Strain Name:
C57BL/6J-MtgxR1365Btlr/Mmmh
Stock Number:
039430-MU
Citation ID:
RRID:MMRRC_039430-MU
Other Names:
R1365 (G1), C57BL/6J-MtgxR1365Btlr
Major Collection:

Strain Information

Uchl3
Name: ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 50933
VEGA: 14
Homologene: 4377
Dst
Name: dystonin
Synonyms: BPAG1-n, BPAG1, 2310001O04Rik, bullous pemphigoid antigen 1, athetoid, nmf203, Macf2, ah, A830042E19Rik, Bpag1, nmf339, Bpag, bullous pemphigoid antigen 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Med1
Name: mediator complex subunit 1
Synonyms: TRAP 220, Pparbp, DRIP205, CRSP210, l11Jus15, TRAP220, PBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19014
HGNC: HGNC:9234
Homologene: 21002
Itch
Name: itchy, E3 ubiquitin protein ligase
Synonyms: 6720481N21Rik, 8030492O04Rik, C230047C07Rik, AIP4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16396
Homologene: 88442
Trmo
Name: tRNA methyltransferase O
Synonyms: 5830415F09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74753
Homologene: 32316
Usp14
Name: ubiquitin specific peptidase 14
Synonyms: dUB-type TGT, nmf375, ax, ataxia, NMF375, 2610005K12Rik, 2610037B11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 59025
Homologene: 3780
Nf1
Name: neurofibromin 1
Synonyms: Dsk9, Nf-1, neurofibromin, Mhdadsk9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18015
HGNC: HGNC:7765
Homologene: 226
Gtpbp4
Name: GTP binding protein 4
Synonyms: 2610028C09Rik, Nog1, Crfg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 69237
VEGA: 13
Homologene: 7100
Sin3a
Name: transcriptional regulator, SIN3A (yeast)
Synonyms: mSin3A, Sin3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20466
Homologene: 32124
Pid1
Name: phosphotyrosine interaction domain containing 1
Synonyms: 5033414K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98496
Homologene: 9924
Brca1
Name: breast cancer 1, early onset
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12189
HGNC: HGNC:1100
Homologene: 5276
Plk1
Name: polo like kinase 1
Synonyms: STPK13, Plk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18817
HGNC: HGNC:9077
Homologene: 3690
Rps24
Name: ribosomal protein S24
Synonyms: MRP S24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 20088
VEGA: 14
Homologene: 68148
Slf1
Name: SMC5-SMC6 complex localization factor 1
Synonyms: 2700017A04Rik, Brctd1, C730024G01Rik, Ankrd32, Brctx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105377
Homologene: 13000
Gtf2b
Name: general transcription factor IIB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229906
HGNC: HGNC:4648
Homologene: 1158
Sem1
Name: SEM1, 26S proteasome complex subunit
Synonyms: Shfg, Shfdg1, DSS1, Shfm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20422
Homologene: 38165
Dars2
Name: aspartyl-tRNA synthetase 2 (mitochondrial)
Synonyms: 5830468K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226539
Homologene: 7093
Zfp979
Name: zinc finger protein 979
Synonyms: Ssm1, 2610305D13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 112422
Homologene: 133076
Vps13a
Name: vacuolar protein sorting 13A
Synonyms: D330038K10Rik, 4930516E05Rik, 4930543C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 271564
VEGA: 19
HGNC: HGNC:1908
Homologene: 22068
Arhgef28
Name: Rho guanine nucleotide exchange factor 28
Synonyms: p190RhoGEF, D13Bwg1089e, RIP2, RhoGEF, Rgnef, 9230110L08Rik, Rho specific exchange factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 110596
VEGA: 13
Homologene: 8078
Zfp804a
Name: zinc finger protein 804A
Synonyms: C630007C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241514
Homologene: 18461
Mfsd13a
Name: major facilitator superfamily domain containing 13a
Synonyms: 4930449A08Rik, 4930538D17Rik, Tmem180
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 75146
Homologene: 12592
Cog2
Name: component of oligomeric golgi complex 2
Synonyms: 2700012E02Rik, Cog2, 1190002B08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 76332
HGNC: HGNC:6546
Homologene: 7206
Fanca
Name: Fanconi anemia, complementation group A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14087
HGNC: HGNC:3582
Homologene: 108
Hsf4
Name: heat shock transcription factor 4
Synonyms: ldis1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 26386
HGNC: HGNC:5227
Homologene: 100128
Mamdc4
Name: MAM domain containing 4
Synonyms: LOC381352
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 381352
Homologene: 17102
Asb15
Name: ankyrin repeat and SOCS box-containing 15
Synonyms: 4930400E23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 78910
Homologene: 43797
Cd48
Name: CD48 antigen
Synonyms: BCM1, BLAST-1, Sgp-60, Bcm-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12506
HGNC: HGNC:1683
Homologene: 1347
Kif28
Name: kinesin family member 28
Synonyms: Gm1305, LOC383592
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 383592
Homologene: 130945
Rasl10b
Name: RAS-like, family 10, member B
Synonyms: B230331P10Rik, VTS58635
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 276952
Homologene: 14108
Oxct2b
Name: 3-oxoacid CoA transferase 2B
Synonyms: Scot-t2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 353371
Homologene: 137359
Vmn1r203
Name: vomeronasal 1 receptor 203
Synonyms: V1rh11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171270
Homologene: 110880
Epn1
Name: epsin 1
Synonyms: Ibp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13854
Homologene: 32172
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 34,188,194 bp
  • T to C, chromosome 1 at 84,038,141 bp
  • G to A, chromosome 1 at 161,044,994 bp
  • A to T, chromosome 1 at 171,699,561 bp
  • G to A, chromosome 1 at 179,739,987 bp
  • T to C, chromosome 2 at 25,566,024 bp
  • T to C, chromosome 2 at 82,257,246 bp
  • A to G, chromosome 2 at 155,213,031 bp
  • T to C, chromosome 3 at 142,771,466 bp
  • A to G, chromosome 4 at 46,380,278 bp
  • G to A, chromosome 4 at 123,117,369 bp
  • A to T, chromosome 4 at 147,613,224 bp
  • T to C, chromosome 6 at 6,560,501 bp
  • T to C, chromosome 6 at 24,567,270 bp
  • G to A, chromosome 7 at 5,093,370 bp
  • A to G, chromosome 7 at 122,168,629 bp
  • G to T, chromosome 8 at 105,271,094 bp
  • G to A, chromosome 8 at 123,304,281 bp
  • A to T, chromosome 8 at 124,540,974 bp
  • C to T, chromosome 9 at 57,125,203 bp
  • A to G, chromosome 11 at 79,547,885 bp
  • G to A, chromosome 11 at 83,417,839 bp
  • T to C, chromosome 11 at 98,155,995 bp
  • T to C, chromosome 11 at 101,501,996 bp
  • T to G, chromosome 13 at 8,992,819 bp
  • T to A, chromosome 13 at 22,524,586 bp
  • C to T, chromosome 13 at 77,126,371 bp
  • G to A, chromosome 13 at 98,075,124 bp
  • A to G, chromosome 14 at 24,491,762 bp
  • A to G, chromosome 14 at 101,654,092 bp
  • C to T, chromosome 18 at 10,000,490 bp
  • A to G, chromosome 19 at 16,619,446 bp
  • C to T, chromosome 19 at 46,366,504 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1365 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039430-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.