Strain Name:
C57BL/6J-MtgxR1346Btlr/Mmmh
Stock Number:
039411-MU
Citation ID:
RRID:MMRRC_039411-MU
Other Names:
R1346 (G1), C57BL/6J-MtgxR1346Btlr
Major Collection:

Strain Information

Cacng6
Name: calcium channel, voltage-dependent, gamma subunit 6
Synonyms: 2310033H20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 54378
Homologene: 15427
Ppp4c
Name: protein phosphatase 4, catalytic subunit
Synonyms: PPX, 1110002D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56420
HGNC: HGNC:9319
Homologene: 2038
Gart
Name: phosphoribosylglycinamide formyltransferase
Synonyms: Gaps, Prgs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 14450
HGNC: HGNC:4163
Homologene: 637
Timeless
Name: timeless circadian clock 1
Synonyms: tim
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 21853
Homologene: 31206
Rbm25
Name: RNA binding motif protein 25
Synonyms: 2610015J01Rik, A130095G20Rik, 2600011C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 67039
Hspbap1
Name: Hspb associated protein 1
Synonyms: 3830421G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 66667
VEGA: 16
Homologene: 11617
Etl4
Name: enhancer trap locus 4
Synonyms: Etl-4, E330027G05Rik, 6620402G01Rik, 9430077C05Rik, Skt, Sickle tail
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 208618
Homologene: 10477
Akap13
Name: A kinase (PRKA) anchor protein 13
Synonyms: AKAP-Lbc, PROTO-LBC, PROTO-LB, Ht31, 5730522G15Rik, 1700026G02Rik, 5830460E08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 75547
HGNC: HGNC:371
Homologene: 4903
Arfgef1
Name: ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)
Synonyms: D730028O18Rik, ARFGEP1, P200, BIG1, D130059B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 211673
Homologene: 4687
Tlr2
Name: toll-like receptor 2
Synonyms: Ly105
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 24088
Homologene: 20695
Bdp1
Name: B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
Synonyms: TFIIIB150, TFIIIB90, TAF3B1, TFC5, Tfnr, G630013P12Rik, B130055N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 544971
Homologene: 34582
Furin
Name: furin (paired basic amino acid cleaving enzyme)
Synonyms: Fur, PACE, SPC1, Pcsk3, 9130404I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18550
HGNC: HGNC:8568
Homologene: 1930
Eif3d
Name: eukaryotic translation initiation factor 3, subunit D
Synonyms: mouse translation initiation factor eIF3 p66, eIF3p66, 66/67kDa, Eif3s7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 55944
VEGA: 15
HGNC: HGNC:3278
Homologene: 2782
Zfp592
Name: zinc finger protein 592
Synonyms: A730014M16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233410
Homologene: 8759
Atf7ip2
Name: activating transcription factor 7 interacting protein 2
Synonyms: 4930558K11Rik, PSM2, Get-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 75329
Homologene: 23509
Pla2g4e
Name: phospholipase A2, group IVE
Synonyms: 2310026J01Rik, Pla2epsilon
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329502
Homologene: 65339
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: CD91, A2mr, b2b1554Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Arap3
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
Synonyms: DRAG1, E030006K04Rik, Centd3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 106952
VEGA: 18
Homologene: 11199
Camta2
Name: calmodulin binding transcription activator 2
Synonyms: Kiaa0909-hp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216874
Homologene: 9021
Stard9
Name: START domain containing 9
Synonyms: N-3 kinesin, Kif16a, 4831403C07Rik, E230025N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 668880
Homologene: 130712
Stx2
Name: syntaxin 2
Synonyms: Epim, G1-536-1, repro34, Syn-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13852
HGNC: HGNC:3403
Homologene: 37559
Kcnh2
Name: potassium voltage-gated channel, subfamily H (eag-related), member 2
Synonyms: merg1a, ether a go-go related, M-erg, LQT, Lqt2, ERG1, merg1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16511
HGNC: HGNC:6251
Homologene: 201
Slc25a32
Name: solute carrier family 25, member 32
Synonyms: 2610043O12Rik, Mftc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 69906
VEGA: 15
Homologene: 6151
Parp9
Name: poly (ADP-ribose) polymerase family, member 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 80285
Homologene: 12720
3425401B19Rik
Name: RIKEN cDNA 3425401B19 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 100504518
VEGA: 14
Homologene: 54908
Skida1
Name: SKI/DACH domain containing 1
Synonyms: 5730507N06Rik, 2810030E01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 72668
Homologene: 66327
Catsperg1
Name: cation channel sperm associated auxiliary subunit gamma 1
Synonyms: A230107C01Rik, Catsperg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 320225
Homologene: 10915
Dyrk2
Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
Synonyms: 1810038L18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 69181
VEGA: 10
HGNC: HGNC:3093
Homologene: 48437
Sema4g
Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 26456
Homologene: 22682
Chrng
Name: cholinergic receptor, nicotinic, gamma polypeptide
Synonyms: Achr-3, Acrg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11449
HGNC: HGNC:1967
Homologene: 3810
Ak5
Name: adenylate kinase 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229949
HGNC: HGNC:365
Homologene: 76103
Gm572
Name: predicted gene 572
Synonyms: LOC230909, b2b1167Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230909
Homologene: 52134
Chfr
Name: checkpoint with forkhead and ring finger domains
Synonyms: RNF116, 5730484M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231600
Homologene: 10078
Cnn2
Name: calponin 2
Synonyms: h2-calponin, Calpo2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12798
HGNC: HGNC:2156
Homologene: 3215
Kcnrg
Name: potassium channel regulator
Synonyms: LOC328424, E030012H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 328424
VEGA: 14
Homologene: 35259
Cers4
Name: ceramide synthase 4
Synonyms: 2900019C14Rik, Trh1, CerS4, Lass4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67260
Homologene: 11582
Rab3c
Name: RAB3C, member RAS oncogene family
Synonyms: 3110037E15Rik, 3110015B08Rik, 2700062I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67295
VEGA: 13
Homologene: 23420
Lhx1
Name: LIM homeobox protein 1
Synonyms: Lim1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16869
HGNC: HGNC:6593
Homologene: 4068
Elovl7
Name: ELOVL family member 7, elongation of long chain fatty acids (yeast)
Synonyms: 9130013K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 74559
VEGA: 13
Homologene: 23672
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 10,159,733 bp
  • C to A, chromosome 1 at 87,208,263 bp
  • T to C, chromosome 2 at 18,048,279 bp
  • T to C, chromosome 2 at 20,806,144 bp
  • G to A, chromosome 2 at 120,182,772 bp
  • T to C, chromosome 2 at 120,713,448 bp
  • T to A, chromosome 3 at 83,836,593 bp
  • G to T, chromosome 3 at 152,533,434 bp
  • G to A, chromosome 4 at 148,654,897 bp
  • T to C, chromosome 5 at 24,322,660 bp
  • A to G, chromosome 5 at 110,140,447 bp
  • G to A, chromosome 5 at 128,988,788 bp
  • G to T, chromosome 7 at 3,434,922 bp
  • A to T, chromosome 7 at 29,182,334 bp
  • G to A, chromosome 7 at 75,609,592 bp
  • C to T, chromosome 7 at 80,392,184 bp
  • A to T, chromosome 7 at 81,038,064 bp
  • C to T, chromosome 7 at 126,792,050 bp
  • A to G, chromosome 8 at 4,515,632 bp
  • T to C, chromosome 10 at 79,993,580 bp
  • T to C, chromosome 10 at 118,859,719 bp
  • T to C, chromosome 10 at 127,605,866 bp
  • C to T, chromosome 10 at 128,242,365 bp
  • T to C, chromosome 11 at 70,676,467 bp
  • T to C, chromosome 11 at 84,522,079 bp
  • T to C, chromosome 12 at 83,644,393 bp
  • G to A, chromosome 13 at 100,078,755 bp
  • A to G, chromosome 13 at 108,274,349 bp
  • G to A, chromosome 13 at 110,260,586 bp
  • C to A, chromosome 14 at 32,660,814 bp
  • A to G, chromosome 14 at 61,611,695 bp
  • T to A, chromosome 15 at 39,100,016 bp
  • A to G, chromosome 15 at 77,968,554 bp
  • G to A, chromosome 16 at 10,234,331 bp
  • G to A, chromosome 16 at 35,801,665 bp
  • A to T, chromosome 16 at 35,956,897 bp
  • G to T, chromosome 16 at 91,628,182 bp
  • A to T, chromosome 18 at 37,975,918 bp
  • T to A, chromosome 19 at 44,997,652 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1346 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039411-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.