,292 bp
  • T to C, chromosome 2 at 32,223,444 bp
  • A to T, chromosome 2 at 40,860,761 bp
  • A to T, chromosome 2 at 66,700,849 bp
  • C to A, chromosome 4 at 58,100,032 bp
  • T to A, chromosome 4 at 101,988,290 bp
  • G to A, chromosome 4 at 127,326,431 bp
  • T to A, chromosome 5 at 59,053,923 bp
  • C to T, chromosome 5 at 114,124,226 bp
  • G to T, chromosome 5 at 122,491,754 bp
  • C to T, chromosome 6 at 147,033,229 bp
  • C to T, chromosome 6 at 149,329,172 bp
  • A to T, chromosome 7 at 5,481,302 bp
  • G to A, chromosome 7 at 25,926,080 bp
  • A to G, chromosome 7 at 85,136,724 bp
  • T to A, chromosome 7 at 105,143,652 bp
  • A to T, chromosome 8 at 25,905,957 bp
  • T to C, chromosome 8 at 36,099,914 bp
  • G to A, chromosome 9 at 109,558,246 bp
  • T to C, chromosome 9 at 110,986,920 bp
  • G to T, chromosome 9 at 122,160,520 bp
  • C to T, chromosome 10 at 39,626,405 bp
  • T to C, chromosome 11 at 78,228,768 bp
  • T to C, chromosome 11 at 96,773,161 bp
  • T to C, chromosome 11 at 100,584,641 bp
  • C to A, chromosome 13 at 68,584,557 bp
  • T to C, chromosome 13 at 74,182,292 bp
  • C to T, chromosome 13 at 77,043,840 bp
  • T to C, chromosome 14 at 7,983,117 bp
  • A to G, chromosome 15 at 102,315,391 bp
  • A to C, chromosome 17 at 33,999,447 bp
  • G to A, chromosome 17 at 47,875,643 bp
  • T to A, chromosome 18 at 10,547,289 bp
  • T to C, chromosome 18 at 74,275,328 bp
  • T to C, chromosome 19 at 44,295,181 bp
  • T to C, chromosome 19 at 47,732,968 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1282 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039348-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.