Strain Name:
C57BL/6J-MtgxR1416Btlr/Mmmh
Stock Number:
039472-MU
Citation ID:
RRID:MMRRC_039472-MU
Other Names:
R1416 (G1), C57BL/6J-MtgxR1416Btlr
Major Collection:

Strain Information

Icos
Name: inducible T cell co-stimulator
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 54167
HGNC: HGNC:5351
Homologene: 8097
Thbs4
Name: thrombospondin 4
Synonyms: TSP-4, TSP4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21828
Homologene: 20691
Arpp21
Name: cyclic AMP-regulated phosphoprotein, 21
Synonyms: ARPP-21, D9Bwg1012e, Tarpp, R3hdm3, 0710001E13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74100
Homologene: 32306
Ubp1
Name: upstream binding protein 1
Synonyms: LBP-1b, LBP-1a, NF2d9
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22221
VEGA: 9
Homologene: 8435
Efnb2
Name: ephrin B2
Synonyms: Epl5, LERK-5, ELF-2, Htk-L, NLERK-1, Eplg5, Lerk5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13642
HGNC: HGNC:3227
Homologene: 3019
Mtor
Name: mechanistic target of rapamycin kinase
Synonyms: flat, RAPT1, 2610315D21Rik, RAFT1, Frap1, mechanistic target of rapamycin (serine/threonine kinase), FKBP-rapamycin-associated protein FRAP
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56717
HGNC: HGNC:3942
Homologene: 3637
Trip10
Name: thyroid hormone receptor interactor 10
Synonyms: Cip4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106628
VEGA: 17
Homologene: 99728
Epb41l5
Name: erythrocyte membrane protein band 4.1 like 5
Synonyms: 1700030C16Rik, Lulu1, NBL5, Epb4.1l5, E230025E14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226352
Homologene: 32492
Cep41
Name: centrosomal protein 41
Synonyms: 1700017E11Rik, 2810431D15Rik, Cep41, Tsga14
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 83922
Homologene: 10284
Arfgef1
Name: ADP ribosylation factor guanine nucleotide exchange factor 1
Synonyms: BIG1, P200, ARFGEP1, D730028O18Rik, D130059B05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 211673
Homologene: 4687
Rarb
Name: retinoic acid receptor, beta
Synonyms: Hap, RARbeta2, RAR beta 2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218772
VEGA: 14
HGNC: HGNC:9865
Homologene: 68100
Taf2
Name: TATA-box binding protein associated factor 2
Synonyms: 4732460C16Rik, TAF2B, TAFII150, 150kDa, CIF150
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 319944
VEGA: 15
Homologene: 31137
Ipo8
Name: importin 8
Synonyms: OM-1, Ranbp8, Om1, C130009K11Rik, 6230418K12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320727
HGNC: HGNC:9853
Homologene: 48430
Sucla2
Name: succinate-Coenzyme A ligase, ADP-forming, beta subunit
Synonyms: 4930547K18Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 20916
Homologene: 2856
Ccdc141
Name: coiled-coil domain containing 141
Synonyms: ENSMUSG00000075261, 2610301F02Rik, CAMDI
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 545428
Homologene: 52149
Pabir2
Name: PABIR family member 2
Synonyms: Fam122b, 4632404H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 78755
Homologene: 12700
Otud6b
Name: OTU domain containing 6B
Synonyms: 2600013N14Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72201
Homologene: 6064
Eya3
Name: EYA transcriptional coactivator and phosphatase 3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14050
HGNC: HGNC:3521
Homologene: 1508
Ern1
Name: endoplasmic reticulum to nucleus signalling 1
Synonyms: Ire1alpha, 9030414B18Rik, Ire1p, Ire1a
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 78943
HGNC: HGNC:3449
Homologene: 55580
Ubr3
Name: ubiquitin protein ligase E3 component n-recognin 3
Synonyms: A130030D10Rik, Zfp650, 4833421P10Rik, 1110059H15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68795
Homologene: 52092
Anxa7
Name: annexin A7
Synonyms: synexin, Anx7
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11750
VEGA: 14
HGNC: HGNC:545
Homologene: 36149
Bcr
Name: BCR activator of RhoGEF and GTPase
Synonyms: 5133400C09Rik, breakpoint cluster region
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 110279
VEGA: 10
HGNC: HGNC:1014
Homologene: 3192
Zfp105
Name: zinc finger protein 105
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22646
Homologene: 2568
Taf4b
Name: TATA-box binding protein associated factor 4b
Synonyms: 105kDa, 4932409F03Rik, Taf2c2, 2610524B04Rik, TAFII105
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 72504
VEGA: 18
Homologene: 28266
Smox
Name: spermine oxidase
Synonyms: B130066H01Rik, SMO
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228608
Homologene: 69268
Zfp287
Name: zinc finger protein 287
Synonyms: B230333C16Rik, SKAT-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 170740
Homologene: 23244
Rusc2
Name: RUN and SH3 domain containing 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100213
Homologene: 18967
Setd1b
Name: SET domain containing 1B
Synonyms: KMT2G
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 208043
Homologene: 134654
Uckl1
Name: uridine-cytidine kinase 1-like 1
Synonyms: Urkl1, 1110007H10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68556
Homologene: 101414
Ush2a
Name: usherin
Synonyms: MUSH2A, LOC269160, Ush2a, A930037M10Rik, A930011D15Rik, LOC381317, Ushrn
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Afm
Name: afamin
Synonyms: Alf, alpha albumin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 280662
HGNC: HGNC:316
Homologene: 881
Lrp12
Name: low density lipoprotein-related protein 12
Synonyms: C820005L12Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239393
Homologene: 8385
Cplane1
Name: ciliogenesis and planar polarity effector 1
Synonyms: Hug, Jbts17, 2410089E03Rik, b2b012Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 73692
Homologene: 11315
Ptpro
Name: protein tyrosine phosphatase receptor type O
Synonyms: D28, PTPROt, Ptpn15, PTP-oc, GLEPP1, PTP-U2, PTP-BK, PTP-phi
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19277
HGNC: HGNC:9678
Homologene: 21564
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Stard9
Name: StAR related lipid transfer domain containing 9
Synonyms: Kif16a, E230025N21Rik, 4831403C07Rik, N-3 kinesin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668880
Homologene: 130712
Scap
Name: SREBF chaperone
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235623
Homologene: 8160
Wdr64
Name: WD repeat domain 64
Synonyms: 4930511H01Rik, 4930415O10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75820
Homologene: 51634
Ccdc39
Name: coiled-coil domain containing 39
Synonyms: b2b1304Clo, b2b2025.1Clo, b2b1735Clo, 4921507O14Rik, prh, D3Ertd789e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 51938
Homologene: 12149
Vmn2r63
Name: vomeronasal 2, receptor 63
Synonyms: EG435975
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 435975
Homologene: 104832
Nsun7
Name: NOL1/NOP2/Sun domain family, member 7
Synonyms: 4921525L17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70918
Homologene: 11653
Or9m1b
Name: olfactory receptor family 9 subfamily M member 1B
Synonyms: Olfr1160, GA_x6K02T2Q125-49498697-49497765, MOR173-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258643
Homologene: 74192
Acad11
Name: acyl-Coenzyme A dehydrogenase family, member 11
Synonyms: 5730439E10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102632
Homologene: 49896
Tmem241
Name: transmembrane protein 241
Synonyms: 6030446N20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 338363
Homologene: 87267
Or5p5
Name: olfactory receptor family 5 subfamily P member 5
Synonyms: MOR204-33P, GA_x6K02T2PBJ9-10144091-10145011, Olfr467
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257919
Homologene: 81542
Nrap
Name: nebulin-related anchoring protein
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18175
HGNC: HGNC:7988
Homologene: 4499
Olfr144
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Col5a1
Name: collagen, type V, alpha 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12831
HGNC: HGNC:2209
Homologene: 55434
Eri2
Name: exoribonuclease 2
Synonyms: 4933424N09Rik, Exod1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71151
Homologene: 12383
Tmem168
Name: transmembrane protein 168
Synonyms: 8430437G11Rik, 5730526F17Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101118
Homologene: 11202
Raly
Name: hnRNP-associated with lethal yellow
Synonyms: Merc
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19383
Homologene: 7216
Or8k27
Name: olfactory receptor family 8 subfamily K member 27
Synonyms: MOR190-1, Olfr1065, GA_x6K02T2Q125-47915274-47914333
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258403
Homologene: 74195
Alox5
Name: arachidonate 5-lipoxygenase
Synonyms: 5LO, 5-LOX, 5LX
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11689
HGNC: HGNC:435
Homologene: 561
Sult4a1
Name: sulfotransferase family 4A, member 1
Synonyms: BR-STL-1, Sultx3, 2400007A17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 29859
VEGA: 15
Homologene: 49378
Tigd3
Name: tigger transposable element derived 3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 332359
VEGA: 19
Homologene: 129795
Vmn1r62
Name: vomeronasal 1 receptor 62
Synonyms: V1rd8, V1rd2, V3R2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 81016
Homologene: 41799
Ppp4r3c2
Name: protein phosphatase 4 regulatory subunit 3C2
Synonyms: 4932429P05Rik
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 245509
Homologene: 87617
Pp2d1
Name: protein phosphatase 2C-like domain containing 1
Synonyms: 4921523A10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 110332
VEGA: 17
Homologene: 16981
Vmn2r67
Name: vomeronasal 2, receptor 67
Synonyms: EG620672
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 620672
Homologene: 115466
Gm17661
Name: predicted gene, 17661
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Pwwp4a
Name: PWWP domain containing 4A
Synonyms: Gm14685
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 574404
Homologene: 128534
Or5an11
Name: olfactory receptor family 5 subfamily AN member 11
Synonyms: Olfr235, Olfr232, Olfr245, MOR214-3, GA_x6K02T2LL2P-1028-792, MOR214-3, GA_x6K02T057QT-4025-4642, GA_x6K02T03CT6-1-477
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258681
Mettl5
Name: methyltransferase 5, N6-adenosine
Synonyms: 2810410A08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75422
Homologene: 8570
Tmem169
Name: transmembrane protein 169
Synonyms: A830020B06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 271711
Homologene: 16305
Shisa3
Name: shisa family member 3
Synonyms: mShisa3, D830007B15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 330096
Homologene: 47831
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 10,172,939 bp
  • T to C, chromosome 1 at 60,994,643 bp
  • G to T, chromosome 1 at 72,300,716 bp
  • T to C, chromosome 1 at 119,549,876 bp
  • A to G, chromosome 1 at 175,806,002 bp
  • C to T, chromosome 1 at 188,436,883 bp
  • T to G, chromosome 2 at 27,922,064 bp
  • A to G, chromosome 2 at 40,998,216 bp
  • A to T, chromosome 2 at 69,871,289 bp
  • A to G, chromosome 2 at 69,945,071 bp
  • T to C, chromosome 2 at 77,014,796 bp
  • T to C, chromosome 2 at 86,445,320 bp
  • T to A, chromosome 2 at 88,006,571 bp
  • GA to GAA, chromosome 2 at 90,917,709 bp
  • T to C, chromosome 2 at 120,700,972 bp
  • C to T, chromosome 2 at 131,522,131 bp
  • G to T, chromosome 2 at 154,857,353 bp
  • A to T, chromosome 2 at 181,569,569 bp
  • T to C, chromosome 3 at 33,826,480 bp
  • A to C, chromosome 4 at 14,818,473 bp
  • A to G, chromosome 4 at 43,421,617 bp
  • T to C, chromosome 4 at 132,707,129 bp
  • G to T, chromosome 4 at 148,491,414 bp
  • T to C, chromosome 5 at 66,261,080 bp
  • C to G, chromosome 5 at 67,611,434 bp
  • T to C, chromosome 5 at 90,526,379 bp
  • C to T, chromosome 5 at 123,160,685 bp
  • A to T, chromosome 6 at 13,591,401 bp
  • C to T, chromosome 6 at 30,657,357 bp
  • G to A, chromosome 6 at 116,423,145 bp
  • T to A, chromosome 6 at 137,443,594 bp
  • A to G, chromosome 6 at 148,789,093 bp
  • T to C, chromosome 7 at 5,675,905 bp
  • T to A, chromosome 7 at 42,927,915 bp
  • T to A, chromosome 7 at 85,151,616 bp
  • T to C, chromosome 7 at 107,815,262 bp
  • A to G, chromosome 7 at 119,791,174 bp
  • A to G, chromosome 8 at 8,622,329 bp
  • G to C, chromosome 9 at 39,238,251 bp
  • T to C, chromosome 9 at 104,073,623 bp
  • T to C, chromosome 9 at 110,384,773 bp
  • T to C, chromosome 9 at 112,179,129 bp
  • T to C, chromosome 9 at 113,970,171 bp
  • A to T, chromosome 9 at 122,930,677 bp
  • A to T, chromosome 10 at 75,061,506 bp
  • A to T, chromosome 11 at 62,714,340 bp
  • C to T, chromosome 11 at 106,421,980 bp
  • G to T, chromosome 13 at 92,761,533 bp
  • T to C, chromosome 14 at 16,435,177 bp
  • G to A, chromosome 14 at 20,462,707 bp
  • C to T, chromosome 14 at 73,560,634 bp
  • C to T, chromosome 15 at 8,246,938 bp
  • T to C, chromosome 15 at 39,878,623 bp
  • G to T, chromosome 15 at 55,038,410 bp
  • C to T, chromosome 15 at 84,086,646 bp
  • T to C, chromosome 17 at 53,515,807 bp
  • A to G, chromosome 17 at 57,250,800 bp
  • T to C, chromosome 18 at 11,993,574 bp
  • T to C, chromosome 18 at 14,821,427 bp
  • T to C, chromosome 19 at 5,891,725 bp
  • C to A, chromosome 19 at 12,268,894 bp
  • A to G, chromosome 19 at 56,327,293 bp
  • T to C, chromosome X at 53,246,146 bp
  • G to T, chromosome X at 73,127,655 bp
  • A to T, chromosome X at 89,753,677 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1416 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039472-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.