Strain Name:
C57BL/6J-MtgxR1298Btlr/Mmmh
Stock Number:
039364-MU
Citation ID:
RRID:MMRRC_039364-MU
Other Names:
R1298 (G1), C57BL/6J-MtgxR1298Btlr
Major Collection:

Gene Information

Dnmt1
Name: DNA methyltransferase (cytosine-5) 1
Synonyms: Dnmt1o, Cxxc9, MommeD2, MTase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 13433
VEGA: 9
HGNC: HGNC:2976
Homologene: 124071
Zbtb25
Name: zinc finger and BTB domain containing 25
Synonyms: Zfp50, 2810462M08Rik, Kup, 2900064P18Rik, Zfp-50
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 109929
VEGA: 12
Homologene: 5070
Cdk18
Name: cyclin-dependent kinase 18
Synonyms: Pctk3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 18557
VEGA: 1
HGNC: HGNC:8751
Homologene: 1949
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Pam, Phr1, C130061D10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 105689
VEGA: 14
Homologene: 9005
Sfswap
Name: splicing factor SWAP
Synonyms: 1190005N23Rik, 6330437E22Rik, Sfrs8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231769
VEGA: 5
Homologene: 134548
Aspm
Name: abnormal spindle microtubule assembly
Synonyms: Sha1, Aspm, MCPH5, D330028K02Rik, Calmbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12316
VEGA: 1
Homologene: 7650
Smg1
Name: SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
Synonyms: C130002K18Rik, 2610207I05Rik, 5430435M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233789
VEGA: 7
Homologene: 56697
Zgrf1
Name: zinc finger, GRF-type containing 1
Synonyms: 4930422G04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 71643
VEGA: 3
Homologene: 34708
Eef2
Name: eukaryotic translation elongation factor 2
Synonyms: Ef-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 13629
VEGA: 10
HGNC: HGNC:3214
Homologene: 134867
Slitrk6
Name: SLIT and NTRK-like family, member 6
Synonyms: 4832410J21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 239250
VEGA: 14
Homologene: 12986
Gm14496
Name: predicted gene 14496
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 672125
Homologene: 129606
Bbs4
Name: Bardet-Biedl syndrome 4 (human)
Synonyms: D9Ertd464e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 102774
VEGA: 9
HGNC: HGNC:969
Homologene: 13197
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: Dnahc6, A730004I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 330355
VEGA: 6
HGNC: HGNC:2951
Homologene: 15221
Cyp2j11
Name: cytochrome P450, family 2, subfamily j, polypeptide 11
Synonyms: Cyp2j11-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 100066
VEGA: 4
Homologene: 133819
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 380698
VEGA: 11
Homologene: 70869
Jag2
Name: jagged 2
Synonyms: D12Ggc2e, Serh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 16450
VEGA: 12
HGNC: HGNC:6189
Homologene: 1677
Sobp
Name: sine oculis binding protein
Synonyms: jc, 2900009C16Rik, 5330439J01Rik, Jxc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 109205
VEGA: 10
Homologene: 41216
Nsd3
Name: nuclear receptor binding SET domain protein 3
Synonyms: WHISTLE, Whsc1l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234135
VEGA: 8
Homologene: 56960
Spock1
Name: sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1
Synonyms: Ticn1, testican 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 20745
VEGA: 13
Homologene: 80193
Alox5
Name: arachidonate 5-lipoxygenase
Synonyms: 5LO, 5-LOX, 5LX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 11689
VEGA: 6
HGNC: HGNC:435
Homologene: 561
Rcbtb2
Name: regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
Synonyms: 2610028E02Rik, 2810420M18Rik, Rc/btb2, Chc1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 105670
VEGA: 14
HGNC: HGNC:1914
Homologene: 970
Olfr747
Name: olfactory receptor 747
Synonyms: GA_x6K02T2PMLR-6420220-6419279, MOR106-7, MOR106-16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 258264
VEGA: 14
Homologene: 10652
H6pd
Name: hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
Synonyms: Gpd-1, G6pd1, Gpd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 100198
VEGA: 4
HGNC: HGNC:4795
Homologene: 48275
Pinlyp
Name: phospholipase A2 inhibitor and LY6/PLAUR domain containing
Synonyms: 2310033E01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 641361
Homologene: 53159
Gsdmc3
Name: gasdermin C3
Synonyms: 9930109F21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 270328
HGNC: HGNC:7151
Homologene: 69487
Hao2
Name: hydroxyacid oxidase 2
Synonyms: Hao3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 56185
VEGA: 3
HGNC: HGNC:4810
Homologene: 97412
Olfr1120
Name: olfactory receptor 1120
Synonyms: GA_x6K02T2Q125-48849180-48850100, MOR264-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 259031
VEGA: 2
Homologene: 72054
Cavin4
Name: caveolae associated 4
Synonyms: 2310039E09Rik, cavin 4, Murc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 68016
VEGA: 4
Homologene: 12224
Pde2a
Name: phosphodiesterase 2A, cGMP-stimulated
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 207728
VEGA: 7
HGNC: HGNC:8777
Homologene: 1952
Mapre3
Name: microtubule-associated protein, RP/EB family, member 3
Synonyms: EB3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 100732
VEGA: 5
HGNC: HGNC:6892
Homologene: 56565
Vmn1r180
Name: vomeronasal 1 receptor 180
Synonyms: LOC232962, V1rd16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 232962
VEGA: 7
Homologene: 104166
Olfr788
Name: olfactory receptor 788
Synonyms: GA_x6K02T2PULF-11151514-11152449, MOR111-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 258544
VEGA: 10
Homologene: 74200
Gm2046
Name: predicted gene 2046
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 100039100
VEGA: 12
Homologene: 103865
Upk3a
Name: uroplakin 3A
Synonyms: 1110017C07Rik, Upk3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 22270
VEGA: 15
Homologene: 5066
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 132,122,451 bp
  • T to A, chromosome 1 at 139,457,419 bp
  • G to A, chromosome 2 at 87,358,070 bp
  • T to C, chromosome 2 at 181,996,092 bp
  • G to T, chromosome 3 at 98,883,669 bp
  • T to C, chromosome 3 at 127,583,889 bp
  • T to C, chromosome 4 at 48,672,593 bp
  • C to T, chromosome 4 at 96,307,260 bp
  • T to C, chromosome 4 at 149,982,514 bp
  • A to G, chromosome 5 at 30,864,867 bp
  • A to G, chromosome 5 at 129,541,378 bp
  • A to T, chromosome 6 at 73,159,135 bp
  • A to G, chromosome 6 at 116,427,264 bp
  • T to C, chromosome 7 at 23,953,147 bp
  • T to A, chromosome 7 at 24,544,966 bp
  • A to G, chromosome 7 at 101,507,202 bp
  • A to T, chromosome 7 at 118,168,211 bp
  • T to A, chromosome 8 at 25,679,936 bp
  • T to C, chromosome 9 at 20,941,456 bp
  • A to T, chromosome 9 at 59,339,813 bp
  • T to A, chromosome 10 at 43,022,335 bp
  • C to CN, chromosome 10 at 81,178,768 bp
  • G to T, chromosome 10 at 129,473,064 bp
  • A to G, chromosome 11 at 59,054,897 bp
  • T to C, chromosome 12 at 76,350,001 bp
  • T to A, chromosome 12 at 87,980,083 bp
  • C to T, chromosome 12 at 112,916,319 bp
  • A to C, chromosome 13 at 57,512,750 bp
  • A to T, chromosome 14 at 50,680,880 bp
  • T to A, chromosome 14 at 73,162,388 bp
  • A to G, chromosome 14 at 103,155,898 bp
  • T to C, chromosome 14 at 110,751,865 bp
  • A to T, chromosome 15 at 63,860,281 bp
  • G to A, chromosome 15 at 85,020,551 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1298 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039364-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.