Strain Name:
C57BL/6J-MtgxR1296Btlr/Mmmh
Stock Number:
039362-MU
Citation ID:
RRID:MMRRC_039362-MU
Other Names:
R1296 (G1), C57BL/6J-MtgxR1296Btlr
Major Collection:

Gene Information

Sufu
Name: SUFU negative regulator of hedgehog signaling
Synonyms: b2b273Clo, Su(Fu), 2810026F04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 24069
Homologene: 9262
Vcan
Name: versican
Synonyms: PG-M, heart defect, DPEAAE, 5430420N07Rik, Cspg2, hdf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Nlgn3
Name: neuroligin 3
Synonyms: A230085M13Rik, NLG3, NL3, HNL3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 245537
Homologene: 23133
Atn1
Name: atrophin 1
Synonyms: Atr1, atrophin-1, Drpla
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 13498
HGNC: HGNC:3033
Homologene: 1461
Ints6
Name: integrator complex subunit 6
Synonyms: 2900075H24Rik, Ddx26, Notch2l, DICE1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 18130
VEGA: 14
Homologene: 8121
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Cdk18
Name: cyclin-dependent kinase 18
Synonyms: Pctk3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18557
HGNC: HGNC:8751
Homologene: 1949
Dmd
Name: dystrophin, muscular dystrophy
Synonyms: dys, X-linked muscular dystrophy, Duchenne muscular dystrophy, Dp71, Dp427, mdx, pke
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 13405
HGNC: HGNC:2928
Homologene: 20856
Psmb2
Name: proteasome (prosome, macropain) subunit, beta type 2
Synonyms: HC7-I, D4Wsu33e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 26445
HGNC: HGNC:9539
Homologene: 2088
Mbtd1
Name: mbt domain containing 1
Synonyms: hemp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103537
Homologene: 41185
Ints8
Name: integrator complex subunit 8
Synonyms: 2810013E07Rik, D130008D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72656
Homologene: 9888
Cep85
Name: centrosomal protein 85
Synonyms: Ccdc21, 2410030J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 70012
Homologene: 11254
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Frs2
Name: fibroblast growth factor receptor substrate 2
Synonyms: SNT1, C330018A15Rik, Frs2alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 327826
VEGA: 10
Homologene: 4846
Nr3c1
Name: nuclear receptor subfamily 3, group C, member 1
Synonyms: Grl1, glucocorticoid receptor, GR, Grl-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 14815
HGNC: HGNC:7978
Homologene: 30960
Lrrk2
Name: leucine-rich repeat kinase 2
Synonyms: 9330188B09Rik, D630001M17Rik, 4921513O20Rik, cI-46, LOC381026
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66725
Homologene: 18982
Tbc1d1
Name: TBC1 domain family, member 1
Synonyms: Nobq1, 1110062G02Rik, Nob1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 57915
Homologene: 56856
Nfyb
Name: nuclear transcription factor-Y beta
Synonyms: Cbf-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18045
HGNC: HGNC:7805
Homologene: 38149
Arhgef17
Name: Rho guanine nucleotide exchange factor (GEF) 17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 207212
Homologene: 129601
Tap2
Name: transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Synonyms: Ham2, Ham-2, PSF2, MTP2, HAM2, Tap-2, Abcb3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 21355
HGNC: HGNC:44
Homologene: 37323
Rbl1
Name: RB transcriptional corepressor like 1
Synonyms: p107, retinoblastoma-like 1 (p107)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19650
HGNC: HGNC:9893
Homologene: 2172
Stau2
Name: staufen double-stranded RNA binding protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 29819
Homologene: 8666
Cbwd1
Name: COBW domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226043
VEGA: 19
Homologene: 6843
Siglecf
Name: sialic acid binding Ig-like lectin F
Synonyms: Siglec5, mSiglec-F
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233186
Homologene: 50482
Stxbp1
Name: syntaxin binding protein 1
Synonyms: Munc18-1, N-sec1, Rb-sec1, Sxtbp1, Unc18h, Munc-18a, nsec1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20910
Homologene: 2382
Mslnl
Name: mesothelin-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 328783
VEGA: 17
Homologene: 18633
Map4k1
Name: mitogen-activated protein kinase kinase kinase kinase 1
Synonyms: Hpk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 26411
HGNC: HGNC:6863
Homologene: 5199
Muc6
Name: mucin 6, gastric
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 353328
HGNC: HGNC:7517
Homologene: 18768
Arhgap29
Name: Rho GTPase activating protein 29
Synonyms: Parg1, C76601, 6720461J18Rik, B130017I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 214137
Homologene: 3539
Tril
Name: TLR4 interactor with leucine-rich repeats
Synonyms: 1200009O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 66873
Homologene: 69404
Col6a6
Name: collagen, type VI, alpha 6
Synonyms: E330026B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 245026
Homologene: 18260
Rmnd5a
Name: required for meiotic nuclear division 5 homolog A
Synonyms: Gid2, 1110007A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 68477
Homologene: 5668
Tnxb
Name: tenascin XB
Synonyms: TN-MHC, Tnx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 81877
Homologene: 49589
Ugt2a3
Name: UDP glucuronosyltransferase 2 family, polypeptide A3
Synonyms: 2010321J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72094
Homologene: 55988
Grik3
Name: glutamate receptor, ionotropic, kainate 3
Synonyms: Glur7, Glur-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14807
HGNC: HGNC:4581
Homologene: 73901
Zc3h7a
Name: zinc finger CCCH type containing 7 A
Synonyms: A430104C18Rik, Zc3h7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 106205
Homologene: 8563
Cntn4
Name: contactin 4
Synonyms: BIG-2A, Axcam
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 269784
HGNC: HGNC:2174
Homologene: 14257
Col6a4
Name: collagen, type VI, alpha 4
Synonyms: 1110001D15Rik, EG235580, Dvwa, Vwa6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 68553
Homologene: 130754
Pcnx2
Name: pecanex homolog 2
Synonyms: E330039K12Rik, Pcnxl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 270109
HGNC: HGNC:8736
Homologene: 8987
Tmprss9
Name: transmembrane protease, serine 9
Synonyms: Serase-1B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 432478
VEGA: 10
Homologene: 115302
Prl2c5
Name: prolactin family 2, subfamily c, member 5
Synonyms: PLF-4, Mrpplf4, MRP-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 107849
Homologene: 40763
Atp8a1
Name: ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
Synonyms: B230107D19Rik, Atp3a2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11980
Homologene: 48402
Vmn2r28
Name: vomeronasal 2, receptor 28
Synonyms: EG665255
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 665255
Homologene: 129605
Adam29
Name: a disintegrin and metallopeptidase domain 29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244486
HGNC: HGNC:207
Homologene: 8607
Spdl1
Name: spindle apparatus coiled-coil protein 1
Synonyms: 2810049B11Rik, 1700018I02Rik, Ccdc99, 2600001J17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70385
Homologene: 9837
Zfp598
Name: zinc finger protein 598
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 213753
VEGA: 17
Homologene: 5672
Zpld1
Name: zona pellucida like domain containing 1
Synonyms: 9430016A21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 239852
Homologene: 18401
Slc23a1
Name: solute carrier family 23 (nucleobase transporters), member 1
Synonyms: Slc23a2, YSPL3, D18Ucla2, SVCT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 20522
Homologene: 40769
Dus2
Name: dihydrouridine synthase 2
Synonyms: 2310016K04Rik, Dus2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 66369
Homologene: 6838
Sele
Name: selectin, endothelial cell
Synonyms: Elam, E-selectin, CD62E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20339
Homologene: 389
Otud4
Name: OTU domain containing 4
Synonyms: 4930431L18Rik, D8Ertd69e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 73945
Homologene: 35370
Gm6990
Name: predicted pseudogene 6990
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 629643
Nxpe4
Name: neurexophilin and PC-esterase domain family, member 4
Synonyms: Fam55d, D930028F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244853
VEGA: 9
Homologene: 83471
Atp13a2
Name: ATPase type 13A2
Synonyms: 1110012E06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74772
Homologene: 56940
Haao
Name: 3-hydroxyanthranilate 3,4-dioxygenase
Synonyms: 0610007K21Rik, 3-HAO, 3-HAOxase, 0610012J07Rik, 3HAO
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 107766
VEGA: 17
HGNC: HGNC:4796
Homologene: 8148
Gpr61
Name: G protein-coupled receptor 61
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229714
Homologene: 12910
Gm5174
Name: predicted gene 5174
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 382395
VEGA: 10
Homologene: 141143
Tlcd4
Name: TLC domain containing 4
Synonyms: C730036B01Rik, Tmem56, 4930577M16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99887
Homologene: 45107
Tbx2
Name: T-box 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 21385
Homologene: 38123
Mrfap1
Name: Morf4 family associated protein 1
Synonyms: 9130413I22Rik, PAM14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 67568
Homologene: 128357
Mrm2
Name: mitochondrial rRNA methyltransferase 2
Synonyms: Ftsj2, 2310037B18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 68017
Homologene: 5907
Apol11a
Name: apolipoprotein L 11a
Synonyms: EG626615
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 626615
VEGA: 15
Homologene: 129975
Slc6a14
Name: solute carrier family 6 (neurotransmitter transporter), member 14
Synonyms: CATB0plus, 9030613J17Rik, ATB0plus, 1110007A17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 56774
Homologene: 38290
Rhox2g
Name: reproductive homeobox 2G
Synonyms: Rhox2.7, EG434766
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 434766
Homologene: 41772
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 16,440,372 bp
  • T to C, chromosome 1 at 132,119,960 bp
  • T to A, chromosome 1 at 164,050,810 bp
  • A to T, chromosome 2 at 32,794,636 bp
  • A to T, chromosome 2 at 157,169,971 bp
  • A to G, chromosome 3 at 108,150,481 bp
  • A to G, chromosome 3 at 121,207,291 bp
  • A to G, chromosome 3 at 121,992,395 bp
  • T to C, chromosome 4 at 11,221,204 bp
  • G to A, chromosome 4 at 125,704,564 bp
  • A to G, chromosome 4 at 126,687,032 bp
  • A to G, chromosome 4 at 134,167,400 bp
  • T to C, chromosome 4 at 140,993,802 bp
  • A to G, chromosome 5 at 36,796,473 bp
  • T to C, chromosome 5 at 64,264,432 bp
  • A to T, chromosome 5 at 67,622,706 bp
  • A to T, chromosome 5 at 87,327,146 bp
  • T to C, chromosome 5 at 140,328,553 bp
  • G to T, chromosome 6 at 53,818,027 bp
  • G to A, chromosome 6 at 71,398,455 bp
  • G to T, chromosome 6 at 106,509,402 bp
  • G to T, chromosome 6 at 124,747,787 bp
  • T to C, chromosome 7 at 5,481,545 bp
  • A to G, chromosome 7 at 28,998,452 bp
  • A to T, chromosome 7 at 43,355,920 bp
  • C to A, chromosome 7 at 100,881,269 bp
  • T to C, chromosome 7 at 141,651,879 bp
  • G to A, chromosome 8 at 55,871,719 bp
  • C to A, chromosome 8 at 79,673,974 bp
  • T to C, chromosome 8 at 106,053,043 bp
  • A to G, chromosome 8 at 125,773,833 bp
  • C to G, chromosome 9 at 48,396,493 bp
  • A to T, chromosome 9 at 53,456,530 bp
  • T to C, chromosome 9 at 105,781,091 bp
  • A to G, chromosome 9 at 106,062,853 bp
  • G to T, chromosome 10 at 80,890,445 bp
  • A to G, chromosome 10 at 82,750,831 bp
  • A to G, chromosome 10 at 86,657,002 bp
  • C to T, chromosome 10 at 117,081,074 bp
  • T to A, chromosome 11 at 34,813,607 bp
  • A to G, chromosome 11 at 85,834,766 bp
  • A to G, chromosome 11 at 93,910,359 bp
  • T to C, chromosome 13 at 11,687,879 bp
  • T to A, chromosome 13 at 13,189,424 bp
  • A to G, chromosome 13 at 89,657,556 bp
  • T to C, chromosome 14 at 62,704,903 bp
  • T to C, chromosome 15 at 77,511,019 bp
  • G to A, chromosome 15 at 91,728,920 bp
  • C to T, chromosome 16 at 11,161,026 bp
  • T to C, chromosome 16 at 55,248,334 bp
  • A to G, chromosome 17 at 24,679,649 bp
  • T to C, chromosome 17 at 25,743,240 bp
  • G to T, chromosome 17 at 34,211,915 bp
  • G to A, chromosome 17 at 34,671,577 bp
  • T to A, chromosome 17 at 83,838,838 bp
  • C to T, chromosome 18 at 35,622,623 bp
  • G to A, chromosome 18 at 39,486,998 bp
  • A to T, chromosome 19 at 24,942,675 bp
  • G to A, chromosome 19 at 46,454,720 bp
  • T to A, chromosome 19 at 56,755,334 bp
  • G to A, chromosome X at 21,721,568 bp
  • C to A, chromosome X at 37,643,212 bp
  • A to T, chromosome X at 83,878,520 bp
  • T to C, chromosome X at 101,308,916 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1296 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039362-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.