Strain Name:
C57BL/6J-MtgxR1297Btlr/Mmmh
Stock Number:
039363-MU
Citation ID:
RRID:MMRRC_039363-MU
Other Names:
R1297 (G1), C57BL/6J-MtgxR1297Btlr
Major Collection:

Gene Information

Ap2b1
Name: adaptor-related protein complex 2, beta 1 subunit
Synonyms: 1300012O03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71770
HGNC: HGNC:563
Homologene: 137384
Thada
Name: thyroid adenoma associated
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240174
VEGA: 17
Homologene: 75175
Cep290
Name: centrosomal protein 290
Synonyms: Nphp6, b2b1752Clo, b2b1454Clo, Kiaa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216274
VEGA: 10
Homologene: 77213
Rbm5
Name: RNA binding motif protein 5
Synonyms: D030069N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 83486
HGNC: HGNC:9902
Homologene: 21177
Tle1
Name: transducin-like enhancer of split 1
Synonyms: Grg1, C230057C06Rik, Estm14, Tle4l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21885
Homologene: 21058
Setdb1
Name: SET domain, bifurcated 1
Synonyms: KMT1E, ESET
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 84505
Homologene: 32157
Mettl25
Name: methyltransferase like 25
Synonyms: BC067068
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216292
Homologene: 32774
Safb2
Name: scaffold attachment factor B2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224902
Homologene: 35210
Hdac2
Name: histone deacetylase 2
Synonyms: D10Wsu179e, Yy1bp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 15182
HGNC: HGNC:4853
Homologene: 68187
Golga3
Name: golgi autoantigen, golgin subfamily a, 3
Synonyms: G1-499-14, 5430416E01Rik, Mea2, Mea-2, repro27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269682
HGNC: HGNC:4426
Homologene: 4308
Rras
Name: related RAS viral (r-ras) oncogene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20130
Homologene: 4565
Itsn2
Name: intersectin 2
Synonyms: Sh3d1B, Sh3p18, Ese2, Eh domain, SH3 domain regulator of endocytosis 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20403
VEGA: 12
HGNC: HGNC:6184
Homologene: 22627
Tnrc6c
Name: trinucleotide repeat containing 6C
Synonyms: 9930033H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217351
Homologene: 23137
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: 2210407G14Rik, E530005C20Rik, LOC224126, Hapip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Pgap1
Name: post-GPI attachment to proteins 1
Synonyms: 9030223K07Rik, PGAP1, D230012E17Rik, oto, 5033403E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241062
Homologene: 41605
Pgk2
Name: phosphoglycerate kinase 2
Synonyms: Tcp-2, Tcp-2, Pgk-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18663
VEGA: 17
HGNC: HGNC:8898
Homologene: 57138
Klrg1
Name: killer cell lectin-like receptor subfamily G, member 1
Synonyms: 2F1-Ag
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 50928
HGNC: HGNC:6380
Homologene: 4244
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: 2810003K23Rik, Dnahcl1, Dnahc17, LOC382552
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Col27a1
Name: collagen, type XXVII, alpha 1
Synonyms: 5730512J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 373864
Homologene: 69400
Wdr24
Name: WD repeat domain 24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268933
Homologene: 6870
Gstt4
Name: glutathione S-transferase, theta 4
Synonyms: 4930583C14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 75886
Homologene: 57104
Tnxb
Name: tenascin XB
Synonyms: TN-MHC, Tnx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 81877
Homologene: 49589
Pou6f1
Name: POU domain, class 6, transcription factor 1
Synonyms: 2310038G18Rik, Emb, cns-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 19009
HGNC: HGNC:9224
Homologene: 7703
Mast1
Name: microtubule associated serine/threonine kinase 1
Synonyms: SAST170, 9430008B02Rik, SAST
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 56527
Homologene: 10543
Vmn1r13
Name: vomeronasal 1 receptor 13
Synonyms: V1rc5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 113862
Homologene: 74368
Rnf215
Name: ring finger protein 215
Synonyms: 0610009J22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71673
Homologene: 12402
Zfyve16
Name: zinc finger, FYVE domain containing 16
Synonyms: B130024H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218441
Homologene: 8826
Cyp2d12
Name: cytochrome P450, family 2, subfamily d, polypeptide 12
Synonyms: 9030605E09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 380997
VEGA: 15
Homologene: 86099
Aebp1
Name: AE binding protein 1
Synonyms: ACLP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11568
HGNC: HGNC:303
Homologene: 878
Sp5
Name: trans-acting transcription factor 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 64406
Homologene: 11190
Nme2
Name: NME/NM23 nucleoside diphosphate kinase 2
Synonyms: non-metastatic cells 2, protein (NM23B) expressed in, nm23-M2, NM23-H2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18103
HGNC: HGNC:7850
Homologene: 133879
Phf11
Name: PHD finger protein 11
Synonyms: Gm6904, Phf11-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 628693
VEGA: 14
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 54,528,523 bp
  • A to G, chromosome 2 at 70,476,529 bp
  • A to T, chromosome 3 at 95,349,876 bp
  • G to A, chromosome 4 at 63,265,631 bp
  • A to G, chromosome 4 at 72,124,838 bp
  • G to A, chromosome 5 at 110,204,843 bp
  • A to G, chromosome 6 at 57,210,407 bp
  • T to A, chromosome 6 at 122,273,579 bp
  • A to G, chromosome 7 at 45,020,579 bp
  • A to G, chromosome 8 at 84,912,716 bp
  • G to A, chromosome 9 at 107,744,242 bp
  • G to A, chromosome 10 at 36,986,374 bp
  • T to A, chromosome 10 at 75,817,299 bp
  • T to A, chromosome 10 at 100,539,100 bp
  • T to C, chromosome 10 at 105,823,265 bp
  • T to C, chromosome 11 at 4,139,806 bp
  • A to G, chromosome 11 at 5,870,834 bp
  • T to A, chromosome 11 at 83,333,109 bp
  • A to T, chromosome 11 at 93,951,956 bp
  • A to G, chromosome 11 at 117,733,703 bp
  • T to C, chromosome 11 at 118,121,366 bp
  • T to C, chromosome 12 at 4,700,378 bp
  • A to G, chromosome 13 at 92,522,332 bp
  • A to T, chromosome 14 at 59,258,547 bp
  • A to T, chromosome 15 at 82,557,686 bp
  • T to A, chromosome 15 at 100,578,305 bp
  • T to C, chromosome 16 at 34,016,498 bp
  • C to T, chromosome 17 at 25,827,348 bp
  • T to C, chromosome 17 at 34,710,166 bp
  • C to A, chromosome 17 at 40,208,364 bp
  • T to C, chromosome 17 at 56,584,265 bp
  • A to G, chromosome 17 at 84,252,435 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1297 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039363-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.