Strain Name:
C57BL/6J-MtgxR1392Btlr/Mmmh
Stock Number:
039454-MU
Citation ID:
RRID:MMRRC_039454-MU
Other Names:
R1392 (G1), C57BL/6J-MtgxR1392Btlr
Major Collection:

Gene Information

Rtn4rl2
Name: reticulon 4 receptor-like 2
Synonyms: Ngr2, Ngrh1, Ngrl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269295
Homologene: 18683
Hunk
Name: hormonally upregulated Neu-associated kinase
Synonyms: Mak-v, Bstk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 26559
VEGA: 16
Homologene: 8742
Dsg4
Name: desmoglein 4
Synonyms: lah, CDHF13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 16769
Homologene: 65341
Hnrnpm
Name: heterogeneous nuclear ribonucleoprotein M
Synonyms: 2610023M21Rik, Hnrpm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 76936
HGNC: HGNC:5046
Homologene: 4354
Myo15
Name: myosin XV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17910
HGNC: HGNC:7594
Homologene: 56504
Olfr351
Name: olfactory receptor 351
Synonyms: GA_x6K02T2NLDC-33554926-33553994, MOR127-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258944
HGNC: HGNC:8221
Homologene: 10583
Csf1
Name: colony stimulating factor 1 (macrophage)
Synonyms: CSF-1, M-CSF, colony-stimulating factor-1, Csfm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12977
HGNC: HGNC:2432
Homologene: 7282
Nlrp2
Name: NLR family, pyrin domain containing 2
Synonyms: PYPAF2, E330007A02Rik, Nalp2, Pan1, Nbs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232827
Homologene: 56789
Vmn2r77
Name: vomeronasal 2, receptor 77
Synonyms: EG546983
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 546983
Homologene: 115466
Rsad2
Name: radical S-adenosyl methionine domain containing 2
Synonyms: Vig1, cig5, 2510004L01Rik, viperin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 58185
Homologene: 10969
Smc1b
Name: structural maintenance of chromosomes 1B
Synonyms: SMC1beta, Smc1l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 140557
VEGA: 15
Homologene: 13786
Spef2
Name: sperm flagellar 2
Synonyms: C230086A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 320277
Homologene: 23371
Olfr310
Name: olfactory receptor 310
Synonyms: GA_x6K02T2NHDJ-9838699-9839697, MOR227-6P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258222
Homologene: 128066
Kcnk4
Name: potassium channel, subfamily K, member 4
Synonyms: TRAAKt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 16528
VEGA: 19
HGNC: HGNC:6279
Homologene: 7391
Cenpj
Name: centromere protein J
Synonyms: 4932437H03Rik, Sas4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219103
Homologene: 10204
Tiam2
Name: T cell lymphoma invasion and metastasis 2
Synonyms: STEF, 3000002F19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 24001
VEGA: 17
Homologene: 40796
Vmn2r65
Name: vomeronasal 2, receptor 65
Synonyms: ENSMUSG00000070600
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100009609
Pgap4
Name: post-GPI attachment to proteins GalNAc transferase 4
Synonyms: 9330170P15Rik, 2810432L12Rik, Tmem246
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67063
Homologene: 12080
Phc2
Name: polyhomeotic 2
Synonyms: Mph2, D4Ertd810e, Edr2, D130050K19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 54383
HGNC: HGNC:3183
Homologene: 75090
Tmcc1
Name: transmembrane and coiled coil domains 1
Synonyms: 3632431M01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330401
Homologene: 8995
A930005H10Rik
Name: RIKEN cDNA A930005H10 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 68161
Mettl7b
Name: methyltransferase like 7B
Synonyms: 0610006F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71664
VEGA: 10
Homologene: 12400
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 2 at 36,860,175 bp
  • A to G, chromosome 2 at 84,880,512 bp
  • A to G, chromosome 3 at 107,756,630 bp
  • T to C, chromosome 3 at 115,888,004 bp
  • A to G, chromosome 4 at 49,586,919 bp
  • A to G, chromosome 4 at 128,745,087 bp
  • G to C, chromosome 6 at 116,022,110 bp
  • A to G, chromosome 7 at 5,329,015 bp
  • A to T, chromosome 7 at 84,947,416 bp
  • A to T, chromosome 7 at 86,268,855 bp
  • A to G, chromosome 7 at 86,801,622 bp
  • T to C, chromosome 10 at 128,960,698 bp
  • A to G, chromosome 11 at 60,477,974 bp
  • A to G, chromosome 12 at 26,445,440 bp
  • T to C, chromosome 14 at 56,534,854 bp
  • C to T, chromosome 15 at 9,647,263 bp
  • T to C, chromosome 15 at 85,107,070 bp
  • T to C, chromosome 16 at 90,472,464 bp
  • A to G, chromosome 17 at 3,414,197 bp
  • A to T, chromosome 17 at 33,658,415 bp
  • T to A, chromosome 18 at 20,446,247 bp
  • C to T, chromosome 19 at 6,927,663 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1392 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039454-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.