Strain Name:
C57BL/6J-MtgxR1397Btlr/Mmmh
Stock Number:
039459-MU
Citation ID:
RRID:MMRRC_039459-MU
Other Names:
R1397 (G1), C57BL/6J-MtgxR1397Btlr
Major Collection:

Strain Information

Drd1
Name: dopamine receptor D1
Synonyms: Drd-1, Gpcr15, D1 receptor, C030036C15Rik, Drd1a
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13488
VEGA: 13
HGNC: HGNC:3020
Homologene: 30992
Tnks2
Name: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Synonyms: Parp5b, 5430432P15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 74493
Homologene: 11890
Srrm1
Name: serine/arginine repetitive matrix 1
Synonyms: SRm160
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 51796
Srrt
Name: serrate RNA effector molecule homolog (Arabidopsis)
Synonyms: Asr2, 2810019G02Rik, Ars2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 83701
Homologene: 9298
Epb41l3
Name: erythrocyte membrane protein band 4.1 like 3
Synonyms: DAL1P, NBL3, Epb4.1l3, 4.1B
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13823
HGNC: HGNC:3380
Homologene: 49308
Iqgap2
Name: IQ motif containing GTPase activating protein 2
Synonyms: 4933417J23Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 544963
VEGA: 13
HGNC: HGNC:6111
Homologene: 101543
Nr2c2
Name: nuclear receptor subfamily 2, group C, member 2
Synonyms: Tr4, TAK1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22026
HGNC: HGNC:7972
Homologene: 2475
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: Loa, dynein heavy chain, retrograde transport, Dnchc1, Swl, MAP1C, 9930018I23Rik, Dnec1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Gtf3c3
Name: general transcription factor IIIC, polypeptide 3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98488
HGNC: HGNC:4666
Homologene: 40805
Vps13d
Name: vacuolar protein sorting 13D
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230895
Homologene: 15583
Abca17
Name: ATP-binding cassette, sub-family A member 17
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381072
Homologene: 86807
Itih5
Name: inter-alpha-trypsin inhibitor, heavy chain 5
Synonyms: 5430408M01Rik, 4631408O11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 209378
Homologene: 57115
Amph
Name: amphiphysin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218038
HGNC: HGNC:471
Homologene: 121585
Trim33
Name: tripartite motif-containing 33
Synonyms: ectodermin, Ecto, 8030451N04Rik, Tif1g
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 94093
Homologene: 9296
Fam13b
Name: family with sequence similarity 13, member B
Synonyms: 2610024E20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225358
VEGA: 18
HGNC: HGNC:1335
Homologene: 9585
Trim55
Name: tripartite motif-containing 55
Synonyms: D830041C10Rik, Murf2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 381485
Homologene: 13205
Trpm1
Name: transient receptor potential cation channel, subfamily M, member 1
Synonyms: 4732499L03Rik, melastatin, Mlsn1, LTRPC1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17364
HGNC: HGNC:7146
Homologene: 19940
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Nrp1
Name: neuropilin 1
Synonyms: NP-1, Npn1, NPN-1, Neuropilin-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18186
HGNC: HGNC:8004
Homologene: 2876
Arhgef10l
Name: Rho guanine nucleotide exchange factor 10-like
Synonyms: 2810441C07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72754
Homologene: 10017
Slc25a48
Name: solute carrier family 25, member 48
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 328258
Homologene: 27065
Rnpepl1
Name: arginyl aminopeptidase (aminopeptidase B)-like 1
Synonyms: 1110014H17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108657
Homologene: 36367
Pign
Name: phosphatidylinositol glycan anchor biosynthesis, class N
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 27392
HGNC: HGNC:8967
Homologene: 6330
Itih1
Name: inter-alpha trypsin inhibitor, heavy chain 1
Synonyms: inter-alpha (globulin) inhibitor, H1 polypeptide, Intin1, Itih-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16424
HGNC: HGNC:6166
Homologene: 1667
Pla2r1
Name: phospholipase A2 receptor 1
Synonyms: Pla2g1br, PLA2-I receptor, M-type receptor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18779
HGNC: HGNC:9042
Homologene: 32016
Trim42
Name: tripartite motif-containing 42
Synonyms: 4930486B16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78911
Homologene: 12712
Ankmy2
Name: ankyrin repeat and MYND domain containing 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217473
VEGA: 12
Homologene: 10662
Rrs1
Name: ribosome biogenesis regulator 1
Synonyms: 5730466A07Rik, D1Ertd701e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 59014
Homologene: 41014
Slc28a2
Name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 2
Synonyms: CNT2, 2010208B10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269346
Homologene: 20891
Sned1
Name: sushi, nidogen and EGF-like domains 1
Synonyms: 6720455I24Rik, D430044C15Rik, Snep
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208777
Homologene: 14708
Nfe2l3
Name: nuclear factor, erythroid derived 2, like 3
Synonyms: Nrf3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18025
HGNC: HGNC:7783
Homologene: 3168
Fam75d3
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Nid1
Name: nidogen 1
Synonyms: entactin, entactin 1, nidogen-1, entactin-1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18073
VEGA: 13
HGNC: HGNC:7821
Homologene: 1878
Chrac1
Name: chromatin accessibility complex 1
Synonyms: YCL1, 2410152E03Rik, 2810406L04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 93696
Homologene: 41174
Mfsd11
Name: major facilitator superfamily domain containing 11
Synonyms: 2600014M03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69900
Homologene: 11517
Rhbg
Name: Rhesus blood group-associated B glycoprotein
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 58176
Homologene: 9469
Rimkla
Name: ribosomal modification protein rimK-like family member A
Synonyms: NAAGS-II, Rimk
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 194237
Homologene: 18336
Pate2
Name: prostate and testis expressed 2
Synonyms: mANLP1, LOC330921
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330921
Homologene: 86016
Rabl3
Name: RAB, member RAS oncogene family-like 3
Synonyms: 4930553C05Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67657
Homologene: 12171
Krt9
Name: keratin 9
Synonyms: Krt1-9, K9
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 107656
HGNC: HGNC:6447
Homologene: 138337
Dmrtb1
Name: DMRT-like family B with proline-rich C-terminal, 1
Synonyms: Dmrt6, Prp13
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56296
Homologene: 13207
D330041H03Rik
Name: RIKEN cDNA D330041H03 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 654822
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 9,545,767 bp
  • C to T, chromosome 1 at 54,417,778 bp
  • C to A, chromosome 1 at 92,917,159 bp
  • G to A, chromosome 1 at 93,281,654 bp
  • A to G, chromosome 1 at 105,657,771 bp
  • A to T, chromosome 2 at 10,240,807 bp
  • C to A, chromosome 2 at 52,243,943 bp
  • T to A, chromosome 2 at 60,534,762 bp
  • T to A, chromosome 2 at 122,460,531 bp
  • T to C, chromosome 3 at 19,644,637 bp
  • C to T, chromosome 3 at 88,248,446 bp
  • A to G, chromosome 3 at 103,310,434 bp
  • G to C, chromosome 4 at 107,677,039 bp
  • C to T, chromosome 4 at 119,468,111 bp
  • A to C, chromosome 4 at 135,321,431 bp
  • C to T, chromosome 4 at 140,544,443 bp
  • C to T, chromosome 4 at 145,141,334 bp
  • A to G, chromosome 5 at 137,300,261 bp
  • T to C, chromosome 6 at 51,433,294 bp
  • T to C, chromosome 6 at 92,149,764 bp
  • T to C, chromosome 7 at 64,217,658 bp
  • T to G, chromosome 8 at 128,418,716 bp
  • T to A, chromosome 9 at 35,669,695 bp
  • T to A, chromosome 9 at 97,365,621 bp
  • A to T, chromosome 11 at 100,192,638 bp
  • T to C, chromosome 11 at 116,873,297 bp
  • T to C, chromosome 12 at 36,170,441 bp
  • G to A, chromosome 12 at 110,636,509 bp
  • G to A, chromosome 13 at 13,508,795 bp
  • G to A, chromosome 13 at 19,142,028 bp
  • A to G, chromosome 13 at 54,053,554 bp
  • A to C, chromosome 13 at 56,465,051 bp
  • C to T, chromosome 13 at 59,705,039 bp
  • A to G, chromosome 13 at 95,632,165 bp
  • C to T, chromosome 14 at 30,929,905 bp
  • A to G, chromosome 15 at 73,090,444 bp
  • C to T, chromosome 16 at 37,539,974 bp
  • T to C, chromosome 17 at 24,285,759 bp
  • C to T, chromosome 17 at 24,412,057 bp
  • T to A, chromosome 17 at 69,262,348 bp
  • C to T, chromosome 18 at 34,445,583 bp
  • T to C, chromosome 19 at 36,880,501 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1397 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039459-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.