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Strain Name:
C57BL/6J-MtgxR1378Btlr/Mmmh
Stock Number:
039442-MU
Citation ID:
RRID:MMRRC_039442-MU
Other Names:
R1378 (G1), C57BL/6J-MtgxR1378Btlr
Major Collection:

Strain Information

Dop1b
Name: DOP1 leucine zipper like protein B
Synonyms: 0610038M01Rik, 2610510B01Rik, Dopey2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70028
VEGA: 16
HGNC: HGNC:1291
Homologene: 21068
Dgka
Name: diacylglycerol kinase, alpha
Synonyms: Dagk1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13139
VEGA: 10
HGNC: HGNC:2849
Homologene: 1028
Elp3
Name: elongator acetyltransferase complex subunit 3
Synonyms: 2610507P14Rik, KAT9
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 74195
VEGA: 14
Homologene: 7105
Vps35l
Name: VPS35 endosomal protein sorting factor like
Synonyms: 9030624J02Rik, Vsp35l
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71517
Homologene: 10659
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: apollon, Bruce, A430032G04Rik, D630005A10Rik, A430040A19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12211
Homologene: 7248
Brwd1
Name: bromodomain and WD repeat domain containing 1
Synonyms: 5330419I02Rik, D530019K20Rik, G1-403-16, Wdr9, repro5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 93871
Homologene: 23130
Sel1l
Name: sel-1 suppressor of lin-12-like (C. elegans)
Synonyms: Sel1h
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20338
Homologene: 31286
Nsmce4a
Name: NSE4 homolog A, SMC5-SMC6 complex component
Synonyms: 2410003A14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67872
Homologene: 9745
Cct7
Name: chaperonin containing TCP1 subunit 7
Synonyms: Cctz, Ccth
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12468
HGNC: HGNC:1622
Homologene: 4694
Ralgapa1
Name: Ral GTPase activating protein, alpha subunit 1
Synonyms: 4930400K19Rik, Tulip1, 2310003F20Rik, Garnl1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56784
VEGA: 12
Homologene: 84805
Afap1
Name: actin filament associated protein 1
Synonyms: 9630044L16Rik, 2600003E23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70292
Homologene: 11009
Cul7
Name: cullin 7
Synonyms: p193, 2510004L20Rik, p185, C230011P08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66515
Homologene: 56683
Clu
Name: clusterin
Synonyms: testosterone repressed prostate message-2, SP-40, complement lysis inhibitor, Sgp-2, ApoJ, Apolipoprotein J, Cli, Sugp-2, Sgp2, D14Ucla3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12759
HGNC: HGNC:2095
Homologene: 1382
Chrne
Name: cholinergic receptor, nicotinic, epsilon polypeptide
Synonyms: Acre, AChrepsilon
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11448
HGNC: HGNC:1966
Homologene: 60
Tex15
Name: testis expressed gene 15 meiosis and synapsis associated
Synonyms: 2210014E14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 104271
Homologene: 12837
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Acz, Pico
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26875
Homologene: 69111
Gvin3
Name: GTPase, very large interferon inducible, family member 3
Synonyms: Gm1966
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434223
Homologene: 32708
Tro
Name: trophinin
Synonyms: necdin and trophinin like, Tnn, trophinin-2, magphinin-gamma, magphinin-beta 2, magphinin-alpha, magphinin, Maged3l, Maged3, Trol
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 56191
Homologene: 75113
Il23r
Name: interleukin 23 receptor
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 209590
Homologene: 16930
Faap24
Name: Fanconi anemia core complex associated protein 24
Synonyms: C230052I12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101831
Homologene: 17535
Clstn3
Name: calsyntenin 3
Synonyms: Cst-3, CSTN3, alcadein-beta, Clstn3b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232370
Homologene: 22836
Or52s1b
Name: olfactory receptor family 52 subfamily S member 1B
Synonyms: GA_x6K02T2PBJ9-5889409-5888465, MOR24-1P, Olfr591
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258139
Homologene: 79429
Atp13a4
Name: ATPase type 13A4
Synonyms: 4631413J11Rik, 9330174J19Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224079
Homologene: 75330
Nell2
Name: NEL-like 2
Synonyms: mel91, A330108N19Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 54003
VEGA: 15
HGNC: HGNC:7751
Homologene: 4488
Tmem132d
Name: transmembrane protein 132D
Synonyms: C630028F04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243274
Homologene: 71684
Ppp4r4
Name: protein phosphatase 4, regulatory subunit 4
Synonyms: 8430415E04Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74521
Homologene: 12571
Nlrp4d
Name: NLR family, pyrin domain containing 4D
Synonyms: Nalp-beta, Nalp4d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 384752
Klra17
Name: killer cell lectin-like receptor, subfamily A, member 17
Synonyms: Ly49q1, Ly-49Q, Ly49Q
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 170733
Ift22
Name: intraflagellar transport 22
Synonyms: 3110017O03Rik, Rabl5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67286
Homologene: 11253
Cenpb
Name: centromere protein B
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12616
HGNC: HGNC:1852
Homologene: 1370
Vmn2r7
Name: vomeronasal 2, receptor 7
Synonyms: 4933425M15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 319217
Homologene: 129754
Unc45b
Name: unc-45 myosin chaperone B
Synonyms: UNC45, D230041A13Rik, Cmya4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217012
Homologene: 14666
Brinp2
Name: bone morphogenic protein/retinoic acid inducible neural-specific 2
Synonyms: 6430517E21Rik, Fam5b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240843
Homologene: 10905
Fam13a
Name: family with sequence similarity 13, member A
Synonyms: D430015B01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58909
Homologene: 135847
Gsdmc3
Name: gasdermin C3
Synonyms: 9930109F21Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 270328
HGNC: HGNC:7151
Homologene: 69487
Zfp174
Name: zinc finger protein 174
Synonyms: LOC385674
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 385674
Homologene: 55755
Edn2
Name: endothelin 2
Synonyms: VIC, vasoactive intestinal contractor peptide
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13615
HGNC: HGNC:3177
Homologene: 1477
Rad18
Name: RAD18 E3 ubiquitin protein ligase
Synonyms: 2810024C04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58186
Homologene: 48572
Rem1
Name: rad and gem related GTP binding protein 1
Synonyms: E030011C07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19700
Homologene: 7514
Or10d4
Name: olfactory receptor family 10 subfamily D member 4
Synonyms: GA_x6K02T2PVTD-33365879-33366814, MOR224-7P, MOR224-13, Olfr963
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258087
VEGA: 9
Homologene: 105216
Or4p8
Name: olfactory receptor family 4 subfamily P member 8
Synonyms: GA_x6K02T2Q125-50372411-50371485, MOR225-4, Olfr1208
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258774
Homologene: 74190
Gm9944
Name: predicted gene 9944
Type: Gene
Species: Mouse
Chromosome: 4
Or52z14
Name: olfactory receptor family 52 subfamily Z member 14
Synonyms: GA_x6K02T2PBJ9-6326488-6327450, MOR31-5, Olfr619
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259080
Homologene: 45095
Ccdc153
Name: coiled-coil domain containing 153
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270150
VEGA: 9
Homologene: 26818
Tubg2
Name: tubulin, gamma 2
Synonyms: Tubgl
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103768
Homologene: 69216
Alg1
Name: ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase
Synonyms: HMT1, HMAT1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208211
Homologene: 5387
Cstdc5
Name: cystatin domain containing 5
Synonyms: BC100530
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 100034684
HGNC: HGNC:2481
Homologene: 104045
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 158,247,054 bp
  • T to A, chromosome 2 at 88,897,026 bp
  • C to T, chromosome 2 at 131,178,310 bp
  • G to A, chromosome 2 at 152,634,535 bp
  • A to G, chromosome 3 at 55,049,729 bp
  • A to G, chromosome 3 at 64,691,604 bp
  • A to G, chromosome 4 at 120,161,898 bp
  • T to A, chromosome 4 at 144,453,203 bp
  • T to C, chromosome 5 at 14,682,313 bp
  • A to G, chromosome 5 at 35,968,686 bp
  • A to T, chromosome 5 at 128,268,947 bp
  • A to C, chromosome 5 at 136,912,903 bp
  • T to G, chromosome 6 at 5,230,813 bp
  • T to A, chromosome 6 at 58,956,751 bp
  • T to A, chromosome 6 at 67,452,410 bp
  • T to A, chromosome 6 at 85,467,563 bp
  • T to C, chromosome 6 at 112,681,336 bp
  • T to A, chromosome 6 at 124,438,419 bp
  • T to A, chromosome 6 at 129,865,684 bp
  • C to A, chromosome 7 at 10,364,184 bp
  • T to C, chromosome 7 at 35,392,901 bp
  • T to C, chromosome 7 at 103,173,268 bp
  • A to T, chromosome 7 at 103,603,938 bp
  • T to A, chromosome 7 at 106,602,166 bp
  • G to T, chromosome 7 at 118,794,572 bp
  • A to T, chromosome 7 at 118,794,573 bp
  • C to T, chromosome 7 at 130,538,170 bp
  • A to T, chromosome 8 at 33,575,216 bp
  • T to C, chromosome 9 at 39,669,666 bp
  • C to G, chromosome 9 at 44,243,661 bp
  • T to C, chromosome 10 at 128,735,827 bp
  • T to A, chromosome 11 at 70,615,130 bp
  • G to A, chromosome 11 at 82,936,852 bp
  • G to T, chromosome 11 at 101,156,873 bp
  • T to C, chromosome 12 at 55,676,926 bp
  • T to C, chromosome 12 at 91,833,097 bp
  • T to C, chromosome 12 at 103,581,492 bp
  • T to C, chromosome 14 at 65,592,931 bp
  • G to T, chromosome 14 at 65,974,901 bp
  • T to C, chromosome 15 at 63,859,586 bp
  • A to T, chromosome 15 at 95,232,521 bp
  • G to A, chromosome 16 at 3,849,489 bp
  • A to G, chromosome 16 at 5,243,716 bp
  • A to T, chromosome 16 at 29,420,428 bp
  • A to G, chromosome 16 at 36,359,567 bp
  • A to G, chromosome 16 at 93,770,392 bp
  • A to T, chromosome 16 at 96,041,370 bp
  • C to T, chromosome 17 at 46,662,126 bp
  • T to A, chromosome 17 at 74,660,455 bp
  • G to T, chromosome X at 150,655,571 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1378 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039442-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.