Strain Name:
C57BL/6J-MtgxR1321Btlr/Mmmh
Stock Number:
039387-MU
Citation ID:
RRID:MMRRC_039387-MU
Other Names:
R1321 (G1), C57BL/6J-MtgxR1321Btlr
Major Collection:

Gene Information

Aco2
Name: aconitase 2, mitochondrial
Synonyms: Aco3, Aco-2, D10Wsu183e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 11429
HGNC: HGNC:118
Homologene: 856
Fbxo42
Name: F-box protein 42
Synonyms: 6720460I06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 213499
Homologene: 16234
Ccn3
Name: cellular communication network factor 3
Synonyms: C130088N23Rik, CCN3, Nov
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18133
HGNC: HGNC:7885
Homologene: 1884
C2cd2l
Name: C2 calcium-dependent domain containing 2-like
Synonyms: 1300006O23Rik, Tmem24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 71764
VEGA: 9
Homologene: 8876
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: A930005E13Rik, LOC381562, D930005K06Rik, 1810009A16Rik, Zubr1, p600
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69116
Homologene: 10804
Sppl3
Name: signal peptide peptidase 3
Synonyms: 4833416I09Rik, Usmg3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74585
Homologene: 15563
Dolpp1
Name: dolichyl pyrophosphate phosphatase 1
Synonyms: LSFR2, 0610011H20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 57170
Homologene: 10663
Pbrm1
Name: polybromo 1
Synonyms: BAF180, 2610016F04Rik, 2310032M22Rik, Pb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 66923
Homologene: 10044
Nrbp1
Name: nuclear receptor binding protein 1
Synonyms: B230344L17Rik, Nrbp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 192292
HGNC: HGNC:7993
Homologene: 8373
Lct
Name: lactase
Synonyms: LOC226413, Lphl, LPH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226413
HGNC: HGNC:6530
Homologene: 124204
Col12a1
Name: collagen, type XII, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12816
HGNC: HGNC:2188
Homologene: 3217
Zfp251
Name: zinc finger protein 251
Synonyms: 9130001M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 71591
VEGA: 15
Homologene: 87789
Galnt18
Name: polypeptide N-acetylgalactosaminyltransferase 18
Synonyms: 2900011G21Rik, Galntl4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233733
Homologene: 18347
Reg3b
Name: regenerating islet-derived 3 beta
Synonyms: RegIII (beta), REG-III, PAP1, Pap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 18489
HGNC: HGNC:8601
Homologene: 130506
Gm10801
Name: predicted gene 10801
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Cass4
Name: Cas scaffolding protein family member 4
Synonyms: F730031O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 320664
Homologene: 75128
Dppa2
Name: developmental pluripotency associated 2
Synonyms: 2410088E07Rik, ECAT15-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 73703
VEGA: 16
Homologene: 79572
Rtraf-ps
Name: RNA transcription, translation and transport factor, pseudogene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 545536
Mybpc1
Name: myosin binding protein C, slow-type
Synonyms: Slow-type C-protein, 8030451F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 109272
HGNC: HGNC:7549
Homologene: 1846
Cps1
Name: carbamoyl-phosphate synthetase 1
Synonyms: CPS, CPSase I, 4732433M03Rik, D1Ucla3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227231
HGNC: HGNC:2323
Homologene: 68208
Celsr3
Name: cadherin, EGF LAG seven-pass G-type receptor 3
Synonyms: Fmi1, flamingo, Adgrc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 107934
HGNC: HGNC:3230
Homologene: 1077
Galnt13
Name: polypeptide N-acetylgalactosaminyltransferase 13
Synonyms: pp-GalNAc-T13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 271786
Homologene: 62167
Vmn2r112
Name: vomeronasal 2, receptor 112
Synonyms: EG628185
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 628185
Homologene: 86604
Vmn2r14
Name: vomeronasal 2, receptor 14
Synonyms: EG231591
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231591
Homologene: 129606
Far2
Name: fatty acyl CoA reductase 2
Synonyms: Mlstd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330450
Homologene: 69247
Fbxw15
Name: F-box and WD-40 domain protein 15
Synonyms: Fbxo12J
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 382105
Homologene: 110776
Lgr5
Name: leucine rich repeat containing G protein coupled receptor 5
Synonyms: Gpr49
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14160
HGNC: HGNC:4504
Homologene: 20807
Syne3
Name: spectrin repeat containing, nuclear envelope family member 3
Synonyms: nesprin-3beta, nesprin-3alpha, nesprin-3, 4831426I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 212073
VEGA: 12
Homologene: 17625
Otud4
Name: OTU domain containing 4
Synonyms: 4930431L18Rik, D8Ertd69e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 73945
Homologene: 35370
Eif2b5
Name: eukaryotic translation initiation factor 2B, subunit 5 epsilon
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224045
HGNC: HGNC:3261
Homologene: 2903
4930447C04Rik
Name: RIKEN cDNA 4930447C04 gene
Synonyms: Six6as, Six6os1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 75801
Homologene: 49922
P2ry12
Name: purinergic receptor P2Y, G-protein coupled 12
Synonyms: P2Y12, 4921504D23Rik, 2900079B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 70839
Homologene: 11260
Prl2c2
Name: prolactin family 2, subfamily c, member 2
Synonyms: MRP-1, PLF-1, Plf, Plf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18811
VEGA: 13
Homologene: 40763
AC115945.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Mrpl42
Name: mitochondrial ribosomal protein L42
Synonyms: MRP-L31, Rpml31, PTD007, HSPC204, 2700009F22Rik, 2900055D03Rik, D10Ertd322e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 67270
VEGA: 10
Homologene: 12106
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 67,143,019 bp
  • A to C, chromosome 1 at 128,300,022 bp
  • A to G, chromosome 2 at 30,395,736 bp
  • G to A, chromosome 2 at 55,098,594 bp
  • C to T, chromosome 2 at 98,663,907 bp
  • T to A, chromosome 2 at 172,424,652 bp
  • C to T, chromosome 3 at 55,472,206 bp
  • T to C, chromosome 3 at 59,217,225 bp
  • T to C, chromosome 3 at 88,576,954 bp
  • T to C, chromosome 4 at 139,460,123 bp
  • C to T, chromosome 4 at 141,167,849 bp
  • T to A, chromosome 5 at 31,245,813 bp
  • C to T, chromosome 5 at 109,216,251 bp
  • TGG to TG, chromosome 5 at 115,088,293 bp
  • A to G, chromosome 6 at 78,372,953 bp
  • G to T, chromosome 6 at 148,173,536 bp
  • A to T, chromosome 7 at 111,779,432 bp
  • T to C, chromosome 8 at 79,669,950 bp
  • A to G, chromosome 9 at 44,317,581 bp
  • A to T, chromosome 9 at 79,617,709 bp
  • G to A, chromosome 9 at 108,835,870 bp
  • G to A, chromosome 9 at 109,558,246 bp
  • C to T, chromosome 10 at 88,529,541 bp
  • T to A, chromosome 10 at 88,570,601 bp
  • C to T, chromosome 10 at 95,493,711 bp
  • T to C, chromosome 10 at 115,478,457 bp
  • A to G, chromosome 12 at 72,898,544 bp
  • A to C, chromosome 12 at 104,975,796 bp
  • G to C, chromosome 13 at 13,002,201 bp
  • A to C, chromosome 14 at 31,067,502 bp
  • G to T, chromosome 15 at 54,749,246 bp
  • C to T, chromosome 15 at 76,854,236 bp
  • C to T, chromosome 15 at 81,895,193 bp
  • C to T, chromosome 16 at 20,504,689 bp
  • A to G, chromosome 16 at 48,311,636 bp
  • C to T, chromosome 17 at 22,618,519 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1321 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039387-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.