Strain Name:
C57BL/6J-MtgxR1317Btlr/Mmmh
Stock Number:
039383-MU
Citation ID:
RRID:MMRRC_039383-MU
Other Names:
R1317 (G1), C57BL/6J-MtgxR1317Btlr
Major Collection:

Strain Information

Mt1
Name: metallothionein 1
Synonyms: MT-I, Mt-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17748
Nphs1
Name: nephrosis 1, nephrin
Synonyms: nephrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 54631
HGNC: HGNC:7908
Homologene: 20974
Scg3
Name: secretogranin III
Synonyms: SgIII, Chgd, 1B1075
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20255
VEGA: 9
Homologene: 7526
Mid1
Name: midline 1
Synonyms: Fxy, 61B3-R, DXHXS1141, Trim18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 17318
HGNC: HGNC:7095
Homologene: 7837
Rbm27
Name: RNA binding motif protein 27
Synonyms: Psc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225432
VEGA: 18
Homologene: 35410
Afdn
Name: afadin, adherens junction formation factor
Synonyms: AF6, Afadin, S-afadin, I-afadin, 5033403D15Rik, Mllt4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17356
HGNC: HGNC:7137
Homologene: 21202
Rps24
Name: ribosomal protein S24
Synonyms: MRP S24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 20088
VEGA: 14
Homologene: 68148
Bcl6
Name: B cell leukemia/lymphoma 6
Synonyms: Bcl5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 12053
HGNC: HGNC:1001
Homologene: 7640
Robo2
Name: roundabout guidance receptor 2
Synonyms: 9430089E08Rik, D230004I22Rik, 2600013A04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 268902
Homologene: 43188
Gmeb1
Name: glucocorticoid modulatory element binding protein 1
Synonyms: 1110050A04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56809
HGNC: HGNC:4370
Homologene: 10647
Smad5
Name: SMAD family member 5
Synonyms: Smad 5, MusMLP, Madh5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17129
HGNC: HGNC:6771
Homologene: 4313
Tom1
Name: target of myb1 trafficking protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 21968
Homologene: 88453
Hnrnpu
Name: heterogeneous nuclear ribonucleoprotein U
Synonyms: scaffold attachment factor A, Sp120, Hnrpu
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 51810
HGNC: HGNC:5048
Homologene: 22991
Zbtb1
Name: zinc finger and BTB domain containing 1
Synonyms: C430003J21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 268564
Homologene: 8974
Fam20a
Name: FAM20A, golgi associated secretory pathway pseudokinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 208659
Homologene: 9719
Depdc1a
Name: DEP domain containing 1a
Synonyms: 5830484J08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 76131
Homologene: 9834
Cryba2
Name: crystallin, beta A2
Synonyms: E130107M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12958
HGNC: HGNC:2395
Homologene: 10991
Irf6
Name: interferon regulatory factor 6
Synonyms: E230028I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 54139
HGNC: HGNC:6121
Homologene: 4479
Jag2
Name: jagged 2
Synonyms: Serh, D12Ggc2e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 16450
VEGA: 12
HGNC: HGNC:6189
Homologene: 1677
Trim30b
Name: tripartite motif-containing 30B
Synonyms: Trim30-1, A530023O14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244183
Myo15b
Name: myosin XVB
Synonyms: LOC217328, LOC380737, E330039G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217328
Ccdc7b
Name: coiled-coil domain containing 7B
Synonyms: 1700008F21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 75453
Homologene: 49919
Tubb1
Name: tubulin, beta 1 class VI
Synonyms: 2810484G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 545486
Homologene: 69474
Cdh15
Name: cadherin 15
Synonyms: Cdh14, Mcad, M cadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12555
HGNC: HGNC:1754
Homologene: 3622
Zdhhc7
Name: zinc finger, DHHC domain containing 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102193
Homologene: 41193
Abi3bp
Name: ABI family member 3 binding protein
Synonyms: 5033411B22Rik, D930038M13Rik, eratin, TARSH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 320712
VEGA: 16
Homologene: 134172
Tspan32
Name: tetraspanin 32
Synonyms: D7Wsu37e, Tssc6, Art-1, Tspan32, Phemx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 27027
Homologene: 10650
Gpr156
Name: G protein-coupled receptor 156
Synonyms: Gababl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 239845
VEGA: 16
Homologene: 17683
Ifi209
Name: interferon activated gene 209
Synonyms: Ifix, Pyhin1, Pyhin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 236312
Homologene: 115929
Gm5519
Name: predicted pseudogene 5519
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 433241
VEGA: 19
Gm9602
Name: predicted gene 9602
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 673676
Homologene: 115686
Slc25a23
Name: solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
Synonyms: 2310067G05Rik, SCaMC-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 66972
Homologene: 11467
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 74,890,676 bp
  • A to G, chromosome 1 at 173,637,463 bp
  • G to A, chromosome 1 at 178,330,257 bp
  • G to A, chromosome 1 at 193,169,301 bp
  • A to G, chromosome 2 at 174,456,896 bp
  • T to C, chromosome 3 at 159,523,287 bp
  • G to A, chromosome 4 at 132,234,887 bp
  • C to T, chromosome 7 at 30,481,831 bp
  • T to A, chromosome 7 at 104,357,335 bp
  • A to G, chromosome 7 at 143,017,591 bp
  • T to C, chromosome 8 at 75,051,551 bp
  • T to C, chromosome 8 at 94,180,153 bp
  • T to A, chromosome 8 at 120,084,900 bp
  • G to C, chromosome 8 at 122,857,495 bp
  • A to T, chromosome 8 at 129,136,646 bp
  • G to A, chromosome 9 at 75,669,340 bp
  • A to T, chromosome 11 at 109,677,838 bp
  • C to A, chromosome 11 at 115,883,634 bp
  • A to G, chromosome 12 at 76,386,799 bp
  • T to A, chromosome 12 at 112,914,501 bp
  • T to C, chromosome 13 at 56,736,071 bp
  • T to A, chromosome 14 at 4,776,499 bp
  • A to G, chromosome 14 at 24,491,762 bp
  • G to T, chromosome 16 at 23,977,542 bp
  • T to C, chromosome 16 at 37,987,567 bp
  • C to T, chromosome 16 at 56,668,309 bp
  • A to G, chromosome 16 at 74,035,024 bp
  • A to G, chromosome 17 at 13,846,273 bp
  • T to C, chromosome 17 at 57,053,888 bp
  • G to A, chromosome 18 at 42,324,051 bp
  • T to C, chromosome 19 at 33,824,991 bp
  • A to C, chromosome X at 169,986,094 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1317 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039383-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.