Strain Name:
C57BL/6J-MtgxR1368Btlr/Mmmh
Stock Number:
039433-MU
Citation ID:
RRID:MMRRC_039433-MU
Other Names:
R1368 (G1), C57BL/6J-MtgxR1368Btlr
Major Collection:

Strain Information

Rgs9
Name: regulator of G-protein signaling 9
Synonyms: Rgs9-2, RGS9-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19739
Homologene: 2845
Cxcl12
Name: chemokine (C-X-C motif) ligand 12
Synonyms: Sdf1b, Sdf1a, SDF-1, PBSF/SDF-1, PBSF, TLSF-b, TLSF-a, TPAR1, Sdf1, Scyb12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20315
Homologene: 128606
Sema3c
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
Synonyms: Semae, 1110036B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20348
Homologene: 36201
Slc32a1
Name: solute carrier family 32 (GABA vesicular transporter), member 1
Synonyms: R75019, VGAT, Viaat
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22348
Homologene: 56451
Serpinc1
Name: serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1
Synonyms: antithrombin, ATIII, At-3, At3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11905
HGNC: HGNC:775
Homologene: 20139
Gnaq
Name: guanine nucleotide binding protein, alpha q polypeptide
Synonyms: G alpha q, Gq, Galphaq, 6230401I02Rik, 1110005L02Rik, Dsk10, Dsk1, GqI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 14682
HGNC: HGNC:4390
Homologene: 1566
Abcc8
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 8
Synonyms: SUR1, Sur, D930031B21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20927
HGNC: HGNC:59
Homologene: 68048
Scn8a
Name: sodium channel, voltage-gated, type VIII, alpha
Synonyms: med, seal, motor end-plate disease, nmf2, ataxia 3, mnd2, mnd-2, C630029C19Rik, nmf58, NaCh6, Nav1.6, nmf335, NMF335, nur14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20273
Homologene: 7927
Psmd3
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
Synonyms: AntP91a, Psd3, Tstap91a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 22123
HGNC: HGNC:9560
Homologene: 2102
Cep290
Name: centrosomal protein 290
Synonyms: Nphp6, b2b1454Clo, b2b1752Clo, Kiaa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216274
VEGA: 10
Homologene: 77213
Cct8
Name: chaperonin containing Tcp1, subunit 8 (theta)
Synonyms: Cctq, Tcpq
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 12469
HGNC: HGNC:1623
Homologene: 4802
Gpatch2l
Name: G patch domain containing 2 like
Synonyms: 1700020O03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 70373
VEGA: 12
Homologene: 9942
Cnn3
Name: calponin 3, acidic
Synonyms: 1600014M03Rik, Calpo3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 71994
HGNC: HGNC:2157
Homologene: 37533
Cog4
Name: component of oligomeric golgi complex 4
Synonyms: D8Ertd515e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102339
Homologene: 7155
Rad50
Name: RAD50 double strand break repair protein
Synonyms: Rad50l, Mrell
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19360
HGNC: HGNC:9816
Homologene: 38092
Stxbp3
Name: syntaxin binding protein 3
Synonyms: Munc-18c, Stxbp3, Stxbp3a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20912
Homologene: 5260
Smc5
Name: structural maintenance of chromosomes 5
Synonyms: Smc5l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226026
VEGA: 19
Homologene: 41009
Eif2b2
Name: eukaryotic translation initiation factor 2B, subunit 2 beta
Synonyms: EIF-2Bbeta, EIF2B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217715
HGNC: HGNC:3258
Homologene: 6507
Ror1
Name: receptor tyrosine kinase-like orphan receptor 1
Synonyms: Ntrkr1, 2810404D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 26563
Homologene: 3675
Lig4
Name: ligase IV, DNA, ATP-dependent
Synonyms: DNA ligase IV, 5830471N16Rik, tiny
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 319583
HGNC: HGNC:6601
Homologene: 1736
Psmg2
Name: proteasome (prosome, macropain) assembly chaperone 2
Synonyms: 1700017I17Rik, Clast3, Tnfsf5ip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 107047
VEGA: 18
Homologene: 41354
Cdh9
Name: cadherin 9
Synonyms: T1-cadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12565
HGNC: HGNC:1768
Homologene: 9450
Tspan3
Name: tetraspanin 3
Synonyms: TM4-A, Tspan-3, tetraspanin, tetraspanin TM4-A homolog, 1700055K04Rik, Tm4sf8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56434
VEGA: 9
Homologene: 21168
Pdcd2
Name: programmed cell death 2
Synonyms: RP-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18567
HGNC: HGNC:8762
Homologene: 1951
Abca13
Name: ATP-binding cassette, sub-family A (ABC1), member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268379
Homologene: 27991
Pigg
Name: phosphatidylinositol glycan anchor biosynthesis, class G
Synonyms: Gpi7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 433931
Homologene: 39421
9930021J03Rik
Name: RIKEN cDNA 9930021J03 gene
Synonyms: Gm9832
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 240613
Homologene: 19046
Fcgbpl1
Name: Fc fragment of IgG binding protein like 1
Synonyms: 9530053A07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 319482
Homologene: 130055
Mfsd6
Name: major facilitator superfamily domain containing 6
Synonyms: 9630025I22Rik, MMR2, 2210010L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98682
Homologene: 9784
Unc79
Name: unc-79 homolog
Synonyms: 9030205A07Rik, Mlca3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217843
Homologene: 41397
Atp10b
Name: ATPase, class V, type 10B
Synonyms: 5930426O13Rik, 9030605H24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 319767
Homologene: 70969
Rsad2
Name: radical S-adenosyl methionine domain containing 2
Synonyms: Vig1, cig5, 2510004L01Rik, viperin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 58185
Homologene: 10969
Topaz1
Name: testis and ovary specific PAZ domain containing 1
Synonyms: Gm9524
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 671232
VEGA: 9
Homologene: 19835
Ppp3cc
Name: protein phosphatase 3, catalytic subunit, gamma isoform
Synonyms: PP2BA gamma, Calnc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 19057
VEGA: 14
HGNC: HGNC:9316
Homologene: 68475
Psg23
Name: pregnancy-specific beta-1-glycoprotein 23
Synonyms: 1620401C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56868
Homologene: 110989
Fanca
Name: Fanconi anemia, complementation group A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14087
HGNC: HGNC:3582
Homologene: 108
Tll2
Name: tolloid-like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 24087
VEGA: 19
Homologene: 56545
Ugt1a6b
Name: UDP glucuronosyltransferase 1 family, polypeptide A6B
Synonyms: A9'
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 394435
Homologene: 85959
Gm7647
Name: predicted gene 7647
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 108169099
Gabbr2
Name: gamma-aminobutyric acid (GABA) B receptor, 2
Synonyms: Gababr2, LOC242425, Gpr51, GB2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242425
HGNC: HGNC:4507
Homologene: 55902
Muc3
Name: mucin 3, intestinal
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 666339
Homologene: 141159
Fktn
Name: fukutin
Synonyms: Fukutin, Fcmd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 246179
HGNC: HGNC:3622
Homologene: 31402
Mpz
Name: myelin protein zero
Synonyms: P0, Mpp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17528
HGNC: HGNC:7225
Homologene: 445
Vmn1r19
Name: vomeronasal 1 receptor 19
Synonyms: V1rc27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 171200
Homologene: 134034
Rasl10b
Name: RAS-like, family 10, member B
Synonyms: VTS58635, B230331P10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 276952
Homologene: 14108
Slc25a11
Name: solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11
Synonyms: 2310022P18Rik, 2oxoc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67863
Homologene: 2637
Gzmg
Name: granzyme G
Synonyms: Ctla-7, Ctla7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14944
VEGA: 14
HGNC: HGNC:4709
Homologene: 133275
Or2f1b
Name: olfactory receptor family 2 subfamily F member 1B
Synonyms: 18A, MOR257-2, GA_x6K02T2P3E9-4797841-4796888, Olfr38
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258988
Homologene: 72050
Entrep2
Name: endosomal transmembrane epsin interactor 2
Synonyms: 5730507A09Rik, Fam189a1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70638
Homologene: 77705
C130073F10Rik
Name: RIKEN cDNA C130073F10 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242574
Chrng
Name: cholinergic receptor, nicotinic, gamma polypeptide
Synonyms: Achr-3, Acrg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11449
HGNC: HGNC:1967
Homologene: 3810
Prl3b1
Name: prolactin family 3, subfamily b, member 1
Synonyms: Pl-2, Pl2, mplII, PL, prolactin-like, Csh2, mPL-II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18776
HGNC: HGNC:9445
Homologene: 7476
Ptgdr
Name: prostaglandin D receptor
Synonyms: DP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 19214
HGNC: HGNC:9591
Homologene: 736
Ikzf2
Name: IKAROS family zinc finger 2
Synonyms: Helios, Zfpn1a2, A730095J18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22779
Homologene: 22659
Sike1
Name: suppressor of IKBKE 1
Synonyms: 2810005O12Rik, 5730470L24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66641
Homologene: 32622
Gm5622
Name: predicted gene 5622
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 434459
Homologene: 115686
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 52,708,605 bp
  • G to A, chromosome 1 at 69,539,315 bp
  • T to A, chromosome 1 at 87,205,853 bp
  • T to C, chromosome 1 at 88,107,636 bp
  • T to A, chromosome 1 at 160,993,524 bp
  • T to C, chromosome 1 at 171,159,964 bp
  • A to G, chromosome 2 at 158,611,320 bp
  • A to G, chromosome 3 at 102,996,184 bp
  • A to G, chromosome 3 at 108,826,000 bp
  • T to C, chromosome 3 at 121,457,137 bp
  • T to C, chromosome 4 at 46,674,464 bp
  • G to A, chromosome 4 at 53,734,880 bp
  • C to T, chromosome 4 at 100,441,137 bp
  • T to A, chromosome 4 at 101,890,756 bp
  • A to G, chromosome 5 at 17,678,332 bp
  • T to C, chromosome 5 at 94,962,980 bp
  • G to T, chromosome 5 at 108,317,288 bp
  • T to C, chromosome 5 at 137,146,826 bp
  • C to A, chromosome 6 at 42,762,679 bp
  • T to C, chromosome 6 at 57,404,671 bp
  • A to G, chromosome 6 at 117,176,150 bp
  • A to G, chromosome 7 at 18,614,720 bp
  • A to G, chromosome 7 at 28,159,478 bp
  • G to A, chromosome 7 at 46,122,860 bp
  • A to T, chromosome 7 at 64,819,877 bp
  • T to C, chromosome 8 at 9,971,176 bp
  • A to G, chromosome 8 at 110,858,525 bp
  • G to A, chromosome 8 at 123,304,281 bp
  • A to T, chromosome 9 at 56,147,499 bp
  • A to G, chromosome 9 at 122,748,250 bp
  • C to T, chromosome 10 at 100,494,966 bp
  • A to G, chromosome 11 at 9,291,836 bp
  • A to G, chromosome 11 at 43,202,154 bp
  • T to A, chromosome 11 at 53,683,245 bp
  • T to A, chromosome 11 at 70,645,526 bp
  • G to A, chromosome 11 at 83,417,839 bp
  • A to G, chromosome 11 at 98,682,920 bp
  • G to A, chromosome 11 at 109,248,151 bp
  • T to C, chromosome 12 at 26,447,148 bp
  • G to A, chromosome 12 at 85,223,456 bp
  • T to G, chromosome 12 at 86,260,665 bp
  • A to G, chromosome 12 at 103,156,513 bp
  • G to A, chromosome 13 at 27,243,865 bp
  • T to A, chromosome 14 at 44,853,342 bp
  • T to A, chromosome 14 at 51,662,190 bp
  • G to A, chromosome 14 at 56,157,806 bp
  • T to C, chromosome 14 at 70,245,862 bp
  • T to A, chromosome 15 at 16,848,482 bp
  • A to G, chromosome 15 at 101,035,541 bp
  • G to A, chromosome 16 at 87,491,312 bp
  • G to T, chromosome 17 at 15,526,584 bp
  • CTTCAGTT to CTTCAGTTCAGTT, chromosome 18 at 67,646,025 bp
  • T to C, chromosome 19 at 16,378,287 bp
  • A to G, chromosome 19 at 23,210,443 bp
  • C to A, chromosome 19 at 29,716,396 bp
  • G to A, chromosome 19 at 41,120,228 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1368 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039433-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.