Strain Name:
C57BL/6J-MtgxR1341Btlr/Mmmh
Stock Number:
039406-MU
Citation ID:
RRID:MMRRC_039406-MU
Other Names:
R1341 (G1), C57BL/6J-MtgxR1341Btlr
Major Collection:

Strain Information

Cacna1g
Name: calcium channel, voltage-dependent, T type, alpha 1G subunit
Synonyms: a1G, Cav3.1d
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12291
HGNC: HGNC:1394
Homologene: 22544
Spen
Name: spen family transcription repressor
Synonyms: Mint
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56381
Homologene: 124461
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Phr1, C130061D10Rik, Pam
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105689
Homologene: 9005
Usp25
Name: ubiquitin specific peptidase 25
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 30940
VEGA: 16
Homologene: 8374
Rfc1
Name: replication factor C (activator 1) 1
Synonyms: RFC140, Alp145, 140kDa, Recc1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19687
HGNC: HGNC:9969
Homologene: 2187
Chchd6
Name: coiled-coil-helix-coiled-coil-helix domain containing 6
Synonyms: 0710001P09Rik, Micos25, 1700021B03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66098
Homologene: 11920
Tab1
Name: TGF-beta activated kinase 1/MAP3K7 binding protein 1
Synonyms: b2b449Clo, 2310012M03Rik, Map3k7ip1, Tak1-binding protein 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66513
VEGA: 15
Homologene: 4461
Bltp3a
Name: bridge-like lipid transfer protein family member 3A
Synonyms: 1110020K19Rik, Uhrf1bp1, F830021D11Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224648
Homologene: 9816
Cramp1
Name: cramped chromatin regulator 1
Synonyms: 5830477H08Rik, Tce4, Cramp1l
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57354
VEGA: 17
Homologene: 35373
Yy1
Name: YY1 transcription factor
Synonyms: delta transcription factor, Yin Yang 1, UCRBP transcription factor, NF-E1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 22632
Homologene: 2556
Morc2a
Name: microrchidia 2A
Synonyms: Zcwcc1, 8430403M08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74522
Homologene: 8966
Nrbp1
Name: nuclear receptor binding protein 1
Synonyms: Nrbp, B230344L17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 192292
HGNC: HGNC:7993
Homologene: 8373
Mgat5b
Name: mannoside acetylglucosaminyltransferase 5, isoenzyme B
Synonyms: GnT-IX
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268510
Homologene: 27821
Hoxa13
Name: homeobox A13
Synonyms: Hox-1.10
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15398
HGNC: HGNC:5102
Homologene: 73882
Col1a2
Name: collagen, type I, alpha 2
Synonyms: Cola-2, Cola2, Col1a-2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12843
HGNC: HGNC:2198
Homologene: 69
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: Dnahc6, A730004I20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Mmp9
Name: matrix metallopeptidase 9
Synonyms: Gelatinase B, B/MMP9, Clg4b, gelatinase B, MMP-9, Gel B
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17395
HGNC: HGNC:7176
Homologene: 3659
Swsap1
Name: SWIM type zinc finger 7 associated protein 1
Synonyms: 2310047B19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66962
VEGA: 9
Homologene: 18487
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Vmn2r78
Name: vomeronasal 2, receptor 78
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 637896
Homologene: 115466
Rab11fip1
Name: RAB11 family interacting protein 1 (class I)
Synonyms: 4833414G05Rik, 2010200K21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75767
Homologene: 11853
Cep126
Name: centrosomal protein 126
Synonyms: AK129341
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 234915
VEGA: 9
Homologene: 28313
Skint10
Name: selection and upkeep of intraepithelial T cells 10
Synonyms: A030001H23Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230613
Homologene: 136292
Gjb3
Name: gap junction protein, beta 3
Synonyms: Gjb-3, connexin 31, D4Wsu144e, Cx31, Cnx31
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14620
HGNC: HGNC:4285
Homologene: 7338
Cfhr4
Name: complement factor H-related 4
Synonyms: Gm4788
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 214403
HGNC: HGNC:4883
Mmp15
Name: matrix metallopeptidase 15
Synonyms: Membrane type 2-MMP, MT2-MMP
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17388
HGNC: HGNC:7161
Homologene: 20549
Itga10
Name: integrin, alpha 10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213119
HGNC: HGNC:6135
Homologene: 2697
Hdac3
Name: histone deacetylase 3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 15183
HGNC: HGNC:4854
Homologene: 48250
AC168120.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Fbxw15
Name: F-box and WD-40 domain protein 15
Synonyms: Fbxo12J
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382105
Homologene: 110776
Mindy4
Name: MINDY lysine 48 deubiquitinase 4
Synonyms: C330043M08Rik, LOC384387, Fam188b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330323
Homologene: 49991
H2bc13
Name: H2B clustered histone 13
Synonyms: Hist1h2bl
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 319185
Homologene: 136773
Mylip
Name: myosin regulatory light chain interacting protein
Synonyms: Idol, 9430057C20Rik, Mir
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218203
VEGA: 13
Homologene: 8309
Or5t7
Name: olfactory receptor family 5 subfamily T member 17
Synonyms: Olfr1086, GA_x6K02T2Q125-48168771-48167839, MOR179-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258585
Homologene: 73975
Or51k2
Name: olfactory receptor family 51 subfamily K member 2
Synonyms: GA_x6K02T2PBJ9-6681230-6682168, MOR12-5, Olfr633
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258351
Homologene: 27136
Pramel29
Name: PRAME like 29
Synonyms: C87977
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 97187
Homologene: 103830
Zbtb39
Name: zinc finger and BTB domain containing 39
Synonyms: 7030401O21Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320080
VEGA: 10
Homologene: 8890
Or11m3
Name: olfactory receptor family 11 subfamily M member 3
Synonyms: GA_x6K02T2NBG7-5241885-5241019, MOR122-1, Olfr234, Olfr279, GA_x6K02T04SN1-554-3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 258502
Homologene: 74008
Prl2c2
Name: prolactin family 2, subfamily c, member 2
Synonyms: Plf, MRP-1, Plf1, PLF-1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18811
VEGA: 13
Homologene: 40763
Or9k2
Name: olfactory receptor family 9 subfamily K member 2
Synonyms: Olfr825, MOR210-1, GA_x6K02T2PULF-11834065-11833103
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258672
Homologene: 121503
Ccdc190
Name: coiled-coil domain containing 190
Synonyms: 1700084C01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 78465
Homologene: 52274
Or10ak13
Name: olfactory receptor family 10 subfamily AK member 13
Synonyms: MOR259-10, Olfr219-ps1, Olfr1337, GA_x6K02T2QD9B-18767132-18768073, GA_x6K02SYWGW3-414-3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258306
Homologene: 121524
Atp6v0e2
Name: ATPase, H+ transporting, lysosomal V0 subunit E2
Synonyms: 0610006O14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 76252
Homologene: 44221
Nat8f4
Name: N-acetyltransferase 8 (GCN5-related) family member 4
Synonyms: 1700019G17Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 75541
Homologene: 136346
Gm17421
Name: predicted gene, 17421
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Wnt1
Name: wingless-type MMTV integration site family, member 1
Synonyms: Wnt-1, Int-1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22408
Homologene: 3963
Tktl1
Name: transketolase-like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 83553
Homologene: 8169
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 139,732,393 bp
  • A to G, chromosome 1 at 169,930,017 bp
  • T to C, chromosome 2 at 86,677,163 bp
  • A to G, chromosome 2 at 164,949,327 bp
  • A to T, chromosome 3 at 75,429,333 bp
  • G to A, chromosome 3 at 96,652,495 bp
  • A to G, chromosome 4 at 112,765,031 bp
  • T to C, chromosome 4 at 118,782,382 bp
  • G to A, chromosome 4 at 127,326,431 bp
  • T to C, chromosome 4 at 141,469,400 bp
  • T to C, chromosome 4 at 144,207,559 bp
  • T to A, chromosome 5 at 31,245,813 bp
  • A to G, chromosome 5 at 65,291,194 bp
  • G to A, chromosome 6 at 4,518,822 bp
  • A to G, chromosome 6 at 48,540,111 bp
  • CCG to CCGCG, chromosome 6 at 52,260,635 bp
  • A to G, chromosome 6 at 55,255,616 bp
  • A to T, chromosome 6 at 73,191,619 bp
  • A to T, chromosome 6 at 85,901,424 bp
  • A to G, chromosome 6 at 89,384,641 bp
  • T to A, chromosome 7 at 86,922,269 bp
  • T to A, chromosome 7 at 103,947,382 bp
  • G to T, chromosome 8 at 27,143,360 bp
  • A to G, chromosome 8 at 95,372,303 bp
  • G to T, chromosome 9 at 8,099,776 bp
  • A to G, chromosome 9 at 21,957,154 bp
  • G to A, chromosome 9 at 109,558,246 bp
  • A to G, chromosome 10 at 127,743,500 bp
  • G to T, chromosome 10 at 130,163,316 bp
  • C to A, chromosome 11 at 3,680,216 bp
  • T to C, chromosome 11 at 59,029,372 bp
  • A to G, chromosome 11 at 94,433,756 bp
  • A to C, chromosome 11 at 116,978,397 bp
  • T to C, chromosome 12 at 108,793,519 bp
  • A to T, chromosome 12 at 113,369,714 bp
  • G to C, chromosome 13 at 13,002,201 bp
  • T to C, chromosome 13 at 21,716,110 bp
  • T to A, chromosome 13 at 45,405,936 bp
  • T to A, chromosome 14 at 103,298,867 bp
  • A to G, chromosome 15 at 80,160,114 bp
  • G to A, chromosome 15 at 98,498,254 bp
  • T to C, chromosome 15 at 98,791,883 bp
  • A to G, chromosome 16 at 77,115,443 bp
  • T to C, chromosome 17 at 24,977,540 bp
  • T to C, chromosome 17 at 27,877,419 bp
  • A to G, chromosome 18 at 37,954,713 bp
  • G to T, chromosome X at 74,197,683 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1341 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039406-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.